cell shape


Summary: The quality of surface form or outline of CELLS.

Top Publications

  1. Legoff L, Rouault H, Lecuit T. A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc. Development. 2013;140:4051-9 pubmed publisher
    ..This pattern has important consequences on cell shape in the wing pouch: cells respond to it by polarizing their acto-myosin cortex, and aligning their divisions with ..
  2. Martin A, Goldstein B. Apical constriction: themes and variations on a cellular mechanism driving morphogenesis. Development. 2014;141:1987-98 pubmed publisher
    Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates...
  3. Razzell W, Wood W, Martin P. Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation. Development. 2014;141:1814-20 pubmed publisher
    ..These events recapitulate cell rearrangements that occur during germband extension, in which intercalation events drive the elongation of tissues. ..
  4. McWhorter F, Wang T, Nguyen P, Chung T, Liu W. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A. 2013;110:17253-8 pubmed publisher
    ..prohealing (M2) activation. Specifically, the role of cell shape has not been explored, even though it has been observed that macrophages adopt different geometries in vivo...
  5. Cadart C, Zlotek Zlotkiewicz E, Le Berre M, Piel M, Matthews H. Exploring the function of cell shape and size during mitosis. Dev Cell. 2014;29:159-69 pubmed publisher
    ..Here we discuss how mitotic rounding contributes to spindle assembly and positioning, as well as the potential consequences of abnormal mitotic cell shape and size on chromosome segregation, tissue growth, and cancer.
  6. Greiner A, Chen H, Spatz J, Kemkemer R. Cyclic tensile strain controls cell shape and directs actin stress fiber formation and focal adhesion alignment in spreading cells. PLoS ONE. 2013;8:e77328 pubmed publisher
    ..In summary, a CTS-induced cell orientation of spreading cells correlates temporary with the development of the acto-myosin system as well as contact to the underlying substrate by cell-matrix adhesions. ..
  7. Zigman M, Laumann Lipp N, Titus T, Postlethwait J, Moens C. Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development. 2014;141:639-49 pubmed publisher
    ..for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented cell division during zebrafish anterior hindbrain neural tube morphogenesis...
  8. Murali A, Rajalingam K. Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci. 2014;71:1703-21 pubmed publisher
    ..Here we present an overview on the role of Rho GTPases in regulating cell shape and plasticity of cell migration...
  9. Heisenberg C, Bellaiche Y. Forces in tissue morphogenesis and patterning. Cell. 2013;153:948-62 pubmed publisher
    ..Thus, the interplay between tissue mechanics and biochemical signaling orchestrates tissue morphogenesis and patterning in development. ..

More Information


  1. Matthews H, Delabre U, Rohn J, Guck J, Kunda P, Baum B. Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell. 2012;23:371-83 pubmed publisher
    ..Ect2 localization therefore defines the stage-specific changes in actin cortex organization critical for accurate cell division. ..
  2. Gelbart M, He B, Martin A, Thiberge S, Wieschaus E, Kaschube M. Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. Proc Natl Acad Sci U S A. 2012;109:19298-303 pubmed publisher
    ..Understanding morphogenetic movements requires precise measurements of whole-cell shape changes over time...
  3. Bizzarri M, Pasqualato A, Cucina A, Pasta V. Physical forces and non linear dynamics mould fractal cell shape: quantitative morphological parameters and cell phenotype. Histol Histopathol. 2013;28:155-74 pubmed publisher
    b>Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome...
  4. Gómez J, Wang Y, Riechmann V. Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. J Cell Biol. 2012;199:1131-43 pubmed publisher
    Regulation of epithelial cell shape, for example, changes in relative sizes of apical, basal, and lateral membranes, is a key mechanism driving morphogenesis. However, it is unclear how epithelial cells control the size of their membranes...
  5. Hachet O, Bendezú F, Martin S. Fission yeast: in shape to divide. Curr Opin Cell Biol. 2012;24:858-64 pubmed publisher
    ..In turn, cellular dimensions are defined by the small GTPase Cdc42 and downstream regulators of vesicle trafficking. Yeast cells then repetitively use their simple rod shape to orchestrate the position and timing of cell division. ..
  6. Diz Muñoz A, Fletcher D, Weiner O. Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol. 2013;23:47-53 pubmed publisher
    ..Here we review current understanding of how changes in PM tension regulate cell shape and movement, as well as how cells sense PM tension.
  7. Maître J, Berthoumieux H, Krens S, Salbreux G, Jülicher F, Paluch E, et al. Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science. 2012;338:253-6 pubmed publisher
    ..Thus, cell adhesion provides the mechanical scaffold for cell cortex tension to drive cell sorting during gastrulation. ..
  8. Wang R, Sun X, Wang C, Hu P, Chu C, Liu S, et al. Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression. PLoS ONE. 2012;7:e42653 pubmed publisher
    ..Cancer-stromal fusion thus lays a foundation for an incessant co-evolution between cancer and the cancer-associated stromal cells in the tumor microenvironment...
  9. Wang G, Manning M, Amack J. Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo. Dev Biol. 2012;370:52-62 pubmed publisher
    ..Live imaging of KV cells revealed region-specific cell shape changes that mediate tight packing of ciliated cells into the anterior pole...
  10. Salbreux G, Charras G, Paluch E. Actin cortex mechanics and cellular morphogenesis. Trends Cell Biol. 2012;22:536-45 pubmed publisher
    ..Because the cortex is attached to the cell membrane, it plays a central role in cell shape control...
  11. Mason F, Tworoger M, Martin A. Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical constriction. Nat Cell Biol. 2013;15:926-36 pubmed publisher
    ..The transcription factor Twist is required to stabilize cell shape. However, it is unknown how Twist spatially coordinates downstream signals to prevent cell relaxation...
  12. Chen Z, Lessey E, Berginski M, Cao L, Li J, Trepat X, et al. Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. PLoS ONE. 2013;8:e52233 pubmed publisher
    The issue of how contractility and adhesion are related to cell shape and migration pattern remains largely unresolved...
  13. Kapustina M, Elston T, Jacobson K. Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape. J Cell Biol. 2013;200:95-108 pubmed publisher
    ..The compression-dilation hypothesis offers a mechanism for large-scale cell shape transformations that is complementary to blebbing, where the plasma membrane detaches from the actin cortex and ..
  14. Laan L, Roth S, Dogterom M. End-on microtubule-dynein interactions and pulling-based positioning of microtubule organizing centers. Cell Cycle. 2012;11:3750-7 pubmed publisher
    ..This effect is predicted to be strongly geometry-dependent, and we therefore finally discuss ongoing efforts to repeat these experiments in three-dimensional, spherical and deformable geometries...
  15. Sadoul K, Wang J, Diagouraga B, Vitte A, Buchou T, Rossini T, et al. HDAC6 controls the kinetics of platelet activation. Blood. 2012;120:4215-8 pubmed publisher
    ..These results are particularly important in view of HDAC6 inhibitors being currently used in clinical trials and represent the first example of cell signaling by lysine acetylation in platelet biology...
  16. Kotadia S, Montembault E, Sullivan W, Royou A. Cell elongation is an adaptive response for clearing long chromatid arms from the cleavage plane. J Cell Biol. 2012;199:745-53 pubmed publisher
    ..These studies reveal a novel pathway linking trailing chromatid arms and cortical myosin that ensures the clearance of chromatids from the cleavage plane at the appropriate time during cytokinesis, thus preserving genome integrity...
  17. Veeman M, Smith W. Whole-organ cell shape analysis reveals the developmental basis of ascidian notochord taper. Dev Biol. 2013;373:281-9 pubmed publisher
    ..We find that cell shape in the intercalated notochord depends strongly on anterior-posterior (AP) position, with cells in the middle of ..
  18. Kim S, Seo G, Oh E, Jin S, Chae G, Lee S. Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells. Atherosclerosis. 2012;225:315-21 pubmed publisher
    ..The possible involvement of RIP1 in palmitate-induced macrophage death and its underlying molecular mechanism was investigated in this study...
  19. Rangamani P, Lipshtat A, Azeloglu E, Calizo R, Hu M, Ghassemi S, et al. Decoding information in cell shape. Cell. 2013;154:1356-69 pubmed publisher
    ..Using analytical approaches and numerical simulations, we studied how elongation of cell shape affects plasma membrane signaling...
  20. Holmes W, Edelstein Keshet L. A comparison of computational models for eukaryotic cell shape and motility. PLoS Comput Biol. 2012;8:e1002793 pubmed publisher
    ..review, we describe some of the recent computational models for cell motility, concentrating on simulations of cell shape changes (mainly in two but also three dimensions)...
  21. Zhang D, Kilian K. The effect of mesenchymal stem cell shape on the maintenance of multipotency. Biomaterials. 2013;34:3962-9 pubmed publisher
    ..This work will prove useful in the development of culture conditions for the maintenance of multipotent MSCs in vitro and for the design of niche-mimetic biomaterials. ..
  22. Mosaliganti K, Noche R, Xiong F, Swinburne I, Megason S. ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes. PLoS Comput Biol. 2012;8:e1002780 pubmed publisher
    The quantification of cell shape, cell migration, and cell rearrangements is important for addressing classical questions in developmental biology such as patterning and tissue morphogenesis...
  23. Kwon O, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016;34:191-202 pubmed publisher
    ..These cells may represent a putative luminal progenitor population and serve as a cellular origin for castration resistant prostate cancer. ..
  24. Scarpini C, Groves I, Pett M, Ward D, Coleman N. Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes. J Pathol. 2014;233:281-93 pubmed publisher
    ..We conclude that HPV16 integration in basal cervical cells does not necessarily lead to increased levels of virus oncogenes, or to a competitive growth advantage, when compared with the initiating episome-containing cells. ..
  25. Patel A, Mukundan S, Wang W, Karumuri A, Sant V, Mukhopadhyay S, et al. Carbon-based hierarchical scaffolds for myoblast differentiation: Synergy between nano-functionalization and alignment. Acta Biomater. 2016;32:77-88 pubmed publisher
  26. Zhang D, Sun M, Lee J, Abdeen A, Kilian K. Cell shape and the presentation of adhesion ligands guide smooth muscle myogenesis. J Biomed Mater Res A. 2016;104:1212-20 pubmed publisher
    ..adhesion turnover, Rac1, RhoA/ROCK, and calpain during smooth muscle differentiation of MSCs in response to cell shape and the affinity of the cell adhesion interface...
  27. Tong S, Xu D, Liu Z, Du Y, Wang X. Synthesis of the New-Type Vascular Endothelial Growth Factor-Silk Fibroin-Chitosan Three-Dimensional Scaffolds for Bone Tissue Engineering and In Vitro Evaluation. J Craniofac Surg. 2016;27:509-15 pubmed publisher
    ..19 cells growth and proliferation in the SF-CS scaffolds, but the enhancement of osteoblasts cell proliferation and activity by VEGF was dependent on time. ..
  28. Harrison T, He Z, Boggs K, Thuret G, Liu H, Defoe D. Corneal endothelial cells possess an elaborate multipolar shape to maximize the basolateral to apical membrane area. Mol Vis. 2016;22:31-9 pubmed
    ..Their unusual geometry may be essential for the endothelium to carry out its role as the principal regulator of corneal extracellular fluid flux, and thus ultimately of tissue clarity. ..
  29. Peela N, Sam F, Christenson W, Truong D, Watson A, Mouneimne G, et al. A three dimensional micropatterned tumor model for breast cancer cell migration studies. Biomaterials. 2016;81:72-83 pubmed publisher
    ..Our results indicate that gelatin methacrylate (GelMA) hydrogel, integrated with the two-step photolithography technique, has great promise in the development of 3D tumor models with well-defined architecture and tunable stiffness. ..
  30. Li Y, Yang F, Zheng W, Hu M, Wang J, Ma S, et al. Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro. Biomed Pharmacother. 2016;80:227-235 pubmed publisher
  31. Guo R, Meng Q, Guo H, Xiao L, Yang X, Cui Y, et al. TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:1105-10 pubmed publisher
    ..Therefore, the results of the present study indicated that TGF-β2 induces EMT by activating the PI3K/Akt/mTOR signaling pathway in cultured HLECs. ..
  32. Oliveira F, Bernardes E, Brand C, Dos Santos S, Cabanel M, Arcanjo K, et al. Lack of galectin-3 up-regulates IgA expression by peritoneal B1 lymphocytes during B cell differentiation. Cell Tissue Res. 2016;363:411-26 pubmed publisher
    ..Thus, a novel role is revealed for galectin-3 in controlling the expression of surface IgA by peritoneal B1 lymphocytes; this might have important implications for manipulating the mucosal immune response. ..
  33. Kashyap M, Ranjan A, Shankardas J, Vishwanatha J. Establishment of human retinal microvascular endothelial cells with extended life-span. In Vivo. 2013;27:685-94 pubmed
    ..These cells will be a valuable tool to further our understanding on the role of HRECs in the human blood-retinal-barrier and in angiogenesis and neovascularization. ..
  34. Zhang C, Guo F, Xu G, Jia W, Ge Y. STAT3 activation mediates epithelial-to-mesenchymal transition in human hepatocellular carcinoma cells. Hepatogastroenterology. 2014;61:1082-9 pubmed
    ..In summary, our study show for the first time that STAT3 activation may induce invasion and metastasis through the mediation of EMT in HCC cells. Activated STAT3 and EMT markers can serve as molecular targets for HCC treatment. ..
  35. Pontes B, Monzo P, Golé L, Le Roux A, Kosmalska A, Tam Z, et al. Membrane tension controls adhesion positioning at the leading edge of cells. J Cell Biol. 2017;216:2959-2977 pubmed publisher
    ..We propose that the mechanical signal of membrane tension exerts upstream control in mechanotransduction by periodically compressing and relaxing the lamellipodium, leading to the positioning of adhesions at the leading edge of cells. ..
  36. Li Y, Hu Q, Miao G, Zhang Q, Yuan B, Zhu Y, et al. Size-Dependent Mechanism of Intracellular Localization and Cytotoxicity of Mono-Disperse Spherical Mesoporous Nano- and Micron-Bioactive Glass Particles. J Biomed Nanotechnol. 2016;12:863-77 pubmed
    ..Their lysosomal escape may damage the lysosomes, inducing cell apoptosis and thus the greater cytotoxicity. ..
  37. Wang H, Chen Z, Tang Y, Li X, Zhang S, Ma L, et al. TSG-6 treatment promoted apoptosis in human fibroblasts of pathological scar. Cell Mol Biol (Noisy-le-grand). 2016;62:33-7 pubmed
    ..Meanwhile, expression level of cell apoptosis related cytokine protein Bax increased and cell proliferation related signal transduction pathways are blocked since the expression level of Bcl-2 was decreased. ..
  38. Holm A, Magnusson K, Vikström E. Pseudomonas aeruginosa N-3-oxo-dodecanoyl-homoserine Lactone Elicits Changes in Cell Volume, Morphology, and AQP9 Characteristics in Macrophages. Front Cell Infect Microbiol. 2016;6:32 pubmed publisher
    ..Thus, 3O-C12-HSL enhanced cell volume and area and induced cell shape and protrusion fluctuations in macrophages, processes tentatively driven by fluxes of water across cell membrane ..
  39. Piotrowska K, Tarnowski M, Zgutka K, Pawlik A. Gender Differences in Response to Prolonged Every-Other-Day Feeding on the Proliferation and Apoptosis of Hepatocytes in Mice. Nutrients. 2016;8:176 pubmed publisher
    ..Our experiment revealed sex-specific expression of mRNA for proto-oncogenes and pro-survival and pro-apoptotic genes in mice as well as sex-specific responses to the EOD treatment. ..
  40. Recek N, Jaganjac M, Kolar M, Milković L, Mozetic M, Stana Kleinschek K, et al. Protein adsorption on various plasma-treated polyethylene terephthalate substrates. Molecules. 2013;18:12441-63 pubmed publisher
    ..In addition, cell adhesion studies support this finding because the best cell adhesion was observed on oxygen-plasma-treated substrates. ..
  41. Liu D, Dai M, Zhang X, Cao W, Liao M. Subgroup J avian leukosis virus infection of chicken dendritic cells induces apoptosis via the aberrant expression of microRNAs. Sci Rep. 2016;6:20188 pubmed publisher
    ..These results provide a solid foundation for the further study of epigenetic influences on ALV-J-induced immunosuppression. ..
  42. McCain M, Yuan H, Pasqualini F, Campbell P, Parker K. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. Am J Physiol Heart Circ Physiol. 2014;306:H1525-39 pubmed publisher
    ..thickening is considered compensatory because it reduces wall stress, but the functional consequences of cell shape remodeling in this pathological setting are unknown...
  43. Lu H, Blunden B, Scarano W, Lu M, Stenzel M. Anti-metastatic effects of RAPTA-C conjugated polymeric micelles on two-dimensional (2D) breast tumor cells and three-dimensional (3D) multicellular tumor spheroids. Acta Biomater. 2016;32:68-76 pubmed publisher
    ..We believe that the presented micelles are suitable carriers for this anti-metastatic drug. The design of the micelle would also allow the encapsulation of other drugs in future studies creating a potentially powerful bullet. ..
  44. Guo H, Torzilli P. Shape of chondrocytes within articular cartilage affects the solid but not the fluid microenvironment under unconfined compression. Acta Biomater. 2016;29:170-179 pubmed publisher
    ..However the mechanisms by which cell shape influences the response of the ECM microenvironment to mechanical loading is yet to be elucidated...
  45. Xu G, Liu Y, Zheng Z. Oriented cell division affects the global stress and cell packing geometry of a monolayer under stretch. J Biomech. 2016;49:401-7 pubmed publisher
    ..For isolated cells, extensive studies show that the orientation of divisions is sensitive to cell shape and the direction of extrinsic mechanical forces...
  46. Yasui Y, Chijimatsu R, Hart D, Koizumi K, Sugita N, Shimomura K, et al. Preparation of Scaffold-Free Tissue-Engineered Constructs Derived from Human Synovial Mesenchymal Stem Cells Under Low Oxygen Tension Enhances Their Chondrogenic Differentiation Capacity. Tissue Eng Part A. 2016;22:490-500 pubmed publisher
    ..The manipulation of oxygen tension is a safe procedure with low cost and, thus, may be a clinically relevant option to improve the quality of TEC-mediated cartilage repair. ..
  47. Harkness L, Zaher W, Ditzel N, Isa A, Kassem M. CD146/MCAM defines functionality of human bone marrow stromal stem cell populations. Stem Cell Res Ther. 2016;7:4 pubmed publisher
  48. Wright K, Mennan C, Fox H, Richardson J, Banerjee R, Roberts S. Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regen Med. 2013;8:699-709 pubmed publisher
    ..This novel report demonstrates that human ACI repair cell phenotypes resemble both chondrocytes and MSCs but at different stages of their isolation and expansion in vitro. ..
  49. Aljohani A, Munguba G, Guerra Y, Lee R, Bhattacharya S. Sphingolipids and ceramides in human aqueous humor. Mol Vis. 2013;19:1966-84 pubmed
    ..Primary human trabecular meshwork cells and video microscopic imaging were used to assess changes in cell shape and motility upon exposure to 20 pmol of Cer(d18:0/18:1(9Z)) in 10% dimethyl sulfoxide (vehicle)...
  50. Chen Y, Wang L, Huang H, Tan R, Zhao J, Yang S, et al. Mechano-regulatory cellular behaviors of NIH/3T3 in response to the storage modulus of liquid crystalline substrates. J Mech Behav Biomed Mater. 2016;57:42-54 pubmed publisher
    ..Our study provides insights into the mechanism of modulus-driven cellular behaviors for better design of bioengineered cell substrates. ..
  51. Dumevska B, Chami O, McKernan R, Goel D, Peura T, Schmidt U. Derivation of Genea016 human embryonic stem cell line. Stem Cell Res. 2016;16:24-8 pubmed publisher
    ..4, Novelty score of 1.37 and Alkaline Phosphatase activity. The cell line was negative for Mycoplasma and any visible contamination. ..
  52. Sun C, Luo Q, Lu X, Zheng D, He D, Wu Z. [Isolation and purification of primary Kupffer cells from mouse liver]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1021-5 pubmed
    ..KC H/R models expressed more MHC II, CD40 and CD86 and produced more TNF-? participating in inflammation. Conclusion The efficient method to isolate and purify KCs from BALB /c mice has been successfully established. ..
  53. Monkkonen T, Landua J, Visbal A, Lewis M. Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland. Development. 2017;144:1317-1327 pubmed publisher