takayasu arteritis


Summary: A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.

Top Publications

  1. Pulsatelli L, Boiardi L, Assirelli E, Pazzola G, Muratore F, Addimanda O, et al. Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study. Clin Exp Rheumatol. 2017;35 Suppl 103:102-110 pubmed
    ..These overall results might suggest a role for sIL-6R as a potential biomarker for disease activity in TAK patients, whereas in GCA, modifications of IL-6 might better identify patients with active disease. ..
  2. Sun Y, Ma L, Yan F, Liu H, Ding Y, Hou J, et al. MMP-9 and IL-6 are potential biomarkers for disease activity in Takayasu's arteritis. Int J Cardiol. 2012;156:236-8 pubmed publisher
  3. Yilmaz H, Gerdan V, Kozaci D, Solmaz D, Akar S, Can G, et al. Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis. Arthritis Res Ther. 2012;14:R272 pubmed publisher
    The current markers of disease activity in Takayasu arteritis (TA) are insufficient for proper assessment...
  4. Keser G, Aksu K. What is new in management of Takayasu arteritis?. Presse Med. 2017;46:e229-e235 pubmed publisher
    Management of Takayasu arteritis (TAK) is challenging mostly due to difficulties in assessing actual disease activity...
  5. Ogino H, Matsuda H, Minatoya K, Sasaki H, Tanaka H, Matsumura Y, et al. Overview of late outcome of medical and surgical treatment for Takayasu arteritis. Circulation. 2008;118:2738-47 pubmed publisher
  6. Yamamoto K, Mori T, Watanabe T, Iwata T, Gondo G, Tanaka M, et al. Successful Hybrid Neurovascular Surgery for a Ruptured Basilar Artery Dissecting Aneurysm in a Patient with Jeopardized Collateral Circulation Associated with Aortitis Syndrome. World Neurosurg. 2017;105:1034.e7-1034.e10 pubmed publisher
    ..To our knowledge, this is the first report of hybrid neurovascular surgery for a BA dissecting aneurysm. A ruptured BA dissecting aneurysm in a patient with aortitis syndrome was successfully treated with hybrid neurovascular surgery. ..
  7. Seeliger B, Sznajd J, Robson J, Judge A, Craven A, Grayson P, et al. Are the 1990 American College of Rheumatology vasculitis classification criteria still valid?. Rheumatology (Oxford). 2017;56:1154-1161 pubmed publisher
    ..Since publication of the ACR criteria for vasculitis, the sensitivity for each type of vasculitis, except GCA, has diminished, although the specificities have remained high, highlighting the need for updated classification criteria. ..
  8. Bonilla Abadía F, Cañas C, Echeverri A. Outcomes of patients with takayasu arteritis treated with infliximab. J Rheumatol. 2013;40:1930-1 pubmed publisher
  9. Renauer P, Sawalha A. The genetics of Takayasu arteritis. Presse Med. 2017;46:e179-e187 pubmed publisher
    b>Takayasu arteritis (TAK) is a rare systemic vasculitis that is characterized by granulomatous inflammation of the aorta and its major branches...

More Information


  1. Alibaz Oner F, Sreih A, Merkel P, Direskeneli H. Patient-reported outcomes in Takayasu's arteritis. Presse Med. 2017;46:e225-e227 pubmed publisher
    ..There are ongoing efforts of Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group to develop disease-specific outcome measures in TAK. ..
  2. Yang Y, Wang Z, Yuan L, Cao T, Liu J, Ren R, et al. Aortic stiffness evaluated by echocardiography in female patients with Takayasu's arteritis. Clin Exp Rheumatol. 2017;35 Suppl 103:134-138 pubmed
    ..This manifestation is prior to the impairment of cardiac diastolic function. This elevated AS can be detected by echocardiographic measured PWVcf with a good reproducibility. ..
  3. Akiyama S, Fujii T, Matsuoka K, Yusuke E, Negi M, Takenaka K, et al. Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis. J Gastroenterol Hepatol. 2017;32:1011-1017 pubmed publisher
    b>Takayasu arteritis (TA) is occasionally complicated with inflammatory bowel disease (IBD). This study assessed the endoscopic and genetic features of IBD complicated with TA (IBD-TA)...
  4. Torre S, Caramaschi P, Faggian G, Luciani G. Takayasu Arteritis Mimicking Type A Intramural Hematoma. Ann Thorac Surg. 2017;104:e35-e37 pubmed publisher
    b>Takayasu arteritis is a panarteritis of unknown etiology involving the aorta and its main branches, with higher prevalence in women and peak of incidence in the second and third decades of life...
  5. Tombetti E, Di Chio M, Sartorelli S, Papa M, Salerno A, Bottazzi B, et al. Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis. Arthritis Res Ther. 2014;16:479 pubmed publisher
    Progression of arterial involvement is often observed in patients with Takayasu arteritis (TA) thought to be in remission...
  6. Tombetti E, Mason J. Application of imaging techniques for Takayasu arteritis. Presse Med. 2017;46:e215-e223 pubmed publisher
    ..with subsequent remodelling and predisposition to arterial stenosis and/or dilation are the hallmarks of Takayasu arteritis. The degree of arterial damage closely aligns with prognosis and therefore its prevention is the predominant ..
  7. Geraldes R, Batista P, Pedro L, Fernandes A, Melo T. Takayasu arteritis presenting with internal carotid artery dissection. Cerebrovasc Dis. 2012;33:408-9 pubmed publisher
  8. Nazareth R, Mason J. Takayasu arteritis: severe consequences of delayed diagnosis. QJM. 2011;104:797-800 pubmed publisher
  9. Alibaz Oner F, Koster M, Unal A, Yildirim H, Çikikçi C, Schmidt J, et al. Assessment of the frequency of cardiovascular risk factors in patients with Takayasu's arteritis. Rheumatology (Oxford). 2017;56:1939-1944 pubmed publisher
    ..We aimed to assess the frequency of cardiovascular (CV) risk factors and the incidence of CV events (CVEs) in patients with TAK from two ethnically different populations...
  10. Soo Hoo S, Seong J, Porten B, Skeik N. Challenges of Takayasu Arteritis in Pregnancy: A Case Report. Vasc Endovascular Surg. 2017;51:195-198 pubmed publisher
    b>Takayasu arteritis is a rare, chronic vasculitis of unknown etiology characterized by inflammation of the aorta and its main branches...
  11. Koster M, Warrington K. Classification of large vessel vasculitis: Can we separate giant cell arteritis from Takayasu arteritis?. Presse Med. 2017;46:e205-e213 pubmed publisher
    The two main variants of large vessel vasculitis include Takayasu arteritis and giant cell arteritis...
  12. Skeik N, Ostertag Hill C, Garberich R, Alden P, Alexander J, Cragg A, et al. Diagnosis, Management, and Outcome of Aortitis at a Single Center. Vasc Endovascular Surg. 2017;51:470-479 pubmed publisher
    ..We retrospectively reviewed all patients' charts who were diagnosed with giant cell arteritis, Takayasu arteritis, or noninfectious aortitis presenting at a single center between January 1, 2009, and April 17, 2015...
  13. Peng Y, Deng Y. Serum Bilirubin Concentrations in Patients With Takayasu Arteritis. Arch Pathol Lab Med. 2017;141:846-850 pubmed publisher
    ..Progression of inflammation involving arteries is a crucial activator in pathogenesis of Takayasu arteritis (TA). - To investigate the relationship between serum bilirubin and TA...
  14. Machen L, Clowse M. Vasculitis and Pregnancy. Rheum Dis Clin North Am. 2017;43:239-247 pubmed publisher
    ..Cyclophosphamide, methotrexate, and mycophenolate mofetil should be avoided in pregnancy. Controlling disease with low-risk medications may allow women with vasculitis to have the pregnancies they desire. ..
  15. Singh N, Hughes M, Sebire N, Brogan P. Takayasu arteritis in infancy. Rheumatology (Oxford). 2013;52:2093-5 pubmed publisher
  16. Mahajan N, Mahmood S, Jain S, Dhawan V. Receptor for advanced glycation end products (RAGE), inflammatory ligand EN-RAGE and soluble RAGE (sRAGE) in subjects with Takayasu's arteritis. Int J Cardiol. 2013;168:532-4 pubmed publisher
  17. Ishihara T, Haraguchi G, Kamiishi T, Tezuka D, Inagaki H, Isobe M. Sensitive assessment of activity of Takayasu's arteritis by pentraxin3, a new biomarker. J Am Coll Cardiol. 2011;57:1712-3 pubmed publisher
  18. Jeong H, Jung J, Song G, Choi S, Hong S. Endovascular balloon angioplasty versus stenting in patients with Takayasu arteritis: A meta-analysis. Medicine (Baltimore). 2017;96:e7558 pubmed publisher
    Symptomatic or significant vascular lesions of Takayasu arteritis (TA) need interventions...
  19. Onen F, Akkoc N. Epidemiology of Takayasu arteritis. Presse Med. 2017;46:e197-e203 pubmed publisher
    b>Takayasu arteritis (TA), a granulomatous large vessel vasculitis involves mostly the aorta and its proximal branches and occurs most commonly in young females...
  20. Rustagi T, Majumder S. Crohn's-Takayasu's arteritis overlap with hypercoagulability: an optimal milieu for ischemic stroke. J Dig Dis. 2011;12:142-6 pubmed publisher
  21. Mahajan N, Dhawan V, Malik S, Jain S. Serum levels of soluble receptor for advanced glycation end products (sRAGE) in Takayasu's arteritis. Int J Cardiol. 2010;145:589-91 pubmed publisher
  22. Ebata T, Uemura J, Yamazaki H, Imai K, Yagita Y. [A Case of Takayasu Arteritis with Acute Bilateral Occlusion of the Internal Carotid Arteries]. Brain Nerve. 2017;69:665-669 pubmed publisher
    ..This finding and an elevated erythrocyte sedimentation rate supported the diagnosis of Takayasu arteritis. Here, we thus report a rare case of Takayasu arteritis with acute bilateral occlusion of the internal ..
  23. Comarmond C, Biard L, Lambert M, Mekinian A, Ferfar Y, Kahn J, et al. Long-Term Outcomes and Prognostic Factors of Complications in Takayasu Arteritis: A Multicenter Study of 318 Patients. Circulation. 2017;136:1114-1122 pubmed publisher
    Because of the wide variation in the course of Takayasu arteritis (TA), predicting outcome is challenging. We assess long-term outcome and prognosis factors for vascular complications in patients with TA...
  24. Wang X, Dang A, Lv N, Cheng N, Cheng X. Inflammation Is Associated With Platelet Coagulation Function Rather Than Enzymatic Coagulation Function in Patients With Takayasu Arteritis. Int Heart J. 2017;58:589-592 pubmed publisher
    ..integral changes of coagulation and fibrinolysis, and their relationships with inflammation in patients with Takayasu arteritis (TA) remain undetermined...
  25. Youngstein T, Mason J. Interleukin 6 targeting in refractory Takayasu arteritis: serial noninvasive imaging is mandatory to monitor efficacy. J Rheumatol. 2013;40:1941-4 pubmed publisher
  26. El Matary W, Persad R. Takayasu's aortitis and infliximab. J Pediatr. 2009;155:151 pubmed publisher