cell death


Summary: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.

Top Publications

  1. Kohr M, Evangelista A, Ferlito M, Steenbergen C, Murphy E. S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death. J Mol Cell Cardiol. 2014;69:67-74 pubmed publisher
    ..that TRIM72(WT) levels were decreased, but not TRIM72(C144S) and this correlated with increased H2O2-induced cell death in TRIM72(WT) cells...
  2. Lämmermann T, Afonso P, Angermann B, Wang J, Kastenmüller W, Parent C, et al. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. 2013;498:371-5 pubmed publisher
    ..intercellular signal relay among neutrophils mediated by the lipid leukotriene B4, which acutely amplifies local cell death signals to enhance the radius of highly directed interstitial neutrophil recruitment...
  3. Mohrenz I, Antonietti P, Pusch S, Capper D, Balss J, Voigt S, et al. Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death. Apoptosis. 2013;18:1416-1425 pubmed publisher
    ..FACS analysis of cell death and ROS production also demonstrated an increased sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells ..
  4. Acharya B, Wang K, Kim I, Kang W, Moon C, Lee B. In vivo imaging of myocardial cell death using a peptide probe and assessment of long-term heart function. J Control Release. 2013;172:367-373 pubmed publisher
    ..Here we determined whether in vivo imaging signals of myocardial cell death by ApoPep-1 (CQRPPR), a peptide probe that binds to apoptotic and necrotic cells through histone H1, at an early ..
  5. Roth T, Nayak D, Atanasijevic T, Koretsky A, Latour L, McGavern D. Transcranial amelioration of inflammation and cell death after brain injury. Nature. 2014;505:223-8 pubmed publisher
    ..Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote ..
  6. Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, et al. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 2013;13:570-583 pubmed publisher
    Caspase-mediated inflammatory cell death acts as an intrinsic defense mechanism against infection. Bacterial pathogens deploy countermeasures against inflammatory cell death, but the mechanisms by which they do this remain largely unclear...
  7. Schokoroy S, Juster D, Kloog Y, Pinkas Kramarski R. Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. PLoS ONE. 2013;8:e75269 pubmed publisher
    ..The effect of Ras and nucleolin inhibition was determined using cell growth, cell death and cell motility assays. Protein expression was determined by immunohistochemistry...
  8. Howard M, Rubenstein J, Baraban S. Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014;111:492-7 pubmed publisher
    ..Thus, in vivo homeostatic plasticity is a highly dynamic and bidirectional process that responds to changes in inhibition. ..
  9. Kano G, Almanan M, Bochner B, Zimmermann N. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol. 2013;132:437-45 pubmed publisher
    ..acid-binding immunoglobulin-like lectin (Siglec)-8 is expressed on human eosinophils, where its ligation induces cell death. Paradoxically, Siglec-8-mediated cell death is markedly enhanced by the presence of the activation and survival ..

More Information


  1. Okahashi N, Nakata M, Sumitomo T, Terao Y, Kawabata S. Hydrogen peroxide produced by oral Streptococci induces macrophage cell death. PLoS ONE. 2013;8:e62563 pubmed publisher
    ..In the present study, we investigated the effect of H2O2 produced by Streptococcus oralis on human macrophage cell death. Infection by S...
  2. Krenciute G, Liu S, Yucer N, Shi Y, Ortiz P, Liu Q, et al. Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death. J Biol Chem. 2013;288:20547-57 pubmed publisher
    ..Here, we provide evidence that nuclear BAG6-UBL4A-GET4 complex mediates DDR signaling and damage-induced cell death. BAG6 appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A ..
  3. Sadeghi Naini A, Papanicolau N, Falou O, Tadayyon H, Lee J, Zubovits J, et al. Low-frequency quantitative ultrasound imaging of cell death in vivo. Med Phys. 2013;40:082901 pubmed publisher
    ..Histological analysis of tumor specimens indicated up to 61% cell death present in the tumors depending on treatments administered, consistent with quantitative ultrasound findings ..
  4. Jones R, Gu D, Bjorklund C, Kuiatse I, Remaley A, Bashir T, et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther. 2013;346:381-92 pubmed publisher
    ..Overall, these findings support the hypothesis that serdemetan functions in part by inhibiting cholesterol transport and that this pathway is a potential new target for the treatment of MCL and MM. ..
  5. Lanvin O, Monferran S, Delmas C, Couderc B, Toulas C, Cohen Jonathan Moyal E. Radiation-induced mitotic cell death and glioblastoma radioresistance: a new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1 alpha and survivin in U87 cells. Eur J Cancer. 2013;49:2884-91 pubmed publisher
    ..kinase (ILK) regulates U87 glioblastoma cell radioresistance by modulating the main radiation-induced cell death mechanism in solid tumours, the mitotic cell death...
  6. Kichev A, Rousset C, Baburamani A, Levison S, Wood T, Gressens P, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem. 2014;289:9430-9 pubmed publisher
    ..The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL signaling in neonatal hypoxia-ischemia (HI)...
  7. Green D, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell. 2014;157:65-75 pubmed publisher
    ..and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery...
  8. Wallach D, Kang T, Kovalenko A. Concepts of tissue injury and cell death in inflammation: a historical perspective. Nat Rev Immunol. 2014;14:51-9 pubmed publisher
    Emerging evidence indicates that the molecular mechanisms of cell death have regulatory roles in inflammation and that the molecular changes that are associated with different forms of cell death affect the course of inflammation in ..
  9. Gaspar J, Martins A, Cruz R, Rodrigues C, Ambrósio A, Santiago A. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. Neuroscience. 2013;253:380-8 pubmed publisher
    ..We found that TUDCA markedly decreased cell death in cultured retinal neural cells induced by exposure to elevated glucose concentration...
  10. Dillon C, Weinlich R, Rodriguez D, Cripps J, Quarato G, Gurung P, et al. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014;157:1189-202 pubmed publisher
    ..protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation...
  11. Neumann K, Castineiras Vilarino M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, et al. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity. 2014;40:389-99 pubmed publisher
    Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood...
  12. Doitsh G, Galloway N, Geng X, Yang Z, Monroe K, Zepeda O, et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014;505:509-14 pubmed publisher
    The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism...
  13. Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, et al. MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. J Cell Physiol. 2013;228:2294-304 pubmed publisher
    ..p53 levels were inversely associated with the expression of Oct4, Sox2, and Nanog in response to cisplatin. Thus, targeting miR-302a may offer new therapeutic interventions in TGCT. ..
  14. Hollevoet K, Antignani A, FitzGerald D, Pastan I. Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells. J Immunother. 2014;37:8-15 pubmed publisher
    ..The aim of this study is to examine whether combining SS1P and BH3-mimetic ABT-737 induces cell death in a panel of PDAC cell lines...
  15. Farr R, Joglekar M, Taylor C, Hardikar A. Circulating non-coding RNAs as biomarkers of beta cell death in diabetes. Pediatr Endocrinol Rev. 2013;11:14-20 pubmed
    ..Furthermore, an outline for identifying and confirming islet-specific miRNA biomarkers is discussed. ..
  16. Chen M, Chen C, Wang J, Tsai A, Liou J, Pan S, et al. The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. Cell Death Dis. 2013;4:e810 pubmed publisher
    ..Taken together, our data provide compelling evidence that MPT0E028 has the potential to improve the treatment of heterogeneous and drug-resistant tumors that cannot be controlled with single-target agents. ..
  17. Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller J, et al. Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res. 2013;37:114-40 pubmed publisher
    Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders, including retinal detachment (RD)...
  18. Chen Z, Sangwan V, Banerjee S, Mackenzie T, Dudeja V, Li X, et al. miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer. 2013;12:105 pubmed publisher
    ..Decrease of Mcl-1 levels, either by siRNA or by treatment with triptolide results in cell death. Using pancreatic cancer cell lines, we have shown that miR-204, a putative regulator of Mcl-1, is repressed in ..
  19. Huang P, Huo Y, Lou L, Li H, Barnstable C, Zhang C, et al. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res. 2013;115:131-9 pubmed publisher
    ..In SCID mice RGCs showed a strong resistance to cell death in response to I/R injury (89% ± 3% of the survival cells in contralateral eye) compared with C57BL/6 (p = ..
  20. Yang P, Baciu P, Kerrigan B, Etheridge M, Sung E, Toimil B, et al. Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. Invest Ophthalmol Vis Sci. 2014;55:3012-21 pubmed publisher
    Retinal pigment epithelial (RPE) cell death is an important feature of the advanced forms of AMD. Complement alternative pathway (AP) activation is associated with RPE cell death in AMD...
  21. Aachoui Y, Sagulenko V, Miao E, Stacey K. Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr Opin Microbiol. 2013;16:319-26 pubmed publisher
    b>Cell death is an effective strategy to limit intracellular infections. Canonical inflammasomes, including NLRP3, NLRC4, and AIM2, recruit and activate caspase-1 in response to a range of microbial stimuli and endogenous danger signals...
  22. Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS ONE. 2013;8:e66558 pubmed publisher
    ..that SNAI1 overexpression results in a dramatic change in signaling pathways involved in the regulation of cell death and stem cell maintenance...
  23. Bai N, Hayashi H, Aida T, Namekata K, Harada T, Mishina M, et al. Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity. Mol Brain. 2013;6:22 pubmed publisher
  24. Lee G, Kikuno K, Nair S, Park J. Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster. J Comp Neurol. 2013;521:3972-91 pubmed publisher
    Crustacean cardioactive peptide (CCAP)-expressing neurons undergo programmed cell death (PCD) within 24 hours after adult eclosion...
  25. Ballaz S, Morales I, Rodriguez M, Obeso J. Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons. J Neurosci Res. 2013;91:1609-17 pubmed publisher
    ..Thus, we tested whether ascorbate can prevent cell death from prolonged exposure to glutamate using dopaminergic neurons of human origin...
  26. Inman D, Lambert W, Calkins D, Horner P. ?-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PLoS ONE. 2013;8:e65389 pubmed publisher
    ..These data demonstrate the utility of dietary therapy for reducing oxidative stress and improving RGC survival in glaucoma. ..
  27. Choudhary S, Sood S, Wang H. Synergistic induction of cancer cell death and reduction of clonogenic resistance by cisplatin and FK228. Biochem Biophys Res Commun. 2013;436:325-30 pubmed publisher
    ..study was to investigate the effectiveness of FK228 in increasing cisplatin's ability to induce bladder cancer cell death and reduce drug resistance...
  28. Kim A, Yim N, Ma J. Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells. BMC Complement Altern Med. 2013;13:233 pubmed publisher
    ..Thus, the present study was designed to determine the effect of SSE on cell death and elucidate its detailed mechanism...
  29. Zhang J, Chiu J, Zhang H, Qi T, Tang Q, Ma K, et al. Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Biochem Pharmacol. 2013;86:317-28 pubmed publisher
    ..In this study, we investigated the involvement of autophagy in resveratrol-induced cell death and its potential molecular mechanisms in A549 human lung adnocarcinoma cells...
  30. Racoma I, Meisen W, Wang Q, Kaur B, Wani A. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. PLoS ONE. 2013;8:e72882 pubmed publisher
    ..permeabilization resulted in a leakage of cathepsin B into the cytosol, which mediates caspase-independent cell death that can be prevented by pre-treatment with a cathepsin B inhibitor...
  31. Yamazaki T, Hannani D, Poirier Colame V, Ladoire S, Locher C, Sistigu A, et al. Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists. Cell Death Differ. 2014;21:69-78 pubmed publisher
    Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) from dying cells...
  32. Sefton E, Qiang W, Serna V, Kurita T, Wei J, Chakravarti D, et al. MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth. Endocrinology. 2013;154:4046-57 pubmed publisher
    ..UL cells exhibited disruption of mitochondrial structures and underwent cell death that was independent of caspases...
  33. Cooper A, García M, Petrovas C, Yamamoto T, Koup R, Nabel G. HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature. 2013;498:376-9 pubmed publisher
    ..viral DNA and are rapidly eliminated at the peak of viraemia, yet the mechanism by which HIV-1 induces helper T-cell death has not been defined. Here we show that virus-induced cell killing is triggered by viral integration...
  34. Ishiga Y, Ishiga T, Uppalapati S, Mysore K. Jasmonate ZIM-domain (JAZ) protein regulates host and nonhost pathogen-induced cell death in tomato and Nicotiana benthamiana. PLoS ONE. 2013;8:e75728 pubmed publisher
    ..syringae disease development and nonhost pathogen-induced hypersensitive response (HR) cell death is not completely understood. In this study, we identified JAZ genes from tomato, a host plant for P...
  35. Kepp O, Menger L, Vacchelli E, Locher C, Adjemian S, Yamazaki T, et al. Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev. 2013;24:311-8 pubmed publisher
    ..may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin...
  36. Yang W, Sriramaratnam R, Welsch M, Shimada K, Skouta R, Viswanathan V, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317-331 pubmed publisher
    Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules...
  37. Vanden Berghe T, Linkermann A, Jouan Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014;15:135-47 pubmed publisher
    b>Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner...
  38. Lin J, Shou X, Mao X, Dong J, Mohabeer N, Kushwaha K, et al. Oxidized low density lipoprotein induced caspase-1 mediated pyroptotic cell death in macrophages: implication in lesion instability?. PLoS ONE. 2013;8:e62148 pubmed publisher
    ..Our study here identified a novel cell death, pyroptosis in ox-LDL induced human macrophage, which may be implicated in lesion macrophages death and play an ..
  39. Duan J, Yu Y, Li Y, Yu Y, Sun Z. Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model. Biomaterials. 2013;34:5853-62 pubmed publisher
    ..In summary, our results suggest that exposure to silica nanoparticles is a possible risk factor to cardiovascular system...
  40. Bejarano Escobar R, Blasco M, Durán A, Martin Partido G, Francisco Morcillo J. Chronotopographical distribution patterns of cell death and of lectin-positive macrophages/microglial cells during the visual system ontogeny of the small-spotted catshark Scyliorhinus canicula. J Anat. 2013;223:171-84 pubmed publisher
    ..with the developmental period during which ganglion cells began to differentiate, an area of programmed cell death occurred in the distal optic stalk and in the retinal pigment epithelium that surrounds the optic nerve head...
  41. Subramanian P, Locatelli Hoops S, Kenealey J, Desjardin J, Notari L, Becerra S. Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site. J Biol Chem. 2013;288:23928-42 pubmed publisher
    ..Our findings establish that PEDF-R is required for the survival and antiapoptotic effects of PEDF on retina cells and has determinants for PEDF binding within its L4 ectodomain that are critical for enzymatic stimulation. ..
  42. Thevenod F, Lee W. Cadmium and cellular signaling cascades: interactions between cell death and survival pathways. Arch Toxicol. 2013;87:1743-86 pubmed publisher
    ..Severe ROS/Ca(2+) signals activate cell death effectors (ceramides, ASK1-JNK/p38, calpains, caspases) and/or cause irreversible damage to vital organelles, ..
  43. Jacquin M, Chiche J, Zunino B, Beneteau M, Meynet O, Pradelli L, et al. GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death. Cell Death Differ. 2013;20:1043-54 pubmed publisher
    Increased glucose catabolism and resistance to cell death are hallmarks of cancers, but the link between them remains elusive...
  44. Weng D, Marty Roix R, Ganesan S, Proulx M, Vladimer G, Kaiser W, et al. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014;111:7391-6 pubmed publisher
    A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous for its role in large pandemics such as the "Black Death" in medieval Europe, induces considerable cytotoxicity...
  45. Gramatzki D, Herrmann C, Happold C, Becker K, Gulbins E, Weller M, et al. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS ONE. 2013;8:e63527 pubmed publisher
    ..Modulation of intrinsic glioma cell ceramide levels by ASM overexpression or GCS inhibition does not enhance the anti-glioma activity of alkylating chemotherapy or irradiation. ..
  46. Dotson R, Rabadi S, Westcott E, Bradley S, Catlett S, Banik S, et al. Repression of inflammasome by Francisella tularensis during early stages of infection. J Biol Chem. 2013;288:23844-57 pubmed publisher
    ..Furthermore, F. tularensis LVS delayed pyroptotic cell death of the infected macrophages in an FTL_0325-dependent manner during the early stages of infection...
  47. Pierdomenico M, Negroni A, Stronati L, Vitali R, Prete E, Bertin J, et al. Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation. Am J Gastroenterol. 2014;109:279-87 pubmed publisher
    A new caspase-independent mode of programmed cell death, termed necroptosis, has recently been identified. Altered expression of molecules involved in the necroptosis pathway has been shown to trigger intestinal inflammation...
  48. Orogo A, Gustafsson A. Cell death in the myocardium: my heart won't go on. IUBMB Life. 2013;65:651-6 pubmed publisher
    ..Much attention has been focused on understanding mechanisms of cell death in myocytes with the ultimate goal being to reduce the extent of injury and improve function in the failing ..
  49. Ofengeim D, Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol. 2013;14:727-36 pubmed publisher
    ..emerged as a key upstream regulator that controls inflammatory signalling as well as the activation of multiple cell death pathways, including apoptosis and necroptosis...
  50. Salmanidis M, Brumatti G, Narayan N, Green B, van den Bergen J, Sandow J, et al. Hoxb8 regulates expression of microRNAs to control cell death and differentiation. Cell Death Differ. 2013;20:1370-80 pubmed publisher
    ..We have uncovered a previously unrecognised link between Hoxb8 expression and microRNAs that provides a new insight into the oncogenic functions of Hoxb8. ..
  51. Sano R, Reed J. ER stress-induced cell death mechanisms. Biochim Biophys Acta. 2013;1833:3460-3470 pubmed publisher
    ..In cases where ER stress cannot be reversed, cellular functions deteriorate, often leading to cell death. Accumulating evidence implicates ER stress-induced cellular dysfunction and cell death as major contributors to ..
  52. Pantic B, Trevisan E, Citta A, Rigobello M, Marin O, Bernardi P, et al. Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface. Cell Death Dis. 2013;4:e858 pubmed publisher
  53. Mashimo M, Kato J, Moss J. ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress. Proc Natl Acad Sci U S A. 2013;110:18964-9 pubmed publisher
    Poly (ADP ribose) (PAR) formation catalyzed by PAR polymerase 1 in response to genotoxic stress mediates cell death due to necrosis and apoptosis...
  54. Koehler B, Scherr A, Lorenz S, Urbanik T, Kautz N, Elssner C, et al. Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. PLoS ONE. 2013;8:e76446 pubmed publisher
    ..already entered clinical trials, very few studies investigated a role of antiapoptotic Bcl-2 proteins beside cell death in the context of metastasis...
  55. Scarfo L, Ghia P. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunol Lett. 2013;155:36-9 pubmed publisher
    The BCL2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (BAX, BAK, and BH3-only proteins) and pro-survival (BCL2 and ..
  56. Linkermann A, Heller J, Prokai A, Weinberg J, De Zen F, Himmerkus N, et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013;24:1545-57 pubmed publisher
    ..In addition, Nec-1 prevented RCM-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of CIAKI.
  57. Eckhart L, Lippens S, Tschachler E, Declercq W. Cell death by cornification. Biochim Biophys Acta. 2013;1833:3471-3480 pubmed publisher
    Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed cell death known as cornification. Cornification leads to the formation of the outermost skin barrier, i.e...
  58. Tao L, Zhu W, Hu B, Qu J, Luo Z. Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages. Infect Immun. 2013;81:3077-88 pubmed publisher
    ..Furthermore, infection of these cells by LPE509 caused extensive cell death in a process that requires the Dot/Icm type IV secretion system...
  59. David J, Owens T, Barwe S, Rajasekaran A. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013;12:2296-307 pubmed publisher
    ..by inhibiting oxidative phosphorylation and glycolysis, leading to cellular energy depletion and nonapoptotic cell death. Finally, gramicidin A effectively reduced the growth of RCC tumor xenografts in vivo...
  60. Goya G, Asin L, Ibarra M. Cell death induced by AC magnetic fields and magnetic nanoparticles: current state and perspectives. Int J Hyperthermia. 2013;29:810-8 pubmed publisher
    This review analyses the advances in the field of magnetically induced cell death using intracellular magnetic nanoparticles (MNPs)...
  61. Booth L, Cruickshanks N, Ridder T, Dai Y, Grant S, Dent P. PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. Cancer Biol Ther. 2013;14:458-65 pubmed publisher
    ..Collectively our data demonstrate that PARP1 and CHK1 inhibitors interact to kill mammary carcinoma cells and that increased DNA damage is a surrogate marker for the response of cells to this drug combination. ..
  62. Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, et al. Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. Blood. 2014;123:2652-62 pubmed publisher
    ..that play crucial roles in embryogenesis and the maintenance of tissue homeostasis by triggering apoptotic cell death. The BH3-only protein Bim is critical for developmental apoptosis of lymphocytes, securing establishment of ..
  63. Ma X, Yang L, Yang Y, Li M, Li W, Xue L. dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila. Dev Biol. 2013;380:211-21 pubmed publisher
    ..Furthermore, loss of dUev1a suppressed TNF ortholog Eiger-induced JNK-mediated cell invasion and cell death. Finally, dUev1a cooperated with Bendless to activate JNK signaling through dTRAF2...
  64. Ferrer Martín R, Martín Oliva D, Sierra A, Carrasco M, Martín Estebané M, Calvente R, et al. Microglial cells in organotypic cultures of developing and adult mouse retina and their relationship with cell death. Exp Eye Res. 2014;121:42-57 pubmed publisher
    ..In addition, the features of microglial response in cultured retinal explants show them to be a useful model for studying interactions between microglial cells and degenerating neurons in retinal diseases. ..
  65. Mohapatra P, Satapathy S, Das D, Siddharth S, Choudhuri T, Kundu C. Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway. Toxicol Appl Pharmacol. 2014;275:221-31 pubmed publisher
    ..Thus, Res caused apoptosis in CSC-induced cancer cells by reduction of LP-BER activity and this phenomenon largely depends on p21. ..
  66. Kim M, Kim D, Park J, Kim S, Lee C, Yong J, et al. PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 2013;63:432-45 pubmed publisher
    ..a time- and dose-dependent manner and protected against lipopolysaccharide- and hydrogen peroxide (H?O?)-induced cell death and cytotoxicity...
  67. Piao J, Cui Z, Furusawa Y, Ahmed K, Rehman M, Tabuchi Y, et al. The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells. Chem Biol Interact. 2013;205:119-27 pubmed publisher
    ..However, the detailed molecular mechanisms involved in the initiation of cell death are still unclear...
  68. Denton D, Aung Htut M, Lorensuhewa N, Nicolson S, Zhu W, Mills K, et al. UTX coordinates steroid hormone-mediated autophagy and cell death. Nat Commun. 2013;4:2916 pubmed publisher
    ..transcriptional regulation of apoptosis and autophagy genes during ecdysone-regulated programmed cell death of Drosophila salivary glands...
  69. Huang C, Cen L, Liu L, Leaver S, Harvey A, Cui Q, et al. Adeno-associated virus-mediated expression of growth-associated protein-43 aggravates retinal ganglion cell death in experimental chronic glaucomatous injury. Mol Vis. 2013;19:1422-32 pubmed
    ..Thus, the finding that this same protein is deleterious to RGC viability after chronic IOP elevation may aid in understanding the mechanisms involved in RGC loss in glaucoma and how best to treat this condition. ..
  70. Jenkins V, Timmons A, McCall K. Diversity of cell death pathways: insight from the fly ovary. Trends Cell Biol. 2013;23:567-74 pubmed publisher
    Multiple types of cell death exist including necrosis, apoptosis, and autophagic cell death...