cell size


Summary: The quantity of volume or surface area of CELLS.

Top Publications

  1. Ahmed M, Langer H, Abed M, Voelkl J, Lang F. The uremic toxin acrolein promotes suicidal erythrocyte death. Kidney Blood Press Res. 2013;37:158-67 pubmed publisher
    ..Erythrocytes could be sensitized to cytosolic Ca(2+) by ceramide. In end stage renal disease, eryptosis may possibly be stimulated by uremic toxins. The present study explored, whether the uremic toxin acrolein could trigger eryptosis...
  2. Truong S, McCormick R, Polymenis M. Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae. G3 (Bethesda). 2013;3:1525-30 pubmed publisher
    ..Surprisingly, there was little, if any, correlation between mean cell size and cell-cycle progression...
  3. Liu Y, Yan X, Zhou T. TBCK influences cell proliferation, cell size and mTOR signaling pathway. PLoS ONE. 2013;8:e71349 pubmed publisher
    ..Depletion of TBCK significantly inhibits cell proliferation, reduces cell size, and disrupts the organization of actin, but not microtubule...
  4. Yin X, Lanza I, Swain J, Sarr M, Nair K, Jensen M. Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. J Clin Endocrinol Metab. 2014;99:E209-16 pubmed publisher
    ..Our goal was to examine whether obesity, independent of fat cell size and fat depot, is associated with mitochondria dysfunction...
  5. Jilani K, Lang F. Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane. Toxins (Basel). 2013;5:703-16 pubmed publisher
    ..The effect on annexin V binding was significantly blunted in the absence of extracellular Ca²?. In conclusion, carmustine stimulates eryptosis at least partially by increasing cytosolic Ca²? activity...
  6. Brodribb T, Jordan G, Carpenter R. Unified changes in cell size permit coordinated leaf evolution. New Phytol. 2013;199:559-70 pubmed publisher
    ..Our data also imply the presence of alternative evolutionary strategies involving cellular miniaturization during radiation into closed forest, and cell size increase in open habitats.
  7. Jilani K, Enkel S, Bissinger R, Almilaji A, Abed M, Lang F. Fluoxetine induced suicidal erythrocyte death. Toxins (Basel). 2013;5:1230-43 pubmed publisher
    ..The effect on annexin V binding was significantly blunted, but not abolished, in the absence of extracellular Ca2+. In conclusion, fluoxetine stimulates eryptosis, an effect at least in part due to increase of cytosolic Ca2+ activity. ..
  8. Hill N, Buske P, Shi Y, Levin P. A moonlighting enzyme links Escherichia coli cell size with central metabolism. PLoS Genet. 2013;9:e1003663 pubmed publisher
    ..Here we report the identification of the glucosyltransferase OpgH as a nutrient-dependent regulator of E. coli cell size. During growth under nutrient-rich conditions, OpgH localizes to the nascent septal site, where it antagonizes ..
  9. Feric M, Brangwynne C. A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. Nat Cell Biol. 2013;15:1253-9 pubmed publisher
    ..All life forms are subject to gravity, and our results may have broad implications for cell growth and size control. ..

Scientific Experts

More Information


  1. Lloyd A. The regulation of cell size. Cell. 2013;154:1194-205 pubmed publisher
    An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood...
  2. Wood E, Nurse P. Pom1 and cell size homeostasis in fission yeast. Cell Cycle. 2013;12:3228-36 pubmed publisher
    ..sense their size and use this information to coordinate cell division with cell growth to maintain a constant cell size within a given population...
  3. Sengupta B, Faisal A, Laughlin S, Niven J. The effect of cell size and channel density on neuronal information encoding and energy efficiency. J Cereb Blood Flow Metab. 2013;33:1465-73 pubmed publisher
    ..Three of the main determinants are cell size, ion channel density, and stimulus statistics...
  4. Goodman R, Echternacht A, Hall J, Deng L, Welch J. Influence of geography and climate on patterns of cell size and body size in the lizard Anolis carolinensis. Integr Zool. 2013;8:184-96 pubmed publisher
    ..This study investigated patterns of body size and cell size of the green anole lizard, Anolis carolinensis, and potential associations with geography or climatic variables...
  5. Hazel J, Krutkramelis K, Mooney P, Tomschik M, Gerow K, Oakey J, et al. Changes in cytoplasmic volume are sufficient to drive spindle scaling. Science. 2013;342:853-6 pubmed publisher
    ..The mechanism responsible for this scaling is unclear, because uncoupling cell size from a developmental or cellular context has proven experimentally challenging...
  6. Starostová Z, Konarzewski M, Kozłowski J, Kratochvíl L. Ontogeny of metabolic rate and red blood cell size in eyelid geckos: species follow different paths. PLoS ONE. 2013;8:e64715 pubmed publisher
  7. Good M, Vahey M, Skandarajah A, Fletcher D, Heald R. Cytoplasmic volume modulates spindle size during embryogenesis. Science. 2013;342:856-60 pubmed publisher
    ..whether spindle size regulation is achieved through a developmental program or is intrinsically specified by cell size or shape, we developed a system to encapsulate cytoplasm from Xenopus eggs and embryos inside cell-like ..
  8. Sarikaya D, Belay A, Ahuja A, Dorta A, Green D, Extavour C. The roles of cell size and cell number in determining ovariole number in Drosophila. Dev Biol. 2012;363:279-89 pubmed publisher
    ..We induced changes in ovariole number in Drosophila melanogaster by genetically altering cell size and cell number in the TFC population, and analyzed TF morphogenesis in these ovaries to understand the cellular ..
  9. Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees E, et al. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS ONE. 2012;7:e32700 pubmed publisher
    ..Moreover, PTP1B does not appear to be the major negative regulator of the IR in adipocytes. ..
  10. Hill N, Kadoya R, Chattoraj D, Levin P. Cell size and the initiation of DNA replication in bacteria. PLoS Genet. 2012;8:e1002549 pubmed publisher
    ..subtilis mutants that are ~30% smaller than wild-type cells, indicating that achievement of a particular cell size is not obligatory for initiation...
  11. Shaik N, Lupescu A, Lang F. Sunitinib-sensitive suicidal erythrocyte death. Cell Physiol Biochem. 2012;30:512-22 pubmed publisher
    ..Sunitinib, however, did not significantly modify cytosolic ATP and ceramide abundance. The present observations reveal that sunitinib is able to trigger suicidal death in erythrocytes even in the absence of nuclei and mitochondria...
  12. Munksgaard P, Vorup Jensen T, Reinholdt J, Söderström C, Poulsen K, Leipziger J, et al. Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes. Cell Microbiol. 2012;14:1904-20 pubmed publisher
    ..We observed that LtxA initially decreases the cell size, followed by a gradual rise in volume until the cell finally lyses...
  13. Moyano Cañete E, Bellido M, García Caparrós N, Medina Puche L, Amil Ruiz F, González Reyes J, et al. FaGAST2, a strawberry ripening-related gene, acts together with FaGAST1 to determine cell size of the fruit receptacle. Plant Cell Physiol. 2013;54:218-36 pubmed publisher
    ..through RNA interference approaches revealed an increase in FaGAST1 expression, but no changes in fruit cell size were observed...
  14. Kucherenko Y, Zelenak C, Eberhard M, Qadri S, Lang F. Effect of casein kinase 1? activator pyrvinium pamoate on erythrocyte ion channels. Cell Physiol Biochem. 2012;30:407-17 pubmed publisher
  15. Lewis R, Feetham C, Barrett Jolley R. Cell volume regulation in chondrocytes. Cell Physiol Biochem. 2011;28:1111-22 pubmed publisher
    ..A critical question is whether disturbances of volume regulation mechanisms lead to, result from or are simply coincidental to cartilage damage. ..
  16. Gao M, Cheung K, Lau I, Yu W, Fung K, Yu B, et al. Polyphyllin D induces apoptosis in human erythrocytes through Ca²? rise and membrane permeabilization. Arch Toxicol. 2012;86:741-52 pubmed publisher
    ..Taken together, we report here for the first time the toxicity of PD in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. ..
  17. Kitami T, Logan D, Negri J, Hasaka T, Tolliday N, Carpenter A, et al. A chemical screen probing the relationship between mitochondrial content and cell size. PLoS ONE. 2012;7:e33755 pubmed publisher
    ..we developed a high-throughput imaging assay that tracks both the per cell mitochondrial content and the cell size in confluent human umbilical vein endothelial cells...
  18. Chien A, Hill N, Levin P. Cell size control in bacteria. Curr Biol. 2012;22:R340-9 pubmed publisher
    ..As single-celled organisms, nutrient availability is one of the strongest influences on bacterial cell size. Classic physiological experiments conducted over four decades ago first demonstrated that cell size is directly ..
  19. Latger Cannard V, Hoarau M, Salignac S, Baumgart D, Nurden P, Lecompte T. Mean platelet volume: comparison of three analysers towards standardization of platelet morphological phenotype. Int J Lab Hematol. 2012;34:300-10 pubmed publisher
  20. Marguerat S, Bahler J. Coordinating genome expression with cell size. Trends Genet. 2012;28:560-5 pubmed publisher
    b>Cell size is highly variable; cells from various tissues differ in volume over orders of magnitudes, from tiny lymphocytes to giant neurons, and cells of a given type change size during the cell cycle...
  21. Anastasia S, Nguyen D, Thai V, Meloy M, Macdonough T, Kellogg D. A link between mitotic entry and membrane growth suggests a novel model for cell size control. J Cell Biol. 2012;197:89-104 pubmed publisher
    ..Growth-dependent signaling could explain how membrane growth is integrated with cell cycle progression. It could also control both cell size and morphogenesis, thereby reconciling divergent models for mitotic checkpoint function.
  22. Bartley S, Tzeng Y, Heel K, Lee C, Mowlaboccus S, Seemann T, et al. Attachment and invasion of Neisseria meningitidis to host cells is related to surface hydrophobicity, bacterial cell size and capsule. PLoS ONE. 2013;8:e55798 pubmed publisher
    ..This study shows that there is diversity in bacterial cell surface area and surface hydrophobicity within N. meningitidis which influence steps in meningococcal pathogenesis...
  23. Lang E, Qadri S, Jilani K, Zelenak C, Lupescu A, Schleicher E, et al. Carbon monoxide-sensitive apoptotic death of erythrocytes. Basic Clin Pharmacol Toxicol. 2012;111:348-55 pubmed publisher
    ..In conclusion, CORM-2 stimulates cell membrane scrambling of erythrocytes, an effect largely due to Ca²? entry and partially reversed by O?...
  24. Peter K, Sommer U. Phytoplankton cell size: intra- and interspecific effects of warming and grazing. PLoS ONE. 2012;7:e49632 pubmed publisher
    ..Size shifts of individual phytoplankton species and community mean size were analyzed. Both, mean cell size of most of the individual species and mean community cell size decreased with temperature under all grazing ..
  25. Abed M, Towhid S, Mia S, Pakladok T, Alesutan I, Borst O, et al. Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells. Am J Physiol Cell Physiol. 2012;303:C991-9 pubmed publisher
    ..Thus exposure to sphingomyelinase or C6-ceramide triggers eryptosis followed by phosphatidylserine- and CXCL16-sensitive adhesion of eryptotic erythrocytes to HUVEC. ..
  26. Davie E, Petersen J. Environmental control of cell size at division. Curr Opin Cell Biol. 2012;24:838-44 pubmed publisher
    ..To increase cell size the active TOR Complex 1 (TORC1) promotes cell growth to delay mitosis and cell division, whereas under limited ..
  27. Qadri S, Kucherenko Y, Zelenak C, Jilani K, Lang E, Lang F. Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling. Cell Physiol Biochem. 2011;28:857-64 pubmed publisher
    ..In conclusion, dicoumarol stimulates suicidal death of erythrocytes by stimulating Ca(2+) entry and subsequent triggering of Ca(2+) dependent cell membrane scrambling...
  28. Compan V, Baroja Mazo A, Lopez Castejon G, Gómez A, Martinez C, Angosto D, et al. Cell volume regulation modulates NLRP3 inflammasome activation. Immunity. 2012;37:487-500 pubmed publisher
    ..Collectively, our data identify cell volume regulation as a basic conserved homeostatic mechanism associated with the formation of the NLRP3 inflammasome and reveal a mechanism for NLRP3 inflammasome activation. ..
  29. Gatidis S, Zelenak C, Fajol A, Lang E, Jilani K, Michael D, et al. p38 MAPK activation and function following osmotic shock of erythrocytes. Cell Physiol Biochem. 2011;28:1279-86 pubmed publisher
    ..In conclusion, p38 kinase is expressed in erythrocytes and participates in the machinery triggering eryptosis following hyperosmotic shock...
  30. Oncel M, Ozdemir R, Yurttutan S, Canpolat F, Erdeve O, Oguz S, et al. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012;26:493-6 pubmed publisher
    ..The aim of this study was to investigate any changes in mean platelet volume (MPV) in patients with neonatal sepsis (NS)...
  31. Tolley B, Sage T, Langdale J, Hibberd J. Individual maize chromosomes in the C(3) plant oat can increase bundle sheath cell size and vein density. Plant Physiol. 2012;159:1418-27 pubmed publisher
    ..These data provide proof of principle that aspects of C(4) biology could be integrated into leaves of C(3) crops. ..
  32. Calvert M, Wright G, Leong F, Chiam K, Chen Y, Jedd G, et al. Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction. J Cell Biol. 2011;195:799-813 pubmed publisher
    ..Because the mechanical characteristics of contractile rings are conserved, we predict that these findings will be relevant to actomyosin ring constriction in other cell types. ..
  33. Andriankaja M, Dhondt S, De Bodt S, Vanhaeren H, Coppens F, De Milde L, et al. Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process. Dev Cell. 2012;22:64-78 pubmed publisher
    ..Hence, differentiation of the photosynthetic machinery is important for regulating the exit from proliferation. ..
  34. Borst O, Abed M, Alesutan I, Towhid S, Qadri S, Foller M, et al. Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX. Am J Physiol Cell Physiol. 2012;302:C644-51 pubmed publisher
    ..The present observations demonstrate that eryptotic erythrocytes adhere to endothelial cells of the vascular wall in part by interaction of phosphatidylserine exposed at the erythrocyte surface with endothelial CXCL16. ..
  35. Janowski M, Lyczek A, Engels C, Xu J, Lukomska B, Bulte J, et al. Cell size and velocity of injection are major determinants of the safety of intracarotid stem cell transplantation. J Cereb Blood Flow Metab. 2013;33:921-7 pubmed publisher
    ..complications, including the development of stroke, for the following experimental variables: cell size, cell dose, cell infusion velocity, delay between artery occlusion and cell infusion, discordant versus ..
  36. Zelenak C, Pasham V, Jilani K, Tripodi P, Rosaclerio L, Pathare G, et al. Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure. Cell Physiol Biochem. 2012;30:282-94 pubmed publisher
    ..e. triggering of Ca(2+) entry, ATP depletion and ceramide formation in erythrocytes, events eventually leading to eryptosis with cell shrinkage and cell membrane scrambling...
  37. Di Giusto G, Flamenco P, Rivarola V, Fernandez J, Melamud L, Ford P, et al. Aquaporin 2-increased renal cell proliferation is associated with cell volume regulation. J Cell Biochem. 2012;113:3721-9 pubmed publisher
    ..Therefore, during cell cycle, a coordinated modulation of the RVD activity may contribute to accelerate proliferation of cells expressing AQP2. ..
  38. Krahe T, El Danaf R, Dilger E, Henderson S, Guido W. Morphologically distinct classes of relay cells exhibit regional preferences in the dorsal lateral geniculate nucleus of the mouse. J Neurosci. 2011;31:17437-48 pubmed publisher
    ..Overall, these data coupled with recent observations in the retina suggest that the mouse has many of the hallmark features of a system-wide parallel organization. ..
  39. Benesova J, Rusnakova V, Honsa P, Pivonkova H, Dzamba D, Kubista M, et al. Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice. PLoS ONE. 2012;7:e29725 pubmed publisher
    ..Thus, we propose that the diverse volume changes displayed by cortical astrocytes during OGD mainly result from their distinct expression patterns of ClC2 and K(2P) channels. ..
  40. Edwards K, Klausmeier C, Litchman E. Evidence for a three-way trade-off between nitrogen and phosphorus competitive abilities and cell size in phytoplankton. Ecology. 2011;92:2085-95 pubmed
    ..Here we demonstrate a three-way trade-off between cell size and competitive abilities for nitrogen and phosphorus in marine and freshwater phytoplankton...
  41. Nicolescu M, Popescu L. Telocytes in the interstitium of human exocrine pancreas: ultrastructural evidence. Pancreas. 2012;41:949-56 pubmed publisher
    ..Telocytes were initially described as interstitial Cajal-like cells, but it gradually became clear that they were a distinct novel cell type not directly related to canonical interstitial Cajal cells...
  42. Zelenak C, Eberhard M, Jilani K, Qadri S, Macek B, Lang F. Protein kinase CK1? regulates erythrocyte survival. Cell Physiol Biochem. 2012;29:171-80 pubmed publisher
    ..In conclusion, CK1 isoform ? participates in the regulation of erythrocyte programmed cell death by modulating cytosolic Ca(2+) activity...
  43. Nicolas P, Lecourieux D, Gom s E, Delrot S, Lecourieux F. The grape berry-specific basic helix-loop-helix transcription factor VvCEB1 affects cell size. J Exp Bot. 2013;64:991-1003 pubmed publisher
    ..Taken together, these data show that VvCEB1 is a fruit-specific bHLH transcription factor involved in grape berry development...
  44. Garrett Q, Khandekar N, Shih S, Flanagan J, Simmons P, Vehige J, et al. Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress. Exp Eye Res. 2013;108:33-41 pubmed publisher
    ..We demonstrated that the transport of betaine was facilitated by increased osmolarity. In conclusion, betaine stabilized corneal epithelial cell volume under hyperosmotic stress and limited hyperosmotic stress-induced HCLE apoptosis...
  45. Zbidah M, Lupescu A, Jilani K, Lang F. Stimulation of suicidal erythrocyte death by fumagillin. Basic Clin Pharmacol Toxicol. 2013;112:346-51 pubmed publisher
    ..The present observations disclose a novel effect of fumagillin, that is, stimulation of eryptosis, paralleled by Ca(2+) entry, ceramide formation, phosphatidylserine exposure and decrease of cell volume. ..
  46. Shaik N, Zbidah M, Lang F. Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. Cell Physiol Biochem. 2012;30:678-86 pubmed publisher
    ..In conclusion, naringin blunts the increase of cytosolic Ca(2+) concentration, the shrinkage, the cell membrane scrambling and thus the suicidal death of erythrocytes following energy depletion or oxidative stress...
  47. Levy D, Heald R. Mechanisms of intracellular scaling. Annu Rev Cell Dev Biol. 2012;28:113-35 pubmed publisher
    b>Cell size varies widely among different organisms as well as within the same organism in different tissue types and during development, which places variable metabolic and functional demands on organelles and internal structures...
  48. Hoose S, Rawlings J, Kelly M, Leitch M, Ababneh Q, Robles J, et al. A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet. 2012;8:e1002590 pubmed publisher
    ..The identity and complete sequence of those events remain unknown. Previous studies relied mainly on cell size changes to identify systematically genes required for the timely completion of START...
  49. Dessalle K, Euthine V, Chanon S, Delarichaudy J, Fujii I, Rome S, et al. SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors. PLoS ONE. 2012;7:e50878 pubmed publisher
    ..Our results point out the roles of MRFs in the maintenance of the protein content and cell size in adult muscle fibre, and contribute to decipher the mechanisms by which SREBP-1 regulate muscle mass.
  50. Akita T, Fedorovich S, Okada Y. Ca2+ nanodomain-mediated component of swelling-induced volume-sensitive outwardly rectifying anion current triggered by autocrine action of ATP in mouse astrocytes. Cell Physiol Biochem. 2011;28:1181-90 pubmed publisher
    ..Thus the swelling-induced VSOR channel activation in mouse astrocytes is partly regulated via Ca(2+) nanodomains, whose generation is triggered by an autocrine action of ATP. ..
  51. Zbidah M, Lupescu A, Shaik N, Lang F. Gossypol-induced suicidal erythrocyte death. Toxicology. 2012;302:101-5 pubmed publisher
    ..The present observations reveal a novel effect of gossypol on human erythrocytes, which contributes to or even accounts for the triggering of anemia by this substance...
  52. Lupescu A, Shaik N, Jilani K, Zelenak C, Lang E, Pasham V, et al. Enhanced erythrocyte membrane exposure of phosphatidylserine following sorafenib treatment: an in vivo and in vitro study. Cell Physiol Biochem. 2012;30:876-88 pubmed publisher
    ..Signaling leading to eryptosis include increase in cytosolic Ca(2+)activity ([Ca(2+)](i)), formation of ceramide, ATP-depletion and oxidative stress. The present study explored, whether sorafenib triggers eryptosis in vitro and in vivo...
  53. Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner M, et al. Direct observation of mammalian cell growth and size regulation. Nat Methods. 2012;9:910-2 pubmed publisher
    ..Cell lineage analysis revealed a decrease in the growth rate variability at the G1-S phase transition, which suggests the presence of a growth rate threshold for maintaining size homeostasis. ..