venous thromboembolism


Summary: Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.

Top Publications

  1. Mandala M, Falanga A, Roila F. Venous thromboembolism in cancer patients: ESMO Clinical Practice Guidelines for the management. Ann Oncol. 2010;21 Suppl 5:v274-6 pubmed publisher
  2. Bauersachs R, Berkowitz S, Brenner B, Buller H, Decousus H, Gallus A, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363:2499-510 pubmed publisher
    ..placebo for an additional 6 or 12 months in patients who had completed 6 to 12 months of treatment for venous thromboembolism. The primary efficacy outcome for both studies was recurrent venous thromboembolism...
  3. Guy J, Bertoletti L, Magne N, Rancoule C, Mahe I, Font C, et al. Venous thromboembolism in radiation therapy cancer patients: Findings from the RIETE registry. Crit Rev Oncol Hematol. 2017;113:83-89 pubmed publisher
    Cancer patients are at high risk of venous thromboembolism, particularly during cancer treatment. Conversely to chemotherapy, data on the epidemiology and clinical features of venous thromboembolism during radiation therapy are scarce...
  4. Lapidus L, Ponzer S, Pettersson H, de Bri E. Symptomatic venous thromboembolism and mortality in orthopaedic surgery - an observational study of 45 968 consecutive procedures. BMC Musculoskelet Disord. 2013;14:177 pubmed publisher
    Little information exists on the presentation of symptomatic venous thromboembolism (VTE) in orthopaedic surgery when a defined protocol for thromboprophylaxis is used...
  5. Merriman E, Kaplan Z, Butler J, Malan E, Gan E, Tran H. Rivaroxaban and false positive lupus anticoagulant testing. Thromb Haemost. 2011;105:385-6 pubmed publisher
  6. Nastasi A, Canner J, Lau B, Streiff M, Aboagye J, Kraus P, et al. Characterizing the relationship between age and venous thromboembolism in adult trauma patients: findings from the National Trauma Data Bank and the National Inpatient Sample. J Surg Res. 2017;216:115-122 pubmed publisher
    b>Venous thromboembolism (VTE) is a tremendous burden in health care. However, current guidelines lack recommendations regarding the prevention of VTE in older adult trauma patients...
  7. Schulman S. How I treat recurrent venous thromboembolism in patients receiving anticoagulant therapy. Blood. 2017;129:3285-3293 pubmed publisher
    Oral anticoagulant therapy for venous thromboembolism is very effective. When oral anticoagulants are managed well, the risk of recurrence is approximately 2 per 100 patient-years...
  8. Landisch R, Hanson S, Cassidy L, Braun K, Punzalan R, Gourlay D. Evaluation of guidelines for injured children at high risk for venous thromboembolism: A prospective observational study. J Trauma Acute Care Surg. 2017;82:836-844 pubmed publisher
    Pharmacologic prophylaxis for venous thromboembolism (VTE) is a widely accepted practice in adult trauma patients to prevent associated morbidity and mortality...
  9. Gyamlani G, Molnar M, Lu J, Sumida K, Kalantar Zadeh K, Kovesdy C. Association of serum albumin level and venous thromboembolic events in a large cohort of patients with nephrotic syndrome. Nephrol Dial Transplant. 2017;32:157-164 pubmed publisher
    ..The risk increases proportionately with declining albumin levels. Clinical trials are needed to determine benefit of prophylactic anticoagulation in NS patients with moderately lower serum albumin levels. ..

More Information


  1. Peltan I, Watkins T. The authors reply. Crit Care Med. 2016;44:e106-7 pubmed publisher
  2. Desai R, Gagne J, Lii J, Liu J, Friedman S, Kim S. Comparative risk of incident venous thromboembolism in patients with inflammatory bowel disease initiating tumour necrosis factor-? inhibitors or nonbiologic agents: a cohort study. CMAJ. 2017;189:E1438-E1447 pubmed publisher
    Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism (VTE) by 2 to 3 times...
  3. Rosovsky R, Merli G. Anticoagulation in Pulmonary Embolism: Update in the Age of Direct Oral Anticoagulants. Tech Vasc Interv Radiol. 2017;20:141-151 pubmed publisher oral anticoagulants (DOACs) represents a major advancement and paradigm shift in the treatment of venous thromboembolism. Currently, dabigatran, rivaroxaban, apixiban, and edoxoban are approved and used routinely for the ..
  4. Naddour M, Kalani M, Hattab Y, Gandhi V, Singh A, Bajwa O. Prognosis and Monitoring of VTE. Crit Care Nurs Q. 2017;40:288-300 pubmed publisher
    b>Venous thromboembolism (VTE) can present in a variety of different clinical settings and in a diverse, comorbid patient population, both of which will guide the clinician toward the appropriate therapeutic response...
  5. Fair K, Connelly C, Hart K, Schreiber M, Watters J. Splenectomy is associated with higher infection and pneumonia rates among trauma laparotomy patients. Am J Surg. 2017;213:856-861 pubmed publisher
    ..41, 95% CI 1.26-1.57, p < 0.001). Splenectomy is not associated with higher overall complication or VTE rates during index hospitalization. However, splenectomy is associated with a higher rate of pneumonia. ..
  6. He Z, Morrissey H, Ball P. Review of current evidence available for guiding optimal Enoxaparin prophylactic dosing strategies in obese patients-Actual Weight-based vs Fixed. Crit Rev Oncol Hematol. 2017;113:191-194 pubmed publisher
    ..Further research is required to compare long-term outcomes after fixed and weight-based dosing of enoxaparin. The optimal dose of enoxaparin per kilogram of body weight for prophylaxis remains to be determined. ..
  7. Migita K, Bito S, Nakamura M, Miyata S, Saito M, Kakizaki H, et al. Venous thromboembolism after total joint arthroplasty: results from a Japanese multicenter cohort study. Arthritis Res Ther. 2014;16:R154 pubmed publisher
    Real-world evidence of the effectiveness of pharmacological thromboprophylaxis for venous thromboembolism (VTE) is limited...
  8. Mont M, Jacobs J, Lieberman J, Parvizi J, Lachiewicz P, Johanson N, et al. Preventing venous thromboembolic disease in patients undergoing elective total hip and knee arthroplasty. J Bone Joint Surg Am. 2012;94:673-4 pubmed publisher
  9. Lyon C, Reed A, Prasad S. PURLs: Direct oral anticoagulants or warfarin for A fib?. J Fam Pract. 2017;66:518-519 pubmed
    ..A recent study evaluated the effectiveness of 3 direct oral anticoagulants and warfarin in patients with atrial fibrillation. So which agents came out on top? ..
  10. Rooney K, Schilling U. Point-of-care testing in the overcrowded emergency department--can it make a difference?. Crit Care. 2014;18:692 pubmed publisher
    ..This review concludes that POCT, when used effectively, may alleviate the negative impacts of overcrowding on the safety, effectiveness, and person-centeredness of care in the ED. ..
  11. Fasanya A, Silvas K, Alhassan S, Patel K, Singh A, Malik K. Venous Thromboembolism and Pulmonary Embolism Response Teams: An Overview. Crit Care Nurs Q. 2017;40:237-250 pubmed publisher
    b>Venous thromboembolism is a common disease with a wide array of signs and symptoms. It has been cited as the third leading cause of cardiovascular death, and if left untreated, it leads to death in 1 in 4 patients...
  12. Hugon Rodin J, Horellou M, Conard J, Flaujac C, Gompel A, Plu Bureau G. First venous thromboembolism and hormonal contraceptives in young French women. Medicine (Baltimore). 2017;96:e7734 pubmed publisher
    ..the clinical and biological characteristics of combined hormonal contraceptives (CHC) users experiencing a venous thromboembolism (VTE) event is scarce...
  13. Dennis J, Medina Rivera A, Truong V, Antounians L, Zwingerman N, Carrasco G, et al. Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels. Genet Epidemiol. 2017;41:455-466 pubmed publisher
    ..of intravascular blood clots, which manifest clinically as ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE)...
  14. Teoh L, Latif M, Choi P, Wu S, Chan C, Plowman G, et al. Use of a reminder sticker improves rates of documentation of resuscitation status and the appropriate prescription of venous thromboembolism prophylaxis. N Z Med J. 2012;125:175-7 pubmed
  15. D Alessio A, Marchetti M, Tartari C, Russo L, Cecchini S, Lambregts K, et al. Long Term Low Molecular Weight Heparin Anticoagulant Therapy Modulates Thrombin Generation and D-dimer in Patients with Cancer and Venous Thromboembolism. Cancer Invest. 2017;35:490-499 pubmed publisher
    We enrolled 62 consecutive patients with advanced stage cancers and venous thromboembolism (VTE), prospectively followed until 1 year. All patients received 6 month low-molecular-weight heparin (LMWH) therapy...
  16. Baluwala I, Favaloro E, Pasalic L. Therapeutic monitoring of unfractionated heparin - trials and tribulations. Expert Rev Hematol. 2017;10:595-605 pubmed publisher
    ..of the oldest biological medicines with an established role in prevention and treatment of arterial and venous thromboembolism. Published therapeutic ranges for unfractionated heparin (UFH) mostly precede the large increase in the ..
  17. Canobbio I, Visconte C, Momi S, Guidetti G, Zarà M, Canino J, et al. Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice. Blood. 2017;130:527-536 pubmed publisher
    ..These results indicate that platelet APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrophil function.
  18. Phillippe H, Hornsby L, Treadway S, Armstrong E, Bellone J. Inherited Thrombophilia. J Pharm Pract. 2014;27:227-33 pubmed publisher
    ..Although vitamin B supplementation has been shown to decrease the levels of homocysteine, the treatment has failed to show a benefit in thrombus prevention and is therefore not recommended. ..
  19. Helms T, Gulba D, Ahrens I, Schafer A, Hankowitz J, Kuhlencordt P, et al. [Treatment and Secondary Prevention of Venous Thromboembolism - Change in Oral Anticoagulation]. Dtsch Med Wochenschr. 2017;142:986-993 pubmed publisher
    ..vitamin K dependent oral anticoagulant (NOAC) edoxaban the range of available NOACs for the treatment of venous thromboembolism (VTE) has expanded...
  20. Rehman T, Deboisblanc B. Persistent fever in the ICU. Chest. 2014;145:158-165 pubmed publisher
    ..Outside the realm of acute brain injury, the practice of treating fever remains controversial. To generate high-quality, evidence-based guidelines for the management of fever, large, prospective, multicenter trials are needed. ..
  21. Ruberto M, Sorbello O, Civolani A, Barcellona D, Demelia L, Marongiu F. Clot wave analysis and thromboembolic score in liver cirrhosis: two opposing phenomena. Int J Lab Hematol. 2017;39:369-374 pubmed publisher
    ..acceleration (2nd derivatives) and density (Delta) of aPTT and the Padua Prediction Score (PPS) for venous thromboembolism were studied in 191 cirrhotic patients...
  22. Laursen C, Sloth E, Lambrechtsen J, Lassen A, Madsen P, Henriksen D, et al. Focused sonography of the heart, lungs, and deep veins identifies missed life-threatening conditions in admitted patients with acute respiratory symptoms. Chest. 2013;144:1868-1875 pubmed publisher
    ..In an ED setting sonography can be used both for ruling in and ruling out acute life-threatening conditions in these patients. ..
  23. Wang L, Baser O, Wells P, Peacock W, Coleman C, Fermann G, et al. Benefit of early discharge among patients with low-risk pulmonary embolism. PLoS ONE. 2017;12:e0185022 pubmed publisher
    ..Propensity score matching (PSM) was used to compare 90-day adverse PE events (APEs) [recurrent venous thromboembolism, major bleed and death], hospital-acquired complications (HACs), healthcare utilization, and costs among ..
  24. Eckert M, Martin M. Trauma: Spinal Cord Injury. Surg Clin North Am. 2017;97:1031-1045 pubmed publisher
    ..Spinal cord injury is associated with numerous life-threatening complications during the acute and long-term phases of care that all acute care surgeons must recognize. ..
  25. Mueller C, Limacher A, Méan M, Rodondi N, Aujesky D. Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study. PLoS ONE. 2017;12:e0184868 pubmed publisher
    Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown...
  26. Karska Basta I, Kubicka Trzaska A, Romanowska Dixon B, Undas A. Altered fibrin clot properties in patients with retinal vein occlusion. J Thromb Haemost. 2011;9:2513-5 pubmed publisher
  27. Hill J, Treasure T. Reducing the risk of venous thromboembolism in patients admitted to hospital: summary of NICE guidance. BMJ. 2010;340:c95 pubmed publisher
  28. Lau B, Shaffer D, Hobson D, Yenokyan G, Wang J, Sugar E, et al. Effectiveness of two distinct web-based education tools for bedside nurses on medication administration practice for venous thromboembolism prevention: A randomized clinical trial. PLoS ONE. 2017;12:e0181664 pubmed publisher
    b>Venous thromboembolism (VTE) is a common cause of preventable harm in hospitalized patients...
  29. Cove C, Hylek E. An updated review of target-specific oral anticoagulants used in stroke prevention in atrial fibrillation, venous thromboembolic disease, and acute coronary syndromes. J Am Heart Assoc. 2013;2:e000136 pubmed publisher
  30. Robison E, Heyborne K, Allshouse A, Valdez C, Metz T. Implementation of a Risk-Based Heparin Protocol for Postpartum Venous Thromboembolism Prevention. Obstet Gynecol. 2017;130:262-269 pubmed publisher
    To evaluate the effect of a postpartum risk-based low-molecular-weight heparin protocol for venous thromboembolism prevention...
  31. Han X, Guo B, Li Y, Zhu B. Tissue factor in tumor microenvironment: a systematic review. J Hematol Oncol. 2014;7:54 pubmed publisher
    The aberrant hemostasis is a common manifestation of cancer, and venous thromboembolism (VTE) is the second leading cause of cancer patients' mortality...
  32. Elsaigh E, Thachil J, Nash M, Tower C, Hay C, Bullough S, et al. The use of fondaparinux in pregnancy. Br J Haematol. 2015;168:762-4 pubmed publisher
  33. Ota H, Sugimura K, Miura M, Shimokawa H. Four-dimensional flow magnetic resonance imaging visualizes drastic change in vortex flow in the main pulmonary artery after percutaneous transluminal pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension. Eur Heart J. 2015;36:1630 pubmed publisher
  34. Robertson L, Yeoh S, Stansby G, Agarwal R. Effect of testing for cancer on cancer- and venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE. Cochrane Database Syst Rev. 2017;8:CD010837 pubmed publisher
    b>Venous thromboembolism (VTE) is a collective term for two conditions: deep vein thrombosis (DVT) and pulmonary embolism (PE)...
  35. Sennstrom M, Rova K, Hellgren M, Hjertberg R, Nord E, Thurn L, et al. Thromboembolism and in vitro fertilization - a systematic review. Acta Obstet Gynecol Scand. 2017;96:1045-1052 pubmed publisher
    ..The antepartum risk of venous thromboembolism (VTE) after IVF is doubled (odds ratio 2.18, 95% CI 1.63-2...
  36. Regitz Zagrosek V, Blomstrom Lundqvist C, Borghi C, Cifkova R, Ferreira R, Foidart J, et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J. 2011;32:3147-97 pubmed publisher
  37. McKenna N, Behm K, Ubl D, Glasgow A, Mathis K, Pemberton J, et al. Analysis of Postoperative Venous Thromboembolism in Patients With Chronic Ulcerative Colitis: Is It the Disease or the Operation?. Dis Colon Rectum. 2017;60:714-722 pubmed publisher
    Patients with IBD have a higher baseline risk of venous thromboembolism, which further increases with surgery. Therefore, extended venous thromboembolism chemoprophylaxis has been suggested in certain high-risk cohorts...
  38. Paneesha S, Lokare A, Lester Z, Nokes T, Arya R, Farren T, et al. Impact of venous thromboembolism on survival in patients with malignancy. Br J Haematol. 2009;145:258-60 pubmed publisher
  39. Rubio G, Zoghbi Y, Karcutskie C, Thaller S. Incidence and risk factors for venous thromboembolism in bilateral breast reduction surgery: An analysis of the National Surgical Quality Improvement Program. J Plast Reconstr Aesthet Surg. 2017;70:1514-1519 pubmed publisher
    The risk of venous thromboembolism (VTE) in patients undergoing bilateral breast reduction surgery remains unknown. This study aimed to determine VTE incidence and risk factors in this patient cohort...
  40. Méan M, Limacher A, Stalder O, Angelillo Scherrer A, Alberio L, Fontana P, et al. Do Factor V Leiden and Prothrombin G20210A Mutations Predict Recurrent Venous Thromboembolism in Older Patients?. Am J Med. 2017;130:1220.e17-1220.e22 pubmed publisher
    The value of genetic thrombophilia testing in elderly patients with an unprovoked venous thromboembolism is unclear...
  41. Yhim H, Lee J, Lee J, Lee J, Bang S. Pharmacological thromboprophylaxis and its impact on venous thromboembolism following total knee and hip arthroplasty in Korea: A nationwide population-based study. PLoS ONE. 2017;12:e0178214 pubmed publisher
    Limited data is available regarding the pharmacological prophylaxis for venous thromboembolism (VTE) in Asian patients undergoing total knee arthroplasty or total hip arthroplasty (TKA/THA)...
  42. Zolcinski M, Ciesla Dul M, Undas A. Effects of atorvastatin on plasma fibrin clot properties in apparently healthy individuals and patients with previous venous thromboembolism. Thromb Haemost. 2012;107:1180-2 pubmed publisher
  43. Zhang Y, Yang Y, Chen W, Guo L, Liang L, Zhai Z, et al. Prevalence and associations of VTE in patients with newly diagnosed lung cancer. Chest. 2014;146:650-658 pubmed publisher
    ..In patients with lung cancer, the factors associated with DVT might be different from those associated with PE. An elevated CEA level might facilitate the identification of patients at a higher risk of developing PE. ..
  44. Tashima Y, Banno F, Kita T, Matsuda Y, Yanamoto H, Miyata T. Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS ONE. 2017;12:e0180981 pubmed publisher
    ..A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity...
  45. Hu B, Wang Q, Tang L, Hu Y. Association of thrombomodulin c.1418C>T polymorphism and venous thromboembolism. Gene. 2017;628:56-62 pubmed publisher
    ..70; CT vs CC: OR=1.41, 95% CI=1.00-2.98; TT+CT vs CC vs CC: OR=1.41, 95% CI=1.02-1.95). Current studies on the thrombomodulin c.1418C>T polymorphism are of great heterogeneity. It might not be a risk factor for venous thromboembolism.
  46. Méan M, Tritschler T, Limacher A, Breault S, Rodondi N, Aujesky D, et al. Association between computed tomography obstruction index and mortality in elderly patients with acute pulmonary embolism: A prospective validation study. PLoS ONE. 2017;12:e0179224 pubmed publisher
    ..Outcomes were 90-day overall and PE-related mortality, recurrent venous thromboembolism (VTE), and length of hospital stay (LOS)...
  47. van Es N, Le Gal G, Otten H, Robin P, Piccioli A, Lecumberri R, et al. Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data. Ann Intern Med. 2017;167:410-417 pubmed publisher
    Screening for cancer in patients with unprovoked venous thromboembolism (VTE) often is considered, but clinicians need precise data on cancer prevalence, risk factors, and the effect of different types of screening strategies...
  48. Mandala M, Falanga A, Roila F. Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2011;22 Suppl 6:vi85-92 pubmed publisher
  49. Northup A, Wilcox S. Thromboprophylaxis Failure in the Adult Medical Inpatient. Am J Med Sci. 2017;354:107-116 pubmed publisher
    b>Venous thromboembolism (VTE), a leading cause of morbidity and mortality among hospitalized patients, is often due to prophylaxis failure rather than omission, but few studies have identified the risk factors for failure...
  50. Bezan A, Posch F, Ploner F, Bauernhofer T, Pichler M, Szkandera J, et al. Risk stratification for venous thromboembolism in patients with testicular germ cell tumors. PLoS ONE. 2017;12:e0176283 pubmed publisher
    Patients with testicular germ cell tumors (TGCT) have an increased risk for venous thromboembolism (VTE). We identified risk factors for VTE in this patient cohort and developed a clinical risk model...
  51. Gibson C, Finks S. Edoxaban: How Does the Newest Agent Fit into the DOAC Landscape?. Am J Med. 2017;130:900-906 pubmed publisher
    ..Like other DOACs, edoxaban was approved by the US Food and Drug Administration for treatment of venous thromboembolism and prevention of stroke in patients with nonvalvular atrial fibrillation...
  52. Kaplan D, Casper T, Elliott C, Men S, Pendleton R, Kraiss L, et al. VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock. Chest. 2015;148:1224-1230 pubmed publisher
    ..More effective VTE prevention strategies are necessary in patients with sepsis.; No.: NCT02353910; URL: ..
  53. Sun M, Wood M, Chan W, Selva D, Sanders P, Casson R, et al. Risk of Intraocular Bleeding With Novel Oral Anticoagulants Compared With Warfarin: A Systematic Review and Meta-analysis. JAMA Ophthalmol. 2017;135:864-870 pubmed publisher
    ..It is unclear if the risk of intraocular bleeding with novel oral anticoagulants differs compared with warfarin...