heart failure

Summary

Summary: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Top Publications

  1. Torp Pedersen C, Møller M, Bloch Thomsen P, Køber L, Sandøe E, Egstrup K, et al. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. N Engl J Med. 1999;341:857-65 pubmed
    Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical deterioration and hospitalization...
  2. Selvais P, Robert A, Ahn S, van Linden F, Ketelslegers J, Pouleur H, et al. Direct comparison between endothelin-1, N-terminal proatrial natriuretic factor, and brain natriuretic peptide as prognostic markers of survival in congestive heart failure. J Card Fail. 2000;6:201-7 pubmed
    ..ET-1) and cardiac natriuretic peptide plasma concentrations have prognostic significance in congestive heart failure (CHF). However, their respective prognostic values in this setting have never been directly compared...
  3. Patten R, Hall Porter M. Small animal models of heart failure: development of novel therapies, past and present. Circ Heart Fail. 2009;2:138-44 pubmed publisher
  4. Lommi J, Pulkki K, Koskinen P, Näveri H, Leinonen H, Harkonen M, et al. Haemodynamic, neuroendocrine and metabolic correlates of circulating cytokine concentrations in congestive heart failure. Eur Heart J. 1997;18:1620-5 pubmed
    ..cytokines in the circulation has been observed in many, though not all, patients with congestive heart failure. To identify the predictors of cytokine activation in congestive heart failure, we assessed the relationship ..
  5. Stram A, Wagner G, Fogler B, Pride P, Hirschey M, Payne R. Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. PLoS ONE. 2017;12:e0178354 pubmed publisher
    ..The underlying pathophysiology of heart failure in FRDA is unclear...
  6. Nomoto H, Satoh Y, Kamiyama M, Yabe K, Masumura M, Sakakibara A, et al. Mechanisms of Diuresis for Acute Decompensated Heart Failure by Tolvaptan. Int Heart J. 2017;58:593-600 pubmed publisher
    ..not affect kidney circulation or cause worsening of renal function (WRF) in patients with acute decompensated heart failure (ADHF)...
  7. Matsue Y, Damman K, Voors A, Kagiyama N, Yamaguchi T, Kuroda S, et al. Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure. J Am Coll Cardiol. 2017;69:3042-3051 pubmed publisher
    Acute heart failure (AHF) is a life-threatening disease requiring urgent treatment, including a recommendation for immediate initiation of loop diuretics...
  8. Palazzuoli A, Ruocco G, De Vivo O, Nuti R, McCullough P. Prevalence of Hyperuricemia in Patients With Acute Heart Failure With Either Reduced or Preserved Ejection Fraction. Am J Cardiol. 2017;120:1146-1150 pubmed publisher
    The relation between uric acid (UA) and heart failure has been described; however, there is little detail concerning acute heart failure (AHF) in patients with reduced versus preserved ejection fraction heart failure (HFrEF, HFpEF)...
  9. Deng K, Li J, She Z, Gong J, Cheng W, Gong F, et al. Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway. Hypertension. 2017;70:770-779 pubmed publisher
    ..response to numerous stimuli like neurohumoral stress, pressure overload, infection, and injury, and leads to heart failure. Mfge8 (milk fat globule-EGF factor 8) is a secreted protein involved in various human diseases, but its ..

More Information

Publications62

  1. So Armah K, Lim J, Lo Re V, Tate J, Chang C, Butt A, et al. FIB-4 stage of liver fibrosis predicts incident heart failure among HIV-infected and uninfected patients. Hepatology. 2017;66:1286-1295 pubmed publisher
    ..HIV-infected individuals have excess congestive heart failure (CHF) risk compared with uninfected people...
  2. Cho J, Zhang R, Kilfoil P, Gallet R, de Couto G, Bresee C, et al. Delayed Repolarization Underlies Ventricular Arrhythmias in Rats With Heart Failure and Preserved Ejection Fraction. Circulation. 2017;136:2037-2050 pubmed publisher
    b>Heart failure with preserved ejection fraction (HFpEF) represents approximately half of heart failure, and its incidence continues to increase...
  3. Kristensen S, Jhund P, Mogensen U, Rørth R, Abraham W, Desai A, et al. Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation. Circ Heart Fail. 2017;10: pubmed publisher
    Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF...
  4. Wu M, Chen T, Chen Y, Tarng D, Wu Y, Lin H, et al. Effects and safety of oral tolvaptan in patients with congestive heart failure: A systematic review and network meta-analysis. PLoS ONE. 2017;12:e0184380 pubmed publisher
    Several studies reported treatment benefits of tolvaptan in patients with congestive heart failure (CHF). However, the optimal dosage remains unclear...
  5. de Denus S, O Meara E, Desai A, Claggett B, Lewis E, Leclair G, et al. Spironolactone Metabolites in TOPCAT - New Insights into Regional Variation. N Engl J Med. 2017;376:1690-1692 pubmed publisher
  6. Kalman J, Sanders P, Rosso R, Calkins H. Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?. Circulation. 2017;136:490-499 pubmed publisher
    ..However, up to 40% of an atrial fibrillation population may be asymptomatic. In 2017, in the absence of randomized studies, are there nevertheless data that support atrial fibrillation ablation in asymptomatic patients? ..
  7. Kosiborod M, Cavender M, Fu A, Wilding J, Khunti K, Holl R, et al. Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotr. Circulation. 2017;136:249-259 pubmed publisher
    Reduction in cardiovascular death and hospitalization for heart failure (HHF) was recently reported with the sodium-glucose cotransporter-2 inhibitor (SGLT-2i) empagliflozin in patients with type 2 diabetes mellitus who have ..
  8. Amsallem M, Sweatt A, Aymami M, Kuznetsova T, Selej M, Lu H, et al. Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..During a mean follow-up of 3.9±2.4 years, the primary end point of death, transplant, or admission for heart failure was reached in 88 patients...
  9. Delgado A, Rodrigues B, Nunes S, Baptista R, Marmelo B, Moreira D, et al. Acute Heart Failure Registry: Risk Assessment Model in Decompensated Heart Failure. Arq Bras Cardiol. 2016;107:557-567 pubmed publisher
    b>Heart failure (HF) is a highly prevalent syndrome. Although the long-term prognostic factors have been identified in chronic HF, this information is scarcer with respect to patients with acute HF...
  10. Gupte A, Hamilton D. Mitochondrial Function in Non-ischemic Heart Failure. Adv Exp Med Biol. 2017;982:113-126 pubmed publisher
    ..It is associated with progressive development of metabolic stress culminating in energy depletion and heart failure. The mitochondria from the ventricular walls undergoing non-ischemic cardiomyopathy are subjected to long ..
  11. McCabe N, Butler J, Dunbar S, Higgins M, Reilly C. Six-minute walk distance predicts 30-day readmission after acute heart failure hospitalization. Heart Lung. 2017;46:287-292 pubmed publisher
    To determine the relationship between 6-min walk test distance (6MWD) and 30-day readmission in hospitalized heart failure (HF) patients...
  12. Ambrosy A, Bhatt A, Gallup D, Anstrom K, Butler J, DeVore A, et al. Trajectory of Congestion Metrics by Ejection Fraction in Patients With Acute Heart Failure (from the Heart Failure Network). Am J Cardiol. 2017;120:98-105 pubmed publisher
    ..clinical course of congestion by underlying ejection fraction (EF) have not been well-characterized in acute heart failure (AHF)...
  13. Winnik S, Elsener C, Seifert B, Starck C, Straub A, Saguner A, et al. "Real world" experience in Cardiac Resynchronization Therapy at a Swiss Tertiary Care Center. Swiss Med Wkly. 2017;147:w14425 pubmed publisher
    ..cardiac resynchronisation therapy (CRT) has evolved as a standard therapy for patients with advanced heart failure. To provide insight into patient demographics, safety, echocardiographic remodelling and long-term follow-up ..
  14. Hanft L, Emter C, McDonald K. Cardiac myofibrillar contractile properties during the progression from hypertension to decompensated heart failure. Am J Physiol Heart Circ Physiol. 2017;313:H103-H113 pubmed publisher
    b>Heart failure arises, in part, from a constellation of changes in cardiac myocytes including remodeling, energetics, Ca2+ handling, and myofibrillar function...
  15. van Veldhuisen D, Ponikowski P, van der Meer P, Metra M, Bohm M, Doletsky A, et al. Effect of Ferric Carboxymaltose on Exercise Capacity in Patients With Chronic Heart Failure and Iron Deficiency. Circulation. 2017;136:1374-1383 pubmed publisher
    Iron deficiency is common in patients with heart failure (HF) and is associated with reduced exercise capacity and poor outcomes...
  16. Rosenbaum A, Naksuk N, Gharacholou S, Brenes Salazar J. Outcomes of Nonagenarians Admitted to the Cardiac Intensive Care Unit by the Elders Risk Assessment Score for Long-Term Mortality Risk Stratification. Am J Cardiol. 2017;120:1421-1426 pubmed publisher
    ..A total of 258 patients were female (57%). Most common admission indication was acute decompensated heart failure (57%) followed by acute myocardial infarction (49%)...
  17. Freitas P, Aguiar C, Ferreira A, Tralhão A, Ventosa A, Mendes M. Comparative Analysis of Four Scores to Stratify Patients With Heart Failure and Reduced Ejection Fraction. Am J Cardiol. 2017;120:443-449 pubmed publisher
    There are several prognostic risk scores available for patients with heart failure with reduced ejection fraction (HFrEF) that can aid in the decision of listing candidates for heart transplant (HTx)...
  18. Andersson H, Ullgren A, Holmberg M, Karlsson T, Herlitz J, Wireklint Sundström B. Acute coronary syndrome in relation to the occurrence of associated symptoms: A quantitative study in prehospital emergency care. Int Emerg Nurs. 2017;33:43-47 pubmed publisher
    ..This means that dyspnoea, nausea and/or vomiting should influence the ANs' assessment and that special education in cardiovascular nursing is required. ..
  19. Costa S, Rassi S, Freitas E, Gutierrez N, Boaventura F, Sampaio L, et al. Prognostic Factors in Severe Chagasic Heart Failure. Arq Bras Cardiol. 2017;108:246-254 pubmed publisher
    Prognostic factors are extensively studied in heart failure; however, their role in severe Chagasic heart failure have not been established...
  20. Shaqura M, Mohamed D, Aboryag N, Bedewi L, Dehe L, Treskatsch S, et al. Pathological alterations in liver injury following congestive heart failure induced by volume overload in rats. PLoS ONE. 2017;12:e0184161 pubmed publisher
    b>Heart failure has emerged as a disease with significant public health implications...
  21. Watanabe S, Ishikawa K, Fish K, Oh J, Motloch L, Kohlbrenner E, et al. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. J Am Coll Cardiol. 2017;70:1744-1756 pubmed publisher
    Increased protein phosphatase-1 in heart failure (HF) induces molecular changes deleterious to the cardiac cell...
  22. Milfred LaForest S, Gee J, Pugacz A, Pina I, Hoover D, Wenzell R, et al. Heart Failure Transitions of Care: A Pharmacist-Led Post-Discharge Pilot Experience. Prog Cardiovasc Dis. 2017;60:249-258 pubmed publisher
    To perform a pilot evaluation of a pharmacist-led, multidisciplinary transitional care clinic for heart failure (HF) patients...
  23. Matone A, Derlindati E, Marchetti L, Spigoni V, Dei Cas A, Montanini B, et al. Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. PLoS ONE. 2017;12:e0182559 pubmed publisher
    ..from publicly available data sets) in IR-related diseases involving excitable cells: type 2 diabetes, chronic heart failure, and Alzheimer's disease...
  24. DeVore A, Thomas L, Albert N, Butler J, Hernandez A, Patterson J, et al. Change the management of patients with heart failure: Rationale and design of the CHAMP-HF registry. Am Heart J. 2017;189:177-183 pubmed publisher
    b>Heart failure (HF) with reduced ejection fraction (HFrEF) is a common and costly condition that diminishes patients' health status and confers a poor prognosis...
  25. Forman D, Santanasto A, Boudreau R, Harris T, Kanaya A, Satterfield S, et al. Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population. Circ Heart Fail. 2017;10: pubmed publisher
    Prevalence of heart failure (HF) increases significantly with age, coinciding with age-related changes in body composition that are common and consequential. Still, body composition is rarely factored in routine HF care...
  26. Li M, Qiu R, Tian G, Zhang X, Li C, Chen S, et al. Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Complement Ther Med. 2017;33:85-93 pubmed publisher
    ..Keli (WXKL) alone or combined with Western medicine in treating ventricular premature complexes (VPCs) with heart failure (HF)...
  27. Racca V, Castiglioni P, Panzarino C, Oliva F, Perna E, Ferratini M. End-stage heart failure: Two surgical approaches with different rehabilitative outcomes. PLoS ONE. 2017;12:e0185717 pubmed publisher
    A rising number of patients are surgically treated for heart failure at the more advanced stage, thanks to the increasing use of left ventricular assist device (LVAD) as a reliable alternative to heart transplantation (HTx)...
  28. Clegg D, Cody M, Palmer B. Challenges in Treating Cardiovascular Disease: Restricting Sodium and Managing Hyperkalemia. Mayo Clin Proc. 2017;92:1248-1260 pubmed publisher
    ..inhibitors, which are currently guideline-recommended treatments for hypertension, chronic kidney disease, and heart failure. Reducing sodium intake is therefore recommended to reduce the risk of adverse cardiorenal outcomes...
  29. Ramirez J, Orini M, Mincholé A, Monasterio V, Cygankiewicz I, Bayes de Luna A, et al. Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model. PLoS ONE. 2017;12:e0186152 pubmed publisher
    Sudden cardiac death (SCD) and pump failure death (PFD) are common endpoints in chronic heart failure (CHF) patients, but prevention strategies are different. Currently used tools to specifically predict these endpoints are limited...
  30. Varga Z, Sabzwari S, Abusaada K. Impact of Consultation on Hospital Outcomes and Resource Utilization for Patients with Acute Congestive Heart Failure. South Med J. 2017;110:452-456 pubmed publisher
    ..is an important tool for acquiring subspecialty support when managing patients with acute congestive heart failure (CHF). The effect of consultation on hospital outcomes and resource utilization in CHF is unknown...
  31. Frączek Jucha M, Rostoff P, Łach J, Nessler J, Gackowski A. [Evaluation of sleep apnea, detected by 24-hour ECG Holter monitoring analysis in patients with stable coronary artery disease and ischemic heart failure - correlations with clinical data]. Pol Merkur Lekarski. 2017;42:231-235 pubmed
    Obstructive sleep apnoea (OSA) is frequently undiagnosed in patients with heart failure (HF) and coronary artery disease (CAD). Simple and widely available screening tests are needed to diagnose patients with SA...
  32. Aubdool A, Thakore P, Argunhan F, Smillie S, Schnelle M, Srivastava S, et al. A Novel ?-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. Circulation. 2017;136:367-383 pubmed publisher
    ..Analogue) could alleviate and reverse cardiovascular disease in 2 distinct murine models of hypertension and heart failure in vivo...
  33. Snipelisky D, Kelly J, Levine J, Koepp G, Anstrom K, McNulty S, et al. Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices. Circ Heart Fail. 2017;10:e003878 pubmed publisher
    ..activity assessed by accelerometers represents a novel method to assess the impact of interventions on heart failure (HF) patients' functional status...
  34. Lewis G, Malhotra R, Hernandez A, McNulty S, Smith A, Felker G, et al. Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial. JAMA. 2017;317:1958-1966 pubmed publisher
    Iron deficiency is present in approximately 50% of patients with heart failure with reduced left ventricular ejection fraction (HFrEF) and is an independent predictor of reduced functional capacity and mortality...
  35. Qureshi M, Glower J, Ewert D, Koenig S. A Novel Idea to Improve Cardiac Output of Mechanical Circulatory Support Devices by Optimizing Kinetic Energy Transfer Available in Forward Moving Aortic Blood Flow. Cardiovasc Eng Technol. 2017;8:131-144 pubmed publisher
    Mechanical circulatory support devices (MCSDs) have gained widespread clinical acceptance as an effective heart failure (HF) therapy...
  36. Ricco J, Benson J, Prasad S. PURLs: SSRIs for depression/heart failure patients? Not so fast. J Fam Pract. 2017;66:564-567 pubmed
    This study should put to rest the practice of starting SSRIs in depressed patients with heart failure in an attempt to affect CVD outcomes.
  37. Hua C, Huang Y, Su Y, Bu J, Tao H. Collaborative care model improves self-care ability, quality of life and cardiac function of patients with chronic heart failure. Braz J Med Biol Res. 2017;50:e6355 pubmed publisher
    Chronic heart failure (CHF) is a common chronic disease that requires much care. This study aimed to explore the effects of collaborative care model (CCM) on patients with CHF...
  38. Karakoyun I, Colak A, Arslan F, Hasturk A, Duman C. Anemia considerations when assessing natriuretic peptide levels in ED patients. Am J Emerg Med. 2017;35:1677-1681 pubmed publisher
    The incidence of heart failure (HF) has reached epidemic levels in western populations, and the majority of these patients are admitted to hospitals through the emergency department (ED)...
  39. Braun M, Mahowald M. Electrolytes: Sodium Disorders. FP Essent. 2017;459:11-20 pubmed
    ..and include hypovolemic (commonly due to fluid loss), hypervolemic (commonly due to fluid retention from heart failure, cirrhosis, or renal failure), and euvolemic (most often because of syndrome of inappropriate secretion of ..
  40. Favarato D, Gutierrez P. Case 2/2017 - 56-Year-Old Male with Refractory Heart Failure, Systemic Arterial Hypertension and Aortic Valve Stenosis That Led to Heart Transplantation. Arq Bras Cardiol. 2017;108:473-479 pubmed publisher
  41. Wong C, Lin Y, Sung L, Chen T, Ma H, Hsu Y, et al. Increased long-term risk of major adverse cardiovascular events in patients with carbon monoxide poisoning: A population-based study in Taiwan. PLoS ONE. 2017;12:e0176465 pubmed publisher
    ..00; 95% confidence interval, 1.83-2.18). This population-based cohort study indicated that patients with CO poisoning have a higher risk of MACE than do individuals without CO poisoning. ..
  42. Twig G, Ben Ami Shor D, Furer A, Levine H, Derazne E, Goldberger N, et al. Adolescent Body Mass Index and Cardiovascular Disease-Specific Mortality by Midlife. J Clin Endocrinol Metab. 2017;102:3011-3020 pubmed publisher
    ..Death attributed to fatal arrhythmias, hypertensive heart disease, cardiomyopathies, arterial disease, heart failure, and pulmonary embolism...
  43. Díaz Toro F, Nazzal Nazal C, Verdejo H, Rossel V, Castro P, Larrea R, et al. [Frailty in patients admitted to hospital with acute decompensated heart failure]. Rev Med Chil. 2017;145:164-171 pubmed publisher
    ..Frailty is more commonly found in heart failure (HF) patients than in general population and it is an independent predictor of rehospitalization, emergency ..
  44. Kotecha D, Flather M, Altman D, Holmes J, Rosano G, Wikstrand J, et al. Heart Rate and Rhythm and the Benefit of Beta-Blockers in Patients With Heart Failure. J Am Coll Cardiol. 2017;69:2885-2896 pubmed publisher
    The relationship between mortality and heart rate remains unclear for patients with heart failure with reduced ejection fraction in either sinus rhythm or atrial fibrillation (AF)...
  45. Shirazi L, Bissett J, Romeo F, Mehta J. Role of Inflammation in Heart Failure. Curr Atheroscler Rep. 2017;19:27 pubmed publisher
    This paper aims to discuss the interactions between inflammatory cytokines, immune cells, and heart failure (HF)...
  46. Reddy Y, Andersen M, Obokata M, Koepp K, Kane G, Melenovsky V, et al. Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2017;70:136-148 pubmed publisher
    Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF)...
  47. Adamo L, Perry A, Novak E, Makan M, Lindman B, Mann D. Abnormal Global Longitudinal Strain Predicts Future Deterioration of Left Ventricular Function in Heart Failure Patients With a Recovered Left Ventricular Ejection Fraction. Circ Heart Fail. 2017;10: pubmed publisher
    ..In patients with a recovered LVEF, an abnormal GLS predicts the likelihood of having a decreased LVEF during follow-up, whereas a normal GLS predicts the likelihood of stable LVEF during recovery. ..
  48. Schardong J, Kuinchtner G, Sbruzzi G, Plentz R, Silva A. Functional electrical stimulation improves muscle strength and endurance in patients after cardiac surgery: a randomized controlled trial. Braz J Phys Ther. 2017;21:268-273 pubmed publisher
    Functional electrical stimulation (FES) has shown benefits in patients with chronic heart failure. Therefore, it is possible that FES can benefit patients similarly after cardiac surgery...
  49. Derval N, Duchateau J, Mahida S, Eschalier R, Sacher F, Lumens J, et al. Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
    In contrast to patients with left bundle branch block (LBBB), heart failure patients with narrow QRS and nonspecific intraventricular conduction delay (NICD) display a relatively limited response to cardiac resynchronization therapy...
  50. Costanzo M, Ronco C, Abraham W, Agostoni P, Barasch J, Fonarow G, et al. Extracorporeal Ultrafiltration for Fluid Overload in Heart Failure: Current Status and Prospects for Further Research. J Am Coll Cardiol. 2017;69:2428-2445 pubmed publisher
    More than 1 million heart failure hospitalizations occur annually, and congestion is the predominant cause. Rehospitalizations for recurrent congestion portend poor outcomes independently of age and renal function...
  51. Ribas F, Gutierrez P. Case 6 / 2016 - Heart Failure in a 23-Year-Old Male with a History of Illicit Drug Use. Arq Bras Cardiol. 2016;107:590-599 pubmed publisher
  52. Meder B, Haas J, Sedaghat Hamedani F, Kayvanpour E, Frese K, Lai A, et al. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure. Circulation. 2017;136:1528-1544 pubmed publisher
    ..To identify epigenetic susceptibility regions and novel biomarkers linked to myocardial dysfunction and heart failure, we performed the first multi-omics study in myocardial tissue and blood of patients with dilated ..
  53. Arts E, Fransen J, den Broeder A, van Riel P, Popa C. Low disease activity (DAS28?3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent Cox regression analysis in a large cohort study. Ann Rheum Dis. 2017;76:1693-1699 pubmed publisher
    ..Our results strengthen the use of tight control strategies in daily clinical practice to achieve low stable disease activity or remission in patients with RA as soon as possible. ..