renovascular hypertension

Summary

Summary: Hypertension due to RENAL ARTERY OBSTRUCTION or compression.

Top Publications

  1. Ostrowska H, Kruszewski K, Kasacka I. Immuno-proteasome subunit LMP7 is up-regulated in the ischemic kidney in an experimental model of renovascular hypertension. Int J Biochem Cell Biol. 2006;38:1778-85 pubmed
    ..exposed to a long-lasting ischemia and inflammation in an experimental model of two-kidney, one-clip renovascular hypertension in the rat...
  2. Ersahin M, Sehirli O, Toklu H, Suleymanoglu S, Emekli Alturfan E, Yarat A, et al. Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J Pineal Res. 2009;47:97-106 pubmed publisher
    The effect of melatonin was investigated in an angiotensin II-dependent renovascular hypertension model in Wistar albino rats by placing a renal artery clip (two-kidney, one-clip; 2K1C), while sham rats did not have clip placement...
  3. Mendonca L, Fernandes Santos C, Mandarim de Lacerda C. Cardiac and aortic structural alterations due to surgically-induced menopause associated with renovascular hypertension in rats. Int J Exp Pathol. 2007;88:301-9 pubmed
    ..These results show that both ovariectomy and renovascular hypertension enhance BP as a single stimulus and therefore produce adverse cardiac remodelling...
  4. Arruda R, Peotta V, Meyrelles S, Vasquez E. Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension. Hypertension. 2005;46:932-6 pubmed
    ..However, the concurrence of both pathophysiologies does not result in additive effects on the vascular function...
  5. Garovic V, Textor S. Renovascular hypertension and ischemic nephropathy. Circulation. 2005;112:1362-74 pubmed
  6. Elliott W. Renovascular hypertension: an update. J Clin Hypertens (Greenwich). 2008;10:522-33 pubmed
    b>Renovascular hypertension, the most common remediable cause of elevated blood pressure, is a controversial topic, but most authorities agree on several principles...
  7. Pang H, Wen Y, Ma N, Wang Y, Shi L. Protective role of a novel erythrocyte-derived depressing factor on blood vessels of renovascular hypertensive rats. Clin Exp Pharmacol Physiol. 2007;34:393-8 pubmed
    ..The effects may be mediated, in part, by enhanced expression of p21 (Cip1) and the inhibition of ERK1/2 phosphorylation and the expression of cyclin D1/CDK4 and PDGF-A...
  8. Stacul F, Gava S, Belgrano M, Cernic S, Pagnan L, Pozzi Mucelli F, et al. Renal artery stenosis: comparative evaluation of gadolinium-enhanced MRA and DSA. Radiol Med. 2008;113:529-46 pubmed publisher
    ..This study was undertaken to evaluate the accuracy of contrast-enhanced magnetic resonance angiography (CE-MRA) in detecting renal artery stenosis using intra-arterial digital subtraction angiography (DSA) as the gold standard...
  9. Hegde S, Wright C, Shenoy M, Moghal N, Coulthard M. Renovascular hypertension commencing during fetal life. Arch Dis Child Fetal Neonatal Ed. 2007;92:F301-4 pubmed
    ..All underwent unilateral nephrectomy, and had a similar histology, with patchy areas having relatively normal glomeruli but immature proximal tubules. This pattern may be a marker for renovascular disease in fetal life...

More Information

Publications62

  1. Kim D, Pica A, Duran R, Duran W. Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases. Microcirculation. 2006;13:577-85 pubmed
    ..To test the hypothesis that acupuncture on stomach 36 point (ST-36) reduces hypertension by activating nitric oxide synthase signaling mechanisms...
  2. Alchi B, Shirasaki A, Narita I, Nishi S, Ueno M, Saeki T, et al. Renovascular hypertension: a unique cause of unilateral focal segmental glomerulosclerosis. Hypertens Res. 2006;29:203-7 pubmed
    ..This case illustrates the heterogeneous effect of the renin-angiotensin system on either kidney in patients with renovascular hypertension due to unilateral renal artery stenosis.
  3. Castro M, Rizzi E, Rodrigues G, Ceron C, Bendhack L, Gerlach R, et al. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med. 2009;46:1298-307 pubmed publisher
    ..05), MMP-2 levels, and MMP-2 activity in hypertensive rats (all p<0.05). Our results suggest that antioxidant approaches decrease MMP-2 upregulation and attenuate the vascular dysfunction and remodeling during 2K-1C hypertension...
  4. Borazan A, Sevindik O, Solmaz D, Gulcu A, Cavdar C, Sifil A, et al. A rare cause of renovascular hypertension: Takayasu arteritis with only renal artery involvement. Ren Fail. 2009;31:327-31 pubmed publisher
    ..Disease affecting solely the renal arteries is rare. We will present a case that had hypertension, hypokalemia, and metabolic alkalosis where the etiology was type 2 Takayasu arteritis, affecting renal arteries...
  5. Garcia Saura M, Galisteo M, Villar I, Bermejo A, Zarzuelo A, Vargas F, et al. Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem. 2005;270:147-55 pubmed
    ..We conclude that chronic oral treatment with quercetin shows both antihypertensive and antioxidant effects in this model of renovascular hypertension.
  6. Salguero G, Akin E, Templin C, Kotlarz D, Doerries C, Landmesser U, et al. Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner. J Hypertens. 2008;26:257-68 pubmed publisher
    ..Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates EPC mobilization in a NAD(P)H oxidase-dependent manner.
  7. Textor S. Renovascular hypertension in 2007: where are we now?. Curr Cardiol Rep. 2007;9:453-61 pubmed
    ..The CORAL study and others seek to randomly assign subjects with high-grade renovascular lesions to optimal medical management with and without stenting...
  8. Matayoshi T, Kamide K, Takiuchi S, Horio T, Yoshihara F, Nakamura S, et al. Relationship between insulin resistance and the renin-angiotensin system: analysis for patients with essential and renovascular hypertension. Clin Exp Hypertens. 2007;29:479-87 pubmed
    ..insulin resistance in 82 patients with EHT and compare the impact of RAS to insulin resistance with 10 renovascular hypertension (RVHT) patients who have a highly activated systemic RAS...
  9. Lucon A, Coelho R, Chambô J, Mitre A, Praxedes J, Srougi M. Hand-assisted laparoscopic right nephrectomy and autotransplantation for treatment of renovascular hypertension. Clinics (Sao Paulo). 2007;62:367-70 pubmed
  10. Ashida A, Matsumura H, Inoue N, Katayama H, Kiyohara Y, Yamamoto T, et al. Two cases of hyponatremic-hypertensive syndrome in childhood with renovascular hypertension. Eur J Pediatr. 2006;165:336-9 pubmed
    We report two children with renovascular hypertension and fibromuscular dysplasia. They initially presented with severe hyponatremia, hypokalemia, polyuria, and transient proteinuria...
  11. Pereira T, Balarini C, Silva I, Cabral A, Vasquez E, Meyrelles S. Endogenous angiotensin II modulates nNOS expression in renovascular hypertension. Braz J Med Biol Res. 2009;42:685-91 pubmed
    ..In conclusion, AT1 receptors and oxidative stress seem to be primary stimuli for increased nNOS expression, but this up-regulation does not result in higher enzyme activity...
  12. Lin J, Zhu X, Chade A, Jordan K, Lavi R, Daghini E, et al. Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension. Arterioscler Thromb Vasc Biol. 2009;29:1810-6 pubmed publisher
    ..This study tested the hypothesis that MCPs regulate cardiac microvascular function and structure in experimental HTN...
  13. Deglise S, Corpataux J, Haller C, Binaghi S, Meuwly J, Qanadli S. Bilateral renal artery entrapment by diaphragmatic crura: a rare cause of renovascular hypertension with a specific management. J Comput Assist Tomogr. 2007;31:481-4 pubmed
    ..This pathology, unlike common renal artery stenoses, requires surgical decompression and sometimes aortorenal bypass graft...
  14. Vo N, Hammelman B, Racadio J, Strife C, Johnson N, Racadio J. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006;36:1032-6 pubmed
    ..We believed that hypertensive children without comorbid conditions had a different lesion distribution and that the difference might have implications for imaging and treatment...
  15. Oliveira Sales E, Dugaich A, Carillo B, Abreu N, Boim M, Martins P, et al. Oxidative stress contributes to renovascular hypertension. Am J Hypertens. 2008;21:98-104 pubmed
  16. Nishi E, Oliveira Sales E, Bergamaschi C, Oliveira T, Boim M, Campos R. Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats. Am J Hypertens. 2010;23:473-80 pubmed publisher
    ..We hypothesized that angiotensin (Ang) II-dependent oxidative stress contributes to the pathophysiology of the two-kidney, one-clip (2K-1C) model...
  17. Gava A, Peotta V, Cabral A, Vasquez E, Meyrelles S. Overexpression of eNOS prevents the development of renovascular hypertension in mice. Can J Physiol Pharmacol. 2008;86:458-64 pubmed publisher
    ..present study we investigated the effects of endothelial nitric oxide synthase (eNOS) overexpression on renovascular hypertension. Experiments were carried out in C57BL/6 mice randomly assigned to either a two-kidney one-clip (2K1C) ..
  18. Polizio A, Balestrasse K, Yannarelli G, Noriega G, Gorzalczany S, Taira C, et al. Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension. Hypertens Res. 2008;31:325-34 pubmed publisher
    ..In summary, the present report indicates that cardiac hypertrophy, induced by renovascular hypertension, depends on angiotensin II through reactive oxygen species and is not prevented by the action of ..
  19. Souza H, Martins Pinge M, Dias da Silva V, Borghi Silva A, Gastaldi A, Blanco J, et al. Heart rate and arterial pressure variability in the experimental renovascular hypertension model in rats. Auton Neurosci. 2008;139:38-45 pubmed publisher
    ..Finally, the increase in the LF components of SAP also suggests an increase in sympathetic activity to peripheral vessels...
  20. Kimura H, Sato O, Deguchi J, Miyata T. Surgical treatment and long-term outcome of renovascular hypertension in children and adolescents. Eur J Vasc Endovasc Surg. 2010;39:731-7 pubmed publisher
    This article describes the long-term outcome of surgical treatment in children with renovascular hypertension (RVH) over a 40-year period.
  21. Hackam D, Spence J, Garg A, Textor S. Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertension. Hypertension. 2007;50:998-1003 pubmed
  22. Krause I, Cleper R, Kovalski Y, Sinai L, Davidovits M. Changes in behavior as an early symptom of renovascular hypertension in children. Pediatr Nephrol. 2009;24:2271-4 pubmed publisher
    b>Renovascular hypertension in children is usually asymptomatic and diagnosed incidentally. Behavioral changes have not yet been well recognized as a part of the clinical spectrum of renovascular disease in children...
  23. Sadjadi J, Kramer G, Yu C, Burress Welborn M, Chappell M, Gregory Modrall J. Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. J Surg Res. 2005;127:65-9 pubmed
    Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH)...
  24. Gomez S, Warner L, Haas J, Bolterman R, Textor S, Lerman L, et al. Increased hypoxia and reduced renal tubular response to furosemide detected by BOLD magnetic resonance imaging in swine renovascular hypertension. Am J Physiol Renal Physiol. 2009;297:F981-6 pubmed publisher
    ..that the magnitude of BOLD-MRI signal change after furosemide is related to impaired renal function in renovascular hypertension. In 16 pigs with unilateral renal artery stenosis, renal hemodynamics, function, and tubular function (..
  25. Santos S, Leite L, Tse T, Beck R, Lee R, Shepherd R. [Renal resistance index predicting outcome of renal revascularization for renovascular hypertension]. Arq Bras Cardiol. 2010;94:452-6 pubmed
    ..Renal artery stenosis (RAS) is a potentially correctable cause of hypertension and ischemic nephropathy. Despite successful renal revascularization, not all patients (pt) overcome it and some get worse...
  26. Adamczak M, Czerwienska B, Chudek J, Wiecek A. Renal extraction of circulating adiponectin in patients with renovascular hypertension. Acta Physiol Hung. 2007;94:143-8 pubmed
    ..the aim of the study was to estimate separate kidney extraction of adiponectin, by measuring its concentration in the aorta and both renal veins, in patients with renovascular hypertension caused by unilateral renal artery stenosis.
  27. Oliveira Sales E, Nishi E, Carillo B, Boim M, Dolnikoff M, Bergamaschi C, et al. Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension. Am J Hypertens. 2009;22:484-92 pubmed publisher
  28. Shroff R, Roebuck D, Gordon I, Davies R, Stephens S, Marks S, et al. Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics. 2006;118:268-75 pubmed
    Our aim was to evaluate the clinical outcomes, safety, and efficacy of percutaneous transluminal angioplasty for renovascular hypertension in children.
  29. Peco Antic A, Djukic M, Sagic D, Kruscic D, Krstic Z. Severe renovascular hypertension in an infant with congenital solitary pelvic kidney. Pediatr Nephrol. 2006;21:437-40 pubmed
    ..b>Renovascular hypertension due to RAS in infants with a solitary kidney is difficult to control by medical treatment alone...
  30. Poręba R, Poczatek K, Gać P, Poręba M, Gonerska M, Jonkisz A, et al. SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension. Pol Arch Med Wewn. 2009;119:219-24 pubmed
    b>Renovascular hypertension caused by renal artery stenosis (RAS) accounts for 3-5% of all cases of hypertension.
  31. Wang D, Wang W, Sun X, Zhao D, Du G. [Effect of tianma gouteng recipe on interfering LV and aortic hypertrophy in renovascular hypertension rats]. Zhongguo Zhong Yao Za Zhi. 2005;30:606-9 pubmed
    To investigate the effect of Tianma Gouteng recipe (TGR) on interfering left ventricular (LV) and aortic hypertrophy and tissue angiotensin II (Ang II) in rats with renovascular hypertension.
  32. Tullus K, Brennan E, Hamilton G, Lord R, McLaren C, Marks S, et al. Renovascular hypertension in children. Lancet. 2008;371:1453-63 pubmed publisher
    ..Modern treatment provided by a multidisciplinary team of paediatric nephrologists, interventional radiologists, and vascular surgeons offers good long-term treatment results...
  33. Covic A, Gusbeth Tatomir P. The role of the renin-angiotensin-aldosterone system in renal artery stenosis, renovascular hypertension, and ischemic nephropathy: diagnostic implications. Prog Cardiovasc Dis. 2009;52:204-8 pubmed publisher
    ..Unfortunately, this issue still remains a major challenge for nephrologists...
  34. Botros F, Olszanecki R, Prieto Carrasquero M, Goodman A, Navar L, Abraham N. Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. Cell Mol Biol (Noisy-le-grand). 2007;53:51-60 pubmed
  35. Rountas C, Vlychou M, Vassiou K, Liakopoulos V, Kapsalaki E, Koukoulis G, et al. Imaging modalities for renal artery stenosis in suspected renovascular hypertension: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiography, and digital substraction angiography. Ren Fail. 2007;29:295-302 pubmed
    ..angiography (DSA) for the detection of renal artery stenosis in patients with clinically suspected renovascular hypertension. Fifty-eight patients with suspected renovascular hypertension were enrolled in the study...
  36. Thorsteinsdottir B, Kane G, Hogan M, Watson W, Grande J, Garovic V. Adverse outcomes of renovascular hypertension during pregnancy. Nat Clin Pract Nephrol. 2006;2:651-6 pubmed
    ..The pregnancy was terminated by induction with oxytocin, followed by a vaginal breech delivery. The patient remained hypertensive for 8 weeks after delivery...
  37. Stanley J, Criado E, Upchurch G, Brophy P, Cho K, Rectenwald J, et al. Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 children. J Vasc Surg. 2006;44:1219-28; discussion 1228-9 pubmed
    This study was undertaken to characterize the contemporary surgical treatment of pediatric renovascular hypertension.
  38. Glodny B, Glodny D. John Loesch, discoverer of renovascular hypertension, and Harry Goldblatt: two great pioneers in circulation research. Ann Intern Med. 2006;144:286-95 pubmed
    ..In this article, the authors share what is known about the studies of Loesch and of Goldblatt. They believe that both Loesch and Goldblatt should receive equal credit for these important first observations...
  39. Shen F, Xie H, Ling G, Xu L, Su D. Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin. 2005;26:1303-8 pubmed
    ..To test the synergistic effects of atenolol and amlodipine on lowering blood pressure (BP) and reducing blood pressure variability (BPV) in 2-kidney, one-clip (2K1C) renovascular hypertensive rats...
  40. Dieter R, Schmidt W, Pacanowski J, Jaff M. Renovascular hypertension. Expert Rev Cardiovasc Ther. 2005;3:413-22 pubmed
  41. Claus T, Schmitt R, Stabroth C, Luft F, Kettritz R, Gross C. Where do we stand with renovascular hypertension?. Nephrol Dial Transplant. 2005;20:1495-8 pubmed
  42. Armenia A, Sattar M, Abdullah N, Khan M, Johns E. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta Pharmacol Sin. 2008;29:564-72 pubmed publisher
    ..This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats...
  43. Ceron C, Castro M, Rizzi E, Montenegro M, Fontana V, Salgado M, et al. Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension. Br J Pharmacol. 2010;160:77-87 pubmed publisher
    ..of matrix metalloproteinases (MMPs) may cause structural and functional vascular changes in renovascular hypertension. We examined whether treatment with spironolactone (SPRL), hydrochlorothiazide (HCTZ) or both drugs ..
  44. Costa C, Amaral T, Carvalho L, Ognibene D, da Silva A, Moss M, et al. Antioxidant treatment with tempol and apocynin prevents endothelial dysfunction and development of renovascular hypertension. Am J Hypertens. 2009;22:1242-9 pubmed publisher
    Two-kidney-one-clip (2K-1C) rats develop renovascular hypertension associated with endothelial dysfunction and elevated levels of oxidative stress...
  45. Kanitkar M. Renovascular hypertension. Indian Pediatr. 2005;42:47-54 pubmed
    b>Renovascular hypertension results from a lesion that impairs blood flow to a part or all, of one or both kidneys...
  46. Soulez G, Oliva V, Turpin S, Lambert R, Nicolet V, Therasse E. Imaging of renovascular hypertension: respective values of renal scintigraphy, renal Doppler US, and MR angiography. Radiographics. 2000;20:1355-68; discussion 1368-72 pubmed
    b>Renovascular hypertension affects 15%-30% of patients who have clinical criteria suggestive of renovascular disease. Noninvasive screening is crucial for patient selection prior to conventional angiography and renal revascularization...
  47. Radermacher J, Chavan A, Bleck J, Vitzthum A, Stoess B, Gebel M, et al. Use of Doppler ultrasonography to predict the outcome of therapy for renal-artery stenosis. N Engl J Med. 2001;344:410-7 pubmed
    ..We evaluated whether a high level of resistance to flow in the segmental arteries of both kidneys (indicated by resistance-index values of at least 80) can be used prospectively to select appropriate patients for treatment...
  48. Wiesel P, Patel A, Carvajal I, Wang Z, Pellacani A, Maemura K, et al. Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res. 2001;88:1088-94 pubmed
    ..We studied chronic renovascular hypertension in mice deficient in the inducible isoform of HO (HO-1) using a one kidney-one clip (1K1C) model of ..
  49. Lee H, Grant E. Sonography in renovascular hypertension. J Ultrasound Med. 2002;21:431-41 pubmed
    ..To familiarize practitioners with different sonographic manifestations of renal artery compromise and the sonographic techniques for renal artery imaging...
  50. Rossi G, Cesari M, Chiesura Corona M, Miotto D, Semplicini A, Pessina A. Renal vein renin measurements accurately identify renovascular hypertension caused by total occlusion of the renal artery. J Hypertens. 2002;20:975-84 pubmed
    ..To assess the usefulness of indexes derived from renal vein renin measurements...
  51. Bude R, Forauer A, Caoili E, Nghiem H. Is it necessary to study accessory arteries when screening the renal arteries for renovascular hypertension?. Radiology. 2003;226:411-6 pubmed
    ..To determine the prevalence of isolated hemodynamically significant stenoses of accessory renal arteries when the main renal arteries are patent...
  52. Gandy S, Sudarshan T, Sheppard D, Allan L, McLeay T, Houston J. Dynamic MRI contrast enhancement of renal cortex: a functional assessment of renovascular disease in patients with renal artery stenosis. J Magn Reson Imaging. 2003;18:461-6 pubmed
    ..To evaluate differences in the magnitude and time course of renal cortical contrast uptake in patients with minimal, moderate, and severe renal artery stenosis (RAS) using contrast-enhanced magnetic resonance renography (CE-MRR)...
  53. Miyamori I, Yasuhara S, Matsubara T, Takasaki H, Takeda R. Comparative effects of captopril and nifedipine on split renal function in renovascular hypertension. Am J Hypertens. 1988;1:359-63 pubmed
    ..and calcium entry blocker nifedipine on the split renal function were studied in six patients with renovascular hypertension (RVH) with unilateral stenosis (38 +/- 5 years)...