fibromuscular dysplasia

Summary

Summary: An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.

Top Publications

  1. Touze E, Oppenheim C, Trystram D, Nokam G, Pasquini M, Alamowitch S, et al. Fibromuscular dysplasia of cervical and intracranial arteries. Int J Stroke. 2010;5:296-305 pubmed publisher
    b>Fibromuscular dysplasia is an uncommon, segmental, nonatherosclerotic arterial disease of unknown aetiology...
  2. Kimura H, Hosoda K, Hara Y, Kohmura E. A very unusual case of fibromuscular dysplasia with multiple aneurysms of the vertebral artery and posterior inferior cerebellar artery. J Neurosurg. 2008;109:1108-12 pubmed publisher
    b>Fibromuscular dysplasia (FMD) is a noninflammatory and nonatheromatous arteriopathy that commonly affects the renal and cervical internal carotid arteries and sometimes the vertebral arteries (VAs)...
  3. Perdu J, Boutouyrie P, Bourgain C, Stern N, Laloux B, Bozec E, et al. Inheritance of arterial lesions in renal fibromuscular dysplasia. J Hum Hypertens. 2007;21:393-400 pubmed
    We have previously shown that patients with renal fibromuscular dysplasia (FMD) have asymptomatic carotid lesions and that familial forms may occur...
  4. Poppe A, Minuk J, Glikstein R, Leventhal M. Fibromuscular dysplasia with carotid artery dissection presenting as an isolated hemianopsia. J Stroke Cerebrovasc Dis. 2007;16:130-4 pubmed
    ..The latter situation can arise when there is persistent fetal circulation of the posterior cerebral artery and has, to our knowledge, never been reported in the setting of fibromuscular dysplasia (FMD) involving the ICA.
  5. Slovut D, Olin J. Fibromuscular dysplasia. N Engl J Med. 2004;350:1862-71 pubmed
  6. Mounier Vehier C, Haulon S, Devos P, Lions C, Jaboureck O, Gaxotte V, et al. Renal atrophy outcome after revascularization in fibromuscular dysplasia disease. J Endovasc Ther. 2002;9:605-13 pubmed
    ..and kidney parameters before and 6 months after revascularization of renal artery stenosis due to fibromuscular dysplasia (FMD). Twenty hypertensive patients (18 women; mean age 48.7 +/- 15...
  7. Amar L, Azarine A, Carreira E, Vidal Trecan T, Plouin P. [Renal artery fibromuscular dysplasia]. Presse Med. 2011;40:720-5 pubmed publisher
    b>Fibromuscular dysplasia (FMD) encompasses a heterogeneous group of idiopathic, segmental, nonatherosclerotic diseases of the musculature of arterial walls, leading to the narrowing of small and medium-sized arteries...
  8. Bofinger A, Hawley C, Fisher P, Daunt N, Stowasser M, Gordon R. Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia. J Hum Hypertens. 2001;15:185-90 pubmed
    b>Fibromuscular dysplasia (FMD) is an important cause of renal artery stenosis, particularly in young females...
  9. Smit J, Wierema T, Kroon A, de Leeuw P. Blood pressure and renal function before and after percutaneous transluminal renal angioplasty in fibromuscular dysplasia: a cohort study. J Hypertens. 2013;31:1183-8 pubmed publisher
    ..percutaneous transluminal renal angioplasty (PTRA) on blood pressure and renal function in patients with fibromuscular dysplasia (FMD)...

More Information

Publications62

  1. Plouin P, Perdu J, La Batide Alanore A, Boutouyrie P, Gimenez Roqueplo A, Jeunemaitre X. Fibromuscular dysplasia. Orphanet J Rare Dis. 2007;2:28 pubmed
    b>Fibromuscular dysplasia (FMD), formerly called fibromuscular fibroplasia, is a group of nonatherosclerotic, noninflammatory arterial diseases that most commonly involve the renal and carotid arteries...
  2. Sabharwal R, Vladica P, Coleman P. Multidetector spiral CT renal angiography in the diagnosis of renal artery fibromuscular dysplasia. Eur J Radiol. 2007;61:520-7 pubmed
    ..with conventional angiography (CA), the commonly accepted gold standard, in the diagnosis of renal artery fibromuscular dysplasia (FMD)...
  3. Guill C, Benavides D, Rees C, Fenves A, Burton E. Fatal mesenteric fibromuscular dysplasia: a case report and review of the literature. Arch Intern Med. 2004;164:1148-53 pubmed
    b>Fibromuscular dysplasia is a rare nonatherosclerotic, noninflammatory angiopathy of uncertain etiology and high morbidity...
  4. Olin J, Sealove B. Diagnosis, management, and future developments of fibromuscular dysplasia. J Vasc Surg. 2011;53:826-36.e1 pubmed publisher
    b>Fibromuscular dysplasia (FMD) is a nonatherosclerotic noninflammatory vascular disease that primarily affects women from age 20 to 60, but may also occur in infants and children, men, and the elderly...
  5. Birrer M, Do D, Mahler F, Triller J, Baumgartner I. Treatment of renal artery fibromuscular dysplasia with balloon angioplasty: a prospective follow-up study. Eur J Vasc Endovasc Surg. 2002;23:146-52 pubmed
    ..although restenosis rate after PTRA in fibromuscular dysplasia is as high as in non-ostial atherosclerotic lesions, there remains a considerable higher therapeutic ..
  6. Perdu J, Gimenez Roqueplo A, Boutouyrie P, Beaujour S, Laloux B, Nau V, et al. Alpha1-antitrypsin gene polymorphisms are not associated with renal arterial fibromuscular dysplasia. J Hypertens. 2006;24:705-10 pubmed
    We previously showed that fibromuscular dysplasia (FMD) of the renal artery may be familial. Case reports have associated alpha1-antitrypsin deficiency and FMD...
  7. Odero A, Bozzani A, Arici V, Agozzino M. Hypoplasia and fibromuscular dysplasia of infrarenal abdominal aorta with downstream aneurysm: case report and review of the literature. J Vasc Surg. 2008;48:1589-92 pubmed publisher
    b>Fibromuscular dysplasia represents one of the more common types of arterial fibrodysplasia, a heterogeneous group of nonatherosclerotic vascular occlusive and aneurysmal diseases...
  8. Oguzkurt L, Tercan F, Gulcan O, Turkoz R. Rupture of the renal artery after cutting balloon angioplasty in a young woman with fibromuscular dysplasia. Cardiovasc Intervent Radiol. 2005;28:360-3 pubmed
    ..high blood pressure for 3 months had significant stenosis of the left renal artery caused by fibromuscular dysplasia (FMD)...
  9. Curry T, Messina L. Fibromuscular dysplasia: when is intervention warranted?. Semin Vasc Surg. 2003;16:190-9 pubmed
    b>Fibromuscular dysplasia is a multifactorial arteriopathy that primarily affects small and medium-sized arteries. It is most common in the renal and internal carotid arteries...
  10. Willoteaux S, Faivre Pierret M, Moranne O, Lions C, Bruzzi J, Finot M, et al. Fibromuscular dysplasia of the main renal arteries: comparison of contrast-enhanced MR angiography with digital subtraction angiography. Radiology. 2006;241:922-9 pubmed
    ..digital subtraction angiography as the reference standard in patients with hypertension and renal artery fibromuscular dysplasia (FMD). Institutional review board approval was obtained, with waiver of informed consent...
  11. Alhadad A, Mattiasson I, Ivancev K, Gottsater A, Lindblad B. Revascularisation of renal artery stenosis caused by fibromuscular dysplasia: effects on blood pressure during 7-year follow-up are influenced by duration of hypertension and branch artery stenosis. J Hum Hypertens. 2005;19:761-7 pubmed
    b>Fibromuscular dysplasia (FMD) mainly affects renal arteries. Percutaneous transluminal renal angioplasty (PTRA) and surgery are effective treatments, but long-time follow-up is lacking. Retrospective follow-up for 7.0+/-4...
  12. Dejardin A, Goffette P, Moulin P, Verhelst R, Cornu G, De Plaen J, et al. Severe hypoplasia of the abdominal aorta and its branches in a patient and his daughter. J Intern Med. 2004;255:130-6 pubmed
    ..It might be the cardinal manifestation of a familial form of fibromuscular dysplasia (FMD)...
  13. Doody O, Adam W, Foley P, Lyon S. Fibromuscular dysplasia presenting with bilateral renal infarction. Cardiovasc Intervent Radiol. 2009;32:329-32 pubmed publisher
    b>Fibromuscular dysplasia (FMD) describes a group of conditions which cause nonatheromatous arterial stenoses, most commonly of the renal and carotid arteries, typically in young women...
  14. Han D, Fishman E, Walkup M, Olin J, Marin M, Faries P. A rare case of familial carotid body tumor in a patient with bilateral fibromuscular dysplasia. J Vasc Surg. 2010;52:746-50 pubmed publisher
    ..b>Fibromuscular dysplasia (FMD) is a disease that causes narrowing of medium-sized arteries...
  15. Surowiec S, Sivamurthy N, Rhodes J, Lee D, Waldman D, Green R, et al. Percutaneous therapy for renal artery fibromuscular dysplasia. Ann Vasc Surg. 2003;17:650-5 pubmed
    b>Fibromuscular dysplasia (FMD) accounts for 10% of cases of renal artery stenosis. This study evaluates the anatomic and functional outcomes of endovascular therapy for symptomatic renal artery FMD at an academic medical center...
  16. Baumgartner I, Lerman L. Renovascular hypertension: screening and modern management. Eur Heart J. 2011;32:1590-8 pubmed publisher
  17. Solinas A, Cadoni R, Usai M, Frongia M. Fibromuscular dysplasia causing renal artery aneurysm and renovascular hypertension: a case report. Arch Ital Urol Androl. 2010;82:181-3 pubmed
    Renal artery aneurysm is a rare disease and usually is due to fibromuscular dysplasia. We describe a case in a woman who had renovascular hypertension due to aneurysm of fibromuscular dysplasia-associated renal artery.
  18. Kaneko K, Someya T, Ohtaki R, Yamashiro Y, Yamataka A, Iizuka Y, et al. Congenital fibromuscular dysplasia involving multivessels in an infant with fatal outcome. Eur J Pediatr. 2004;163:241-4 pubmed
    We report the unusual case of a 2-month-old boy with systemic fibromuscular dysplasia (FMD)...
  19. Boutouyrie P, Gimenez Roqueplo A, Fine E, Laloux B, Fiquet Kempf B, Plouin P, et al. Evidence for carotid and radial artery wall subclinical lesions in renal fibromuscular dysplasia. J Hypertens. 2003;21:2287-95 pubmed
    b>Fibromuscular dysplasia (FD) is a non-atherosclerotic, non-inflammatory arterial disease of unknown cause, and most frequently affects the renal and internal carotid arteries...
  20. Trinquart L, Mounier Vehier C, Sapoval M, Gagnon N, Plouin P. Efficacy of revascularization for renal artery stenosis caused by fibromuscular dysplasia: a systematic review and meta-analysis. Hypertension. 2010;56:525-32 pubmed publisher
    In patients with fibromuscular dysplasia and renal artery stenosis, renal artery revascularization has been used to cure hypertension or to improve blood pressure control...
  21. Andreoni K, Weeks S, Gerber D, Fair J, Mauro M, McCoy L, et al. Incidence of donor renal fibromuscular dysplasia: does it justify routine angiography?. Transplantation. 2002;73:1112-6 pubmed
    ..Although CTA and MRA can detect some proximal moderate to severe arterial changes caused by fibromuscular dysplasia (FMD), mild and distal moderate FMD are not detected well without angiography...
  22. Tanemoto M, Takase K, Yamada T, Satoh A, Abe T, Ito S. Dilation of renal artery stenosis after administration of losartan. Hypertens Res. 2007;30:999-1002 pubmed
    ..angioplasty with a balloon catheter is effective to dilate renal artery stenosis (RAS) caused by fibromuscular dysplasia (FMD), but lesions resistant to the angioplasty exist...
  23. Saarinen H, Palomäki A. Acute renal infarction resulting from fibromuscular dysplasia: a case report. J Med Case Rep. 2016;10:118 pubmed publisher
    ..Further tests confirmed a diagnosis of renal infarction as a result of fibromuscular dysplasia. He recovered well and was discharged on the tenth day of hospitalization. His renal function was normal...
  24. Yoshida S, Eguchi K, Onodera K, Suzuki K, Fujishiro K, Riku S. [Bilateral internal carotid artery occlusion and severe basilar artery stenosis in a patient with fibromuscular dysplasia: a case report]. Rinsho Shinkeigaku. 2013;53:439-45 pubmed
    b>Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory arterial disease of unknown etiology...
  25. Fuse T, Umezu M, Yamamoto M, Demura K, Nishikawa Y, Niwa Y. External carotid artery aneurysm developing after embolization of a ruptured posterior inferior cerebellar artery aneurysm in a patient with cervicocephalic fibromuscular dysplasia--case report. Neurol Med Chir (Tokyo). 2006;46:290-3 pubmed
    ..Angiography demonstrated string-of-beads sign typical of fibromuscular dysplasia (FMD) in the extracranial carotid and vertebral arteries...
  26. Hayashida M, Watanabe N, Imamura H, Kumazaki S, Kitabayashi H, Takahashi W, et al. Congenital solitary kidney with renovascular hypertension diagnosed by means of captopril-enhanced renography and magnetic resonance angiography. Int Heart J. 2005;46:347-53 pubmed
    A 24 year-old woman had a congenital solitary kidney with renovascular hypertension due to fibromuscular dysplasia. She had been treated as having essential hypertension until she developed preeclampsia and HELLP (hemolysis, elevated ..
  27. Stahlfeld K, Means J, Didomenico P. Carotid artery fibromuscular dysplasia. Am J Surg. 2007;193:71-2 pubmed
    Extracranial carotid artery fibromuscular dysplasia (FMD) is a rare finding that is frequently incidental and asymptomatic...
  28. Hatayama K, Karasawa H, Naito H, Hirota N, Sugiyama K, Ueno J, et al. [Anterior cerebral artery dissecting aneurysm associated with fibromuscular dysplasia (FMD): a case report]. No Shinkei Geka. 2001;29:451-6 pubmed
    ..artery dissecting aneurysm, presenting cerebral infarction and subarachnoid hemorrhage, associated with fibromuscular dysplasia (FMD). A 50-year-old woman was admitted to our hospital with complaints of headache and hemiparesis...
  29. Vasuri F, Freyrie A, Pasquinelli G. Unusual lamellar calcifications in two rare cases of splenic aneurysms associated with fibromuscular dysplasia. Ultrastruct Pathol. 2016;40:116-20 pubmed publisher
    b>Fibromuscular dysplasia (FMD) of the splenic artery is a rare underdiagnosed condition. Here, we report two cases of FMD affecting the splenic artery: one alone and one concomitantly with the renal artery...
  30. Connor A, Mathieson P. A string of beads. Am J Med. 2008;121:580-2 pubmed publisher
  31. Rice R, Armstrong P. Brachial artery fibromuscular dysplasia. Ann Vasc Surg. 2010;24:255.e1-4 pubmed publisher
    b>Fibromuscular dysplasia is a rare vascular disease that is characterized as nonatherosclerotic and noninflammatory in nature...
  32. Park S, Cha I, Kim C, Jeon H, Park J, Hong S, et al. improved patency of transjugular intrahepatic portosystemic shunt: the efficacy of cilostazol for the prevention of pseudointimal hyperplasia in swine TIPS models. Cardiovasc Intervent Radiol. 2007;30:719-24 pubmed
    ..97 +/- 0.33 mm) and treatment group (0.73 +/- 0.27 mm). Oral administration of cilostazol may have been effective in reducing pseudointimal/intimal hyperplasia in swine TIPS models. ..
  33. Ebaugh J, Chiou A, Morasch M, Pearce W, Yao J. Staged embolization and operative treatment of multiple visceral aneurysms in a patient with fibromuscular dysplasia--a case report. Vasc Surg. 2001;35:145-8 pubmed
  34. Finsterer J, Strassegger J, Haymerle A, Hagmüller G. Bilateral stenting of symptomatic and asymptomatic internal carotid artery stenosis due to fibromuscular dysplasia. J Neurol Neurosurg Psychiatry. 2000;69:683-6 pubmed
    Stent grafting of internal carotid artery (ICA) stenoses due to fibromuscular dysplasia has been rarely and only unilaterally carried so far...
  35. Kuhlemann J, Blondin D, Grotemeyer D, Zgoura P, Reichelt D, Heinen W, et al. Gadofosveset-enhanced MR imaging for the preoperative evaluation of potential living kidney donors: correlation with intraoperative findings. Rofo. 2010;182:1001-9 pubmed publisher
    ..One accessory artery and one case of fibromuscular dysplasia were missed by MRA. The venous anatomy and the collecting system were assessed correctly with MRI...
  36. Verhelst H, Lauwers G, Schroe H. Fibromuscular dysplasia of the external iliac artery. Acta Chir Belg. 1999;99:171-3 pubmed
    A 47-year-old female with fibromuscular dysplasia of both external iliac arteries was treated by percutaneous balloon catheter angioplasty. The immediate result was unsatisfactory...
  37. Das C, Neyaz Z, Thapa P, Sharma S, Vashist S. Fibromuscular dysplasia of the renal arteries: a radiological review. Int Urol Nephrol. 2007;39:233-8 pubmed
    b>Fibromuscular dysplasia is the most common cause of renovascular hypertension in young patients...
  38. Hans F, Krings T, Reinges M, Mull M. Spontaneous regression of two supraophthalmic internal cerebral artery aneurysms following flow pattern alteration. Neuroradiology. 2004;46:469-73 pubmed
    We report on a patient with fibromuscular dysplasia who presented with a right-sided giant calcified cavernous internal carotid artery (ICA) aneurysm and two additional supraophthalmic ICA aneurysms...
  39. Park D, Kang S, Lim D, Kwon T, Park J, Chung Y, et al. Multiple intracranial aneurysms with intraventricular hemorrhage in a child with unilateral fibromuscular dysplasia of the renal artery. Pediatr Neurosurg. 2008;44:486-9 pubmed publisher
    ..intracranial aneurysms with intraventricular hemorrhage (IVH) in a child, accompanied by unilateral fibromuscular dysplasia (FMD) of the renal artery, is reported...
  40. Hausleiter J, Sebastian M, Li A, Abbey C, Honda H, Makkar R, et al. A porcine coronary stent model of increased neointima formation in the left anterior descending coronary artery. Z Kardiol. 2002;91:614-9 pubmed
    ..The findings may be useful for understanding and developing systemic and local antirestenotic strategies. ..
  41. Wolters H, Vowinkel T, Schult M, Heidenreich S, Senninger N, Dietl K. Fibromuscular dysplasia in a living donor: early post-operative allograft artery stenosis with successful venous interposition. Nephrol Dial Transplant. 2002;17:153-5 pubmed
  42. Flores Río de la Loza L. [Septal fibromuscular dysplasia of the internal carotid artery, associated to systemic lupus erythematosus]. Rev Neurol. 2006;43:185-6 pubmed
  43. Ashida A, Matsumura H, Inoue N, Katayama H, Kiyohara Y, Yamamoto T, et al. Two cases of hyponatremic-hypertensive syndrome in childhood with renovascular hypertension. Eur J Pediatr. 2006;165:336-9 pubmed
    We report two children with renovascular hypertension and fibromuscular dysplasia. They initially presented with severe hyponatremia, hypokalemia, polyuria, and transient proteinuria...
  44. Vincent D, Guillevin L, Levesque M, Authier F, Vadrot D, Pradalier A, et al. Association of macrophagic myofasciitis and fibromuscular dysplasia with renal fibromuscular dysplasia: first case report. Clin Exp Rheumatol. 2000;18:753-4 pubmed
    Two rare muscular diseases, macrophagic myofasciitis and fibromuscular dysplasia, are associated in the patient reported here. Their respective etiologies are unknown. The possible link has to be discussed.
  45. Marks S, Gullett A, Brennan E, Tullus K, Jaureguiberry G, Klootwijk E, et al. Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. Pediatr Nephrol. 2011;26:1857-61 pubmed publisher
    Renal fibromuscular dysplasia (FMD) can cause hypertension, and previous reports suggest that FMD is familial...
  46. Ishikawa Y, Sekiguchi K, Akasaka Y, Ito K, Akishima Y, Zhang L, et al. Fibromuscular dysplasia of coronary arteries resulting in myocardial infarction associated with hypertrophic cardiomyopathy in Noonan's syndrome. Hum Pathol. 2003;34:282-4 pubmed
    The first autopsy case of fibromuscular dysplasia in the coronary arteries associated with hypertrophic cardiomyopathy in Noonan's syndrome is reported...
  47. Pietra G, Ruttner J. Specificity of pulmonary vascular lesions in primary pulmonary hypertension. A reappraisal. Respiration. 1987;52:81-5 pubmed
    ..Therefore, in the present study, we propose an objective descriptive approach to the diagnosis of hypertensive pulmonary vascular disease, to correlate morphology and function. ..
  48. Garnier P, Michel D, Barral F, Beauchet O, Ollagnier M, Guy C, et al. [Roles of arterial dysplasia, chronic ergotism and other factors in a case multiple spontaneous arterial dissections]. Rev Med Interne. 2000;21:701-4 pubmed
    ..She also suffered from Raynaud's syndrome worsened by treatment. The respective roles of arterial dysplasia, chronic ergotism, renovascular hypertension and migraine are discussed. ..
  49. Ortiz Fandiño J, Terre Boliart R, Orient López F, Guevara Espinosa D, Ramón Rona S, Bernabeu Guitart M. [Ischemic stroke, secondary to fibromuscular dysplasia: a case report]. Rev Neurol. 2004;38:34-7 pubmed
    b>Fibromuscular dysplasia is an infrequent angiopathy that occurs more often in young women. It consists in a series of heterogeneous histological changes that finally lead to the narrowing of arteries...
  50. Rosa C, Blake J, Bratton G, Dehn L, Gray M, O Hara T. Heavy metal and mineral concentrations and their relationship to histopathological findings in the bowhead whale (Balaena mysticetus). Sci Total Environ. 2008;399:165-78 pubmed publisher
  51. Airoldi F, Palatresi S, Marana I, Bencini C, Benti R, Lovaria A, et al. Angioplasty of atherosclerotic and fibromuscular renal artery stenosis: time course and predicting factors of the effects on renal function. Am J Hypertens. 2000;13:1210-7 pubmed
  52. Green R, Gu X, Kline Rogers E, Froehlich J, Mace P, Gray B, et al. Differences between the pediatric and adult presentation of fibromuscular dysplasia: results from the US Registry. Pediatr Nephrol. 2016;31:641-50 pubmed publisher
    b>Fibromuscular dysplasia (FMD) is a non-inflammatory arteriopathy that causes significant morbidity in children...
  53. Soulen M, Cohen D, Itkin M, Townsend R, Roberts D. Segmental arterial mediolysis: angioplasty of bilateral renal artery stenoses with 2-year imaging follow-up. J Vasc Interv Radiol. 2004;15:763-7 pubmed
    ..The clinical presentation is usually catastrophic as a result of vascular occlusion or rupture. Herein an unusual case of renovascular hypertension resulting from SAM is reported, which was successfully treated with balloon angioplasty. ..