cell dedifferentiation


Summary: A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.

Top Publications

  1. Mastronikolis N, Tsiambas E, Papadas T, Karameris A, Ragos V, Peschos D, et al. Deregulation of PTEN Expression in Laryngeal Squamous Cell Carcinoma Based on Tissue Microarray Digital Analysis. Anticancer Res. 2017;37:5521-5524 pubmed
    ..PTEN acts as a negative regulator in PI3K/AKT/mTOR signaling transduction pathway. Our aim was to investigate PTEN protein expression patterns in laryngeal squamous cell carcinomas (LSCC)...
  2. Li X, Chen R, Zhu S. bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression. Dev Biol. 2017;431:239-251 pubmed publisher
    ..Taken together, these findings reveal mechanisms underlying the regulation of the maintenance of type II NBs and differentiation of INPs through the differential expression of bHLH-O family proteins. ..
  3. Öztürk E, Despot Slade E, Pichler M, Zenobi Wong M. RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway. Exp Cell Res. 2017;360:113-124 pubmed publisher
    ..These data provide insights on the context-dependent role of RhoA and Wnt signaling in de-differentiation and on mechanisms to induce chondrogenic markers for therapeutic approaches. ..
  4. Hwang Y, Broxmeyer H, Lee M. Generating autologous hematopoietic cells from human-induced pluripotent stem cells through ectopic expression of transcription factors. Curr Opin Hematol. 2017;24:283-288 pubmed publisher
  5. Nakayama E, Matsumoto T, Kazama T, Kano K, Tokuhashi Y. Transplantation of dedifferentiation fat cells promotes intervertebral disc regeneration in a rat intervertebral disc degeneration model. Biochem Biophys Res Commun. 2017;493:1004-1009 pubmed publisher
    ..Because adipose tissue is abundant and easily accessible, DFAT cell transplantation may be an attractive therapeutic strategy against IDD. ..
  6. Kavvadas P, Abed A, Poulain C, Authier F, Labéjof L, Calmont A, et al. Decreased Expression of Connexin 43 Blunts the Progression of Experimental GN. J Am Soc Nephrol. 2017;28:2915-2930 pubmed publisher
    ..Given that this protein is highly induced in individuals with glomerular diseases, connexin 43 may be a novel target for therapeutic treatment of GN. ..
  7. Donati G, Rognoni E, Hiratsuka T, Liakath Ali K, Hoste E, Kar G, et al. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. Nat Cell Biol. 2017;19:603-613 pubmed publisher
    ..This resolves the long-standing debate about the contribution of terminally differentiated cells to epidermal wound repair. ..
  8. Quwaider D, Corchete L, Misiewicz Krzeminska I, Sarasquete M, Perez J, Krzeminski P, et al. DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma. J Hematol Oncol. 2017;10:92 pubmed publisher
    ..Primary samples used in this study correspond to patients entered into GEM2010 trial (registered at www.clinicaltrials.gov as #NCT01237249, 4 November 2010). ..
  9. Hruska K. Vascular smooth muscle cells in the pathogenesis of vascular calcification. Circ Res. 2009;104:710-1 pubmed publisher

More Information


  1. Zhang L, Jambusaria A, Hong Z, Marsboom G, Toth P, Herbert B, et al. SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells. Circulation. 2017;135:2505-2523 pubmed publisher
    ..These findings identify the intermediate CD34+ progenitor state as a critical bifurcation point, which can be tuned to generate functional blood vessels or erythrocytes and salvage ischemic tissue. ..
  2. Desai T, Krasnow M. Stem cells: Differentiated cells in a back-up role. Nature. 2013;503:204-5 pubmed publisher
  3. Kurisaki Arakawa A, Akaike K, Hara K, Arakawa A, Takahashi M, Mitani K, et al. A case of dedifferentiated solitary fibrous tumor in the pelvis with TP53 mutation. Virchows Arch. 2014;465:615-21 pubmed
    ..The patient died of the disease 4 months after surgery. This case identifies a possible role of p53 dysfunction in the dedifferentiation process of SFT as reported in other sarcomas. ..
  4. Kim D, Kim C, Moon J, Chung Y, Chang M, Han B, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009;4:472-6 pubmed publisher
  5. Ma J, Yao Y, Wang J, Dong Z, Zhou T, Lu F, et al. Dedifferentiated Adipocytes Promote Adipose Tissue Generation within an External Suspension Device. Plast Reconstr Surg. 2017;140:525-536 pubmed publisher
    ..05). Dedifferentiated adipocytes in adipose flaps can participate in adipose tissue generation as seed cells and increase the volume of adipose tissue. ..
  6. Han X, Han J, Ding F, Cao S, Lim S, Dai Y, et al. Generation of induced pluripotent stem cells from bovine embryonic fibroblast cells. Cell Res. 2011;21:1509-12 pubmed publisher
  7. Surani A, Tischler J. Stem cells: a sporadic super state. Nature. 2012;487:43-5 pubmed publisher
  8. Nguyen A, Gomez D, Bell R, Campbell J, Clowes A, Gabbiani G, et al. Smooth muscle cell plasticity: fact or fiction?. Circ Res. 2013;112:17-22 pubmed publisher
  9. Kienzler A, Rizzi M, Reith M, Nutt S, Eibel H. Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid. J Allergy Clin Immunol. 2013;131:1695-9 pubmed publisher
  10. Tricaud N, Park H. Wallerian demyelination: chronicle of a cellular cataclysm. Cell Mol Life Sci. 2017;74:4049-4057 pubmed publisher
    ..Wallerian demyelination is a wonderful model for myelin degeneration occurring in the diverse forms of demyelinating peripheral neuropathies that plague human beings. ..
  11. Makise N, Yoshida A, Komiyama M, Nakatani F, Yonemori K, Kawai A, et al. Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features. Am J Surg Pathol. 2017;41:1523-1531 pubmed publisher
    ..Whether these latter tumors belong to DDLPS with epithelioid features requires further study. ..
  12. Zhang H, Cheng H, Wang Y, Zheng Y, Liu Y, Liu K, et al. Reprogramming of Notch1-induced acute lymphoblastic leukemia cells into pluripotent stem cells in mice. Blood Cancer J. 2016;6:e444 pubmed publisher
  13. Barbolina M, Moss N, Westfall S, Liu Y, Burkhalter R, Marga F, et al. Microenvironmental regulation of ovarian cancer metastasis. Cancer Treat Res. 2009;149:319-34 pubmed publisher
  14. Denker H. Ethical concerns over use of new cloning technique in humans. Nature. 2009;461:341 pubmed publisher
  15. White R, Neiman J, Reddi A, Han G, Birlea S, Mitra D, et al. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013;123:4390-404 pubmed publisher
    ..Additionally, tumor initiation and metastatic properties of CSCs can be uncoupled, with miR-9 regulating the expansion of metastatic CSCs. ..
  16. Ezati R, Etemadzadeh A, Soheili Z, Samiei S, Ranaei Pirmardan E, Davari M, et al. The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study. J Cell Physiol. 2018;233:1222-1235 pubmed publisher
    ..However, the increased number of PAX6, CHX10, Thy1, and rhodopsin positive cells in adult hRPE treated cultures clearly indicated the considerable generation of neuro-retinal terminally differentiated cells. ..
  17. Espinosa I, Lee C, D Angelo E, Palacios J, Prat J. Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis. Am J Surg Pathol. 2017;41:1121-1128 pubmed publisher
    ..023) and patients had significantly better outcome (disease-specific survival) than those without POLE exonuclease domain mutations (P=0.02). Determination of the POLE mutation status is important for the management of these patients. ..
  18. Dor Y, Glaser B. ?-cell dedifferentiation and type 2 diabetes. N Engl J Med. 2013;368:572-3 pubmed publisher
  19. Ishida E, Kim Muller J, Accili D. Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice. Diabetes. 2017;66:2092-2101 pubmed publisher
    ..In this study, we asked whether β-cell dedifferentiation can be prevented with diet or pharmacological treatment of diabetes...
  20. Roberts S, Kolewe M. Plant natural products from cultured multipotent cells. Nat Biotechnol. 2010;28:1175-6 pubmed publisher
  21. Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher
    ..Taken together, our data suggest that Cacna1g exclusively expressed in serosal PDGFRα+ cells is a new pathological marker for gastrointestinal diseases. ..