cell membrane permeability


Summary: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.

Top Publications

  1. Lowe J, Lee M, Akella L, Davoine E, Donckele E, Durak L, et al. Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. J Org Chem. 2012;77:7187-211 pubmed publisher
    ..The solid-phase synthesis of a 1976-membered library of spirocyclic azetidines is also described. ..
  2. Di L, Artursson P, Avdeef A, Ecker G, Faller B, Fischer H, et al. Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. Drug Discov Today. 2012;17:905-12 pubmed publisher
    ..Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization. ..
  3. Beutheu Youmba S, Belmonte L, Galas L, Boukhettala N, Bole Feysot C, Dechelotte P, et al. Methotrexate modulates tight junctions through NF-?B, MEK, and JNK pathways. J Pediatr Gastroenterol Nutr. 2012;54:463-70 pubmed publisher
    ..These are potential targets to limit the adverse effects of chemotherapy. ..
  4. Browne L, Compan V, Bragg L, North R. P2X7 receptor channels allow direct permeation of nanometer-sized dyes. J Neurosci. 2013;33:3557-66 pubmed publisher
    ..The results demonstrate that the open channel of the P2X7 receptor can allow passage of molecules with sizes up to 1.4 nm. ..
  5. Bischofberger M, Iacovache I, van der Goot F. Pathogenic pore-forming proteins: function and host response. Cell Host Microbe. 2012;12:266-75 pubmed publisher
    ..Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection. ..
  6. Sanyal S, Claessen J, Ploegh H. A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. J Biol Chem. 2012;287:23594-603 pubmed publisher
    ..Our data provide new mechanistic insight in the dislocation reaction and support a model where failure to deubiquitylate an ER-resident protein occludes the dislocon and causes upstream misfolded intermediates to accumulate. ..
  7. Li Y, Powell D, Shaffer S, Rasko D, Pelletier M, Leszyk J, et al. LPS remodeling is an evolved survival strategy for bacteria. Proc Natl Acad Sci U S A. 2012;109:8716-21 pubmed publisher
  8. Elamin E, Jonkers D, Juuti Uusitalo K, van Ijzendoorn S, Troost F, Duimel H, et al. Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS ONE. 2012;7:e35008 pubmed publisher
  9. Teixeira V, Feio M, Bastos M. Role of lipids in the interaction of antimicrobial peptides with membranes. Prog Lipid Res. 2012;51:149-77 pubmed publisher

More Information


  1. Rosenthal R, Gunzel D, Finger C, Krug S, Richter J, Schulzke J, et al. The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials. 2012;33:2791-800 pubmed publisher
    ..These results suggest that the rapid and reversible absorption-enhancing chitosan effect is due to changes in intracellular pH caused by the activation of a chloride-bicarbonate exchanger resulting in the opening of the TJ...
  2. Buyck J, Plesiat P, Traore H, Vanderbist F, Tulkens P, Van Bambeke F. Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability. Clin Infect Dis. 2012;55:534-42 pubmed publisher
    ..Macrolides show antimicrobial activity against P. aeruginosa in eukaryotic media through increased uptake and reduced efflux. These data may help explain the clinical efficacy of macrolides against pseudomonal infections. ..
  3. Schweizer H. Understanding efflux in Gram-negative bacteria: opportunities for drug discovery. Expert Opin Drug Discov. 2012;7:633-42 pubmed publisher
  4. Fanning A, Van Itallie C, Anderson J. Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell. 2012;23:577-90 pubmed publisher
  5. Siarheyeva A, Senisterra G, Allali Hassani A, Dong A, Dobrovetsky E, Wasney G, et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure. 2012;20:1425-35 pubmed publisher
    ..These data demonstrate an allosteric mechanism for inhibition of protein arginine methyltransferases, an emerging class of therapeutic targets. ..
  6. Corrotte M, Fernandes M, Tam C, Andrews N. Toxin pores endocytosed during plasma membrane repair traffic into the lumen of MVBs for degradation. Traffic. 2012;13:483-94 pubmed publisher
    ..Thus, cells dispose of SLO transmembrane pores by ubiquitination/ESCRT-dependent sorting into the lumen of late endosomes/lysosomes. ..
  7. Zebda N, Tian Y, Tian X, Gawlak G, Higginbotham K, Reynolds A, et al. Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability. J Biol Chem. 2013;288:18290-9 pubmed publisher
  8. Smith P, Giroud M, Wiggins H, Gower F, Thorley J, Stolpe B, et al. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization. Int J Nanomedicine. 2012;7:2045-55 pubmed publisher
    ..Finally, experiments performed with cells cooled to 4°C suggest that a proportion of the accumulation of nanoparticles in cells was likely due to direct permeabilization of the plasma membrane. ..
  9. Luo T, Chen B, Zhao Z, He N, Zeng Z, Wu B, et al. Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function. Basic Res Cardiol. 2013;108:342 pubmed publisher
    ..These findings indicate that H2R activation exaggerates myocardial I/R injury by promoting myocardial mitochondrial dysfunction and by increasing cardiac vascular endothelial permeability...
  10. Sifaoui I, López Arencibia A, Martín Navarro C, Reyes Batlle M, Wagner C, Chiboub O, et al. Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts. PLoS ONE. 2017;12:e0183795 pubmed publisher
    ..Further studies are needed in order to establish the true potential of these molecules against these emerging opportunistic pathogenic protozoa. ..
  11. Xu M, Yu Q, Zhao Q, Chen W, Lin Y, Jin Y. Development and in vitro-in vivo evaluation of a water-in-oil microemulsion formulation for the oral delivery of troxerutin. Drug Dev Ind Pharm. 2016;42:280-7 pubmed publisher
    ..55% compared to control solution. These results suggest that novel W/O microemulsion could be used as an effective formulation for improving the oral bioavailability of troxerutin. ..
  12. Silve A, Guimerà Brunet A, Al Sakere B, Ivorra A, Mir L. Comparison of the effects of the repetition rate between microsecond and nanosecond pulses: electropermeabilization-induced electro-desensitization?. Biochim Biophys Acta. 2014;1840:2139-51 pubmed publisher
  13. Elsabrouty R, Jo Y, Dinh T, DeBose Boyd R. Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells. Mol Biol Cell. 2013;24:3300-8 pubmed publisher
    ..Considered together, these results establish permeabilized cells as a viable system in which to elucidate mechanisms for postubiquitination steps in sterol-accelerated degradation of reductase. ..
  14. Jiang C, Davalos R, Bischof J. A review of basic to clinical studies of irreversible electroporation therapy. IEEE Trans Biomed Eng. 2015;62:4-20 pubmed
    ..Further, this study provides organized data and facts to assist further research, optimization, and clinical applications of IRE. ..
  15. Zhang Z, Xu K, Bi Y, Yu G, Wang S, Qi X, et al. Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo. PLoS ONE. 2013;8:e70685 pubmed publisher
    ..These results indicate that LIUS could increase the toxicity sensitivity of glioma by down-regulating the expressions of P-gp and MRP1, which might be mediated by the PI3K/Akt/NF-?B pathway. ..
  16. Netti V, Iovane A, Vatrella M, Zotta E, Fellet A, Balaszczuk A. Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart. Biomed Pharmacother. 2016;81:225-34 pubmed publisher
    ..Increased AQP1 S-nitrosylation in the youngest group may decrease osmotic water permeability of cardiac membranes, having a negative impact on cardiac water balance. ..
  17. Marciniak A, Walczyna B, Rajtar G, Marciniak S, Wojtak A, Lasiecka K. Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model. Oxid Med Cell Longev. 2016;2016:4139851 pubmed publisher
    ..On the basis of these studies, it is possible to conclude that tempol has a profound protective effect against cardiac and pancreatic damage induced by AP. ..
  18. Lee H, Kim Y. Antifungal Activity of Salvia miltiorrhiza Against Candida albicans Is Associated with the Alteration of Membrane Permeability and (1,3)-?-D-Glucan Synthase Activity. J Microbiol Biotechnol. 2016;26:610-7 pubmed publisher
    ..These findings indicate that S. miltiorrhiza displays effective activity against C. albicans in vitro and merits further investigation to treat C. albicans-associated infections. ..
  19. Tammam S, Azzazy H, Lamprecht A. A high throughput method for quantification of cell surface bound and internalized chitosan nanoparticles. Int J Biol Macromol. 2015;81:858-66 pubmed publisher
  20. Modgill V, Garg T, Goyal A, Rath G. Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes. Artif Cells Nanomed Biotechnol. 2016;44:122-7 pubmed publisher
    ..Nanofiber being 2D nanoscale material provides numerous advantages to be used as an encapsulated carrier system to improve the therapeutic effectiveness. ..
  21. Xu Y, Zhang L, Xu J, Wei Y, Xu X. Membrane permeability of the human pluripotent stem cells to Me?SO, glycerol and 1,2-propanediol. Arch Biochem Biophys. 2014;550-551:67-76 pubmed publisher
    ..Evaluating the cell membrane permeability and the corresponding activation energy of hESCs and hiPSCs for water and different cryoprotective ..
  22. Moldoveanu S, Dorubeţ D, Astarastoae V, Butnaru E. Hyponatremia at autopsy: cause of death or simply a marker of severity of the underlying disease. Rev Med Chir Soc Med Nat Iasi. 2013;117:1028-34 pubmed
    ..The values obtained by us are in agreement with the data in the literature. Our findings plead for the scenario hyponatremia as a marker of the severity of the underlying disease. ..
  23. Fecchio C, De Franceschi G, Relini A, Greggio E, Dalla Serra M, Bubacco L, et al. ?-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. PLoS ONE. 2013;8:e82732 pubmed publisher
    ..Our biophysical and cellular findings are consistent with a model where ?-synuclein oligomers are embedded into the lipid bilayer causing transient alteration of membrane permeability. ..
  24. Petrovich E, Asher C, Garty H. Induction of FKBP51 by aldosterone in intestinal epithelium. J Steroid Biochem Mol Biol. 2014;139:78-87 pubmed publisher
    ..Overexpression or silencing FKBP51 in the kidney collecting duct cell line M1 had little or no effect on the aldosterone-induced increase in transepithelial Na(+) transport. ..
  25. Park H, Han K, Oh S, Jo S, Woo J, Yoon B, et al. High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte. Mol Brain. 2013;6:54 pubmed publisher
  26. Yan L, Yan C, Qian K, Su H, Kofsky Wofford S, Lee W, et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J Med Chem. 2014;57:2611-22 pubmed publisher
    ..Furthermore, cellular studies revealed that 1 is cell membrane permeable and effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions. ..
  27. Zeuthen T, Alsterfjord M, Beitz E, MacAulay N. Osmotic water transport in aquaporins: evidence for a stochastic mechanism. J Physiol. 2013;591:5017-29 pubmed publisher
  28. Torrens G, Pérez Gallego M, Moya B, Munar Bestard M, Zamorano L, Cabot G, et al. Targeting the permeability barrier and peptidoglycan recycling pathways to disarm Pseudomonas aeruginosa against the innate immune system. PLoS ONE. 2017;12:e0181932 pubmed publisher
    ..Thus, our results help to delineate new strategies against P. aeruginosa infections, simultaneously targeting ?-lactam resistance, cell-wall metabolism and virulence, ultimately enhancing the activity of our innate immune weapons. ..
  29. Carlson M, Bao H, Duong F. Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter. J Biol Chem. 2016;291:12119-25 pubmed publisher
  30. Sha X, Liu H, Ma T. Osmotic water permeability diversification in primary trophoblast cultures from aquaporin 1-deficient pregnant mice. J Obstet Gynaecol Res. 2015;41:1399-405 pubmed publisher
  31. Phez E, Gibot L, Rols M. How transient alterations of organelles in mammalian cells submitted to electric field may explain some aspects of gene electrotransfer process. Bioelectrochemistry. 2016;112:166-72 pubmed publisher
    ..These modifications, detected in the minutes following pulse delivery, were transient. They may have direct consequences on molecule delivery and therefore may explain various aspects of the mechanisms of DNA electrotransfer. ..
  32. Yumura S. A novel low-power laser-mediated transfer of foreign molecules into cells. Sci Rep. 2016;6:22055 pubmed publisher
    ..This new technique will provide a powerful tool not only to research but also to many applied fields. ..
  33. Rea A, Tempone A, Pinto E, Mesquita J, Rodrigues E, Silva L, et al. Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction. PLoS Negl Trop Dis. 2013;7:e2556 pubmed publisher
    ..cruzi, secondary metabolites of plants affecting the bioenergetic system as soulamarin may contribute as scaffolds for the design of novel and selective drug candidates for neglected diseases, mainly Chagas disease. ..
  34. Lee H, Choi H, Ko H, Woo E, Lee D. Antifungal effect and mode of action of glochidioboside against Candida albicans membranes. Biochem Biophys Res Commun. 2014;444:30-5 pubmed publisher
    ..In conclusion, this study suggests that glochidioboside exerts an antifungal activity through a membrane-disruptive mechanism...
  35. Artetxe I, Ugarte Uribe B, Gil D, Valle M, Alonso A, García Sáez A, et al. Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism. Biophys J. 2017;113:860-868 pubmed publisher
  36. Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale T, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets ?-Catenin Protein-Protein Interactions. Cell Chem Biol. 2017;24:958-968.e5 pubmed publisher
    ..We expect that this type of integrative strategy that endows stapled peptides with CPP features will be generally useful for developing inhibitors of intracellular PPIs. ..
  37. Gao C, Guo N, Li N, Peng X, Wang P, Wang W, et al. Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes. Arch Dermatol Res. 2016;308:79-86 pubmed publisher
    ..acnes by disrupting their membrane, DNA and proteins and finally leaded to the cell death. The obtained data highlighted the potential of using aspidin BB as an alternative treatment for acne vulgaris. ..
  38. Carpenter J, Wang Y, Wu G, Feng J, Ye X, Morales C, et al. Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists. J Med Chem. 2017;60:6166-6190 pubmed publisher
    ..Oral administration of 69 to rats reduced food intake in an ad libitum feeding model, which could be completely reversed by a selective 5-HT2C antagonist. ..
  39. Ljones K, Ness H, Solvang Garten K, Gaustad S, Andre Høydal M. Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats. PLoS ONE. 2017;12:e0173449 pubmed publisher
    ..Acute exhaustive treadmill exercise is associated with impairment of cardiomyocyte Ca2+ handling and mitochondrial respiration that causes depression in both contraction and diastolic relaxation of cardiomyocytes. ..
  40. Québatte G, Kitas E, Seelig J. riDOM, a cell penetrating peptide. Interaction with phospholipid bilayers. Biochim Biophys Acta. 2014;1838:968-77 pubmed publisher
    ..This packing arrangement guarantees a good solubility of riDOM both in the aqueous and in the membrane phase. The membrane binding enthalpy is small and riDOM binding is thus entropy-driven. ..
  41. Stalmans S, Wynendaele E, Bracke N, Gevaert B, D Hondt M, Peremans K, et al. Chemical-functional diversity in cell-penetrating peptides. PLoS ONE. 2013;8:e71752 pubmed publisher
    ..e. positive charge and amphipathicity, the shape, structure complexity and the 3D-pattern of constituting atoms influence the cellular uptake capacity of peptides. ..
  42. Tavano R, Malachin G, De Zotti M, Peggion C, Biondi B, Forrnaggio F, et al. The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. Biochim Biophys Acta. 2015;1848:134-44 pubmed
    ..Replacement of one Gly with Lys plus the simultaneous esterification of the (-terminus, strongly increased trichogin GA IV anti-Gram+ activity (MIC 1-4 ~ ). but further mitigated its cytotoxicity on human cells. ..
  43. Paul K, Chattopadhyay K. Pre-pore oligomer formation by Vibrio cholerae cytolysin: insights from a truncated variant lacking the pore-forming pre-stem loop. Biochem Biophys Res Commun. 2014;443:189-93 pubmed publisher
    ..Present study extends our insights regarding the structure-function mechanism associated with the membrane pore formation by VCC, in the context of the ?-PFT mode of action. ..
  44. García Añoveros J, Wiwatpanit T. TRPML2 and mucolipin evolution. Handb Exp Pharmacol. 2014;222:647-58 pubmed publisher
    ..Given the restricted expression of TRPML2 in immune cells, this evolutionary history suggests a functional role in the adaptive immunity characteristic of vertebrates. ..
  45. León Juárez M, Martínez Castillo M, Shrivastava G, García Cordero J, Villegas Sepulveda N, Mondragón Castelán M, et al. Recombinant Dengue virus protein NS2B alters membrane permeability in different membrane models. Virol J. 2016;13:1 pubmed publisher
    ..Our data suggest that the DENV-2 NS2B viral protein is capable of oligomerizing and organizing to form pore-like structures in different lipid environments, thereby modifying the permeability of cell membranes. ..
  46. Miyagawa T, Fujita T, Yumoto H, Yoshimoto T, Kajiya M, Ouhara K, et al. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α. Arch Oral Biol. 2016;62:64-9 pubmed publisher
    ..These results suggested that AZM regulated gingival epithelial permeability through p38 MAP kinase and ERK signaling, and may contribute to suppress the inflammation in gingival tissue. ..
  47. Jiao Y, Sun L, Song Y, Wang L, Liu L, Zhang L, et al. AtrbohD and AtrbohF positively regulate abscisic acid-inhibited primary root growth by affecting Ca2+ signalling and auxin response of roots in Arabidopsis. J Exp Bot. 2013;64:4183-92 pubmed publisher
    ..ROS activate Ca(2+) signalling and reduce auxin sensitivity of roots, thus positively regulating ABA-inhibited primary root growth in Arabidopsis. ..
  48. Lee S. Monocytes: a novel drug delivery system targeting atherosclerosis. J Drug Target. 2014;22:138-45 pubmed publisher
    ..We anticipate numerous applications of the monocyte-based drug delivery system, given its target specificity to activated EC. ..
  49. Lichtenegger M, Groschner K. TRPC3: a multifunctional signaling molecule. Handb Exp Pharmacol. 2014;222:67-84 pubmed publisher
    ..Here, we summarize current knowledge on ion channel features as well as possible signaling functions of TRPC3 and discuss the potential biological relevance of this signaling molecule. ..
  50. Grzesik B, Vohwinkel C, Morty R, Mayer K, Herold S, Seeger W, et al. Efficient gene delivery to primary alveolar epithelial cells by nucleofection. Am J Physiol Lung Cell Mol Physiol. 2013;305:L786-94 pubmed publisher
  51. Zheng N, Yin L, Song Z, Ma L, Tang H, Gabrielson N, et al. Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting. Biomaterials. 2014;35:1302-14 pubmed publisher
  52. Golan Y, Itsumura N, Glaser F, Berman B, Kambe T, Assaraf Y. Molecular Basis of Transient Neonatal Zinc Deficiency: NOVEL ZnT2 MUTATIONS DISRUPTING ZINC BINDING AND PERMEATION. J Biol Chem. 2016;291:13546-59 pubmed publisher
    ..These results highlight the burning need for the development of a suitable genetic screen for the early diagnosis of TNZD to prevent morbidity. ..
  53. Nesin V, Tsiokas L. TRPC1. Handb Exp Pharmacol. 2014;222:15-51 pubmed publisher
    ..Genetic and functional studies have implicated TRPC1 in diabetic nephropathy, Parkinson's disease, Huntington's disease, Duchenne muscular dystrophy, cancer, seizures, and Darier-White skin disease. ..