arteriovenous malformations

Summary

Summary: Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.

Top Publications

  1. Corti P, Young S, Chen C, Patrick M, Rochon E, Pekkan K, et al. Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development. 2011;138:1573-82 pubmed publisher
    b>Arteriovenous malformations (AVMs) are fragile direct connections between arteries and veins that arise during times of active angiogenesis...
  2. Gao P, Chen Y, Lawton M, Barbaro N, Yang G, Su H, et al. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010;67:1029-35 pubmed publisher
    Brain and spinal cord arteriovenous malformations (AVMs) are characterized by aberrant angiogenesis and vascular remodeling...
  3. Yao Y, Jumabay M, Wang A, BOSTROM K. Matrix Gla protein deficiency causes arteriovenous malformations in mice. J Clin Invest. 2011;121:2993-3004 pubmed publisher
    b>Arteriovenous malformations (AVMs) in organs, such as the lungs, intestine, and brain, are characteristic of hereditary hemorrhagic telangiectasia (HHT), a disease caused by mutations in activin-like kinase receptor 1 (ALK1), which is an ..
  4. Hou F, Dai Y, Dornhoffer J, Suen J, Fan C, Saad A, et al. Expression of endoglin (CD105) and endothelial nitric oxide synthase in head and neck arteriovenous malformations. JAMA Otolaryngol Head Neck Surg. 2013;139:237-43 pubmed publisher
    ..To clarify the role of endoglin and eNOS in the growth of extracranial head and neck arteriovenous malformations (AVMs), an invasive and high-flow vascular anomaly...
  5. Gross B, Du R. Rate of re-bleeding of arteriovenous malformations in the first year after rupture. J Clin Neurosci. 2012;19:1087-8 pubmed publisher
    Prior rupture is an established risk factor for subsequent hemorrhage from arteriovenous malformations (AVM)...
  6. Hänggi D, Etminan N, Steiger H. The impact of microscope-integrated intraoperative near-infrared indocyanine green videoangiography on surgery of arteriovenous malformations and dural arteriovenous fistulae. Neurosurgery. 2010;67:1094-103; discussion 1103-4 pubmed publisher
    ..To evaluate intraoperative ICG videoangiography for surgery of arteriovenous malformations (AVMs) and dural arteriovenous fistulas (dAVFs)...
  7. Mason C, Shovlin C. Flight-related complications are infrequent in patients with hereditary haemorrhagic telangiectasia/pulmonary arteriovenous malformations, despite low oxygen saturations and anaemia. Thorax. 2012;67:80-1 pubmed publisher
    Individuals with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia (HHT) commonly have low oxygen saturations and anaemia, two parameters generally used to indicate medical fitness to fly...
  8. Friedman W, Bova F. Radiosurgery for arteriovenous malformations. Neurol Res. 2011;33:803-19 pubmed publisher
  9. Vaknin Z, Sadeh Mefpechkin D, Halperin R, Altshuler A, Amir P, Maymon R. Pregnancy-related uterine arteriovenous malformations: experience from a single medical center. Ultraschall Med. 2011;32 Suppl 2:E92-9 pubmed publisher
    ..and the outcomes of post-pregnancy patients with acquired uterine vascular abnormalities including arteriovenous malformations (AVMs)...

More Information

Publications62

  1. Kano H, Kondziolka D, Flickinger J, Park K, Iyer A, Yang H, et al. Stereotactic radiosurgery after embolization for arteriovenous malformations. Prog Neurol Surg. 2013;27:89-96 pubmed publisher
    ..In the future, the role of embolization after SRS should be explored. ..
  2. McGrath S, Harding V, Lim A, Burfitt N, Seckl M, Savage P. Embolization of uterine arteriovenous malformations in patients with gestational trophoblastic tumors: a review of patients at Charing Cross Hospital, 2000-2009. J Reprod Med. 2012;57:319-24 pubmed
    ..For GTT patients with heavy bleeding from AVMs, uterine artery embolization is a safe and effective treatment with low short-term toxicity and no obvious detrimental effect on future fertility. ..
  3. Peitsidis P, Manolakos E, Tsekoura V, Kreienberg R, Schwentner L. Uterine arteriovenous malformations induced after diagnostic curettage: a systematic review. Arch Gynecol Obstet. 2011;284:1137-51 pubmed publisher
    ..Ultrasound imaging with appropriate knowledge of color Doppler features minimizes the use of inappropriate interventional procedures such as diagnostic curettage. UAE is effective in treatment, and rarely leads to complications. ..
  4. Buonamico P, Suppressa P, Lenato G, Pasculli G, d Ovidio F, Memeo M, et al. Liver involvement in a large cohort of patients with hereditary hemorrhagic telangiectasia: echo-color-Doppler vs multislice computed tomography study. J Hepatol. 2008;48:811-20 pubmed publisher
    ..A new Doppler parameter ("color-spots") with an optimal accuracy for detecting HAVMs is proposed for easy periodic screening of HHT patients. ..
  5. Vernimmen F, Slabbert J. Assessment of the alpha/beta ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma. Int J Radiat Biol. 2010;86:486-98 pubmed publisher
    To determine alpha/beta (alpha/beta) values of arteriovenous malformations (AVM), meningiomas, acoustic neuromas (AN), and the optic chiasma using clinical data...
  6. Post M, van Gent M, Plokker H, Westermann C, Kelder J, Mager J, et al. Pulmonary arteriovenous malformations associated with migraine with aura. Eur Respir J. 2009;34:882-7 pubmed publisher
    ..We prospectively studied the association between pulmonary arteriovenous malformations (PAVMs) and MA in hereditary haemorrhagic telangiectasia (HHT)...
  7. McElhinney D, Kreutzer J, Lang P, Mayer J, del Nido P, Lock J. Incorporation of the hepatic veins into the cavopulmonary circulation in patients with heterotaxy and pulmonary arteriovenous malformations after a Kawashima procedure. Ann Thorac Surg. 2005;80:1597-603 pubmed
    ..polysplenia syndrome and azygous continuation of an interrupted inferior vena cava (IVC), pulmonary arteriovenous malformations (PAVMs) are relatively common after bidirectional cavopulmonary anastomosis (BCPA, Kawashima procedure)...
  8. Cura M, Elmerhi F, Suri R, Bugnone A, Dalsaso T. Vascular malformations and arteriovenous fistulas of the kidney. Acta Radiol. 2010;51:144-9 pubmed publisher
    ..of the kidney are disease processes that involve renal veins and arteries and include congenital arteriovenous malformations (AVMs) and arteriovenous fistulas...
  9. Achrol A, Pawlikowska L, McCulloch C, Poon K, Ha C, Zaroff J, et al. Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations. Stroke. 2006;37:231-4 pubmed
    ..A TNF-alpha SNP was associated with increased risk of new ICH in the natural course of BAVMs. The role of inflammatory cytokines in the pathogenesis of BAVM hemorrhage merits further study. ..
  10. Kademani D, Costello B, Ditty D, Quinn P. An alternative approach to maxillofacial arteriovenous malformations with transosseous direct puncture embolization. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:701-6 pubmed
    ..Surgical treatment of arteriovenous malformations has been associated with significant morbidity and mortality due to potential for massive blood loss...
  11. McKevitt E, Attwell A, Davis J, Yoshida E. Diminutive but dangerous: a case of a polypoid rectal arteriovenous malformation. Endoscopy. 2002;34:429 pubmed
  12. Tipps R, Mumtaz M, Leahy P, Duncan B. Gene array analysis of a rat model of pulmonary arteriovenous malformations after superior cavopulmonary anastomosis. J Thorac Cardiovasc Surg. 2008;136:283-9 pubmed publisher
    Pulmonary arteriovenous malformations commonly develop in children who have undergone a cavopulmonary anastomosis as part of the palliative sequence for single-ventricle physiology...
  13. Letteboer T, Mager J, Snijder R, Koeleman B, Lindhout D, Ploos van Amstel J, et al. Genotype-phenotype relationship in hereditary haemorrhagic telangiectasia. J Med Genet. 2006;43:371-7 pubmed
    ..by vascular malformations in multiple organ systems, resulting in mucocutaneous telangiectases and arteriovenous malformations predominantly in the lungs (pulmonary arteriovenous malformation; PAVM), brain (cerebral arteriovenous ..
  14. Turnbull M, Humeniuk V, Stein B, Suthers G. Arteriovenous malformations in Cowden syndrome. J Med Genet. 2005;42:e50 pubmed
    ..Malignancies often arise in the affected tissues. Visceral arteriovenous malformations are a recognised component of the Bannayan-Riley-Ruvalcaba syndrome but have been reported rarely in ..
  15. Marler J, Mulliken J. Current management of hemangiomas and vascular malformations. Clin Plast Surg. 2005;32:99-116, ix pubmed
    ..We describe the nomenclature, diagnosis, and management of the different types of anomalies. Specific indications for pharmacologic and surgical intervention are discussed. ..
  16. Nasseri Moghaddam S, Mohamadnejad M, Malekzadeh R, Tavangar S. Images of interest. Gastrointestinal: polypoid arteriovenous malformation of the colon. J Gastroenterol Hepatol. 2004;19:1419 pubmed
  17. Buscarini E, Danesino C, Plauchu H, de Fazio C, Olivieri C, Brambilla G, et al. High prevalence of hepatic focal nodular hyperplasia in subjects with hereditary hemorrhagic telangiectasia. Ultrasound Med Biol. 2004;30:1089-97 pubmed
    ..Prevalence of FNH in patients with HHT is far greater than that reported in the general population; Doppler US role in its diagnosis and follow-up is highlighted. ..
  18. Shovlin C, Bamford K, Wray D. Post-NICE 2008: Antibiotic prophylaxis prior to dental procedures for patients with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia. Br Dent J. 2008;205:531-3 pubmed publisher
    ..Individuals with pulmonary arteriovenous malformations and hereditary haemorrhagic telangiectasia are at risk of brain abscess from dental bacteraemias...
  19. Mager J, Overtoom T, Blauw H, Lammers J, Westermann C. Embolotherapy of pulmonary arteriovenous malformations: long-term results in 112 patients. J Vasc Interv Radiol. 2004;15:451-6 pubmed
    To evaluate the long-term results of embolotherapy of pulmonary arteriovenous malformations (PAVMs) in a large group of patients...
  20. Pierucci P, Murphy J, Henderson K, Chyun D, White R. New definition and natural history of patients with diffuse pulmonary arteriovenous malformations: twenty-seven-year experience. Chest. 2008;133:653-61 pubmed publisher
    Patients with diffuse pulmonary arteriovenous malformations (PAVM), a small but important subset of the PAVM population, have significant morbidity and mortality rates...
  21. Mori K, Shiigai M, Saida T, Anno I, Wada M, Minami M. A modified metallic coil embolization technique for pulmonary arteriovenous malformations using coil anchors and occlusion balloon catheters. Cardiovasc Intervent Radiol. 2008;31:638-42 pubmed
    ..To evaluate the feasibility and efficacy of a modified metallic coil embolization technique for pulmonary arteriovenous malformations (PAVMs) using coil anchors and occlusion balloon catheters...
  22. Dupuis Girod S, Chesnais A, Ginon I, Dumortier J, Saurin J, Finet G, et al. Long-term outcome of patients with hereditary hemorrhagic telangiectasia and severe hepatic involvement after orthotopic liver transplantation: a single-center study. Liver Transpl. 2010;16:340-7 pubmed publisher
    ..74% of patients with hereditary hemorrhagic telangiectasia (HHT) and is characterized by a spectrum of arteriovenous malformations. Three different types of intrahepatic shunting may be present: hepatic artery to hepatic veins, ..
  23. Do Y, Yakes W, Shin S, Lee B, Kim D, Liu W, et al. Ethanol embolization of arteriovenous malformations: interim results. Radiology. 2005;235:674-82 pubmed
    To assess retrospectively the interim results and the complications of ethanol embolization treatment of arteriovenous malformations (AVMs)...
  24. Larsson E, Solymar L, Eriksson B, de Wahl Granelli A, Mellander M. Bubble contrast echocardiography in detecting pulmonary arteriovenous malformations after modified Fontan operations. Cardiol Young. 2001;11:505-11 pubmed
    The development of pulmonary arteriovenous malformations is a well-known complication after Fontan operations, and may result in significant morbidity due to increasing arterial desaturation...
  25. Lee B, Do Y, Yakes W, Kim D, Mattassi R, Hyon W. Management of arteriovenous malformations: a multidisciplinary approach. J Vasc Surg. 2004;39:590-600 pubmed
    Management of arteriovenous malformations (AVMs) remains challenging because of their unpredictable behavior and high recurrence rate...
  26. Richter G, Suen J, North P, James C, Waner M, Buckmiller L. Arteriovenous malformations of the tongue: a spectrum of disease. Laryngoscope. 2007;117:328-35 pubmed
    To examine our vascular anomalies team's experience with tongue arteriovenous malformations (AVM) with specific emphasis on the spectrum on disease and surgical management...
  27. D Arienzo A, Manguso F, D Armiento F, Bennato R, Somma P, Pisani A, et al. Colonoscopic removal of a polypoid arteriovenous malformation. Dig Liver Dis. 2001;33:435-7 pubmed
    ..Endoscopically, arteriovenous malformations generally appear as flat or elevated bright red lesions...
  28. Pollak J, Saluja S, Thabet A, Henderson K, Denbow N, White R. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006;17:35-44; quiz 45 pubmed
    ..Patients with persistent, reperfused, or enlarging lesions often have symptoms, but a significant minority of patients are asymptomatic. More frequent assessment may improve detection before the onset of symptoms. ..
  29. Tarkan O, Sürmelioğlu O, Tuncer U, Akgul E. Face skin necrosis following embolization for arteriovenous malformations: a case report. Oral Maxillofac Surg. 2010;14:49-52 pubmed publisher
    b>Arteriovenous malformations (AVMs) are rare in the oral and maxillofacial regions. AVMs may induce severe complications such as uncontrollable bleeding...
  30. Thenganatt J, Schneiderman J, Hyland R, Edmeads J, Mandzia J, Faughnan M. Migraines linked to intrapulmonary right-to-left shunt. Headache. 2006;46:439-43 pubmed
    ..asked about a history of migraines and systematically screened for pulmonary and cerebral arteriovenous malformations (AVMs)...
  31. Bassuk A, Burrowes D, Velimirovic B, Grant J, Keating G. A child with spinal cord AVM presenting with raised intracranial pressure. Neurology. 2003;60:1724-5 pubmed
  32. Defreyne L, Meersschaut V, van Damme S, Berrevoet F, Robberecht E, Praet M. Colonic arteriovenous malformation in a child misinterpreted as an idiopathic colonic varicosis on angiography: remarks on current classification of childhood intestinal vascular malformations. Eur Radiol. 2003;13 Suppl 4:L138-41 pubmed
    ..The role of angiography and shortcomings in nomenclature and classification of intestinal vascular anomalies in childhood are discussed. ..
  33. Imoto Y, Sese A, Joh K. Redirection of the hepatic venous flow for the treatment of pulmonary arteriovenous malformations after Fontan operation. Pediatr Cardiol. 2006;27:490-2 pubmed
    ..Cardiac catheterization showed a preferential flow of the hepatic venous blood to the right lung and arteriovenous malformations (PAVMs) in the left lung...
  34. Andersen P, Kjeldsen A. Occlusion of pulmonary arteriovenous malformations by use of vascular plug. Acta Radiol. 2007;48:496-9 pubmed
    Pulmonary arteriovenous malformations are commonly treated by embolization with coils or balloons to prevent cerebral complications and to raise the oxygenation of the blood...
  35. Blanchet A, Cottin V, Cordier J. [Pulmonary vascular manifestations in hereditary hemorrhagic telangiectasia]. Presse Med. 2005;34:1487-95 pubmed
    ..Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications...
  36. Lim A, Agarwal R, Seckl M, Newlands E, Barrett N, Mitchell A. Embolization of bleeding residual uterine vascular malformations in patients with treated gestational trophoblastic tumors. Radiology. 2002;222:640-4 pubmed
    ..Selective uterine artery embolization is a safe and effective treatment for severe bleeding from residual uterine vascular malformations in patients with treated gestational trophoblastic tumors. ..
  37. Han S, Lim D, Chung Y, Cho T, Lim S, Kim W, et al. The multiple brain abscesses associated with congenital pulmonary arteriovenous malformations: a case report. J Korean Med Sci. 2002;17:407-11 pubmed
    ..report, we describe a case of multiple brain abscesses associated with diffuse congenital pulmonary arteriovenous malformations (PAVM)...
  38. Dar P, Karmin I, Einstein M. Arteriovenous malformations of the uterus: long-term follow-up. Gynecol Obstet Invest. 2008;66:157-61 pubmed publisher
    b>Arteriovenous malformations (AVMs) of the uterus have various clinical presentations...
  39. Post M, Thijs V, Schonewille W, Budts W, Snijder R, Plokker H, et al. Embolization of pulmonary arteriovenous malformations and decrease in prevalence of migraine. Neurology. 2006;66:202-5 pubmed
    To determine if embolization of pulmonary arteriovenous malformations (PAVMs) decreases the occurrence of migraine...
  40. Schmidt D, Pache M, Schumacher M. The congenital unilateral retinocephalic vascular malformation syndrome (bonnet-dechaume-blanc syndrome or wyburn-mason syndrome): review of the literature. Surv Ophthalmol. 2008;53:227-49 pubmed publisher
    Retinal arteriovenous malformations represent a rare syndrome in which a direct connection of major vessels without interposition of capillaries may lead to various complications such as thrombosis and vessel occlusion...
  41. Remy Jardin M, Dumont P, Brillet P, Dupuis P, Duhamel A, Remy J. Pulmonary arteriovenous malformations treated with embolotherapy: helical CT evaluation of long-term effectiveness after 2-21-year follow-up. Radiology. 2006;239:576-85 pubmed
    To retrospectively evaluate the long-term results of transcatheter embolotherapy of pulmonary arteriovenous malformations (PAVMs) with helical computed tomography (CT)...
  42. Brown J, Ruzmetov M, Vijay P, Rodefeld M, Turrentine M. Pulmonary arteriovenous malformations in children after the Kawashima operation. Ann Thorac Surg. 2005;80:1592-6 pubmed
    Pulmonary arteriovenous malformations are a major cause of progressive late cyanosis in patients treated with cavopulmonary anastomoses...
  43. Boon L, Mulliken J, Vikkula M. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005;15:265-9 pubmed
    ..association with high-flow lesions: cutaneous, subcutaneous, intramuscular, intraosseous and cerebral arteriovenous malformations and arteriovenous fistulas...
  44. Cottin V, Plauchu H, Bayle J, Barthelet M, Revel D, Cordier J. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia. Am J Respir Crit Care Med. 2004;169:994-1000 pubmed
    Pulmonary arteriovenous malformations (PAVMs) associated with hereditary hemorrhagic telangiectasia may cause severe cerebral complications that may be prevented by embolization therapy...
  45. Sabba C, Pasculli G, Lenato G, Suppressa P, Lastella P, Memeo M, et al. Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers. J Thromb Haemost. 2007;5:1149-57 pubmed
    ..HHT) is a genetic disorder characterized by epistaxis, mucocutaneous telangiectases and visceral arteriovenous malformations (AVMs), particularly in the brain (CAVMs), lungs (PAVMs), liver (HAVMs) and gastrointestinal tract (GI)...
  46. Richter G, Suen J. Clinical course of arteriovenous malformations of the head and neck: a case series. Otolaryngol Head Neck Surg. 2010;142:184-90 pubmed publisher
    To demonstrate, in a case series, the relentless growth of arteriovenous malformations (AVMs) of the head and neck and the importance of their vigilant management within the context of a modified staging system. Retrospective review...
  47. Brillet P, Dumont P, Bouaziz N, Duhamel A, Laurent F, Remy J, et al. Pulmonary arteriovenous malformation treated with embolotherapy: systemic collateral supply at multidetector CT angiography after 2-20-year follow-up. Radiology. 2007;242:267-76 pubmed
    To retrospectively evaluate frequency of systemic arterial collateral supply to treated pulmonary arteriovenous malformations (PAVMs) in long-term follow-up with multi-detector row helical computed tomography (CT)...
  48. Siu W, Weill A, Gariepy J, Moret J, Marotta T. Arteriovenous malformation of the mandible: embolization and direct injection therapy. J Vasc Interv Radiol. 2001;12:1095-8 pubmed
    ..The authors describe three cases of successfully treated mandibular AVM by percutaneous and/or endovascular techniques. ..
  49. Gupta P, Mordin C, Curtis J, Hughes J, Shovlin C, Jackson J. Pulmonary arteriovenous malformations: effect of embolization on right-to-left shunt, hypoxemia, and exercise tolerance in 66 patients. AJR Am J Roentgenol. 2002;179:347-55 pubmed
    This study assessed the effect and safety of percutaneous transcatheter coil embolization of pulmonary arteriovenous malformations. In 58 (88%) of 66 patients, all malformations with feeding vessels greater than or equal to 3 mm in ..
  50. Ziyeh S, Schumacher M, Strecker R, Rossler J, Hochmuth A, Klisch J. Head and neck vascular malformations: time-resolved MR projection angiography. Neuroradiology. 2003;45:681-6 pubmed
    ..High-flow arteriovenous malformations showed early, intense enhancement...
  51. Duncan B, Desai S. Pulmonary arteriovenous malformations after cavopulmonary anastomosis. Ann Thorac Surg. 2003;76:1759-66 pubmed
    Pulmonary arteriovenous malformations (PAVMs) are a cause of progressive cyanosis after cavopulmonary anastomosis in children with single ventricle physiology who are on the pathway leading to a Fontan procedure...
  52. Carlson T, Yan Y, Wu X, Lam M, Tang G, Beverly L, et al. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A. 2005;102:9884-9 pubmed
    ..communication between arteries and veins without intervening capillary beds is the primary pathology of arteriovenous malformations (AVMs)...
  53. Kim H, Marchuk D, Pawlikowska L, Chen Y, Su H, Yang G, et al. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008;105:199-206 pubmed
    Brain arteriovenous malformations (AVMs) cause intracranial hemorrhage (ICH), especially in young adults...