cell physiological phenomena


Summary: Cellular processes, properties, and characteristics.

Top Publications

  1. Nielsen J. Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine. Cell Metab. 2017;25:572-579 pubmed publisher
    ..It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine. ..
  2. Kearse M, Wilusz J. Non-AUG translation: a new start for protein synthesis in eukaryotes. Genes Dev. 2017;31:1717-1731 pubmed publisher
  3. Fuller C, Insel P. I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". Am J Physiol Cell Physiol. 2014;306:C1-2 pubmed publisher
  4. Killilea A, Csencsits R, Le E, Patel A, Kenny S, Xu K, et al. Cytoskeletal organization in microtentacles. Exp Cell Res. 2017;357:291-298 pubmed publisher
    ..This work provides a significant step in this direction. ..
  5. Guimaraes G, DeLuca J. Connecting with Ska, a key complex at the kinetochore-microtubule interface. EMBO J. 2009;28:1375-7 pubmed publisher
  6. Cooper S, Bakal C. Accelerating Live Single-Cell Signalling Studies. Trends Biotechnol. 2017;35:422-433 pubmed publisher
    ..Moreover, we discuss novel approaches that are allowing us to explore how pathways respond to changes in inputs and even predict the fate of a cell based upon its signalling history and state. ..
  7. Lo C, Wang H, Dembo M, Wang Y. Cell movement is guided by the rigidity of the substrate. Biophys J. 2000;79:144-52 pubmed
    ..We conclude that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion. ..
  8. Harding H, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F, et al. Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. Cold Spring Harb Symp Quant Biol. 2001;66:499-508 pubmed
  9. Lee S, Morishita Y. Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis. PLoS Comput Biol. 2017;13:e1005651 pubmed publisher

More Information


  1. Lynch I, Salvati A, Dawson K. Protein-nanoparticle interactions: What does the cell see?. Nat Nanotechnol. 2009;4:546-7 pubmed publisher
    ..Fluorescence correlation spectroscopy is used as a quantitative method to understand the binding and exchange behaviour of proteins on the surfaces of nanoparticles. ..
  2. Lombardi A, Elrod J. Mediating ER-mitochondrial cross-talk. Science. 2017;358:591-592 pubmed publisher
  3. Mogen A, Carroll R, James K, Lima G, Silva D, Culver J, et al. Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology. Mol Microbiol. 2017;105:139-157 pubmed publisher
    ..Collectively, these findings demonstrate a key contribution of saNOS to S. aureus aerobic respiratory metabolism. ..
  4. Pelkmans L. Cell Biology. Using cell-to-cell variability--a new era in molecular biology. Science. 2012;336:425-6 pubmed publisher
  5. Salomão P, Oliveira F, Rodrigues P, Al Ahj L, Gasque K, Jeggle P, et al. The cytotoxic effect of TiF4 and NaF on fibroblasts is influenced by the experimental model, fluoride concentration and exposure time. PLoS ONE. 2017;12:e0179471 pubmed publisher
    ..Therefore, we compared the cytotoxicity of TiF4 with sodium fluoride (NaF) (already applied in Dentistry) considering different fluoride concentrations, pH values and experimental models...
  6. Krenkel M, Toepperwien M, Alves F, Salditt T. Three-dimensional single-cell imaging with X-ray waveguides in the holographic regime. Acta Crystallogr A Found Adv. 2017;73:282-292 pubmed publisher
    ..As a result, it is shown that phase retrieval is no longer a bottleneck for holographic imaging of cells, and how advanced schemes can be implemented to cope also with high noise and inconsistencies in the data. ..
  7. Thomas G, Renjith M, Manna T. Kinetochore-microtubule interactions in chromosome segregation: lessons from yeast and mammalian cells. Biochem J. 2017;474:3559-3577 pubmed publisher
    ..The present review focuses on the most recent advances in understanding of the molecular and structural aspects of kinetochore-microtubule interaction based on the studies in yeast and vertebrate cells...
  8. Dietrich C. A model for cell-cell recognition and control of cell growth mediated by sulfated glycosaminoglycans. Braz J Med Biol Res. 1984;17:5-15 pubmed
  9. Thielens N, Tedesco F, Bohlson S, Gaboriaud C, Tenner A. C1q: A fresh look upon an old molecule. Mol Immunol. 2017;89:73-83 pubmed publisher
    ..This review summarizes the classical functions of C1q and reviews novel discoveries within the field. ..
  10. Salehi Reyhani A, Ces O, Elani Y. Artificial cell mimics as simplified models for the study of cell biology. Exp Biol Med (Maywood). 2017;242:1309-1317 pubmed publisher
  11. Schmitt D, An S. Spatial Organization of Metabolic Enzyme Complexes in Cells. Biochemistry. 2017;56:3184-3196 pubmed publisher
  12. Zhang Y, Wei F, Poh Y, Jia Q, Chen J, Chen J, et al. Interfacing 3D magnetic twisting cytometry with confocal fluorescence microscopy to image force responses in living cells. Nat Protoc. 2017;12:1437-1450 pubmed publisher
    ..The integrated 3D-MTC-microscopy platform takes ?20 d to construct, and the experimental procedures require ?4 d when carried out by a life sciences graduate student. ..
  13. Holmes W, Park J, Levchenko A, Edelstein Keshet L. A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns. PLoS Comput Biol. 2017;13:e1005524 pubmed publisher
  14. Petsko G. Open questions: Zombie projects, translational research, and the real secret of the inside of the cell. BMC Biol. 2013;11:97 pubmed publisher
  15. Kay A. What gets a cell excited? Kinky curves. Adv Physiol Educ. 2014;38:376-80 pubmed publisher
  16. Benovic J, von Zastrow M. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014;27:v-vi pubmed publisher
  17. Skandalis S, Dobra K, Götte M, Karousou E, Misra S. Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease. Biomed Res Int. 2015;2015:482879 pubmed publisher
  18. Fruman D, Chiu H, Hopkins B, Bagrodia S, Cantley L, Abraham R. The PI3K Pathway in Human Disease. Cell. 2017;170:605-635 pubmed publisher
    ..We also discuss recent progress developing PI3K-targeted therapies for treatment of cancer and other diseases. ..
  19. Gao F, Almeida S, López González R. Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder. EMBO J. 2017;36:2931-2950 pubmed publisher
    ..These exciting advances reveal the complexity of the pathogenic mechanisms of FTD and ALS and suggest promising molecular targets for future therapeutic interventions in these devastating disorders. ..
  20. Ziats N, Miller K, Anderson J. In vitro and in vivo interactions of cells with biomaterials. Biomaterials. 1988;9:5-13 pubmed
    ..In this review, we summarize the interaction of cells with biomaterials in vitro and in vivo. ..
  21. Benson R, Meyer R, Zaruba M, McKhann G. Cellular autofluorescence--is it due to flavins?. J Histochem Cytochem. 1979;27:44-8 pubmed
    ..Measurements of fluorescence intensity and spectra of a variety of cell types and assays of neuronal homogenates are presented to demonstrate that this autofluorescence is most likely due to endogenous flavoproteins. ..
  22. Theillet F, Binolfi A, Frembgen Kesner T, Hingorani K, Sarkar M, Kyne C, et al. Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014;114:6661-714 pubmed publisher
  23. Binder P, Danchin A. Life's demons: information and order in biology. What subcellular machines gather and process the information necessary to sustain life?. EMBO Rep. 2011;12:495-9 pubmed publisher
  24. Alt W, Deutsch A, Preziosi L. Computational cell biology: second theme issue on "computational biology". J Math Biol. 2009;58:1-5 pubmed publisher
  25. Proia R, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015;125:1379-87 pubmed publisher
    ..The unique mode of signaling of this lysophospholipid mediator is providing novel opportunities for therapeutic intervention, with possibilities to target not only GPCRs but also transporters, metabolic enzymes, and chaperones. ..
  26. Schaff J, Fink C, Slepchenko B, Carson J, Loew L. A general computational framework for modeling cellular structure and function. Biophys J. 1997;73:1135-46 pubmed
    ..The results can be directly compared to experimental observations and provide insight into the role of experimentally inaccessible components of the overall mechanism. ..
  27. Zigmond S. How WASP regulates actin polymerization. J Cell Biol. 2000;150:F117-20 pubmed
  28. Schmid A, Neubauer P. Analytical biotechnology: from single molecule and single cell analyses to population dynamics of metabolites and cells. Curr Opin Biotechnol. 2010;21:1-3 pubmed publisher
  29. Huttlin E, Bruckner R, Paulo J, Cannon J, Ting L, Baltier K, et al. Architecture of the human interactome defines protein communities and disease networks. Nature. 2017;545:505-509 pubmed publisher
  30. . Abstracts of the 5th Asian-Pacific Organization for Cell Biology (APOCB) Congress, October 28-31, 2006, Beijing, China. Cell Res. 2006;16 Suppl 1:S1-169 pubmed
  31. Markowetz F. How to understand the cell by breaking it: network analysis of gene perturbation screens. PLoS Comput Biol. 2010;6:e1000655 pubmed publisher
  32. Beebe D, Ingber D, den Toonder J. Organs on Chips 2013. Lab Chip. 2013;13:3447-8 pubmed publisher
  33. Virzi G, Day S, De Cal M, Vescovo G, Ronco C. Heart-kidney crosstalk and role of humoral signaling in critical illness. Crit Care. 2014;18:201 pubmed publisher
    ..This review briefly summarizes relevant research and focuses on the role of signaling in heart-kidney crosstalk in the critical care setting. ..
  34. Cramer L. Myosin VI: roles for a minus end-directed actin motor in cells. J Cell Biol. 2000;150:F121-6 pubmed
  35. Cuypers T, Rutten J, Hogeweg P. Evolution of evolvability and phenotypic plasticity in virtual cells. BMC Evol Biol. 2017;17:60 pubmed publisher
    ..Moreover, after continued evolution, evolvability can be a viable alternative with comparable fitness to regulated phenotypic plasticity in all but the most rapidly changing environments. ..
  36. Herrero A, Stavans J, Flores E. The multicellular nature of filamentous heterocyst-forming cyanobacteria. FEMS Microbiol Rev. 2016;40:831-854 pubmed publisher
  37. Ntambi J. miRNAs Caught Up in Metabolic Organ Crosstalk to Combat Obesity. EBioMedicine. 2016;5:10-1 pubmed publisher
  38. Rost B, Schneider Warme F, Schmitz D, Hegemann P. Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron. 2017;96:572-603 pubmed publisher
    ..Finally, we discuss useful tools and targeting strategies that are currently missing from the optogenetics repertoire and provide suggestions for novel subcellular optogenetic applications...
  39. Chiarugi D, Falaschi M, Hermith D, Olarte C, Torella L. Modelling non-Markovian dynamics in biochemical reactions. BMC Syst Biol. 2015;9 Suppl 3:S8 pubmed publisher
    ..We show that our methodology makes it possible to obtain accurate models of enzymatic reactions that, in specific cases, fit experimental data better than the corresponding Markovian models. ..
  40. McManus M, Churchwell K, Strange K. Regulation of cell volume in health and disease. N Engl J Med. 1995;333:1260-6 pubmed
  41. Swedlow J, Danuser G. Scale integration: the structure and dynamics of macromolecular assemblies, cells and tissues. Curr Opin Cell Biol. 2012;24:1-3 pubmed publisher
  42. Morimoto R. Susan Lindquist 1949-2016. Nat Struct Mol Biol. 2016;23:1072-1073 pubmed publisher
  43. Gray M, Lukes J, Archibald J, Keeling P, Doolittle W. Cell biology. Irremediable complexity?. Science. 2010;330:920-1 pubmed publisher
  44. Lawley S, Keener J. Rebinding in biochemical reactions on membranes. Phys Biol. 2017;14:056002 pubmed publisher
    ..Further, we compute a new concentration-dependent rebinding probability for reactions in three space dimensions. Our analysis predicts that rebinding plays a much larger role in reactions on membranes compared to reactions in cytoplasm. ..
  45. Habchi J, Tompa P, Longhi S, Uversky V. Introducing protein intrinsic disorder. Chem Rev. 2014;114:6561-88 pubmed publisher
  46. Kaganovich D. There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions. Trends Biochem Sci. 2017;42:765-776 pubmed publisher
    ..In this review we examine the emerging idea of protein granules as a new functional and structural unit of cellular organization. ..
  47. Kostarelos K, Novoselov K. Materials science. Exploring the interface of graphene and biology. Science. 2014;344:261-3 pubmed publisher
  48. Ebnet K. Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development. Physiol Rev. 2017;97:1529-1554 pubmed publisher
  49. Serio T. Susan Lindquist (1949-2016). Nat Chem Biol. 2017;13:127 pubmed publisher
  50. Galeota E, Gravila C, Castiglione F, Bernaschi M, Cesareni G. The hierarchical organization of natural protein interaction networks confers self-organization properties on pseudocells. BMC Syst Biol. 2015;9 Suppl 3:S3 pubmed publisher
  51. Mattick J. Long noncoding RNAs in cell and developmental biology. Semin Cell Dev Biol. 2011;22:327 pubmed publisher
  52. Bach L. Insulin-Like Growth Factor Binding Proteins--an Update. Pediatr Endocrinol Rev. 2015;13:521-30 pubmed
    ..Understanding the balance between the various actions of IGFBPs in vivo may lead to novel insights into disease processes and possible IGFBP-based therapeutics. ..