aortic valve stenosis


Summary: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Top Publications

  1. Deutsch M, Bleiziffer S, Elhmidi Y, Piazza N, Voss B, Lange R, et al. Beyond adding years to life: health-related quality-of-life and functional outcomes in patients with severe aortic valve stenosis at high surgical risk undergoing transcatheter aortic valve replacement. Curr Cardiol Rev. 2013;9:281-94 pubmed
    b>Aortic valve stenosis (AVS) is the most frequent acquired valvular heart disease in western industrialized countries and its prevalence considerably increases with age. Once becoming symptomatic severe AVS has a very poor prognosis...
  2. Pierard S, de Meester C, Seldrum S, Pasquet A, Gerber B, Vancraeynest D, et al. Impact of preoperative symptoms on postoperative survival in severe aortic stenosis: implications for the timing of surgery. Ann Thorac Surg. 2014;97:803-9 pubmed publisher
    ..These findings plead in favor of an earlier surgical correction of SAS, before the onset of severe symptoms, especially in low-risk patients. ..
  3. Nagy E, Eriksson P, Yousry M, Caidahl K, Ingelsson E, Hansson G, et al. Valvular osteoclasts in calcification and aortic valve stenosis severity. Int J Cardiol. 2013;168:2264-71 pubmed publisher
    ..These findings suggest a critical role of bone turnover as a determinant of aortic stenosis severity. ..
  4. Lenders G, Paelinck B, Wouters K, Claeys M, Rodrigus I, Van Herck P, et al. Transesophageal echocardiography for cardiac thromboembolic risk assessment in patients with severe, symptomatic aortic valve stenosis referred for potential transcatheter aortic valve implantation. Am J Cardiol. 2013;111:1470-4 pubmed publisher
    ..One hundred four consecutive patients with severe symptomatic aortic valve stenosis and at high or very high risk for surgery were included and underwent transesophageal echocardiography...
  5. Rieck A, Gerdts E, Lønnebakken M, Bahlmann E, Cioffi G, Gohlke Bärwolf C, et al. Global left ventricular load in asymptomatic aortic stenosis: covariates and prognostic implication (the SEAS trial). Cardiovasc Ultrasound. 2012;10:43 pubmed publisher
    ..In asymptomatic AS, assessment of global LV load adds complementary information on prognosis to that provided by hypertension or established prognosticators like AS severity and LV ejection fraction. ..
  6. Vizzardi E, D Aloia A, Fiorina C, Bugatti S, Parrinello G, De Carlo M, et al. Early regression of left ventricular mass associated with diastolic improvement after transcatheter aortic valve implantation. J Am Soc Echocardiogr. 2012;25:1091-8 pubmed publisher
    ..implantation (TAVI) on left ventricular (LV) hypertrophy and diastolic function in patients with severe aortic valve stenosis (AVS). There are few and conflicting data on LV mass remodeling and LV diastolic function after TAVI...
  7. Petronio A, De Carlo M, Bedogni F, Maisano F, Ettori F, Klugmann S, et al. 2-year results of CoreValve implantation through the subclavian access: a propensity-matched comparison with the femoral access. J Am Coll Cardiol. 2012;60:502-7 pubmed publisher
    ..The goal of this study was to assess the procedural and 2-year results of the subclavian approach for transcatheter aortic valve implantation (TAVI) compared with those of the femoral approach by using propensity-matched analysis...
  8. Krane M, Deutsch M, Piazza N, Muhtarova T, Elhmidi Y, Mazzitelli D, et al. One-year results of health-related quality of life among patients undergoing transcatheter aortic valve implantation. Am J Cardiol. 2012;109:1774-81 pubmed publisher
    ..We performed a prospective analysis of 186 patients with symptomatic severe aortic valve stenosis ineligible for conventional aortic valve replacement, who underwent TAVI with either the Medtronic ..
  9. Garcia J, Marrufo O, Rodríguez A, Larose E, Pibarot P, Kadem L. Cardiovascular magnetic resonance evaluation of aortic stenosis severity using single plane measurement of effective orifice area. J Cardiovasc Magn Reson. 2012;14:23 pubmed publisher
    ..The novel CMR-based methods proposed in this study may be helpful to corroborate stenosis severity in patients for whom Doppler-echocardiography exam is inconclusive. ..

More Information


  1. Haensig M, Lehmkuhl L, Rastan A, Kempfert J, Mukherjee C, Gutberlet M, et al. Aortic valve calcium scoring is a predictor of significant paravalvular aortic insufficiency in transapical-aortic valve implantation. Eur J Cardiothorac Surg. 2012;41:1234-40; discussion 1240-1 pubmed publisher
    ..AVCS prior to TA-AVI might serve as an additional tool to reconsider the TAVI indication to reduce the risk of paravalvular leaks especially in so-called operable patients. ..
  2. Bleiziffer S, Mazzitelli D, Opitz A, Hettich I, Ruge H, Piazza N, et al. Beyond the short-term: clinical outcome and valve performance 2 years after transcatheter aortic valve implantation in 227 patients. J Thorac Cardiovasc Surg. 2012;143:310-7 pubmed publisher
    ..and overall low morbidity at 2 years, transcatheter aortic valve implantation may be considered the treatment of choice for aortic valve stenosis in elderly patients with an increased risk for surgery with a heart-lung machine.
  3. Bijuklic K, Tuebler T, Reichenspurner H, Treede H, Wandler A, Harreld J, et al. Midterm stability and hemodynamic performance of a transfemorally implantable nonmetallic, retrievable, and repositionable aortic valve in patients with severe aortic stenosis. Up to 2-year follow-up of the direct-flow medical valve: a pilot study. Circ Cardiovasc Interv. 2011;4:595-601 pubmed publisher
  4. Bapat V, Khawaja M, Attia R, Narayana A, Wilson K, Macgillivray K, et al. Transaortic Transcatheter Aortic valve implantation using Edwards Sapien valve: a novel approach. Catheter Cardiovasc Interv. 2012;79:733-40 pubmed publisher
    ..The TA-TAVI approach may not be desirable in patients with severe chest deformity, poor lung function or poor left ventricular function. TAo-TAVI via a partial sternotomy is safe and feasible in these patients. ..
  5. Fairbairn T, Mather A, Bijsterveld P, Worthy G, Currie S, Goddard A, et al. Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status. Heart. 2012;98:18-23 pubmed publisher
    ..Overall HRQoL improved and there was no association between the number of new cerebral infarcts and altered health status. ..
  6. Kupreishvili K, Baidoshvili A, ter Weeme M, Huybregts M, Krijnen P, van Hinsbergh V, et al. Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx. J Heart Valve Dis. 2011;20:29-36 pubmed
    Recent studies have indicated that atherosclerosis-like changes are involved in the pathogenesis of aortic valve stenosis. Increased blood and valve tissue levels of C-reactive protein (CRP) have been reported in patients with aortic ..
  7. Abdel Wahab M, Zahn R, Horack M, Gerckens U, Schuler G, Sievert H, et al. Aortic regurgitation after transcatheter aortic valve implantation: incidence and early outcome. Results from the German transcatheter aortic valve interventions registry. Heart. 2011;97:899-906 pubmed publisher
    ..Long-term follow-up is critical to further define the impact of residual AR on clinical outcome. Until these data become available, every effort should be made to prevent and treat this complication. ..