Genomes and Genes
Summary: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
- Oellermann M, Portner H, Mark F. Mitochondrial dynamics underlying thermal plasticity of cuttlefish (Sepia officinalis) hearts. J Exp Biol. 2012;215:2992-3000 pubmed publisher..We conclude that cuttlefish sustain cardiac performance and, thus, systemic oxygen delivery over short- and long-term changes of temperature and environmental conditions by multiple adjustments in cellular and mitochondrial energetics. ..
- Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley K, Eliseev R. Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J Biol Chem. 2011;286:22331-8 pubmed publisher..Our study provides insight into mechanisms of mitochondrial dysfunction in cancer and may offer potential therapeutic targets. ..
- Hoeks J, Arany Z, Phielix E, Moonen Kornips E, Hesselink M, Schrauwen P. Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1? overexpressing mice. J Cell Physiol. 2012;227:1026-33 pubmed publisher..001). Taken together, in addition to stimulating mitochondrial proliferation in skeletal muscle, we show here that overexpression of PGC-1? leads to intrinsic mitochondrial adaptations that seem restricted to fat metabolism. ..
- Domijan A, Abramov A. Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis--implication to mechanism of cell toxicity. Int J Biochem Cell Biol. 2011;43:897-904 pubmed publisher..After 24h of FB(1) exposure, no cell death was observed. Thus, mitochondria appear to be the primary target of FB(1), which leads to sustained deregulation of calcium homeostasis and presumably to cell death. ..
- Hwang A, Lee S. Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY). 2011;3:304-10 pubmed..In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration. ..
- Zelickson B, Benavides G, Johnson M, Chacko B, Venkatraman A, Landar A, et al. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta. 2011;1807:1573-82 pubmed publisher..These data support the concept that the combined effects of NO and ethanol contribute to an increased susceptibility to hypoxia and the deleterious effects of alcohol consumption on liver. ..
- Fercher A, Borisov S, Zhdanov A, Klimant I, Papkovsky D. Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles. ACS Nano. 2011;5:5499-508 pubmed publisher..High brightness and photostability allow its use in screening experiments with cell populations on a commercial TR-F reader, and for single cell analysis on a fluorescent microscope. ..
- Clerc P, Polster B. Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons. PLoS ONE. 2012;7:e34465 pubmed publisher..Sequential measurements of intact and permeabilized cell respiration should be particularly useful for evaluating indirect mitochondrial toxicity due to drugs or cellular ..
- Lemieux H, Semsroth S, Antretter H, Hofer D, Gnaiger E. Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol. 2011;43:1729-38 pubmed publisher..Targeting these mitochondrial injuries with metabolic therapy may offer a promising approach to delay the progression of heart disease. ..
- Barthel M, Hammerle A, Sturm P, Baur T, Gentsch L, Knohl A. The diel imprint of leaf metabolism on the ?13 C signal of soil respiration under control and drought conditions. New Phytol. 2011;192:925-38 pubmed publisher..2.5, depending on the photosynthetic rate. Drought slows the coupling between photosynthesis and soil respiration and alters the underlying mechanism causing diel variations of ?(13) C(SR). ..
- Karicheva O, Kolesnikova O, Schirtz T, Vysokikh M, Mager Heckel A, Lombes A, et al. Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria. Nucleic Acids Res. 2011;39:8173-86 pubmed publisher..These findings prove the possibility to direct tRNAs with changed aminoacylation specificities into mitochondria, thus extending the potential therapeutic strategy of allotopic expression to address mitochondrial disorders...
- Lee S, Hwang A, Kenyon C. Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol. 2010;20:2131-6 pubmed publisher..In this way, HIF-1 appears to link respiratory stress in the mitochondria to a nuclear transcriptional response that promotes longevity. ..
- Sjövall F, Morota S, Hansson M, Friberg H, Gnaiger E, Elmér E. Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care. 2010;14:R214 pubmed publisher..This may reflect a compensatory response to severe sepsis or septic shock, that was most pronounced in non-survivors, likely correlating to the severity of the septic insult. ..
- Mauro C, Leow S, Anso E, Rocha S, Thotakura A, Tornatore L, et al. NF-?B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol. 2011;13:1272-9 pubmed publisher..Our findings identify NF-?B as a physiological regulator of mitochondrial respiration and establish a role for NF-?B in metabolic adaptation in normal cells and cancer. ..
- Keren I, Tal L, des Francs Small C, Araujo W, Shevtsov S, Shaya F, et al. nMAT1, a nuclear-encoded maturase involved in the trans-splicing of nad1 intron 1, is essential for mitochondrial complex I assembly and function. Plant J. 2012;71:413-26 pubmed publisher..Homozygous nMat1 plants show retarded growth and developmental phenotypes, modified respiration activities and altered stress responses that are tightly correlated with mitochondrial complex I defects. ..
- Chen Y, Taylor E, Dephoure N, Heo J, Tonhato A, Papandreou I, et al. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012;15:348-60 pubmed publisher..We suggest that Rcf1 is a member of an evolutionarily conserved protein family that acts to promote respiratory supercomplex assembly and activity. ..
- Groschner L, Waldeck Weiermair M, Malli R, Graier W. Endothelial mitochondria--less respiration, more integration. Pflugers Arch. 2012;464:63-76 pubmed publisher..In this review, we want to outline the significance of mitochondria in both physiology and pathology of the vascular endothelium. ..
- Smith H, Mann B, Motterlini R, Poole R. The carbon monoxide-releasing molecule, CORM-3 (RU(CO)(3) CL(glycinate)), targets respiration and oxidases in Campylobacter jejuni, generating hydrogen peroxide. IUBMB Life. 2011;63:363-71 pubmed publisher..This work shows that CO-RMs have valuable properties as antimicrobial agents; however, growth inhibition does not always accompany inhibition of respiration, even when ambient oxygen concentrations are low. ..
- Schuh R, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H, et al. Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity. J Neurosci Res. 2011;89:1979-88 pubmed publisher..When coupled with cell type-specific pharmacology or genetic manipulations, the ability to measure O(2) consumption efficiently from whole slices should advance our understanding of mitochondrial roles in physiology and neuropathology. ..
- Lo Iacono L, Boczkowski J, Zini R, Salouage I, Berdeaux A, Motterlini R, et al. A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species. Free Radic Biol Med. 2011;50:1556-64 pubmed publisher..These findings disclose a counterintuitive action of CORM-3 suggesting that CO at low levels acts as an important regulator of mitochondrial respiration...
- Searle S, Thomas S, Griffin K, Horton T, Kornfeld A, Yakir D, et al. Leaf respiration and alternative oxidase in field-grown alpine grasses respond to natural changes in temperature and light. New Phytol. 2011;189:1027-39 pubmed publisher..Alternative oxidase appears to be involved in the plant response to both seasonal changes in temperature and daily changes in light, highlighting the complexity of the function of AOX in the field. ..
- Hansson M, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, et al. Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria. J Neurotrauma. 2011;28:143-53 pubmed publisher..We concluded that adult viable human brain and liver mitochondria possess an active CypD-sensitive mPT. Our findings support the rationale of CypD and mPT inhibition as pharmacological targets in acute and chronic neurodegeneration. ..
- Osanai T, Kuwahara A, Iijima H, Toyooka K, Sato M, Tanaka K, et al. Pleiotropic effect of sigE over-expression on cell morphology, photosynthesis and hydrogen production in Synechocystis sp. PCC 6803. Plant J. 2013;76:456-65 pubmed publisher..These results provide insights into the inter-relationship among metabolism, cell morphology, photosynthesis and hydrogen production in this unicellular cyanobacterium. ..
- Busch F. Current methods for estimating the rate of photorespiration in leaves. Plant Biol (Stuttg). 2013;15:648-55 pubmed publisher..Six different methods used to estimate photorespiration are reviewed, and their advantages and disadvantages discussed. ..
- Corbet C, Feron O. Tumour acidosis: from the passenger to the driver's seat. Nat Rev Cancer. 2017;17:577-593 pubmed publisher..Finally, recent advances in the different therapeutic modalities aiming to either block pH-regulatory systems or exploit acidosis will be discussed. ..
- Ravera S, Vaccaro D, Cuccarolo P, Columbaro M, Capanni C, Bartolucci M, et al. Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A. Biochimie. 2013;95:1828-37 pubmed publisher..Electron microscopy measures indeed show profound alterations in mitochondrial ultrastructure and shape. ..
- Chen X, Chen S, Liu M, Jiao J, Li H, Hu F. [Effects of nitrogen fertilization and straw amendment on soil microbial biomass and soil functions after heat stress]. Ying Yong Sheng Tai Xue Bao. 2013;24:467-72 pubmed..It was suggested that straw amendment and its combination with nitrogen fertilization could improve soil functions in natural conditions or after environmental stress. ..
- Lin T, Lin H, Chen S, Chuang Y, Chuang J, Wang P, et al. The creation of cybrids harboring mitochondrial haplogroups in the Taiwanese population of ethnic Chinese background: an extensive in vitro tool for the study of mitochondrial genomic variations. Oxid Med Cell Longev. 2012;2012:824275 pubmed publisher..With this mtDNA haplogroup population, the underlying mechanisms of aging-related diseases may be better understood, and therapeutic interventions can be accelerated. ..
- Tozzi E, Easlon H, Richards J. Interactive effects of water, light and heat stress on photosynthesis in Fremont cottonwood. Plant Cell Environ. 2013;36:1423-34 pubmed publisher..Interactions with heat and light stress are more important in these effects than water stress alone. ..
- Xu F, Yuan S, Zhang D, Lv X, Lin H. The role of alternative oxidase in tomato fruit ripening and its regulatory interaction with ethylene. J Exp Bot. 2012;63:5705-16 pubmed publisher..These findings indicate that AOX is involved in respiratory climacteric and ethylene-mediated fruit ripening of tomato. ..
- Koester R, Nohl B, Diers B, Ainsworth E. Has photosynthetic capacity increased with 80 years of soybean breeding? An examination of historical soybean cultivars. Plant Cell Environ. 2016;39:1058-67 pubmed publisher..Better understanding of the mechanisms that have improved conversion efficiency in the past may help identify new, promising targets for the future. ..
- Cogliati S, Frezza C, Soriano M, Varanita T, Quintana Cabrera R, Corrado M, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155:160-71 pubmed publisher..We demonstrate that, accordingly, the efficiency of mitochondria-dependent cell growth depends on cristae shape. Thus, RCS assembly emerges as a link between membrane morphology and function. ..
- Cabrera Orefice A, Chiquete Felix N, Espinasa Jaramillo J, Rosas Lemus M, Guerrero Castillo S, Pena A, et al. The branched mitochondrial respiratory chain from Debaryomyces hansenii: components and supramolecular organization. Biochim Biophys Acta. 2014;1837:73-84 pubmed publisher..Binding of the alternative enzymes to supercomplexes was not detected. This is the first report on the structure and organization of the mitochondrial respiratory chain from D. hansenii. ..
- Li W, Liu J, Zhao Y. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells. Mol Carcinog. 2014;53:403-12 pubmed publisher..These results suggest that shikonin bears chemopreventive potential for human skin cancers in which PKM2 is upregulated, which might be mediated by inhibiting oncogenic activation, PKM2 activation, and mitochondrial dysfunction. ..
- Kuhn A, Engqvist M, Jansen E, Weber A, Jakobs C, Maurino V. D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant. Plant Biol (Stuttg). 2013;15:776-84 pubmed publisher..Thus, a novel interaction of the photorespiratory pathway with cellular processes involving D-2HG has been identified. ..
- Ju X, Wen Y, Metzger D, JUNG M. The role of p38 in mitochondrial respiration in male and female mice. Neurosci Lett. 2013;544:152-6 pubmed publisher..These data suggest that p38 is required for the mitochondrial respiration of male mice. When p38 is below a normal level, females may maintain mitochondrial respiration through COX up-regulation. ..
- van der Lans A, Hoeks J, Brans B, Vijgen G, Visser M, Vosselman M, et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 2013;123:3395-403 pubmed publisher..The combined results suggest that a variable indoor environment with frequent cold exposures might be an acceptable and economic manner to increase energy expenditure and may contribute to counteracting the current obesity epidemic. ..
- Majewska E, Wittek N, Rysz J, Baj Z. The influence of uremic high cystatin C concentration on neutrophil apoptosis and selected neutrophil functions isolated from healthy subjects. Med Sci Monit. 2012;18:CR667-73 pubmed
- Wang J, Chen Y, Tew K, Meng P, Chen C. Physiological and biochemical performances of menthol-induced aposymbiotic corals. PLoS ONE. 2012;7:e46406 pubmed publisher..Our studies showed that menthol could successfully bleach corals and provided aposymbiotic corals for further exploration of coral-alga symbioses. ..
- Macchioni L, Fettucciari K, Davidescu M, Vitale R, Ponsini P, Rosati E, et al. Impairment of brain mitochondrial functions by ?-hemolytic Group B Streptococcus. Effect of cardiolipin and phosphatidylcholine. J Bioenerg Biomembr. 2013;45:519-29 pubmed publisher..DPPC, which is not able to fuse with mitochondrial membranes, exerted its effect outside mitochondria, likely by shielding mitochondria against GBS ?-hemolysin attack. ..
- Cunha Oliveira T, Silva L, Silva A, Moreno A, Oliveira C, Santos M. Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria. Toxicol Lett. 2013;219:298-306 pubmed publisher..In summary, cocaine and cocaine+morphine induce mitochondrial complex I dysfunction in isolated brain and liver mitochondria, with specific effects in each tissue. ..
- Adams T, McCormack M, Eissenstat D. Foraging strategies in trees of different root morphology: the role of root lifespan. Tree Physiol. 2013;33:940-8 pubmed publisher..Our results are discussed in the context of different strategies of foraging of nutrient patches in species of different root morphology. ..
- King A, Swain T, Mao Z, Udoh U, Oliva C, Betancourt A, et al. Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306:G265-77 pubmed publisher..We conclude that chronic ethanol consumption likely lowers the threshold for CypD-regulated and -independent characteristics of the ethanol-mediated MPT pore in liver mitochondria. ..
- Mooranian A, Negrulj R, Chen Tan N, Fakhoury M, Arfuso F, Jones F, et al. Advanced bile acid-based multi-compartmental microencapsulated pancreatic ?-cells integrating a polyelectrolyte-bile acid formulation, for diabetes treatment. Artif Cells Nanomed Biotechnol. 2016;44:588-95 pubmed publisher..01). UDCA reduced the cells' biochemical activities, mitochondrial respiration, and energy production, post-microencapsulation. This is the first time biological functions of microencapsulated ?-cells have been analyzed in real-time. ..
- Lozano R, Pérez Maceda B, Carboneras M, Onofre Bustamante E, Garcia Alonso M, Escudero M. Response of MC3T3-E1 osteoblasts, L929 fibroblasts, and J774 macrophages to fluoride surface-modified AZ31 magnesium alloy. J Biomed Mater Res A. 2013;101:2753-62 pubmed publisher..Results reported here, for and against AZ31HF, should be taken into account when considering the potential use of this modified alloy in bone repair applications. ..
- Lee H, Kim S, Lee J, Yang Y, Nam J, Kim B, et al. Mitochondrial oxidative phosphorylation complexes exist in the sarcolemma of skeletal muscle. BMB Rep. 2016;49:116-21 pubmed..Based on these data, we conclude that a portion of OXPHOS complexes is localized in the sarcolemma of skeletal muscle and may have non-canonical functions. [BMB Reports 2016; 49(2): 116-121]. ..