endocardial cushions

Summary

Summary: A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE.

Top Publications

  1. Saxon J, Baer D, Barton J, Hawkins T, Wu B, Trusk T, et al. BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling. Dev Biol. 2017;430:113-128 pubmed publisher
    ..Mesenchymalized AV endocardial cushions give rise to the AV valves and the membranous ventricular septum (VS)...
  2. Boselli F, Steed E, Freund J, Vermot J. Anisotropic shear stress patterns predict the orientation of convergent tissue movements in the embryonic heart. Development. 2017;144:4322-4327 pubmed publisher