cell cycle

Summary

Summary: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Top Publications

  1. Zopf C, Quinn K, Zeidman J, Maheshri N. Cell-cycle dependence of transcription dominates noise in gene expression. PLoS Comput Biol. 2013;9:e1003161 pubmed publisher
    ..The cell cycle has a pronounced global role in affecting transcriptional and translational output, but how this influences ..
  2. Wang S, Romano F, Field C, Mitchison T, Rapoport T. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013;203:801-14 pubmed publisher
    In metazoans the endoplasmic reticulum (ER) changes during the cell cycle, with the nuclear envelope (NE) disassembling and reassembling during mitosis and the peripheral ER undergoing extensive remodeling...
  3. Fish K, Chen J, Longnecker R. Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma. Blood. 2014;123:530-40 pubmed publisher
    ..Our study demonstrates a novel function of EBV LMP2A in maximizing MYC expression, resulting in hyperproliferation and cellular transformation into cancer cells in vivo. ..
  4. Kueh H, Champhekar A, Champhekhar A, Nutt S, Elowitz M, Rothenberg E. Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science. 2013;341:670-3 pubmed publisher
    ..1 accumulation. Exogenous PU.1 expression in progenitors increases endogenous PU.1 levels by inducing cell cycle lengthening, implying positive feedback between a regulatory factor and the cell cycle...
  5. Ufkin M, Peterson S, Yang X, Driscoll H, Duarte C, Sathyanarayana P. miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. Leuk Res. 2014;38:402-10 pubmed publisher
    ..Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic ..
  6. Qu K, Lin T, Wei J, Meng F, Wang Z, Huang Z, et al. Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1253-9 pubmed
    ..The changes in cell cycle were analyzed by flow cytometry, and cellular senescence was detected with senescence associated ?-galactosidase ..
  7. Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott R, et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell. 2013;24:167-81 pubmed publisher
    In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies...
  8. Peyric E, Moore H, Whitmore D. Circadian clock regulation of the cell cycle in the zebrafish intestine. PLoS ONE. 2013;8:e73209 pubmed publisher
    ..The aim of this study was to explore circadian clock regulation of cell proliferation and cell cycle gene expression in the zebrafish intestine...
  9. Du Z, Tong X, Ye X. Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4. J Biol Chem. 2013;288:26678-87 pubmed publisher
    Cyclin/cyclin-dependent kinases (Cdks) are critical protein kinases in regulating cell cycle progression. Among them, cyclin D1/Cdk4 exerts its function mainly in the G1 phase...
  10. Neophytou C, Constantinou C, Papageorgis P, Constantinou A. D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells. Biochem Pharmacol. 2014;89:31-42 pubmed publisher
    ..Our results show that TPGS can induce G1/S cell cycle arrest and apoptosis in breast cancer cell lines (MCF-7 and MDA-MB-231) but not in "normal" (non-..

Detail Information

Publications62

  1. Zopf C, Quinn K, Zeidman J, Maheshri N. Cell-cycle dependence of transcription dominates noise in gene expression. PLoS Comput Biol. 2013;9:e1003161 pubmed publisher
    ..The cell cycle has a pronounced global role in affecting transcriptional and translational output, but how this influences ..
  2. Wang S, Romano F, Field C, Mitchison T, Rapoport T. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013;203:801-14 pubmed publisher
    In metazoans the endoplasmic reticulum (ER) changes during the cell cycle, with the nuclear envelope (NE) disassembling and reassembling during mitosis and the peripheral ER undergoing extensive remodeling...
  3. Fish K, Chen J, Longnecker R. Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma. Blood. 2014;123:530-40 pubmed publisher
    ..Our study demonstrates a novel function of EBV LMP2A in maximizing MYC expression, resulting in hyperproliferation and cellular transformation into cancer cells in vivo. ..
  4. Kueh H, Champhekar A, Champhekhar A, Nutt S, Elowitz M, Rothenberg E. Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science. 2013;341:670-3 pubmed publisher
    ..1 accumulation. Exogenous PU.1 expression in progenitors increases endogenous PU.1 levels by inducing cell cycle lengthening, implying positive feedback between a regulatory factor and the cell cycle...
  5. Ufkin M, Peterson S, Yang X, Driscoll H, Duarte C, Sathyanarayana P. miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. Leuk Res. 2014;38:402-10 pubmed publisher
    ..Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic ..
  6. Qu K, Lin T, Wei J, Meng F, Wang Z, Huang Z, et al. Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1253-9 pubmed
    ..The changes in cell cycle were analyzed by flow cytometry, and cellular senescence was detected with senescence associated ?-galactosidase ..
  7. Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott R, et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell. 2013;24:167-81 pubmed publisher
    In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies...
  8. Peyric E, Moore H, Whitmore D. Circadian clock regulation of the cell cycle in the zebrafish intestine. PLoS ONE. 2013;8:e73209 pubmed publisher
    ..The aim of this study was to explore circadian clock regulation of cell proliferation and cell cycle gene expression in the zebrafish intestine...
  9. Du Z, Tong X, Ye X. Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4. J Biol Chem. 2013;288:26678-87 pubmed publisher
    Cyclin/cyclin-dependent kinases (Cdks) are critical protein kinases in regulating cell cycle progression. Among them, cyclin D1/Cdk4 exerts its function mainly in the G1 phase...
  10. Neophytou C, Constantinou C, Papageorgis P, Constantinou A. D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells. Biochem Pharmacol. 2014;89:31-42 pubmed publisher
    ..Our results show that TPGS can induce G1/S cell cycle arrest and apoptosis in breast cancer cell lines (MCF-7 and MDA-MB-231) but not in "normal" (non-..
  11. Zhang Y, Hu H, Song L, Cai L, Wei R, Jin W. Epirubicin-mediated expression of miR-302b is involved in osteosarcoma apoptosis and cell cycle regulation. Toxicol Lett. 2013;222:1-9 pubmed publisher
    ..Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell ..
  12. Grant G, Brooks L, Zhang X, Mahoney J, Martyanov V, Wood T, et al. Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors. Mol Biol Cell. 2013;24:3634-50 pubmed publisher
    We identify the cell cycle-regulated mRNA transcripts genome-wide in the osteosarcoma-derived U2OS cell line...
  13. Florio M, Huttner W. Neural progenitors, neurogenesis and the evolution of the neocortex. Development. 2014;141:2182-94 pubmed publisher
    ..Here, we review the diversity of neocortical neural progenitors, their interspecies variations and their roles in determining the evolutionary increase in neuron numbers and neocortex size. ..
  14. Penterman J, Abo R, De Nisco N, Arnold M, Longhi R, Zanda M, et al. Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis. Proc Natl Acad Sci U S A. 2014;111:3561-6 pubmed publisher
    ..meliloti populations to determine how treatment with a sublethal NCR peptide affects the cell cycle and physiology of bacteria at the molecular level...
  15. Mathiasen D, Lisby M. Cell cycle regulation of homologous recombination in Saccharomyces cerevisiae. FEMS Microbiol Rev. 2014;38:172-84 pubmed publisher
    ..error-free repair of DNA double-strand breaks (DSBs) primarily during the S and G2 phases of the mitotic cell cycle, while nonhomologous end joining (NHEJ) is the preferred pathway for DSB repair in G1 phase...
  16. Lindås A, Bernander R. The cell cycle of archaea. Nat Rev Microbiol. 2013;11:627-38 pubmed publisher
    ..Recent findings have provided insight into the cell cycle of archaea, including the multiple-origin mode of DNA replication, the initial characterization of a genome ..
  17. Shaltiël I, Aprelia M, Saurin A, Chowdhury D, Kops G, Voest E, et al. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A. 2014;111:7313-8 pubmed publisher
    The basic machinery that detects DNA damage is the same throughout the cell cycle. Here, we show, in contrast, that reversal of DNA damage responses (DDRs) and recovery are fundamentally different in G1 and G2 phases of the cell cycle...
  18. Chiang K, Yeh C, Hsu J, Chen L, Kuo S, Sun C, et al. MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase. J Steroid Biochem Mol Biol. 2013;138:427-34 pubmed publisher
    ..that MART-10 is more potent than 1?,25(OH)2D3 in suppressing FaDu and SCC-25 cell growth through greater cell cycle arrest at G0/G1, accompanied by a greater downregulation of ki-67 expression and upregulation of p21 and p27...
  19. Kozdon J, Melfi M, Luong K, Clark T, Boitano M, Wang S, et al. Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle. Proc Natl Acad Sci U S A. 2013;110:E4658-67 pubmed publisher
    ..we determined the methylation state of the entire chromosome at every base pair at five time points in the cell cycle using single-molecule, real-time sequencing...
  20. Fortier M, Figeac N, White R, Knopp P, Zammit P. Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells. Dev Biol. 2013;382:504-16 pubmed publisher
    ..S1PR3 levels were high in quiescent myogenic cells before falling during entry into cell cycle. Retrovirally-mediated constitutive expression of S1PR3 led to suppressed cell cycle progression in satellite ..
  21. Aviner R, Geiger T, Elroy Stein O. Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation. Genes Dev. 2013;27:1834-44 pubmed publisher
    ..Using PUNCH-P, we measured cell cycle-specific fluctuations in synthesis for >5000 proteins in mammalian cells, identified proteins not previously ..
  22. Fang G, Passalacqua K, Hocking J, Llopis P, Gerstein M, Bergman N, et al. Transcriptomic and phylogenetic analysis of a bacterial cell cycle reveals strong associations between gene co-expression and evolution. BMC Genomics. 2013;14:450 pubmed publisher
    The genetic network involved in the bacterial cell cycle is poorly understood even though it underpins the remarkable ability of bacteria to proliferate. How such network evolves is even less clear...
  23. Lecona E, Rojas L, Bonasio R, Johnston A, Fernandez Capetillo O, Reinberg D. Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. PLoS Biol. 2013;11:e1001737 pubmed publisher
    ..of genes involved in development and differentiation, and also maintain repression of key genes involved in the cell cycle, indirectly regulating cell proliferation...
  24. Chandler H, Peters G. Stressing the cell cycle in senescence and aging. Curr Opin Cell Biol. 2013;25:765-71 pubmed publisher
    Senescence represents a permanent exit from the cell cycle and its role in curtailing the proliferation of damaged and potentially oncogenic cells has relevance both as a front-line defense against cancer and as an underlying cause of ..
  25. Liu X, Chhipa R, Pooya S, Wortman M, Yachyshin S, Chow L, et al. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci U S A. 2014;111:E435-44 pubmed publisher
    ..Metformin directly inhibited mTOR by enhancing PRAS40's association with RAPTOR, whereas AICAR blocked the cell cycle through proteasomal degradation of the G2M phosphatase cdc25c...
  26. Cheffer A, Tarnok A, Ulrich H. Cell cycle regulation during neurogenesis in the embryonic and adult brain. Stem Cell Rev. 2013;9:794-805 pubmed publisher
    ..However, the mechanisms, by which cell cycle components control neural stem cell proliferation and consequently neurogenesis, still lack further ..
  27. Xue Q, Lv L, Wan C, Chen B, Li M, Ni T, et al. Expression and clinical role of small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) as a novel cell cycle protein in NSCLC. J Cancer Res Clin Oncol. 2013;139:1539-49 pubmed publisher
    ..These findings suggested that SGTA might play an important role in promoting the tumorigenesis of NSCLC, and thus be a promising therapeutic target to prevent NSCLC progression. ..
  28. Machado Neto J, Lazarini M, Favaro P, Franchi G, Nowill A, Saad S, et al. ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Exp Cell Res. 2014;324:137-45 pubmed publisher
    ..were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth...
  29. Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher
    ..Ectopic overexpression of miR-26b in rat primary postmitotic neurons led to the DNA replication and aberrant cell cycle entry (CCE) and, in parallel, increased tau-phosphorylation, which culminated in the apoptotic cell death of ..
  30. Luo Q, Li X, Li J, Kong X, Zhang J, Chen L, et al. MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer. Int J Oncol. 2013;43:1212-8 pubmed publisher
    ..MTT assays, colony formation assays, transwell chamber migration assays, cell cycle and apoptosis assays were used to explore the potential function of miR-15a in MDA-MB-231 human breast cancer ..
  31. Wang Q, Tiffen J, Bailey C, Lehman M, Ritchie W, Fazli L, et al. Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst. 2013;105:1463-73 pubmed publisher
    ..LAT inhibition suppressed M-phase cell cycle genes regulated by E2F family transcription factors including critical castration-resistant prostate cancer ..
  32. Herrup K. Post-mitotic role of the cell cycle machinery. Curr Opin Cell Biol. 2013;25:711-6 pubmed publisher
    ..Although the demands placed on these cell cycle proteins are high, once cells such as neurons differentiate they enter a long non-mitotic phase where evolution ..
  33. Pauklin S, Vallier L. The cell-cycle state of stem cells determines cell fate propensity. Cell. 2013;155:135-47 pubmed publisher
    ..pluripotent stem cells and show that their capacity of differentiation varies during the progression of their cell cycle. These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control differentiation signals ..
  34. Kim I, Lee M, Park J, Jeon R, Baek S, Kim K. ?TrCP-mediated ubiquitylation regulates protein stability of Mis18? in a cell cycle-dependent manner. Biochem Biophys Res Commun. 2014;443:62-7 pubmed publisher
    Ubiquitin E3 ligases including SCF complex are key regulators of cell cycle. Here, we show that Mis18?, a component of Mis18 complex governing CENP-A localization, is a new substrate of ?TrCP-containing SCF complex...
  35. Sawada G, Ueo H, Matsumura T, Uchi R, Ishibashi M, Mima K, et al. CHD8 is an independent prognostic indicator that regulates Wnt/?-catenin signaling and the cell cycle in gastric cancer. Oncol Rep. 2013;30:1137-42 pubmed publisher
    ..GSEA revealed that CHD8 was significantly associated with genes involved in the Wnt/??catenin pathway and in the cell cycle. In addition, knockdown of CHD8 expression in the gastric cancer cell lines, MKN45 and NUGC4, promoted ..
  36. McCormick C, Akamatsu M, Ti S, Pollard T. Measuring affinities of fission yeast spindle pole body proteins in live cells across the cell cycle. Biophys J. 2013;105:1324-35 pubmed publisher
    ..we infer that Sid2p and Mob1p both exist as monomeric, heterodimeric, and homodimeric species throughout the cell cycle. During interphase these species have widely different affinities for their common receptor Cdc11p on the SPB...
  37. Lamb R, Lehn S, Rogerson L, Clarke R, Landberg G. Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity. Cell Cycle. 2013;12:2384-94 pubmed publisher
    Cyclin D1 and its binding partners CDK4/6 are essential regulators of cell cycle progression and are implicated in cancer progression...
  38. Wang P, Galan J, Normandin K, Bonneil E, Hickson G, Roux P, et al. Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. J Cell Biol. 2013;202:277-93 pubmed publisher
    ..We found that the subcellular localization of Gwl changed dramatically during the cell cycle in Drosophila. Gwl translocated from the nucleus to the cytoplasm in prophase...
  39. Lee Y, Dominy J, Choi Y, Jurczak M, Tolliday N, Camporez J, et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014;510:547-51 pubmed publisher
    ..Although insulin is a mitogenic signal in proliferative cells, whether components of the cell cycle machinery contribute to its metabolic action is poorly understood...
  40. Dowling M, Kan A, Heinzel S, Zhou J, Marchingo J, Wellard C, et al. Stretched cell cycle model for proliferating lymphocytes. Proc Natl Acad Sci U S A. 2014;111:6377-82 pubmed publisher
    Stochastic variation in cell cycle time is a consistent feature of otherwise similar cells within a growing population...
  41. De Nisco N, Abo R, Wu C, Penterman J, Walker G. Global analysis of cell cycle gene expression of the legume symbiont Sinorhizobium meliloti. Proc Natl Acad Sci U S A. 2014;111:3217-24 pubmed publisher
    In ?-proteobacteria, strict regulation of cell cycle progression is necessary for the specific cellular differentiation required for adaptation to diverse environmental niches...
  42. Wu J, Renn C, Faden A, Dorsey S. TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. J Neurosci. 2013;33:12447-63 pubmed publisher
    ..Whole genome analysis, confirmed at the protein level, revealed that cell cycle genes were upregulated in trkB.T1(+/+) but not trkB.T1(-/-) spinal cord after SCI...
  43. Murray S, Panis G, Fumeaux C, Viollier P, Howard M. Computational and genetic reduction of a cell cycle to its simplest, primordial components. PLoS Biol. 2013;11:e1001749 pubmed publisher
    What are the minimal requirements to sustain an asymmetric cell cycle? Here we use mathematical modelling and forward genetics to reduce an asymmetric cell cycle to its simplest, primordial components...
  44. Tsioras K, Papastefanaki F, Politis P, Matsas R, Gaitanou M. Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells. PLoS ONE. 2013;8:e82172 pubmed publisher
    BM88/Cend1 is a neuronal-lineage specific modulator with a pivotal role in coordination of cell cycle exit and differentiation of neuronal precursors...
  45. Longhin E, Holme J, Gutzkow K, Arlt V, Kucab J, Camatini M, et al. Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved. Part Fibre Toxicol. 2013;10:63 pubmed publisher
    This study explores and characterizes cell cycle alterations induced by urban PM2.5 in the human epithelial cell line BEAS-2B, and elucidates possible mechanisms involved.
  46. Reinhardt H, Yaffe M. Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol. 2013;14:563-80 pubmed publisher
    Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells...
  47. Tane S, Ikenishi A, Okayama H, Iwamoto N, Nakayama K, Takeuchi T. CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014;443:1105-9 pubmed publisher
    Mammalian cardiomyocytes actively proliferate during embryonic stages, following which cardiomyocytes exit their cell cycle after birth...
  48. De Santis M, Rinaldi F, Falcone E, Lucidi S, Piaggio G, Gurtner A, et al. Combining optimization and machine learning techniques for genome-wide prediction of human cell cycle-regulated genes. Bioinformatics. 2014;30:228-33 pubmed publisher
    The identification of cell cycle-regulated genes through the cyclicity of messenger RNAs in genome-wide studies is a difficult task due to the presence of internal and external noise in microarray data...
  49. Cronin J, Watkins Chow D, Incao A, Hasskamp J, Schönewolf N, Aoude L, et al. SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Res. 2013;73:5709-18 pubmed publisher
    ..Melanoma cells with stable loss of SOX10 were arrested in the G1 phase of the cell cycle, with reduced expression of the melanocyte determining factor microphthalmia-associated transcription factor, ..
  50. Kempf H, Hatzikirou H, Bleicher M, Meyer Hermann M. In silico analysis of cell cycle synchronisation effects in radiotherapy of tumour spheroids. PLoS Comput Biol. 2013;9:e1003295 pubmed publisher
    Tumour cells show a varying susceptibility to radiation damage as a function of the current cell cycle phase...
  51. Bertoli C, Skotheim J, de Bruin R. Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol. 2013;14:518-28 pubmed publisher
    The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of eukaryotic cell proliferation, and its misregulation promotes oncogenesis...
  52. Kazantseva J, Kivil A, Tints K, Kazantseva A, Neuman T, Palm K. Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE. 2013;8:e74799 pubmed publisher
  53. Gonzalez L, Lukamowicz Rajska M, Thomassen L, Kirschhock C, Leyns L, Lison D, et al. Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes. Nanotoxicology. 2014;8:876-84 pubmed publisher
    ..Assessment of the cell viability, cell cycle changes and induction of MN by SNPs ranging from 12 to 174 nm was performed in presence or absence of serum, ..
  54. Zhang J, Han L, Bao Z, Wang Y, Chen L, Yan W, et al. HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol. 2013;15:1595-603 pubmed publisher
    ..Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance and function of HOTAIR in glioma remains unclear...
  55. Guo H, Xu Y, Ye Z, Yu J, Hu X. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013;68:431-4 pubmed
    ..We treated these cells with curcumin and then evaluated the effects of curcumin on cell cycle profiling and apoptosis, as well as the activation of NF-kaapaB and c-jun in these cells...
  56. Ridenour D, McLennan R, Teddy J, Semerad C, Haug J, Kulesa P. The neural crest cell cycle is related to phases of migration in the head. Development. 2014;141:1095-103 pubmed publisher
    ..Yet details of individual cell division events and how cell cycle is related to phases of migration remain unclear...
  57. Wang L, Lee H, Fang L, Mayfield A, Chen C. Fatty acid and phospholipid syntheses are prerequisites for the cell cycle of Symbiodinium and their endosymbiosis within sea anemones. PLoS ONE. 2013;8:e72486 pubmed publisher
    ..players in the regulation of cell proliferation in various eukaryotes, including microalgae, their role in the cell cycle of cnidarian-dinoflagellate (genus Symbiodinium) endosymbioses remains to be elucidated...
  58. Abel S, Bucher T, Nicollier M, Hug I, Kaever V, Abel Zur Wiesch P, et al. Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. PLoS Genet. 2013;9:e1003744 pubmed publisher
    ..Relating these values to c-di-GMP levels modeled for single cells progressing through the cell cycle sets a quantitative frame for the successive activation of c-di-GMP dependent processes during the C...
  59. Martin O, Ivashkevich A, Choo S, Woodbine L, Jeggo P, Martin R, et al. Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity. DNA Repair (Amst). 2013;12:844-55 pubmed publisher
    ..These studies indicate new dimensions of the ?-H2AX assay that, with further elaboration and exemplification, have the potential to augment its power to predict radiosensitivity. ..
  60. Sadasivam S, DeCaprio J. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer. 2013;13:585-95 pubmed publisher
    ..RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1...
  61. Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajoie B, Mirny L, et al. Organization of the mitotic chromosome. Science. 2013;342:948-53 pubmed publisher
    ..We applied chromosome conformation capture methods, 5C and Hi-C, across the cell cycle and revealed two distinct three-dimensional folding states of the human genome...
  62. Nishihama R, Kohchi T. Evolutionary insights into photoregulation of the cell cycle in the green lineage. Curr Opin Plant Biol. 2013;16:630-7 pubmed publisher
    ..How light controls the cell cycle depends on growth habitats, body plans (unicellular vs. multicellular), and photosensors...