acute coronary syndrome


Summary: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.

Top Publications

  1. Frere C, Cuisset T, Gaborit B, Alessi M, Hulot J. The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome. J Thromb Haemost. 2009;7:1409-11 pubmed publisher
  2. Stock E, Redberg R. Cardiovascular disease in women. Curr Probl Cardiol. 2012;37:450-526 pubmed publisher
    ..We have made great progress in understanding gender-related differences in CVDs, but much remains to be done to optimize the prevention of CVD for both men and women. ..
  3. Lever M, George P, Slow S, Bellamy D, Young J, Ho M, et al. Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS ONE. 2014;9:e114969 pubmed publisher
    ..We speculate that the difference reflects control of osmolyte retention in tissues. Elevated plasma TMAO is a strong risk marker in diabetes. ..
  4. Pagidipati N, Hess C, Clare R, Akerblom A, Tricoci P, Wojdyla D, et al. An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome. Am Heart J. 2017;187:53-61 pubmed publisher
    ..serum uric acid (sUA) levels and an elevated risk of subsequent ischemic cardiovascular outcomes among acute coronary syndrome (ACS) patients; this relationship may be modified by a clinical history of gout and has not been studied ..
  5. Libby P. Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med. 2013;368:2004-13 pubmed publisher
  6. Lindahl B. Acute coronary syndrome - the present and future role of biomarkers. Clin Chem Lab Med. 2013;51:1699-706 pubmed publisher
    Over the past two decades there have been dramatic changes in the diagnosis, treatment and prognosis of acute coronary syndrome (ACS). Several new treatment modalities have been added and the prognosis has improved dramatically...
  7. Giusti B, Gori A, Marcucci R, Abbate R. Current status of clopidogrel pharmacogenomics. Pharmacogenomics. 2012;13:1671-4 pubmed publisher
  8. Blanco S, Ferrieres J, Bongard V, Toulza O, Sebai F, Billet S, et al. Prognosis Impact of Frailty Assessed by the Edmonton Frail Scale in the Setting of Acute Coronary Syndrome in the Elderly. Can J Cardiol. 2017;33:933-939 pubmed publisher
    Elderly patients represent a large proportion of patients admitted for acute coronary syndrome (ACS)...
  9. Sun B, Liu Z, Yin H, Wang T, Chen T, Yang S, et al. Intralesional versus intracoronary administration of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention in patients with acute coronary syndromes: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017;96:e8223 pubmed publisher
    ..IL) administration of GPIs improves myocardial reperfusion without increasing bleeding in patients with acute coronary syndrome (ACS) compared with intracoronary (IC) administration has not been well addressed...

More Information


  1. Amsterdam E, Kirk J, Bluemke D, Diercks D, Farkouh M, Garvey J, et al. Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation. 2010;122:1756-76 pubmed publisher
    ..Inadvertent discharge of patients with acute coronary syndrome from the emergency department is associated with increased mortality and liability, whereas inappropriate ..
  2. Camm A, Kirchhof P, Lip G, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace. 2010;12:1360-420 pubmed publisher
  3. Yu J, Zhou Z, McEvoy R, Anderson C, Rodgers A, Perkovic V, et al. Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis. JAMA. 2017;318:156-166 pubmed publisher
    ..Positive airway pressure (PAP) provides symptomatic relief, whether delivered continuously (CPAP) or as adaptive servo-ventilation (ASV), but the associations with cardiovascular outcomes and death are unclear...
  4. Cook S, Windecker S. Early stent thrombosis: past, present, and future. Circulation. 2009;119:657-9 pubmed publisher
  5. Welsford M, Nikolaou N, Beygui F, Bossaert L, Ghaemmaghami C, Nonogi H, et al. Part 5: Acute Coronary Syndromes: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2015;132:S146-76 pubmed publisher
  6. Hamm C, Bassand J, Agewall S, Bax J, Boersma E, Bueno H, et al. [ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment el. G Ital Cardiol (Rome). 2012;13:171-228 pubmed publisher
  7. Hubacek J, Stanek V, Gebauerova M, Adamkova V, Lesauskaite V, Zaliaduonyte Peksiene D, et al. Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. Physiol Res. 2017;66:S121-S128 pubmed
    ..and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS)...
  8. Bittner D, Mayrhofer T, Bamberg F, Hallett T, Janjua S, Addison D, et al. Impact of Coronary Calcification on Clinical Management in Patients With Acute Chest Pain. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..We determined whether CAC affects efficiency of coronary CTA in patients with suspected acute coronary syndrome (ACS)...
  9. Jaguszewski M, Wyss C, Alibegovic J, Luscher T, Templin C. Acute thrombosis of bioabsorbable scaffold in a patient with acute coronary syndrome. Eur Heart J. 2013;34:2046 pubmed publisher
  10. Kobalava Z, Tolkacheva V. [Hyperglycemia in patients with acute coronary syndrome: contemporary state of the problem. A scientific statement from the American Heart Association diabetes committee]. Kardiologiia. 2009;49:77-85 pubmed
    Hyperglycemia in patients with acute coronary syndrome (ACS) is one of main predictors of cardiovascular complications...
  11. O Connor R, Al Ali A, Brady W, Ghaemmaghami C, Menon V, Welsford M, et al. Part 9: Acute Coronary Syndromes: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015;132:S483-500 pubmed publisher
  12. Miura K, Saita E, Suzuki Sugihara N, Miyata K, Ikemura N, Ohmori R, et al. Plasma interleukin-27 levels in patients with coronary artery disease. Medicine (Baltimore). 2017;96:e8260 pubmed publisher
    ..CAD was present in 177 patients [30 acute coronary syndrome (ACS) and 147 stable CAD]...
  13. Ferreiro J, Angiolillo D. Diabetes and antiplatelet therapy in acute coronary syndrome. Circulation. 2011;123:798-813 pubmed publisher
  14. Hoorweg B, Willemsen R, Cleef L, Boogaerts T, Buntinx F, Glatz J, et al. Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses. Heart. 2017;103:1727-1732 pubmed publisher
    ..4/women 53 years). In this cohort of 281 patients, in 38.1% of patients, acute coronary syndrome (ACS) was suspected at least temporarily during consultation, 40...
  15. . Updated ESC Guidelines for managing patients with suspected non-ST-elevation acute coronary syndromes. Eur Heart J. 2011;32:2909-10 pubmed publisher
  16. Anderson J, Morrow D. Acute Myocardial Infarction. N Engl J Med. 2017;376:2053-2064 pubmed publisher
  17. Badreldin H, Carter D, Cook B, Qamar A, Vaduganathan M, Bhatt D. Safety and Tolerability of Transitioning from Cangrelor to Ticagrelor in Patients Who Underwent Percutaneous Coronary Intervention. Am J Cardiol. 2017;120:359-361 pubmed publisher
    ..Most patients receiving cangrelor underwent PCI with a drug-eluting stent for acute coronary syndrome via a radial approach in the background of unfractionated heparin...
  18. Figueiredo J, Silva N, Pereira B, Oliveira G. Major Depression and Acute Coronary Syndrome-Related Factors. Arq Bras Cardiol. 2017;108:217-227 pubmed publisher
    ..MDD) is one of the most common mental illnesses in psychiatry, being considered a risk factor for Acute Coronary Syndrome (ACS)...
  19. Stähli B, Gebhard C, Yonekawa K, Gebhard C, Altwegg L, von Eckardstein A, et al. Gender-Related Differences in Patients Presenting with Suspected Acute Coronary Syndromes: Clinical Presentation, Biomarkers and Diagnosis. Cardiology. 2015;132:189-98 pubmed publisher
    ..41, 95% CI 0.23-0.78, p = 0.006). In patients with suspected ACS, women presented with different biomarker profiles, and were less often diagnosed with ACS and referred to coronary angiography. ..
  20. Pavasini R, Cirillo C, Campo G, Nobre Menezes M, Biscaglia S, Tonet E, et al. Extracorporeal Circulatory Support in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis. Crit Care Med. 2017;45:e1173-e1183 pubmed publisher
    ..A meta-analysis on pooled event rate of short-term mortality and complications of acute coronary syndrome patients treated with extracorporeal circulatory support was performed...
  21. Xiang L, Wang M, You T, Jiao Y, Chen J, Xu W. Prognostic Value of Ventricular Wall Motion Score and Global Registry of Acute Coronary Events Score in Patients With Acute Myocardial Infarction. Am J Med Sci. 2017;354:27-32 pubmed publisher
    ..812 (P < 0.05), respectively. WMS and GRACE score were independent predictors of MACE in patients with AMI in 12-month follow-up, and the combined application of WMS and GRACE score can significantly improve the predictive value. ..
  22. Sobczyk D, Nycz K, Zmudka K. Usefulness of limited echocardiography with A-F mnemonic in patients with suspected non?ST-segment elevation acute coronary syndrome. Pol Arch Med Wewn. 2014;124:688-94 pubmed
    ..TTE with the A-F mnemonic covers a sufficient spectrum of cardiac abnormalities and has a significant effect on therapeutic decision making in patients with suspected NSTE-ACS.   ..
  23. . Management of acute coronary syndromes in developing countries: acute coronary events-a multinational survey of current management strategies. Am Heart J. 2011;162:852-859.e22 pubmed publisher
    ..These findings suggest opportunities to further reduce the risk of long-term ischemic events in patients with ACS in developing countries. ..
  24. Lip G, Windecker S, Huber K, Kirchhof P, Marin F, ten Berg J, et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Grou. Eur Heart J. 2014;35:3155-79 pubmed publisher
  25. Fihn S, Gardin J, Abrams J, Berra K, Blankenship J, Dallas A, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, an. J Am Coll Cardiol. 2012;60:e44-e164 pubmed publisher
  26. Jakimov T, Mrdović I, Filipović B, Zdravković M, Djoković A, Hinić S, et al. Comparison of RISK-PCI, GRACE, TIMI risk scores for prediction of major adverse cardiac events in patients with acute coronary syndrome. Croat Med J. 2017;58:406-415 pubmed
    ..This single-center retrospective study involved 200 patients with acute coronary syndrome (ACS) who underwent invasive diagnostic approach, ie, coronary angiography and myocardial ..
  27. Arntz H, Bossaert L, Danchin N, Nikolaou N. European Resuscitation Council Guidelines for Resuscitation 2010 Section 5. Initial management of acute coronary syndromes. Resuscitation. 2010;81:1353-63 pubmed publisher
  28. Cerit L. Major Depression as a Complicating Factor for Acute Coronary SyndromeReply. Arq Bras Cardiol. 2017;109:271-272 pubmed publisher
  29. Arts E, Fransen J, den Broeder A, van Riel P, Popa C. Low disease activity (DAS28?3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent Cox regression analysis in a large cohort study. Ann Rheum Dis. 2017;76:1693-1699 pubmed publisher
    ..Our results strengthen the use of tight control strategies in daily clinical practice to achieve low stable disease activity or remission in patients with RA as soon as possible. ..
  30. Ito S, Hasuo T. Intravascular Images of Coronary Stenosis with Multiple Channels in a Patient with Antiphospholipid Syndrome: The Optical Coherence Tomography Findings. Intern Med. 2017;56:1351-1356 pubmed publisher optical coherence tomography (OCT) revealed the microstructure of complex coronary stenosis, which had ambiguous findings on angiography and intravascular ultrasound (IVUS) in an acute coronary syndrome (ACS) patient with APS/SLE.
  31. Cannon C, Brindis R, Chaitman B, Cohen D, Cross J, Drozda J, et al. 2013 ACCF/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes and coronary artery disease: a report of the American College of Cardiology Foundation/American Heart Associa. J Am Coll Cardiol. 2013;61:992-1025 pubmed publisher
  32. Turner R, Yin P, Hanson A, FitzGerald R, Morris A, Stables R, et al. Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. J Clin Lipidol. 2017;11:204-214 pubmed publisher
    ..the prevalence and predictors of deviation from high-potency statin use early after a non-ST elevation acute coronary syndrome (NSTE-ACS) and its association with subsequent major adverse cardiovascular events (MACE) and all-cause ..
  33. Amsterdam E, Wenger N, Brindis R, Casey D, Ganiats T, Holmes D, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;130:e344-426 pubmed publisher
  34. Terlemez S, Eryilmaz U, Tokgöz Y, Uysal P, Coşan A, Bulut Y. Kounis syndrome caused by metronidazole--a case of 14 year-old boy. Int J Cardiol. 2015;179:222-4 pubmed publisher
  35. Deedwania P, Acharya T, Kotak K, Fonarow G, Cannon C, Laskey W, et al. Compliance with guideline-directed therapy in diabetic patients admitted with acute coronary syndrome: Findings from the American Heart Association's Get With The Guidelines-Coronary Artery Disease (GWTG-CAD) program. Am Heart J. 2017;187:78-87 pubmed publisher
    ..Concerted efforts are needed to continue this positive trend. ..
  36. Illmann A, Riemer T, Erbel R, Giannitsis E, Hamm C, Haude M, et al. Disease distribution and outcome in troponin-positive patients with or without revascularization in a chest pain unit: results of the German CPU-Registry. Clin Res Cardiol. 2014;103:29-40 pubmed
    ..implemented to promptly clarify acute chest pain of uncertain origin, including patients with suspected acute coronary syndrome (ACS)...
  37. Jarcho J, Keaney J. Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT. N Engl J Med. 2015;372:2448-50 pubmed publisher
  38. Amsterdam E, Wenger N, Brindis R, Casey D, Ganiats T, Holmes D, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64:e139-e228 pubmed publisher
  39. Mahajan V, Jarolim P. How to interpret elevated cardiac troponin levels. Circulation. 2011;124:2350-4 pubmed publisher
  40. Alvin M, Jaffe A, Ziegelstein R, Trost J. Eliminating Creatine Kinase-Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement. JAMA Intern Med. 2017;177:1508-1512 pubmed publisher
  41. Wang Z, Zhang L, Elmariah S, Han H, Zhou Y. Prevalence and Prognosis of Nonobstructive Coronary Artery Disease in Patients Undergoing Coronary Angiography or Coronary Computed Tomography Angiography: A Meta-Analysis. Mayo Clin Proc. 2017;92:329-346 pubmed publisher
    ..among patients with stable angina and 13% (95% CI, 11%-16%) among patients with non-ST-segment elevation acute coronary syndrome. The prevalence varied depending on sex, clinical setting, and risk profile of the population ..
  42. Kerr A, Williams M, White H, Grey C, Jiang Y, Nunn C. 30-day mortality after percutaneous coronary intervention in New Zealand public hospitals (ANZACS-QI 18). N Z Med J. 2017;130:54-63 pubmed
    ..66% for those treated for other acute coronary syndrome (ACS) or non-ACS indications...
  43. Lockie T, Nagel E, Redwood S, Plein S. Use of cardiovascular magnetic resonance imaging in acute coronary syndromes. Circulation. 2009;119:1671-81 pubmed publisher
  44. Gudnadóttir G, Andersen K, Thrainsdottir I, James S, Lagerqvist B, Gudnason T. Gender differences in coronary angiography, subsequent interventions, and outcomes among patients with acute coronary syndromes. Am Heart J. 2017;191:65-74 pubmed publisher
    ..In the group with 2- or 3-vessel disease or left main stem stenosis, women were more likely to undergo PCI but less likely to undergo CABG. However, there was no gender difference in 30-day mortality. ..
  45. Hazinski M, Nolan J, Billi J, Böttiger B, Bossaert L, de Caen A, et al. Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010;122:S250-75 pubmed publisher
  46. Cayla G, Leclercq F, Cornillet L, Ledermann B, Schmutz L, Lattuca B. [New oral anticoagulants in coronary artery disease]. Presse Med. 2017;46:714-718 pubmed publisher
    ..Dedicated studies are currently being conducted to confirm the optimal doses and the ideal association of antithrombotic drugs in different settings of coronary artery disease. ..
  47. Dehghani P, Habib B, Windle S, Roy N, Old W, Grondin F, et al. Smokers and Postcessation Weight Gain After Acute Coronary Syndrome. J Am Heart Assoc. 2017;6: pubmed publisher
    Smoking cessation and weight management are recommended after acute coronary syndrome (ACS); however, little is known about the effects of smoking cessation on weight change after ACS...
  48. Bueno H, Fernandez Aviles F. Use of risk scores in acute coronary syndromes. Heart. 2012;98:162-8 pubmed publisher
  49. Dereziński T, Fórmankiewicz B, Migdalski A, Brazis P, Jakubowski G, Woda Ł, et al. The prevalence of abdominal aortic aneurysms in the rural/urban population in central Poland - Gniewkowo Aortic Study. Kardiol Pol. 2017;75:705-710 pubmed publisher
    ..0048), age of men (p = 0.0009), and history of myocardial infarction/acute coronary syndrome (MI/ACS) (p = 0.0079) was found...
  50. Giugliano R, Braunwald E. The year in acute coronary syndrome. J Am Coll Cardiol. 2014;63:201-14 pubmed publisher
  51. Lamelas P, Schwalm J, Quazi I, Mehta S, Devereaux P, Jolly S, et al. Effect of Body Mass Index on Clinical Events After Acute Coronary Syndromes. Am J Cardiol. 2017;120:1453-1459 pubmed publisher
    The association between body mass index (BMI) and major clinical events after acute coronary syndrome (ACS) remains controversial...
  52. Schiebinger L, Stefanick M. Gender Matters in Biological Research and Medical Practice. J Am Coll Cardiol. 2016;67:136-138 pubmed publisher
  53. Reed S. How country-specific should a country-specific cost-effectiveness analysis be?. Eur Heart J. 2013;34:166-7 pubmed publisher