renal hypertension

Summary

Summary: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.

Top Publications

  1. Hoy W, Hughson M, Singh G, Douglas Denton R, Bertram J. Reduced nephron number and glomerulomegaly in Australian Aborigines: a group at high risk for renal disease and hypertension. Kidney Int. 2006;70:104-10 pubmed
    ..Optimization of fetal growth should ultimately reduce the florid epidemic of renal disease, hypertension, and cardiovascular disease...
  2. Janssen U, Riley S, Vassiliadou A, Floege J, Phillips A. Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy. Kidney Int. 2003;63:2162-70 pubmed
    ..The aim of this study was to investigate the effect of superimposed hypertension on renal function and morphology under conditions of hyper- and normoglycemia...
  3. Munagala V, Hart C, Burnett J, Meyer D, Redfield M. Ventricular structure and function in aged dogs with renal hypertension: a model of experimental diastolic heart failure. Circulation. 2005;111:1128-35 pubmed
    ..Our objective was to develop a clinically relevant large-animal model to better understand the pathophysiology of DHF...
  4. Scaglione R, Argano C, Corrao S, Di Chiara T, Licata A, Licata G. Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial. J Hypertens. 2005;23:657-64 pubmed
  5. Nishikimi T, Akimoto K, Wang X, Mori Y, Tadokoro K, Ishikawa Y, et al. Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. J Hypertens. 2004;22:1787-96 pubmed
    ..The present study was designed to clarify whether the Rho-Rho-kinase pathway is involved in the process of hypertensive glomerulosclerosis and to assess the therapeutic effect of fasudil, a specific Rho-kinase inhibitor...
  6. Scaglione R, Argano C, Di Chiara T, Colomba D, Parrinello G, Corrao S, et al. Central obesity and hypertensive renal disease: association between higher levels of BMI, circulating transforming growth factor beta1 and urinary albumin excretion. Blood Press. 2003;12:269-76 pubmed
    ..In this study, the relationship between circulating transforming growth factor beta1 (TGFbeta1) and urinary albumin excretion (UAE) has been investigated in non-obese and central obese hypertensive patients...
  7. Vonend O, Marsalek P, Russ H, Wulkow R, Oberhauser V, Rump L. Moxonidine treatment of hypertensive patients with advanced renal failure. J Hypertens. 2003;21:1709-17 pubmed
    ..A secondary endpoint was to test whether the sympatholytic drug moxonidine slows decline of renal function when added to standard therapy with an angiotensin-converting enzyme inhibitor or AT(1) receptor antagonist plus loop diuretic...
  8. Jensen B. Reduced nephron number, renal development and 'programming' of adult hypertension. J Hypertens. 2004;22:2065-6 pubmed
  9. Hu D, Burtner C, Hong A, Lobo P, Okusa M. Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. Am J Med Sci. 2006;331:105-9 pubmed
    ..Furthermore, this case suggests the potential use of thiazide diuretics in the treatment of calcineurin-induced hypertension...

More Information

Publications62

  1. Tash J, Stock J, Hanna M. The role of partial nephrectomy in the treatment of pediatric renal hypertension. J Urol. 2003;169:625-8 pubmed
    ..We present our results of partial nephrectomy in this unique group of pediatric patients with hypertension in whom renin dependent hypertension involved only a segment of the kidney...
  2. Procopciuc L, Sitar Tăut A, Pop D, Sitar Tăut D, Olteanu I, Zdrenghea D. Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS). Eur J Intern Med. 2010;21:414-8 pubmed publisher
    ..The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS)...
  3. Song T, Laine A, Chen Q, Rusinek H, Bokacheva L, Lim R, et al. Optimal k-space sampling for dynamic contrast-enhanced MRI with an application to MR renography. Magn Reson Med. 2009;61:1242-8 pubmed publisher
    ..4 sec temporal resolution. The proposed method can be generalized to other dynamic contrast-enhanced MRI applications, e.g., MR angiography or cancer imaging...
  4. Fava C, Montagnana M, Burri P, Almgren P, Minuz P, Hulthén U, et al. Determinants of kidney function in Swedish families: role of heritable factors. J Hypertens. 2008;26:1773-9 pubmed publisher
    ..The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation...
  5. Zidek W. [Treatment of hypertension in patients with renal dialysis]. MMW Fortschr Med. 2008;150:37-8 pubmed
  6. Bankir L, Bochud M, Maillard M, Bovet P, Gabriel A, Burnier M. Nighttime blood pressure and nocturnal dipping are associated with daytime urinary sodium excretion in African subjects. Hypertension. 2008;51:891-8 pubmed publisher
    ..This observation may help us to understand the pathophysiology and clinical consequences of nighttime BP and to develop therapeutic strategies to normalize the dipping profile in hypertensive patients...
  7. Veldhorst M, Smeets A, Soenen S, Hochstenbach Waelen A, Hursel R, Diepvens K, et al. Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav. 2008;94:300-7 pubmed publisher
  8. Baines E. Spotlight: Luis Miguel Ruilope, MD. Circulation. 2007;115:f43-4 pubmed
  9. McBane R, Gloviczki P, Wysokinski W. Images in vascular medicine. Cross-clamp injury: an unusual cause of intermittent claudication. Vasc Med. 2006;11:173-4 pubmed
  10. Lim A, Donnan G, Chambers B, Ierino F. Mycophenolate mofetil substitution for cyclosporine-dependent myasthenia gravis and nephrotoxicity. Intern Med J. 2007;37:55-9 pubmed
    ..We believe that total cyclosporine withdrawal is feasible, but strongly recommend overlapping mycophenolate mofetil treatment with cyclosporine...
  11. Kulah E, Dursun A, Acikgoz S, Can M, Kargi S, Ilikhan S, et al. The relationship of target organ damage and 24-hour ambulatory blood pressure monitoring with vitamin D receptor gene fok-I polymorphism in essential hypertension. Kidney Blood Press Res. 2006;29:344-50 pubmed
    ..The contribution of genetic factors in hypertension cannot be denied...
  12. Maduwegedera D, Kett M, Flower R, Lambert G, Bertram J, Wintour E, et al. Sex differences in postnatal growth and renal development in offspring of rabbit mothers with chronic secondary hypertension. Am J Physiol Regul Integr Comp Physiol. 2007;292:R706-14 pubmed
    ..demonstrated that adult blood pressure was increased in offspring of rabbit mothers with chronic secondary renal hypertension. Our study identified sex-specific differences in the programming of hypertension, with female, not male, ..
  13. Nicholls M. Unilateral renal ischemia causing the hyponatremic hypertensive syndrome in children--more common than we think?. Pediatr Nephrol. 2006;21:887-90 pubmed
    ..The HH syndrome due to unilateral renal ischemia in children may be much more common than we think...
  14. Whaley Connell A, Chowdhury N, Hayden M, Stump C, Habibi J, Wiedmeyer C, et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006;291:F1308-14 pubmed
    ..Thus reductions in blood pressure, albuminuria, and tissue oxidative stress with AT1R blockade were associated with improved indexes of glomerular filtration barrier integrity and renal RAS in Ren2 rats...
  15. Gu J, Tian N, Shparago M, Tan W, Bailey A, Manning R. Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1817-24 pubmed
    ..These findings support the hypothesis that activation of NF-kappaB and upregulation of TNF-alpha are the important renal mechanisms linking proinflammatory response to SS hypertension...
  16. Czekalski S, Oko A, Pawlaczyk K. [Inherited reduced number of nephrons versus primary arterial hypertension]. Pol Merkur Lekarski. 2006;21:120-2; discussion 123-4 pubmed
    ..The results of the described studies may be of significant importance for clarification of the pathogenesis of primary arterial hypertension...
  17. Kinouchi K, Ichihara A, Sakoda M, Kurauchi Mito A, Murohashi Bokuda K, Itoh H. Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients. Kidney Blood Press Res. 2010;33:304-12 pubmed publisher
    ..This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients...
  18. Schrier R. Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2009;20:1888-93 pubmed publisher
  19. Rajapakse N, De Miguel C, Das S, Mattson D. Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats. Hypertension. 2008;52:1084-90 pubmed publisher
    ..This latter observation is most exciting because it indicates that increasing NO bioavailability, in addition to lowering arterial pressure, can greatly reduce hypertension-induced renal damage...
  20. Febba A, Sesso R, Barreto G, Liboni C, Franco M, Casarini D. Stunting growth: association of the blood pressure levels and ACE activity in early childhood. Pediatr Nephrol. 2009;24:379-86 pubmed publisher
    ..Our findings suggest that the reported high risk of hypertension in stunted adolescents and adults are, at least partly, associated with abnormalities in the renin-angiotensin system...
  21. Tomic M, Galesic K, Morovic Vergles J, Romic Z, Mikulić I. The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Coll Antropol. 2008;32:93-8 pubmed
    The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients...
  22. Kimura G. Kidney and circadian blood pressure rhythm. Hypertension. 2008;51:827-8 pubmed publisher
  23. Thompson A, Pickering T. The role of ambulatory blood pressure monitoring in chronic and end-stage renal disease. Kidney Int. 2006;70:1000-7 pubmed
    ..Ambulatory or some form of home BP monitoring should be more widely adopted in patients with chronic and end-stage renal disease...
  24. Salazar F, Reverte V, Saez F, Loria A, Llinas M, Salazar F. Age- and sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number. Hypertension. 2008;51:1184-9 pubmed publisher
    ..This study shows that the reduction of angiotensin II effects during the nephrogenic period modifies renal function and induces the development of an angiotensin II-dependent hypertension that becomes sodium sensitive during aging...
  25. Patel T, Goes N. Page kidney. Kidney Int. 2007;72:1562 pubmed
  26. Ito S. [Diagnosis of secondary hypertension]. Nihon Naika Gakkai Zasshi. 2007;96:23-8 pubmed
  27. Vaneckova I, Kopkan L, Husková Z, Vanourková Z, Schejbalová S, Cervenka L, et al. Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade. Kidney Blood Press Res. 2007;30:38-44 pubmed
  28. Fujita T, Ando K. [Kidney and hypertension]. Nihon Jinzo Gakkai Shi. 2007;49:25-8 pubmed
  29. Evans R, Burke S, Lambert G, Head G. Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1247-56 pubmed
    ..These findings do not support the hypothesis that enhanced neural control of renal function contributes to maintenance of hypertension associated with activation of the renin-angiotensin system...
  30. Hart P, Bakris G. Should beta-blockers be used to control hypertension in people with chronic kidney disease?. Semin Nephrol. 2007;27:555-64 pubmed
    ..In addition, carvedilol may retard progression of albuminuria, and provide cardiorenal protection in chronic kidney disease patients with hypertension, congestive heart failure, and at high risk for sudden cardiac death...
  31. Tedla F, Hayashi R, McFarlane S, Salifu M. Hypertension after renal transplant. J Clin Hypertens (Greenwich). 2007;9:538-45 pubmed
    ..In this review, the authors outline the pathogenesis, diagnostic workup, and treatment of hypertension after renal transplant...
  32. Dhaunsi G, Yousif M, Benter I. FPTIII mitigates peroxisome-mediated oxidative stress in kidneys of spontaneously hypertensive diabetic rats. Kidney Blood Press Res. 2010;33:60-5 pubmed publisher
    ..In this study, we have examined the effect of FPTIII on peroxisomal enzymes in relation to oxidative stress in kidneys of DH rats...
  33. Khosla N, Kalaitzidis R, Bakris G. Predictors of hyperkalemia risk following hypertension control with aldosterone blockade. Am J Nephrol. 2009;30:418-24 pubmed publisher
    ..This study assesses the risk factors for hyperkalemia in patients with chronic kidney disease (CKD) and resistant hypertension whose blood pressure (BP) is reduced to a guideline goal...
  34. Bicakci K, Soker G, Binokay F, Akgul E, Aksungur E, Sertdemir Y. Estimation of the ratio of renal artery stenosis with magnetic resonance angiography using parallel imaging technique in suspected renovascular hypertension. Nephron Clin Pract. 2006;104:c169-75 pubmed
    ..of hardware and software systems, has become a very promising technique in screening patients with suspected renal hypertension. In this study, we aimed to assess renal artery stenosis on MRA in patients with suspected renovascular ..
  35. Iseki K, Tokuyama K, Shiohira Y, Higa A, Hirano H, Toma S, et al. Olmesartan clinical trial in Okinawan patients under OKIDS (OCTOPUS) study: design and methods. Clin Exp Nephrol. 2009;13:145-151 pubmed publisher
    ..Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of antihypertensive drugs have not been examined in prospective studies...
  36. Danchuk S, Sukhanov S, Horvat D, Uddin M, Puschett J. Effects of resibufogenin in experimental hypertension. Am J Nephrol. 2008;28:8-13 pubmed
    ..Furthermore, their hypertension is corrected by administration of resibufogenin (RBG), a compound structurally similar to MBG...
  37. Sierra Verruga B, Navarro Calzada J, Sánchez Marteles M, Navarro Gil J. [Hypernephroma in horseshoe kidney]. An Med Interna. 2008;25:45-6 pubmed
  38. Lee T, Lin M, Tsai C, Chang N. Effect of pravastatin on left ventricular mass in the two-kidney, one-clip hypertensive rats. Am J Physiol Heart Circ Physiol. 2006;291:H2705-13 pubmed
    ..Pravastatin is endowed with cardiac antihypertrophic properties probably through activation of K(ATP) channels, independent of lipid and hemodynamic changes...
  39. Diaz Encarnacion M, Warner G, Gray C, Cheng J, Keryakos H, Nath K, et al. Signaling pathways modulated by fish oil in salt-sensitive hypertension. Am J Physiol Renal Physiol. 2008;294:F1323-35 pubmed publisher
    ..05). We propose that FO ameliorates renal injury in Dahl salt-sensitive rats through the inhibition of ERK, decreased NF-kappaB activation, inhibition of COX-2 expression, and decreased NADPH oxidase activation...
  40. Franco M, Martinez F, Rodriguez Iturbe B, Johnson R, Santamaría J, Montoya A, et al. Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2006;291:F1281-7 pubmed
    ..We conclude that the cortical vasoconstriction occurring with salt-sensitive hypertension following exposure to ANG II is mediated by intrarenal ANG II, related, at least in part, to the interstitial inflammation...
  41. Namikoshi T, Tomita N, Satoh M, Haruna Y, Kobayashi S, Komai N, et al. Pioglitazone enhances the antihypertensive and renoprotective effects of candesartan in Zucker obese rats fed a high-protein diet. Hypertens Res. 2008;31:745-55 pubmed publisher
    ..The combination therapy of ARB and TZD may protect against renal injury in patients with metabolic syndrome...
  42. de Borst M, Diks S, Bolbrinker J, Schellings M, van Dalen M, Peppelenbosch M, et al. Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage. Am J Physiol Renal Physiol. 2007;293:F428-37 pubmed
    ..Array-based profiling of tissue kinase activities in ANG II-mediated renal damage provides a powerful tool for identification of relevant kinase pathways in vivo and may lead to novel strategies for therapy...
  43. Katori M, Majima M. A role of the renal kallikrein-kinin system in the kidney. Acta Physiol Hung. 2008;95:127-8; author reply 129-30 pubmed publisher
  44. Donner K, Hiltunen T, Suonsyrja T, Hannila Handelberg T, Tikkanen I, Antikainen M, et al. CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men. J Hypertens. 2009;27:2001-9 pubmed publisher
    ..Cytochrome P450 (CYP) enzymes are also involved in eicosanoid biosynthesis and regulation of blood pressure (BP) and sodium homeostasis...
  45. LIEB D, Kemp B, Howell N, Gildea J, Carey R. Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis. Hypertension. 2009;54:1278-83 pubmed publisher
    ..The results support an intrarenal positive-feedback loop wherein RI cGMP increases RIHP, which, in turn, increases RI cGMP, contributing to the reinforcement of pressure-natriuresis...
  46. Fernandez Llama P, Bover J. Is albuminuria a marker of arterial remodeling?. J Hypertens. 2008;26:633-5 pubmed publisher
  47. El Hout Y, Licht C, Pippi Salle J, Ngan B, Bagli D, Lorenzo A, et al. Hypertension in children with poorly functioning unilateral kidneys: predictors of resolution after nephrectomy. BJU Int. 2010;106:1376-80 pubmed publisher
  48. Liu Q, Adams L, Broyde A, Fernandez R, Baron A, Parkes D. The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats. Cardiovasc Diabetol. 2010;9:32 pubmed publisher
    ..Hypothetically, chronic AC3174 treatment could attenuate salt-induced hypertension, cardiac morbidity, insulin resistance, and renal dysfunction in Dahl salt-sensitive (DSS) rats...
  49. Liu C, Liao S, Zeng J, Lin J, Li C, Xie L, et al. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. J Neurol Sci. 2007;260:106-13 pubmed
    ..Our data suggest that NBP prevents cold-induced ischemic stroke via improvement of cerebral microvessels...
  50. Labinson P, White W, Tendler B, Mansoor G. Primary hyperaldosteronism associated with hypertensive emergencies. Am J Hypertens. 2006;19:623-7 pubmed
    ..The differential diagnosis of hypertensive emergencies should include primary hyperaldosteronism...
  51. Henskens L, Kroon A, van Oostenbrugge R, Haest R, Lodder J, de Leeuw P. Different classifications of nocturnal blood pressure dipping affect the prevalence of dippers and nondippers and the relation with target-organ damage. J Hypertens. 2008;26:691-8 pubmed publisher
  52. Xie C, Wang D. Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension. 2009;54:1298-305 pubmed publisher
  53. Dasgupta I, Porter C, Innes A, Burden R. "Benign" hypertensive nephrosclerosis. QJM. 2007;100:113-9 pubmed
    ..Whether benign hypertensive nephrosclerosis (BHN) causes end-stage renal failure (ESRF) is controversial. One reason for this is the lack of biopsy evidence confirming the clinical diagnosis in most cases...