heart

Summary

Summary: The hollow, muscular organ that maintains the circulation of the blood.

Top Publications

  1. Rog Zielinska E, Thomson A, Kenyon C, Brownstein D, Moran C, Szumska D, et al. Glucocorticoid receptor is required for foetal heart maturation. Hum Mol Genet. 2013;22:3269-82 pubmed publisher
    ..Echocardiography shows impaired heart function in both SMGRKO and GR(-/-) mice at embryonic day (E)17.5, associated with generalized oedema...
  2. Acharya B, Wang K, Kim I, Kang W, Moon C, Lee B. In vivo imaging of myocardial cell death using a peptide probe and assessment of long-term heart function. J Control Release. 2013;172:367-373 pubmed publisher
    ..apoptotic and necrotic cells through histone H1, at an early stage after AMI showed correlation with the long-term heart function. AMI was induced using a rat model of ischemia and reperfusion (I/R) injury...
  3. Lencinas A, Chhun D, Dan K, Ross K, Hoover E, Antin P, et al. Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart. Dis Model Mech. 2013;6:632-42 pubmed publisher
    Endothelia in the atrioventricular (AV) canal of the developing heart undergo a prototypical epithelial mesenchymal transition (EMT) to begin heart valve formation...
  4. Markussen T, Dahle M, Tengs T, Løvoll M, Finstad Ø, Wiik Nielsen C, et al. Sequence analysis of the genome of piscine orthoreovirus (PRV) associated with heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar). PLoS ONE. 2013;8:e70075 pubmed publisher
    Piscine orthoreovirus (PRV) is associated with heart- and skeletal muscle inflammation (HSMI) of farmed Atlantic salmon (Salmo salar)...
  5. Britton O, Bueno Orovio A, Van Ammel K, Lu H, Towart R, Gallacher D, et al. Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology. Proc Natl Acad Sci U S A. 2013;110:E2098-105 pubmed publisher
  6. Richards D, Glosli J, Draeger E, Mirin A, Chan B, Fattebert J, et al. Towards real-time simulation of cardiac electrophysiology in a human heart at high resolution. Comput Methods Biomech Biomed Engin. 2013;16:802-5 pubmed publisher
    We have developed the capability to rapidly simulate cardiac electrophysiological phenomena in a human heart discretised at a resolution comparable with the length of a cardiac myocyte...
  7. Surges R, Jordan A, Elger C. Ictal modulation of cardiac repolarization, but not of heart rate, is lateralized in mesial temporal lobe epilepsy. PLoS ONE. 2013;8:e64765 pubmed publisher
    ..Here, we investigated whether seizure-related changes in heart rate (HR) and cardiac repolarization depend on the side of seizure-activity in people with mesial temporal lobe ..
  8. Nakata T, Nakajima K, Yamashina S, Yamada T, Momose M, Kasama S, et al. A pooled analysis of multicenter cohort studies of (123)I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6:772-84 pubmed publisher
    ..studies and to determine the quantitative iodine-123-labeled mIBG indices for identifying patients with chronic heart failure (HF) at greatest and lowest risk of lethal events...
  9. Bakshi M, Barjaktarovic Z, Azimzadeh O, Kempf S, Merl J, Hauck S, et al. Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study. Radiat Environ Biophys. 2013;52:451-61 pubmed publisher
    ..It will contribute to the understanding of the long-term consequences of radiation-induced injury and developmental alterations in the neonatal heart.

More Information

Publications32

  1. Fang Y, Gupta V, Karra R, Holdway J, Kikuchi K, Poss K. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2013;110:13416-21 pubmed publisher
    ..vertebrates like zebrafish activate proliferation of spared cardiomyocytes after cardiac injury to regenerate lost heart muscle...
  2. Gao D, Zhang L, Dhillon R, Hong T, Shaw R, Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS ONE. 2013;8:e60967 pubmed publisher
    b>Heart failure due to diastolic dysfunction exacts a major economic, morbidity and mortality burden in the United States. Therapeutic agents to improve diastolic dysfunction are limited...
  3. Lataro R, Silva C, Fazan R, Rossi M, Prado C, Godinho R, et al. Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure. Am J Physiol Regul Integr Comp Physiol. 2013;305:R908-16 pubmed publisher
    b>Heart failure (HF) is characterized by elevated sympathetic activity and reduced parasympathetic control of the heart...
  4. Wystub K, Besser J, Bachmann A, Boettger T, Braun T. miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development. PLoS Genet. 2013;9:e1003793 pubmed publisher
    ..Overexpression of myocardin in the embryonic heart essentially recapitulated the miR-1/133a mutant phenotype at the molecular level, arresting embryonic ..
  5. Queirós A, Eschen C, Fliegner D, Kararigas G, Dworatzek E, Westphal C, et al. Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart. Int J Cardiol. 2013;169:331-8 pubmed publisher
    ..Estrogen regulates a network of miRNAs in a sex-specific manner via ER?. Our data suggest that the sex-specific expression of these miRNAs may be related to sex differences in fibrosis after pressure overload. ..
  6. Wang W, Razy Krajka F, Siu E, Ketcham A, Christiaen L. NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field. PLoS Biol. 2013;11:e1001725 pubmed publisher
    The heart and head muscles share common developmental origins and genetic underpinnings in vertebrates, including humans...
  7. Chng S, Ho L, Tian J, Reversade B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell. 2013;27:672-80 pubmed publisher
    ..Loss of Ela causes embryos to develop with a rudimentary heart or no heart at all, surprisingly phenocopying the loss of the apelin receptor (aplnr), which we show serves as Ela'..
  8. van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-41 pubmed publisher
    If and how the heart regenerates after an injury event is highly debated. c-kit-expressing cardiac progenitor cells have been reported as the primary source for generation of new myocardium after injury...
  9. Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, et al. Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome. Clin Exp Pharmacol Physiol. 2013;40:443-8 pubmed publisher
    ..Using echocardiography, we demonstrated reduced systolic function in 32-week-old SHR/cp. Changes in myocardial cytokine concentrations could be involved in worsening of cardiac function in our animal model of metabolic syndrome. ..
  10. Chen J, Huang Z, Seok H, Ding J, Kataoka M, Zhang Z, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013;112:1557-66 pubmed publisher
    ..in pathological cardiac conditions and the lack of regeneration capacity of adult hearts are primary causes of heart failure and mortality...
  11. Darby S, Ewertz M, McGale P, Bennet A, Blom Goldman U, Brønnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987-98 pubmed publisher
    Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain...
  12. Habbout A, Guenancia C, Lorin J, Rigal E, Fassot C, Rochette L, et al. Postnatal overfeeding causes early shifts in gene expression in the heart and long-term alterations in cardiometabolic and oxidative parameters. PLoS ONE. 2013;8:e56981 pubmed publisher
    ..postnatal period in mice leads to early changes in cardiac gene expression, which may permanently modify the heart's structural organization and metabolism and could contribute to a greater susceptibility to myocardial ischemia-..
  13. Hourde C, Joanne P, Medja F, Mougenot N, Jacquet A, Mouisel E, et al. Voluntary physical activity protects from susceptibility to skeletal muscle contraction-induced injury but worsens heart function in mdx mice. Am J Pathol. 2013;182:1509-18 pubmed publisher
    ..It also suggests that activity exerts a beneficial effect on dystrophic skeletal muscle but not on the heart.
  14. Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, et al. Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013;140:1475-85 pubmed publisher
    ..sympathetic axon extension in the subepicardial layer of the dorsal ventricular wall of the developing mouse heart. Vascular smooth muscle cells (VSMCs) associate with large diameter veins during angiogenesis...
  15. Ichikawa R, Daimon M, Miyazaki T, Kawata T, Miyazaki S, Maruyama M, et al. Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013;12:38 pubmed publisher
    ..We studied 148 asymptomatic patients with T2DM without overt heart disease. Echocardiographic findings were compared between diabetic patients and 68 age-matched healthy subjects...
  16. Reyes del Paso G, Langewitz W, Mulder L, van Roon A, Duschek S. The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: a review with emphasis on a reanalysis of previous studies. Psychophysiology. 2013;50:477-87 pubmed publisher
    This article evaluates the suitability of low frequency (LF) heart rate variability (HRV) as an index of sympathetic cardiac control and the LF/high frequency (HF) ratio as an index of autonomic balance...
  17. de Oliveira T, de Alvarenga Mattos R, da Silva R, Rezende R, de Lima J. Absence of parasympathetic reactivation after maximal exercise. Clin Physiol Funct Imaging. 2013;33:143-9 pubmed publisher
    ..Although the dynamics of heart rate recovery after maximal exercise has been studied, little is known about heart rate variability after this ..
  18. Nam H, Wang C, Zhang L, Zhang W, Hojyo S, Fukada T, et al. ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica. 2013;98:1049-57 pubmed publisher
    The liver, pancreas, and heart are particularly susceptible to iron-related disorders. These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload...
  19. Parente V, Balasso S, Pompilio G, Verduci L, Colombo G, Milano G, et al. Hypoxia/reoxygenation cardiac injury and regeneration in zebrafish adult heart. PLoS ONE. 2013;8:e53748 pubmed publisher
    the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injury in mammalian heart...
  20. Mollova M, Bersell K, Walsh S, Savla J, Das L, Park S, et al. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013;110:1446-51 pubmed publisher
    The human heart is believed to grow by enlargement but not proliferation of cardiomyocytes (heart muscle cells) during postnatal development...
  21. Shim W, Mehta A, Wong P, Chua T, Koh T. Critical path in cardiac stem cell therapy: an update on cell delivery. Cytotherapy. 2013;15:399-415 pubmed publisher
    ..pre-clinical results, stem cell therapy has developed rapidly into a potentially promising treatment for ischemic heart disease, myocardial infarction and congestive heart failure...