varicose ulcer

Summary

Summary: Skin breakdown or ulceration caused by varicose veins in which there is too much hydrostatic pressure in the superficial venous system of the leg. Venous hypertension leads to increased pressure in the capillary bed, transudation of fluid and proteins into the interstitial space, altering blood flow and supply of nutrients to the skin and subcutaneous tissues, and eventual ulceration.

Webpages

  1. exudates and transudates
    lib.bioinfo.pl/meid:44303
  2. search of: varicose ulcer - list results - clinicaltrials.gov
    clinicaltrials.gov/ct/screen/BrowseAny?path=%2Fbrowse%2Fby-c ...
  3. nineteen eighty-four / george orwell
    ebooks.adelaide.edu.au/o/orwell/george/o79n/

Publications

  1. A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers
    V Colletta
    I Department of Plastic Surgery, University of Bari, Italy
    J Wound Care 12:357-60
  2. Treating venous insufficiency with soft silicone dressing
    Diana Cunningham
    Center for Wound Care and Hyperbaric Medicine, Wilson County Hospital, Neodesha, Kan
    Ostomy Wound Manage 50:8-10
  3. Patient with chronic venous stasis ulcer
    Dorothy V Gunder
    Surgery Clinic, Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
    J Wound Ostomy Continence Nurs 30:53-6; discussion 56-8
  4. Wound bed score and its correlation with healing of chronic wounds
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Dermatol Ther 19:383-90
  5. Profuse bleeding in patients with chronic venous insufficiency
    P Labas
    1st Department of Surgery, University Hospital Bratislava, Bratislava, Slovakia
    Int Angiol 26:64-6
  6. Management of mixed arterial and venous leg ulcers
    M L Humphreys
    Department of Vascular Surgery, Cheltenham General Hospital, Sandford Road, Cheltenham, UK
    Br J Surg 94:1104-7
  7. Combining bioengineered human dermal replacement and multilayered compression dressings to manage ulcers in a person with diabetes mellitus: a case study
    Arush K Angirasa
    Loyola University Medical Center, Department of Orthopaedic Surgery and Rehabilitation, Maywood, IL, USA
    Ostomy Wound Manage 52:60-4
  8. Exploring debridement options for chronic venous leg ulcers
    Colin E Davies
    Gloucestershire Leg Ulcer Service, Cheltenham General Hospital, Cheltenham, Gloucestershire
    Br J Nurs 14:393-7
  9. Experience with the use of apligraf to heal complicated surgical and nonsurgical wounds in a private practice setting
    Fred G Shealy
    Shealy Surgical Center, PA, Hendersonville, NC, USA
    Adv Skin Wound Care 19:310-22
  10. Improving quality of life in venous leg ulceration: a case study
    Jenny Bentley
    Florence Nightingale School of Nursing and Midwifery, King's College London, UK
    Br J Nurs 15:S4-8

Scientific Experts

Detail Information

Webpages3

  1. exudates and transudates
    lib.bioinfo.pl/meid:44303
  2. search of: varicose ulcer - list results - clinicaltrials.gov
    clinicaltrials.gov/ct/screen/BrowseAny?path=%2Fbrowse%2Fby-c ...
  3. nineteen eighty-four / george orwell
    ebooks.adelaide.edu.au/o/orwell/george/o79n/

Publications62

  1. A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers
    V Colletta
    I Department of Plastic Surgery, University of Bari, Italy
    J Wound Care 12:357-60
    ..However, further clinical trials should be performed involving a control group to verify these data. DECLARATION OF INTEREST: This study was sponsored by Fidia Advanced Biopolymers, Italy...
  2. Treating venous insufficiency with soft silicone dressing
    Diana Cunningham
    Center for Wound Care and Hyperbaric Medicine, Wilson County Hospital, Neodesha, Kan
    Ostomy Wound Manage 50:8-10
  3. Patient with chronic venous stasis ulcer
    Dorothy V Gunder
    Surgery Clinic, Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
    J Wound Ostomy Continence Nurs 30:53-6; discussion 56-8
  4. Wound bed score and its correlation with healing of chronic wounds
    Vincent Falanga
    Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA
    Dermatol Ther 19:383-90
    ..If confirmed and widely adopted in this and other types of wounds, it could be a useful tool in both the clinical and research setting...
  5. Profuse bleeding in patients with chronic venous insufficiency
    P Labas
    1st Department of Surgery, University Hospital Bratislava, Bratislava, Slovakia
    Int Angiol 26:64-6
    ..2% sodium tetradecyl sulfate), it is possible to treat bleeding varicose veins effectively with significantly faster healing of the wound...
  6. Management of mixed arterial and venous leg ulcers
    M L Humphreys
    Department of Vascular Surgery, Cheltenham General Hospital, Sandford Road, Cheltenham, UK
    Br J Surg 94:1104-7
    ..Combined 30-day mortality for revascularization was 6.5 per cent. CONCLUSION: A protocol including supervised modified compression and selective revascularization achieved good healing rates for mixed arterial and venous leg ulceration...
  7. Combining bioengineered human dermal replacement and multilayered compression dressings to manage ulcers in a person with diabetes mellitus: a case study
    Arush K Angirasa
    Loyola University Medical Center, Department of Orthopaedic Surgery and Rehabilitation, Maywood, IL, USA
    Ostomy Wound Manage 52:60-4
    ..No complications were observed. The results observed suggest that studies examining the effects of treatment regimens that address the multifactorial etiology of some lower extremity ulcers are warranted...
  8. Exploring debridement options for chronic venous leg ulcers
    Colin E Davies
    Gloucestershire Leg Ulcer Service, Cheltenham General Hospital, Cheltenham, Gloucestershire
    Br J Nurs 14:393-7
    ..This article reviews the debridement options available to practitioners and discusses rationales for treatment and implications for clinical practice with specific reference to chronic venous leg ulcer management...
  9. Experience with the use of apligraf to heal complicated surgical and nonsurgical wounds in a private practice setting
    Fred G Shealy
    Shealy Surgical Center, PA, Hendersonville, NC, USA
    Adv Skin Wound Care 19:310-22
    ..Patients generally stated that they were satisfied with their degree of healing and with the opportunity to avoid the surgical procedures associated with autograft donor sites...
  10. Improving quality of life in venous leg ulceration: a case study
    Jenny Bentley
    Florence Nightingale School of Nursing and Midwifery, King's College London, UK
    Br J Nurs 15:S4-8
    ..In this case study, a number of challenges were presented to the nursing team in implementing evidence-based practice and accommodating patient choice, but these were overcome and the patient's quality of life has significantly improved...
  11. [Treatment of chronic wounds with an alginate dressing containing calcium zinc and manganese]
    U E Ziegler
    Plastische Chirurgie und Handchirurgie, Chirurgische Universitätsklinik Würzburg
    Fortschr Med Orig 121:19-26
    ..604 patients (47.0%) considered handling of the dressing to be "much better", and 411 (32.0%) to be "better" than previous treatment. The frequency of dressing changes decreased from 5.2 to 3.2 a week...
  12. Postthrombotic or non-postthrombotic severe venous insufficiency: impact of removal of superficial venous reflux with or without subcutaneous fasciotomy
    Jan T Christenson
    Division of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    J Vasc Surg 46:316-21
    ..Eradication of all superficial reflux lowers s.c. tissue pressure, while additional fasciotomy lowers both i.m. and s.c. tissue pressures and increases TcPO(2), which seems to promote ulcer healing...
  13. Making sense of the venous leg ulcer debate: a literature review
    M J Leach
    Royal District Nursing Service SA, School of Nursing and Midwifery, University of South Australia, Adelaide, Australia
    J Wound Care 13:52-6
    ..Treating them is expensive, with many hidden costs. As understanding of the causes and development of this condition improves, debate over the best treatments or treatment combinations is growing...
  14. Compression and peri-ulcer skin in outpatients' venous leg ulcers: results of a French survey
    O Dereure
    Department of Dermatology, Hôpital Saint Eloi, Montpellier, France
    J Wound Care 14:265-71
    ..However, the acceptability of compression to patients is poor, and continuous effort is required to convince them of its importance...
  15. Prognostic factors for venous ulcer healing in a non-selected population of ambulatory patients
    S Meaume
    Department of Geriatrics, Hôpital Charles Foix, Ivry sur Seine, France
    J Wound Care 14:31-4
    ..CONCLUSION: Clinical indicators such as simple ulcer length measurement and ulcer duration may help physicians to detect patients with a prognosis of poor healing...
  16. Randomised, comparative study of three primary dressings for the treatment of venous ulcers
    H Charles
    Tissue Viability, London
    Br J Community Nurs 7:48-54
    ..Study personnel rated Cutinova Foam as easy, if not easier, to use than Comfeel or Granuflex. This study suggests that Cutinova Foam is as safe and effective as both Comfeel and Granuflex, in the treatment of venous leg ulcers...
  17. Evaluation of SurePress Comfort: a new compression system for the management of venous leg ulcers
    R Polignano
    IOT Hospital Cardiovascular Rehabilitation, Florence, Italy
    J Wound Care 13:387-91
    ..It may therefore provide an effective solution for the delivery of graduated compression and has the potential to improve concordance, compared with short- stretch bandages. DECLARATION OF INTEREST: This study was sponsored by ConvaTec...
  18. The K-Four bandage system: evaluating its effectiveness on recalcitrant venous leg ulcers
    K R Vowden
    Department of Vascular Surgery, Bradford Royal Infirmary, UK
    J Wound Care 10:182-4
    ..5% and 80%, respectively, at 12 and 20 weeks. It would seem more likely that treatment outcome is related to patient risk factors for delayed healing and bandaging expertise than to the bandage system employed...
  19. A non-adhesive foam dressing for exuding venous leg ulcers and pressure ulcers: six case studies
    H Charles
    St. Charles Hospital, London, UK
    J Wound Care 13:58-62
    ..The dressing was assessed for its effect on the wound and patient comfort, with promising results...
  20. A reduction in serum cytokine levels parallels healing of venous ulcers in patients undergoing compression therapy
    M A Murphy
    Royal College of Surgeons, Beaumont Hospital, Dublin, Ireland
    Eur J Vasc Endovasc Surg 23:349-52
    ..CONCLUSION: these data, for the first time, suggest a central role for both TNF(alpha) and VEGF in the pathogenesis of venous ulceration which may constitute a causative link between venous hypertension and tissue pathology...
  21. Venous ulcers: pathophysiology and treatment options
    Jennifer T Trent
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Fla, USA
    Ostomy Wound Manage 51:38-54; quiz 55-6
    ..The epidemiology, pathophysiology, diagnosis, and management options regarding venous ulcers are reviewed...
  22. Hydrocapillary dressing to manage exudate in venous leg ulcers
    Tonny Karlsmark
    Bispebjerg University Hospital, Copenhagen Wound Healing Center, Copenhagen, Denmark
    Br J Nurs 13:S29-35
    ..This study has demonstrated that Alione is safe and easy to use, and exhibits convincing clinical performance and exudate-handling properties in the treatment of chronic venous leg ulcers...
  23. Shave therapy for chronic venous ulcers: a guideline for surgical management and postoperative wound care
    Falk Georges Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, St Josef Hospital, Gudrunstrasse 56, 44791 Bochum, Germany
    Plast Surg Nurs 26:29-34
    ..Besides the indication for shave therapy, we focus on the operative technique and important therapy during postoperative convalescence time...
  24. Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration
    Ralf Smeets
    Interdisciplinary Centre of Clinical Research BioMAT, University Hospital Aachen, D 52074 Aachen, Germany
    Int Wound J 5:195-203
    ..The results show a significant and immediate reduction in protease activity in wound exudates from venous leg ulcers treated with ORC/collagen...
  25. Combination of hydrocolloid dressing and medical compression stockings versus Unna's boot for the treatment of venous leg ulcers
    Cengiz Koksal
    SSK Sureyyapasa Thoracic and Cardiovascular Disease Hospital, Turkey
    Swiss Med Wkly 133:364-8
    ..59 +/- 34.73 min, compared to 134.54 +/- 43.39 min in group B (p >0.05). CONCLUSIONS: These results demonstrate the superiority of hydrocolloid dressing plus elastic compression treatment in terms of patient convenience...
  26. [Conservative therapy adapted to findings of superficial chronic venous ulcers]
    M K Billmann
    Abteilung für Gefässchirurgie des UniversitätsSpitals Zürich, Schweiz
    Vasa 33:97-101
    ..By choosing a conservative therapeutical regime adapted to clinical findings superinfected, chronic venous ulcers are turned into a stable condition...
  27. Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial
    Jamie R Barwell
    Department of Vascular Surgery, Cheltenham General Hospital, Cheltenham GL53 7AN, UK
    Lancet 363:1854-9
    ..INTERPRETATION: Surgical correction of superficial venous reflux reduces 12-month ulcer recurrence. Most patients with chronic venous ulceration will benefit from the addition of simple venous surgery...
  28. Severe chronic venous insufficiency treated by foamed sclerosant
    Luigi Pascarella
    Vein Institute of La Jolla, La Jolla, CA, USA
    Ann Vasc Surg 20:83-91
    ..Treatment of severe CVI with compression and foam sclerotherapy causes more rapid resolution of the venous insufficiency complications and does so without an increase in morbidity...
  29. [Therapy of ulcus cruris venosum]
    S Braun
    Klinik und Poliklinik für Hautkrankheiten, Greifswald
    Hautarzt 54:1059-64
    ..Compression bandages or stockings form the mainstay of treatment, generally in combination with moist dressings for chronic wounds...
  30. Role of endovenous laser treatment in the management of chronic venous insufficiency
    M A Sharif
    Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, Northern Ireland, UK
    Ann Vasc Surg 21:551-5
    ..These results demonstrate that EVLT, carried out in an outpatient setting, is effective in the treatment and prevention of chronic venous ulcers, with good patient satisfaction and no major complication...
  31. Current management of venous ulceration
    Nima P Patel
    Division of Vascular Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Plast Reconstr Surg 117:254S-260S
    ....
  32. Recognizing and managing venous leg ulcers
    Mary Y Sieggreen
    Harper University Hospital, Detroit Medical Center, Detroit, MI, USA
    Adv Skin Wound Care 17:302-11; quiz 312-3
    ....
  33. Bacteriology, inflammation, and healing: a study of nanocrystalline silver dressings in chronic venous leg ulcers
    R Gary Sibbald
    Public Health Sciences and Medicine, University of Toronto, Toronto, Ontario, Canada
    Adv Skin Wound Care 20:549-58
    ..Healing was associated with a reduction in wound bacteria and neutrophilic inflammation with an associated persistent or high lymphocyte count, as determined by wound biopsy...
  34. Improved healing rates for chronic venous leg ulcers: pilot study results from a randomized controlled trial of a community nursing intervention
    Helen Edwards
    School of Nursing, Centre for Health Research-Nursing, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Queensland 4059, Australia
    Int J Nurs Pract 11:169-76
    ..Knowledge gained from this study provides evidence to guide service delivery and improve client outcomes...
  35. Chronic venous leg ulcers: effect of a community nursing intervention on pain and healing
    Helen Edwards
    School of Nursing, Queensland University of Technology, Australia
    Nurs Stand 19:47-54
    ..CONCLUSION: Results from this study have implications for health professionals providing care for clients with chronic leg ulcers...
  36. Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers
    T Karlsmark
    Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark
    J Wound Care 12:351-4
    ..DECLARATION OF INTEREST: This study was supported by Coloplast A/S, Humlebaek, Denmark...
  37. Effectiveness of acupuncture, special dressings and simple, low-adherence dressings for healing venous leg ulcers in primary healthcare: study protocol for a cluster-randomized open-labeled trial
    Jorge Vas
    Pain Treatment Unit, Primary Healthcare Centre, Dos Hermanas, Spain
    BMC Complement Altern Med 8:29
    ..Moreover, for the first time a high-quality study will evaluate the effectiveness of acupuncture in the process of healing venous leg ulcers. TRIAL REGISTRATION: Current Controlled Trials ISRCTN26438275...
  38. [Indications and results of v.a.C therapy treatments in vascular surgery - state of the art in the treatment of chronic wounds]
    T Karl
    Gefässchirurgische Klinik der Städtischen Kliniken Karlsruhe, Akademisches Lehrkrankenhaus der Universität Freiburg
    Zentralbl Chir 129:S74-9
    ....
  39. A systematic review of randomized controlled trials of wound dressings for chronic venous ulcer
    Joseph Lau
    Vascular Service and the Center for Wound Healing, Tufts New England Medical Center, Boston, MA 02111, USA
    J Vasc Surg 44:1118-25
    ..The selection of a specific dressing, however, will depend on the dressing characteristics for ease of application, patient comfort, wound drainage absorption, and expense...
  40. Does the pattern of venous insufficiency influence healing of venous leg ulcers after skin transplantation?
    M L Kjaer
    Copenhagen Wound Healing Center, Copenhagen University Hospital, Bispebjerg, Denmark
    Eur J Vasc Endovasc Surg 25:562-7
    ....
  41. VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers
    C Iglesias
    Department of Health Sciences, University of York, UK
    Health Technol Assess 8:iii, 1-105
    ....
  42. Does low output laser stimulation enhance the healing of crural ulceration? Some critical remarks
    Andrzej Franek
    Katedra i Zaklz.shtsls;ad Biofizyki Lekarskiej, Slaska Akademia Medyczna, ul. Medyków 18, bud. C2, 40-752, PL, Katowice-Ligota, Poland
    Med Eng Phys 24:607-15
    ..No significant impact of laser light (lambda=810 nm, P=65 mW, p=4 J/cm2) on any of the stages of ulceration healing was observed...
  43. Evaluating a superabsorbent hydropolymer dressing for exuding venous leg ulcers
    H J Schulze
    Department of Dermatology, Institute for Tumours of the Skin, University of Münster, Germany
    J Wound Care 10:511-8
    ..It is anticipated that this reduction in dressing frequency will translate into a cost-effective wound treatment...
  44. Efficacy and safety of the freeze-dried cultured human keratinocyte lysate, LyphoDerm 0.9%, in the treatment of hard-to-heal venous leg ulcers
    Keith G Harding
    Department of Surgery, Wound Healing Research Unit, University of Wales, College of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 13:138-47
    ....
  45. Less pain with Biatain-Ibu: initial findings from a randomised, controlled, double-blind clinical investigation on painful venous leg ulcers
    Finn Gottrup
    University Centre for Wound Healing, Odense University Hospital, Odense, Denmark
    Int Wound J 4:24-34
    ..The full report of this study will be published in Wound Repair and Regeneration...
  46. A randomised controlled study of four-layer compression versus Unna's Boot for venous ulcers
    R Polignano
    Camerata Hospital, Florence, Italy
    J Wound Care 13:21-4
    ..04), again favouring Profore, but this was not sustained at the final application (p = 0.18). CONCLUSION: Profore is as effective as Unna's Boot in the treatment of venous leg ulcers...
  47. Guidelines in practice: the effect on healing of venous ulcers
    M McGuckin
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Adv Skin Wound Care 14:33-6
    ..00 [$250.00] vs Pound Sterling 272.00 [$395.00]). CONCLUSION: Use of compression was influenced by guidelines that emphasize a vascular assessment. Choice of dressing or type of compression was not a significant factor in healing rates...
  48. Venous valve reconstruction in patients with secondary chronic venous insufficiency
    A Rosales
    Faculty of Medicine, Oslo Vascular Centre, Aker University Hospital, University of Oslo, Oslo, Norway
    Eur J Vasc Endovasc Surg 36:466-72
    ..VVR should be considered in the treatment of patients with SCVI who do not respond to superficial venous surgery and compression treatment...
  49. Randomized clinical trial of four-layer and short-stretch compression bandages for venous leg ulcers (VenUS I)
    E A Nelson
    Department of Health Sciences, Seebohm Rowntree Building (Area 4, University of York, Heslington, York YO10 5DD, UK
    Br J Surg 91:1292-9
    ..57 to 0.91). More adverse events and withdrawals were reported with the short-stretch bandage. CONCLUSION: Venous leg ulcers treated using a four-layer bandage healed more quickly than those treated with a short-stretch bandage...
  50. Multicentre, randomised controlled trial of four-layer bandaging versus short-stretch bandaging in the treatment of venous leg ulcers
    H Partsch
    Wilhelminenspital, Wien, Austria
    Vasa 30:108-13
    ..In centres who are experienced users of short-stretch bandages, no statistically significant different healing rates of venous ulcers could be found after 4LB or SSB...
  51. Healing venous ulcers with cycloidal multidirectional vibration therapy
    J M Wilson
    Oxford Wound Healing Institute, Churchill Hospital, Oxford, UK
    J Wound Care 11:395-8
    ..CONCLUSION: This preliminary study shows that gentle cycloid vibration, combined with standard compression bandaging, enhances the healing rate of venous ulcers and helps to relieve pain...
  52. Iodoflex and Iodosorb in the treatment of venous leg ulcers
    J Bianchi
    Monklands Hospital, Airdrie
    Br J Nurs 10:342-6
    ..Application and method of use of Iodoflex and Iodosorb in venous leg ulcers is then detailed along with relevant clinical evidence. A case study describes the use of Iodoflex in a difficult-to-heal venous leg ulcer...
  53. Venous leg ulcer treatment and practice--Part 2: Wound management
    S Rajendran
    Centre for Materials Research and Innovation, University of Bolton, Bolton, UK
    J Wound Care 16:68-70
  54. Measured improvement in rate of healing of venous ulceration
    Robert J Goldman
    Department of Rehabilitation Medicine, University of Pennsylvania, Philadelphia, USA
    Br J Nurs 12:177-83
    ..This case provides data in favour of wound care protocols featuring Vacutex, specifically designed to address the consequences that wound drainage and eschar have in dramatically large venous stasis ulcers...
  55. Cost-effectiveness of Apligraf in the treatment of venous leg ulcers
    R G Sibbald
    University of Toronto, Toronto, Ontario
    Ostomy Wound Manage 47:36-46
    ..The results come from a model that is based on a series of estimates and assumptions, and accordingly, confirmation of this finding in a prospective study is encouraged...
  56. Leg ulcerations: a clinical appraisal
    Jean Marie Bonnetblanc
    Service de Dermatologie, CHRU Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges cedex France
    Eur J Dermatol 15:127-32
    ..The figures of the article may be looked at first, without reading the legend, so the reader may suggest diagnostic hypotheses before discovering the true diagnosis...
  57. [Topical therapy of ulcers]
    S Karrer
    Klinik und Poliklinik für Dermatologie, Universität Regensburg
    Hautarzt 56:1165-78; quiz 1179
    ..There are a large number of modern wound dressings for local, phase-dependent or phase-independent ulcer therapy, making the optimal treatment of each kind of chronic wound possible...
  58. Using an artificial neural network to predict healing times and risk factors for venous leg ulcers
    R J Taylor
    Department of Medical Physics, Salford Royal Hospitals NHS Trust, Salford, UK
    J Wound Care 11:101-5
    ..CONCLUSION: The ability to identify at presentation ulcers that might be resistant to standard therapy would allow early consideration of more radical treatments such as hospitalisation, wound debridement or venous surgery...