patent ductus arteriosus

Summary

Summary: A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.

Top Publications

  1. Knight D. The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials. Semin Neonatol. 2001;6:63-73 pubmed
    b>Patent ductus arteriosus (PDA) is a common problem in very preterm infants. It results in a significant left-to-right shunt and an increase in left ventricular output. Pulmonary compliance can be reduced...
  2. Khetyar M, Syrris P, Tinworth L, Abushaban L, Carter N. Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus. Genet Test. 2008;12:457-9 pubmed publisher
    ..We investigated a consanguineous family with isolated patent ductus arteriosus (PDA) for mutations in TFAP2B...
  3. Chang L, McCurnin D, Yoder B, Shaul P, Clyman R. Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus. Pediatr Res. 2008;63:299-302 pubmed publisher
    Premature newborn baboons [125 d (67%) gestation], exposed to a moderate-size patent ductus arteriosus (PDA) [pulmonary-to-systemic blood-flow-ratio (Qp/Qs) = 1...
  4. Meier S, Eble B, Stapleton G, Morales D, Chang A, Andropoulos D. Mesenteric oxyhemoglobin desaturation improves with patent ductus arteriosus ligation. J Perinatol. 2006;26:562-4 pubmed
    ..monitor cerebral and mesenteric regional oximetry in a preterm neonate undergoing surgical ligation of a patent ductus arteriosus. This patient initially demonstrated severe mesenteric oxyhemoglobin desaturation, which improved ..
  5. Hamrick S, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics. 2010;125:1020-30 pubmed publisher
    A persistently patent ductus arteriosus (PDA) in preterm infants can have significant clinical consequences, particularly during the recovery period from respiratory distress syndrome...
  6. Onji K, Matsuura W. Pulmonary endarteritis and subsequent pulmonary embolism associated with clinically silent patent ductus arteriosus. Intern Med. 2007;46:1663-7 pubmed
    ..We had the rare opportunity to follow a case of pulmonary bacterial endarteritis and subsequent pulmonary embolism with clinically silent patent ductus arteriosus (PDA) that was confirmed by 3-dimensional CT.
  7. Knight D, Laughon M. Evidence for active closure of patent ductus arteriosus in very preterm infants. J Pediatr. 2008;152:446-7; author reply 447-8 pubmed publisher
  8. Bhandari V, Zhou G, Bizzarro M, Buhimschi C, Hussain N, Gruen J, et al. Genetic contribution to patent ductus arteriosus in the premature newborn. Pediatrics. 2009;123:669-73 pubmed publisher
    The most common congenital heart disease in the newborn population, patent ductus arteriosus, accounts for significant morbidity in preterm newborns...
  9. Roclawski M, Sabiniewicz R, Potaz P, Smoczynski A, Pankowski R, Mazurek T, et al. Scoliosis in patients with aortic coarctation and patent ductus arteriosus: does standard posterolateral thoracotomy play a role in the development of the lateral curve of the spine?. Pediatr Cardiol. 2009;30:941-5 pubmed publisher
    ..on the development of scoliosis in subjects undergoing repair of coarctation of the aorta (CoA) and patent ductus arteriosus (PDA). A group of 133 patients with CoA and PDA was evaluated...

More Information

Publications62

  1. Zhu X, Chen H, Zhang D, Han X, Sheng X, Cui C, et al. [Effects of transcatheter closure of patent ductus arteriosus in 139 adult patients]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37:998-1000 pubmed
    To analyze the clinical feature and the effects of transcatheter closure of adult patients with patent ductus arteriosus (PDA). Between January 2000 and April 2009, 139 patients [22 male, aged from 40 to 74: (49.8 +/- 6...
  2. Nuntnarumit P, Khositseth A, Thanomsingh P. N-terminal probrain natriuretic peptide and patent ductus arteriosus in preterm infants. J Perinatol. 2009;29:137-42 pubmed publisher
    ..probrain natriuretic peptide (NT-proBNP) in premature infants could identify hemodynamically significant patent ductus arteriosus (HsPDA) and to determine the correlation between serial plasma NT-proBNP and echocardiographic assessment ..
  3. Smith M, King J, Elsherif A, Muntz H, Park A, Kouretas P. Should all newborns who undergo patent ductus arteriosus ligation be examined for vocal fold mobility?. Laryngoscope. 2009;119:1606-9 pubmed publisher
    To determine the incidence of left vocal fold paralysis (LVFP) in premature infants who undergo patent ductus arteriosus (PDA) ligation. Prospective cohort...
  4. Zhu L, Bonnet D, Boussion M, Vedie B, Sidi D, Jeunemaitre X. Investigation of the MYH11 gene in sporadic patients with an isolated persistently patent arterial duct. Cardiol Young. 2007;17:666-72 pubmed
    ..07, than among controls, when the figure was 0.22 (OR 0.23 [0.08-0.27]). Our findings suggest that the MYH11 gene is involved in only rare instances when persistent patency of the arterial duct occurs in sporadic fashion. ..
  5. Kumar A, Lakkundi A, McNamara P, Sehgal A. Surfactant and patent ductus arteriosus. Indian J Pediatr. 2010;77:51-5 pubmed publisher
    ..Whether the relationship reflects their underlying lung disease or is a direct effect of surfactant requires prospective evaluation. ..
  6. Satoh T, Nishida N. Patent ductus arteriosus with infective endocarditis at age 92. Intern Med. 2008;47:263-8 pubmed
    This report describes a 92-year-old woman patient with patent ductus arteriosus (PDA). She seems to be the oldest patient with PDA hitherto reported in the medical history...
  7. McCurnin D, Clyman R. Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons. Pediatrics. 2008;122:e1262-7 pubmed publisher
    ..Although a patent ductus arteriosus can affect superior mesenteric artery perfusion in nonfeeding infants, there is no information about its ..
  8. Feng X, Krebs L, Gridley T. Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development. 2010;137:4191-9 pubmed publisher
    ..Failure of the ductus arteriosus to close after birth is termed patent ductus arteriosus and is one of the most common congenital heart defects...
  9. Benitz W. Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?. J Perinatol. 2010;30:241-52 pubmed publisher
    Medical and surgical interventions are widely used to close a persistently patent ductus arteriosus in preterm infants. Objective evidence to support these practices is lacking, causing some to question their usage...
  10. Giliberti P, De Leonibus C, Giordano L, Giliberti P. The physiopathology of the patent ductus arteriosus. J Matern Fetal Neonatal Med. 2009;22 Suppl 3:6-9 pubmed publisher
    b>Patent ductus arteriosus (PDA) remains a frequent problem for the very low birth weight infants...
  11. Sekar K, Corff K. Treatment of patent ductus arteriosus: indomethacin or ibuprofen?. J Perinatol. 2008;28 Suppl 1:S60-2 pubmed publisher
    Persistent patent ductus arteriosus (PDA) in preterm infants can result in serious hemodynamic changes causing respiratory, gastrointestinal and renal morbidities if not treated within the first week of life...
  12. Clement W, El Hakim H, Phillipos E, Coté J. Unilateral vocal cord paralysis following patent ductus arteriosus ligation in extremely low-birth-weight infants. Arch Otolaryngol Head Neck Surg. 2008;134:28-33 pubmed publisher
    To determine if unilateral vocal cord paralysis (UVCP) following patent ductus arteriosus (PDA) ligation is associated with respiratory and swallowing morbidities in extremely low-birth-weight (ELBW) infants. Case-control study...
  13. McCurnin D, Seidner S, Chang L, Waleh N, Ikegami M, Petershack J, et al. Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung. Pediatrics. 2008;121:945-56 pubmed publisher
    The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia.
  14. Spanos W, Brookes J, Smith M, Burkhart H, Bell E, Smith R. Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. Ann Otol Rhinol Laryngol. 2009;118:750-3 pubmed
    ..factors associated with unilateral iatrogenic vocal fold paralysis (IVFP) in the context of ligation of patent ductus arteriosus (PDA) and compared the rates of paralysis between vascular clip and suture ligation procedures...
  15. Giroud J, Jacobs J. Evolution of strategies for management of the patent arterial duct. Cardiol Young. 2007;17 Suppl 2:68-74 pubmed publisher
    ..0 to 2.5 millimetres in diameter, our preference is to use the Amplatzer occluder. For smaller ducts, we typically use stainless steel coils. Using this strategy, we close all patent arterial ducts, regardless of their size. ..
  16. Beani L, Moscardini A, Souza A, Souza A, Yamamoto A, Croti U, et al. Late pulmonary tomography assessment in premature infants with bronchopulmonary dysplasia submitted to patent ductus arteriosus management. Rev Bras Cir Cardiovasc. 2007;22:400-6 pubmed
    ..tomography the pulmonary parenchyma of children prematurely born with both very low birth weight and patent ductus arteriosus submitted to medical or surgical treatment that developed bronchopulmonary dysplasia...
  17. Dagle J, Lepp N, Cooper M, Schaa K, Kelsey K, Orr K, et al. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Pediatrics. 2009;123:1116-23 pubmed publisher
    b>Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to approximately 70% in infants born at 25 weeks' gestation...
  18. Tsao P, Chen S, Yang C, Lee Y, Jeng M, Soong W, et al. Comparison of intravenous and enteral indomethacin administration for closure of patent ductus arteriosus in extremely-low-birth-weight infants. J Chin Med Assoc. 2010;73:15-20 pubmed
    The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes...
  19. Hsu J, Yang S, Chen H, Tseng H, Dai Z, Wu J. B-type natriuretic peptide predicts responses to indomethacin in premature neonates with patent ductus arteriosus. J Pediatr. 2010;157:79-84 pubmed publisher
    ..whether B-type natriuretic peptide (BNP) predicts indomethacin responsiveness in premature neonates with patent ductus arteriosus (PDA). Premature neonates receiving indomethacin for an echocardiograhically large (diameter>1...
  20. Hirt D, Van Overmeire B, Treluyer J, Langhendries J, Marguglio A, Eisinger M, et al. An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study. Br J Clin Pharmacol. 2008;65:629-36 pubmed publisher
    Ibuprofen is a nonsteroidal anti-inflammatory agent that induces closure of the patent ductus arteriosus in neonates...
  21. Jaeggi E, Fasnacht M, Arbenz U, Beghetti M, Bauersfeld U, Friedli B. Transcatheter occlusion of the patent ductus arteriosus with a single device technique: comparison between the Cook detachable coil and the Rashkind umbrella device. Int J Cardiol. 2001;79:71-6 pubmed
    Transcatheter coil occlusion of the patent ductus arteriosus (PDA) has become the interventional treatment option of choice...
  22. Nakahira M, Nakatani H, Takeda T. Left vocal cord paralysis associated with long-standing patent ductus arteriosus. AJNR Am J Neuroradiol. 2001;22:759-61 pubmed
    Left vocal cord paralysis in association with patent ductus arteriosus is unusual...
  23. Satoda M, Zhao F, Diaz G, Burn J, Goodship J, Davidson H, et al. Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Nat Genet. 2000;25:42-6 pubmed
    Char syndrome is an autosomal dominant trait characterized by patent ductus arteriosus, facial dysmorphism and hand anomalies...
  24. Hijazi Z. Catheter closure of ductus arteriosus in adolescents and adults: what to use?. Catheter Cardiovasc Interv. 2002;55:519-20 pubmed
  25. Gordon S, Miller M. Transarterial coil embolization for canine patent ductus arteriosus occlusion. Clin Tech Small Anim Pract. 2005;20:196-202 pubmed
    Left to right shunting patent ductus arteriosus (PDA) is the most common canine congenital heart defect. If not occluded PDA is associated with high morbidity and mortality...
  26. Niinikoski H, Alanen M, Parvinen T, Aantaa R, Ekblad H, Kero P. Surgical closure of patent ductus arteriosus in very-low-birth-weight infants. Pediatr Surg Int. 2001;17:338-41 pubmed
    ..This study evalutes the results of early surgical closure of patent ductus arteriosus (PDA)...
  27. Khau Van Kien P, Wolf J, Mathieu F, Zhu L, Salve N, Lalande A, et al. Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity. Eur J Hum Genet. 2004;12:173-80 pubmed
    ..In all, 11 cases of patent ductus arteriosus (PDA) were observed, two of which were associated with TAA and one with AD...
  28. Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts R, Saigal S, et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med. 2001;344:1966-72 pubmed
    The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)...
  29. Jaillard S, Larrue B, Rakza T, Magnenant E, Warembourg H, Storme L. Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants. Ann Thorac Surg. 2006;81:231-4 pubmed
    ..arteriosus were: (1) medical treatment failure (ie, indomethacin or ibuprofen) and (2) hemodynamically patent ductus arteriosus: systemic arterial pressure less than gestational age in mm Hg, heart failure, left atrial-aortic root ..
  30. Burke R, Jacobs J, Cheng W, Trento A, Fontana G. Video-assisted thoracoscopic surgery for patent ductus arteriosus in low birth weight neonates and infants. Pediatrics. 1999;104:227-30 pubmed
    ..We report our experience with 34 low birth weight infants undergoing VATS interruption of patent ductus arteriosus (PDA). VATS allows PDA interruption without the muscle cutting or rib spreading of a standard thoracotomy...
  31. Pass R, Hijazi Z, Hsu D, Lewis V, Hellenbrand W. Multicenter USA Amplatzer patent ductus arteriosus occlusion device trial: initial and one-year results. J Am Coll Cardiol. 2004;44:513-9 pubmed
    ..Transcatheter closure of a moderate to large patent ductus arteriosus (PDA) using conventional techniques is challenging. The ADO can close a PDA up to 12 mm in diameter...
  32. Bilge M, Uner A, Ozeren A, Aydin M, Demirel F, Ermis B, et al. Pulmonary endarteritis and subsequent embolization to the lung as a complication of a patent ductus arteriosus--a case report. Angiology. 2004;55:99-102 pubmed
    ..describe a case of pulmonary endarteritis and subsequent embolization to the lungs as a complication of a patent ductus arteriosus (PDA)...
  33. Liang C, Ko S, Huang S, Huang C, Niu C. Vocal cord paralysis after transcatheter coil embolization of patent ductus arteriosus. Am Heart J. 2003;146:367-71 pubmed
    In patients with patent ductus arteriosus (PDA) after Gianturco coil embolization, vocal cord paralysis (VCP) had not been previously described. This study investigates the risk factors of coil embolization associated with VCP...
  34. Khau Van Kien P, Mathieu F, Zhu L, Lalande A, Betard C, Lathrop M, et al. Mapping of familial thoracic aortic aneurysm/dissection with patent ductus arteriosus to 16p12.2-p13.13. Circulation. 2005;112:200-6 pubmed
    ..We recently described a large family in which TAA/AD associates with patent ductus arteriosus (PDA) and provided genetic arguments for a unique pathophysiological entity...
  35. Chang S, Hung K, Hsieh I, Chang H, Chern M, Lin F, et al. Evaluation of shunt flow by multiplane transesophageal echocardiography in adult patients with isolated patent ductus arteriosus. J Am Soc Echocardiogr. 2002;15:1367-73 pubmed
    The role of multiplane (M) transesophageal echocardiography (TEE) in the diagnosis of isolated patent ductus arteriosus (PDA) in adults and its effectiveness in the assessment of the pulmonary to systemic flow ratio were evaluated and ..
  36. Pladys P, Beuchee A, Wodey E, Treguier C, Lassel L, Betremieux P. Patent ductus arteriosus and cystic periventricular leucomalacia in preterm infants. Acta Paediatr. 2001;90:309-15 pubmed
    ..Forty-six preterm infants (27-32 wk) admitted to the neonatal intensive care unit with risk criteria. Patent ductus arteriosus was evaluated on days 1 and 4, and was significant (sPDA) in cases of absent or reversed end diastolic ..
  37. Hwang M, Su W. Iatrogenic cardiovocal syndrome caused by transcatheter coil closure of patent ductus arteriosus. Acta Paediatr. 2005;94:372-4 pubmed
    Two infants developed hoarseness unexpectedly the day after transcatheter coil closure of a slender patent ductus arteriosus (PDA). The pathogenesis of this complication appears to be similar to that of the classic cardiovocal syndrome...
  38. Thebaud B, Michelakis E, Wu X, Moudgil R, Kuzyk M, Dyck J, et al. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004;110:1372-9 pubmed
    ..Modulation of Kv channels may have therapeutic potential in diseases associated with impaired O2 responsiveness, including persistent DA. ..
  39. Hammerman C, Kaplan M. Comparative tolerability of pharmacological treatments for patent ductus arteriosus. Drug Saf. 2001;24:537-51 pubmed
    ..this review, however, is on pharmacological approaches designed to prevent and/or treat the persistently patent ductus arteriosus (PDA) which often fails to constrict spontaneously in the premature infant...
  40. O Donovan D, Baetiong A, Adams K, Chen A, Smith E, Adams J, et al. Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. J Perinatol. 2003;23:286-90 pubmed
    Indomethacin is the most frequently used pharmacological agent for closure of a patent ductus arteriosus (PDA) in premature infants...
  41. Hines M, Raines K, Payne R, Covitz W, Cnota J, Smith T, et al. Video-assisted ductal ligation in premature infants. Ann Thorac Surg. 2003;76:1417-20; discussion 1420 pubmed
    Video-assisted thoracic surgery has been shown to be a safe and effective method of closing the patent ductus arteriosus in infants and children...
  42. Sadiq M, Malick N, Qureshi S. Simultaneous treatment of native coarctation of the aorta combined with patent ductus arteriosus using a covered stent. Catheter Cardiovasc Interv. 2003;59:387-90 pubmed
    A 19-year-old girl with coarctation of the aorta and patent ductus arteriosus underwent simultaneous treatment of native coarctation and closure of ductus arteriosus using a covered Cheatham-Platinum stent...
  43. Glancy D, Wegmann M, Dhurandhar R. Aortic dissection and patent ductus arteriosus in three generations. Am J Cardiol. 2001;87:813-5, A9 pubmed
    ..was found in a woman, her 2 sons, and 1 of her 3 daughters, and the 3 affected children and a granddaughter had patent ductus arteriosus. The pattern of inheritance of this unique syndrome probably is an autosomal dominant one.
  44. Al Ata J, Arfi A, Hussain A, Kouatli A, Jalal M. The efficacy and safety of the Amplatzer ductal occluder in young children and infants. Cardiol Young. 2005;15:279-85 pubmed
    ..If the device is to be deployed completely in the ductal ampulla, and to avoid descending aortic obstruction, the size of the retention flanges of the occluder should not exceed the largest diameter of the patent arterial duct. ..
  45. Desfrere L, Zohar S, Morville P, Brunhes A, Chevret S, Pons G, et al. Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method. J Clin Pharm Ther. 2005;30:121-32 pubmed
    Intravenous ibuprofen (IBU) has been found to be as effective as indomethacin for the treatment of patent ductus arteriosus (PDA) in preterm infants and has been associated with fewer adverse effects in comparative phase III studies...
  46. Mani A, Meraji S, Houshyar R, Radhakrishnan J, Mani A, Ahangar M, et al. Finding genetic contributions to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus. Proc Natl Acad Sci U S A. 2002;99:15054-9 pubmed
    ..We found that patent ductus arteriosus (PDA), a common congenital heart disease, accounts for a higher fraction of congenital heart disease in ..
  47. Van Overmeire B, Smets K, Lecoutere D, Van de Broek H, Weyler J, Degroote K, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med. 2000;343:674-81 pubmed
    Indomethacin is the conventional treatment for hemodynamically important patent ductus arteriosus in preterm infants. However, its use is associated with various side effects...
  48. Bilkis A, Alwi M, Hasri S, Haifa A, Geetha K, Rehman M, et al. The Amplatzer duct occluder: experience in 209 patients. J Am Coll Cardiol. 2001;37:258-61 pubmed
    ..to assess the safety and efficacy of the Amplatzer ductal occluder (ADO) in transcatheter occlusion of patent ductus arteriosus (PDA). Transcatheter closure of small to moderate sized PDAs is an established procedure...
  49. Patole S, Kumaran V, Travadi J, Brooks J, Doherty D. Does patent ductus arteriosus affect feed tolerance in preterm neonates?. Arch Dis Child Fetal Neonatal Ed. 2007;92:F53-5 pubmed
    b>Patent ductus arteriosus (PDA), especially PDA with sepsis, has been reported as a risk factor for feed intolerance in preterm neonates...
  50. Clyman R, Chorne N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr. 2007;150:216-9 pubmed
  51. Lee C, Leung Y, Kwong N, Kwok O, Yip A, Chow W. Transcatheter closure of patent ductus arteriosus in Chinese adults: immediate and long-term results. J Invasive Cardiol. 2003;15:26-30 pubmed
    Transcatheter closure of patent ductus arteriosus (PDA) has been established as a safe and effective treatment for pediatric patients. However, long-term experience in adults remains limited...
  52. Gould D, Montenegro L, Gaynor J, Lacy S, Ittenbach R, Stephens P, et al. A comparison of on-site and off-site patent ductus arteriosus ligation in premature infants. Pediatrics. 2003;112:1298-301 pubmed
    Persistent patent ductus arteriosus (PDA) often produces hemodynamic and respiratory derangement necessitating use of inotropic drugs and escalating ventilatory support in premature infants...
  53. Moin F, Kennedy K, Moya F. Risk factors predicting vasopressor use after patent ductus arteriosus ligation. Am J Perinatol. 2003;20:313-20 pubmed
    Ligation of the patent ductus arteriosus (PDA) is sometimes complicated by postoperative hypotension requiring vasopressor(s). It is unclear which infants are at risk for this complication...