umbilical arteries

Summary

Summary: Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.

Top Publications

  1. Seyam Y, Al Mahmeid M, Al Tamimi H. Umbilical artery Doppler flow velocimetry in intrauterine growth restriction and its relation to perinatal outcome. Int J Gynaecol Obstet. 2002;77:131-7 pubmed
  2. Soregaroli M, Bonera R, Danti L, Dinolfo D, Taddei F, Valcamonico A, et al. Prognostic role of umbilical artery Doppler velocimetry in growth-restricted fetuses. J Matern Fetal Neonatal Med. 2002;11:199-203 pubmed
    ..To correlate umbilical artery Doppler velocimetry with perinatal outcome in a group of growth-restricted fetuses...
  3. Morales Roselló J, Hervás Marín D, Fillol Crespo M, Perales Marín A. Doppler changes in the vertebral, middle cerebral, and umbilical arteries in fetuses delivered after 34 weeks: relationship to severity of growth restriction. Prenat Diagn. 2012;32:960-7 pubmed publisher
    To determine the association between Doppler changes in the fetal vertebral (VA), middle cerebral (MCA), and umbilical arteries (UA) and severity of growth restriction (FGR) in fetuses delivered after 34 weeks.
  4. Stanley J, Andersson I, Poudel R, Rueda Clausen C, Sibley C, Davidge S, et al. Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. Hypertension. 2012;59:1021-8 pubmed publisher
    ..The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction...
  5. Krause B, Prieto C, Muñoz Urrutia E, San Martin S, Sobrevia L, Casanello P. Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins. Placenta. 2012;33:360-6 pubmed publisher
    ..and the changes in the expression of arginase-2 and eNOS proteins by hypoxia in endothelial cells from umbilical arteries (HUAEC) and veins (HUVEC)...
  6. Paternotte E, Kerdjoudj H, Kokten T, Stoltz J, Kearney Schwartz A, Voegel J, et al. Endothelialized and preconditioned natural umbilical arteries with long term patency open the route for future human uses. Clin Hemorheol Microcirc. 2013;54:223-34 pubmed publisher
    ..b>Umbilical arteries were de-endothelialized, coated with 3...
  7. Janeczek S, Karlman R, MacMillan W. Left versus right intra-abdominal umbilical arteries: comparison of their Doppler waveforms. J Ultrasound Med. 2012;31:679-83 pubmed
    The purpose of this study was to compare Doppler velocimetric indices between the left and right intra-abdominal umbilical arteries in normally grown and growth-restricted fetuses.
  8. Wang Y, Zhu D, An Y, Sun J, Cai L, Zheng J. Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries. Prostaglandins Leukot Essent Fatty Acids. 2012;86:79-84 pubmed publisher
  9. Helbig A, Kaasen A, Malt U, Haugen G. Psychological distress after recent detection of fetal malformation: short-term effect on second-trimester uteroplacental and fetoplacental circulation. BJOG. 2011;118:1653-7 pubmed publisher
    ..Psychological distress was high in the anomaly group, but circulatory outcome measures did not differ between groups. Multiple regression analyses did not show an increase in circulatory resistance measures even at high distress levels...

More Information

Publications62

  1. Baschat A. Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction. Ultrasound Obstet Gynecol. 2011;37:501-14 pubmed publisher
    ..In late-onset FGR further research needs to establish benefits of perinatal intervention, as the pattern of vulnerability and effects of fetal deterioration appear to differ in the third trimester...
  2. Vythilingum B, Geerts L, Fincham D, Roos A, Faure S, Jonkers J, et al. Association between antenatal distress and uterine artery pulsatility index. Arch Womens Ment Health. 2010;13:359-64 pubmed publisher
  3. Crouzier T, McClendon T, Tosun Z, McFetridge P. Inverted human umbilical arteries with tunable wall thicknesses for nerve regeneration. J Biomed Mater Res A. 2009;89:818-28 pubmed publisher
    ..These investigations show the potential of the iHUA as a unique 3D scaffold that may enhance nerve regeneration...
  4. Storck J, Zimmermann E. Regulation of the thrombin receptor response in human endothelial cells. Thromb Res. 1996;81:121-31 pubmed
    ..Desensitisation is similar in thrombin and TRAP stimulated cells. We assumed a transport mechanism for intracellular stored vesicles for receptor resensitisation; a co-localisation with vWf in the Weibel-Palade bodies is improbable...
  5. Balbis S, Gaglioti P, Todros T, Guiot C. Doppler indices in the umbilical arteries: influence of vessel curvature induced by bladder filling. Ultrasound Med Biol. 2007;33:1895-900 pubmed
    ..In obstetrics, the assessment of abnormal values in some critical compartments, such as the umbilical arteries (UA), may be crucial in the clinical management of growth-restricted foetuses...
  6. Figueras F, Eixarch E, Meler E, Iraola A, Figueras J, Puerto B, et al. Small-for-gestational-age fetuses with normal umbilical artery Doppler have suboptimal perinatal and neurodevelopmental outcome. Eur J Obstet Gynecol Reprod Biol. 2008;136:34-8 pubmed
    ..To evaluate the perinatal and neurodevelopmental outcome of small-for-gestational-age fetuses with normal umbilical artery Doppler managed expectantly during pregnancy and delivery...
  7. Dorling J, Kempley S, Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal Ed. 2005;90:F359-63 pubmed
    ..Trials are required to determine the optimum timing for introduction of enteral feeds in growth restricted infants with fetal AREDF...
  8. Albuquerque C, Smith K, Johnson C, Chao R, Harding R. Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows. Early Hum Dev. 2004;80:31-42 pubmed
    ..Cigarette smoking during pregnancy is a major cause of adverse perinatal outcome but effects on critical fetal and maternal circulations remain unclear...
  9. Gortner L, van Husen M, Thyen U, Gembruch U, Friedrich H, Landmann E. Outcome in preterm small for gestational age infants compared to appropriate for gestational age preterms at the age of 2 years: a prospective study. Eur J Obstet Gynecol Reprod Biol. 2003;110 Suppl 1:S93-7 pubmed
    ..To investigate the effects of small for gestational age (SGA) in preterm infants on growth and development until the age of 22 months...
  10. Sebire N, Sepulveda W. Correlation of placental pathology with prenatal ultrasound findings. J Clin Pathol. 2008;61:1276-84 pubmed publisher
  11. Mihatsch W, Pohlandt F, Franz A, Flock F. Early feeding advancement in very low-birth-weight infants with intrauterine growth retardation and increased umbilical artery resistance. J Pediatr Gastroenterol Nutr. 2002;35:144-8 pubmed
  12. Andreani M, Locatelli A, Assi F, Consonni S, Malguzzi S, Paterlini G, et al. Predictors of umbilical artery acidosis in preterm delivery. Am J Obstet Gynecol. 2007;197:303.e1-5 pubmed
    ..The purpose of this study was to investigate the significance of preterm acidosis and its risk factors...
  13. Schlembach D, Wallner W, Sengenberger R, Stiegler E, Mörtl M, Beckmann M, et al. Angiogenic growth factor levels in maternal and fetal blood: correlation with Doppler ultrasound parameters in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Ultrasound Obstet Gynecol. 2007;29:407-13 pubmed
    ..To correlate levels of angiogenic growth factors with Doppler ultrasound parameters in pregnancies complicated by pre-eclampsia and intrauterine growth restriction (IUGR)...
  14. Girsen A, Ala Kopsala M, Mäkikallio K, Vuolteenaho O, Rasanen J. Cardiovascular hemodynamics and umbilical artery N-terminal peptide of proB-type natriuretic peptide in human fetuses with growth restriction. Ultrasound Obstet Gynecol. 2007;29:296-303 pubmed
    ..To test our hypothesis that human fetal N-terminal peptide of proB-type natriuretic peptide (NT-proBNP) secretion is increased in proportion to the severity of fetal cardiovascular compromise in intrauterine growth restriction...
  15. Malhotra N, Chanana C, Kumar S, Roy K, Sharma J. Comparison of perinatal outcome of growth-restricted fetuses with normal and abnormal umbilical artery Doppler waveforms. Indian J Med Sci. 2006;60:311-7 pubmed
    ..To evaluate the role of umbilical artery Doppler in growth- restricted fetuses...
  16. Predanic M, Kolli J, Yousefzadeh P, Pennisi J. Disparate blood flow patterns in parallel umbilical arteries. Obstet Gynecol. 1998;91:757-60 pubmed
    To compare resistance to blood flow between two umbilical arteries at the same cord site during the second half of pregnancy.
  17. Leung T, Tam W, Leung T, Lok I, Lau T. Effect of twin-to-twin delivery interval on umbilical cord blood gas in the second twins. BJOG. 2002;109:63-7 pubmed
    ..To examine the effect of twin-to-twin delivery interval on the umbilical cord blood gas status of the second twin following vaginal delivery...
  18. van den Wijngaard J, Westerhof B, Faber D, Ramsay M, Westerhof N, van Gemert M. Abnormal arterial flows by a distributed model of the fetal circulation. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1222-33 pubmed
    ..and brain resistances, placental compliance, heart rate, stiffness of the arterial wall, and length of the umbilical arteries. The PI increases in the umbilical artery and decreases in the cerebral arteries, as a result of increasing ..
  19. Weissman A, Drugan A. Sonographic findings of the umbilical cord: implications for the risk of fetal chromosomal anomalies. Ultrasound Obstet Gynecol. 2001;17:536-41 pubmed
    ..Therefore, level II prenatal sonography should also include a careful examination of the umbilical cord...
  20. Ellis C, Pymar H, Windrim R, Keating S, Kingdom J. A puzzling intrauterine death: non-compaction of the fetal ventricular myocardium presenting with reversed end-diastolic flow velocity in the umbilical arteries. J Obstet Gynaecol Can. 2005;27:695-8 pubmed
    Absent or reversed end-diastolic flow velocity (ARED) in the umbilical arteries is typically associated with severe intrauterine growth restriction (IUGR), although there may be other causes, such as aneuploidy.
  21. Crispi F, Hernandez Andrade E, Pelsers M, Plasencia W, Benavides Serralde J, Eixarch E, et al. Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol. 2008;199:254.e1-8 pubmed publisher
    ..The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration...
  22. McAdams R, Richardson R. Imaging casebook. Resolution of multiple aortic aneurysms in a neonate. J Perinatol. 2005;25:60-2 pubmed
  23. Ullberg U, Sandstedt B, Lingman G. Hyrtl's anastomosis, the only connection between the two umbilical arteries. A study in full term placentas from AGA infants with normal umbilical artery blood flow. Acta Obstet Gynecol Scand. 2001;80:1-6 pubmed
    The aim of this study was to describe the variable anatomy in the anastomosis between the umbilical arteries for better understanding of the physical characteristics of the umbilical flow velocity waveform (FVW).
  24. Kadner A, Zund G, Maurus C, Breymann C, Yakarisik S, Kadner G, et al. Human umbilical cord cells for cardiovascular tissue engineering: a comparative study. Eur J Cardiothorac Surg. 2004;25:635-41 pubmed
    ..This study evaluates cells isolated from human umbilical cord artery, umbilical cord vein and whole cord as alternative autologous cell sources for cardiovascular tissue engineering...
  25. Spinillo A, Montanari L, Bergante C, Gaia G, Chiara A, Fazzi E. Prognostic value of umbilical artery Doppler studies in unselected preterm deliveries. Obstet Gynecol. 2005;105:613-20 pubmed
    ..To evaluate the prognostic value of umbilical artery Doppler studies in premature deliveries...
  26. Predanic M, Perni S. Antenatal assessment of discordant umbilical arteries in singleton pregnancies. Croat Med J. 2006;47:701-8 pubmed
    ..To assess the relationship between discordant umbilical arterial size and resultant blood flow parameters and determine the impact of discordance on fetal outcome...
  27. Potter S, Dennedy M, Morrison J. Corticosteroids and fetal vasculature: effects of hydrocortisone, dexamethasone and betamethasone on human umbilical artery. BJOG. 2002;109:1126-31 pubmed
    ..To investigate the direct effects of corticosteroids on human umbilical artery resistance, in vitro...
  28. Sezik M, Tuncay G, Yapar E. Prediction of adverse neonatal outcomes in preeclampsia by absent or reversed end-diastolic flow velocity in the umbilical artery. Gynecol Obstet Invest. 2004;57:109-13 pubmed
    ..Therefore, live-born infants of preeclamptic patients with AREDF velocities, independent of prematurity and growth restriction, are prone to hypoglycemia and polycythemia...
  29. Santos Silva A, Cairrão E, Morgado M, Alvarez E, Verde I. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. Eur J Pharmacol. 2008;582:102-9 pubmed publisher
  30. Wienerroither H, Steiner H, Tomaselli J, Lobendanz M, Thun Hohenstein L. Intrauterine blood flow and long-term intellectual, neurologic, and social development. Obstet Gynecol. 2001;97:449-53 pubmed
    ..To study the long-term effects of severely abnormal (absent or reversed diastolic) blood flow in the umbilical artery associated with fetal growth restriction on postnatal intellectual, neurologic, and social development...
  31. Fong K, Ohlsson A, Hannah M, Grisaru S, Kingdom J, Cohen H, et al. Prediction of perinatal outcome in fetuses suspected to have intrauterine growth restriction: Doppler US study of fetal cerebral, renal, and umbilical arteries. Radiology. 1999;213:681-9 pubmed
  32. Baschat A, Gembruch U, Harman C. The sequence of changes in Doppler and biophysical parameters as severe fetal growth restriction worsens. Ultrasound Obstet Gynecol. 2001;18:571-7 pubmed
    ..To test the hypothesis that hemodynamic changes depicted by Doppler precede deteriorating biophysical profile score in severe intrauterine growth restriction...
  33. Locatelli A, Incerti M, Ghidini A, Greco M, Villa E, Paterlini G. Factors associated with umbilical artery acidemia in term infants with low Apgar scores at 5 min. Eur J Obstet Gynecol Reprod Biol. 2008;139:146-50 pubmed publisher
    ..To evaluate predictors of umbilical artery acidemia in term neonates with low Apgar score...
  34. Acharya G, Wilsgaard T, Berntsen G, Maltau J, Kiserud T. Doppler-derived umbilical artery absolute velocities and their relationship to fetoplacental volume blood flow: a longitudinal study. Ultrasound Obstet Gynecol. 2005;25:444-53 pubmed
  35. Sodian R, Lueders C, Kraemer L, Kuebler W, Shakibaei M, Reichart B, et al. Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg. 2006;81:2207-16 pubmed
  36. Ulrich Merzenich G, Metzner C, Bhonde R, Malsch G, Schiermeyer B, Vetter H. Simultaneous isolation of endothelial and smooth muscle cells from human umbilical artery or vein and their growth response to low-density lipoproteins. In Vitro Cell Dev Biol Anim. 2002;38:265-72 pubmed
    ..Further differences of venous and arterial ECs in tolerance toward minimal oxLDLs could be of clinical relevance for coronary artery bypass grafts...
  37. Kocylowski R, Dubiel M, Gudmundsson S, Sieg I, Fritzer E, Alkasi O, et al. Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood. Am J Obstet Gynecol. 2009;200:273.e1-273.e25 pubmed publisher
    ..We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal...
  38. Marconi A, Ronzoni S, Vailati S, Bozzetti P, Morabito A, Battaglia F. Neonatal morbidity and mortality in intrauterine growth restricted (IUGR) pregnancies is predicated upon prenatal diagnosis of clinical severity. Reprod Sci. 2009;16:373-9 pubmed publisher
    ..The data confirm that the classification of clinical severity of intrauterine growth restriction based on biophysical parameters is clinically relevant to predict neonatal outcome...
  39. Kerdjoudj H, Berthelemy N, Rinckenbach S, Kearney Schwartz A, Montagne K, Schaaf P, et al. Small vessel replacement by human umbilical arteries with polyelectrolyte film-treated arteries: in vivo behavior. J Am Coll Cardiol. 2008;52:1589-97 pubmed publisher
    The aim of this study was to evaluate the patency of human umbilical arteries treated with polyelectrolyte multilayers (PEMs) after rabbit implantation.
  40. Dennedy M, Houlihan D, McMillan H, Morrison J. Beta2- and beta3-adrenoreceptor agonists: human myometrial selectivity and effects on umbilical artery tone. Am J Obstet Gynecol. 2002;187:641-7 pubmed
    ..This study also aimed comparatively to evaluate the in vitro effects of BRL 37344 and ritodrine on human vascular tissue tone...
  41. Yildiz O, Nacitarhan C, Seyrek M. Potassium channels in the vasodilating action of levosimendan on the human umbilical artery. J Soc Gynecol Investig. 2006;13:312-5 pubmed
    ..We investigated the type of potassium channels that play a role on the dilatating effect of levosimendan on the contractile tones of the isolated human umbilical artery (HUA)...
  42. Sergent F, Lefevre A, Verspyck E, Marpeau L. [Decreased fetal movements in the third trimester: what to do?]. Gynecol Obstet Fertil. 2005;33:861-9 pubmed
    ..To appreciate at the end of pregnancy, in a low-risk pregnant population, the interest of a screening for fetal well-being in case of decreased fetal movements. To define the most adapted screening...
  43. Gui L, Muto A, Chan S, Breuer C, Niklason L. Development of decellularized human umbilical arteries as small-diameter vascular grafts. Tissue Eng Part A. 2009;15:2665-76 pubmed publisher
    ..This study was conducted to develop a decellularized umbilical artery and to evaluate its composition, endothelial cell compatibility, mechanical properties, and in vivo stability for potential use as a small-diameter vascular graft...
  44. Martín de Llano J, Fuertes G, Torro I, Garcia Vicent C, Fayos J, Lurbe E. Birth weight and characteristics of endothelial and smooth muscle cell cultures from human umbilical cord vessels. J Transl Med. 2009;7:30 pubmed publisher
    ..Further follow-up studies could show the association of those vascular properties with infancy and adulthood blood pressure...
  45. Harville E, Savitz D, Dole N, Herring A, Thorp J, Light K. Stress and placental resistance measured by Doppler ultrasound in early and mid-pregnancy. Ultrasound Obstet Gynecol. 2008;32:23-30 pubmed publisher
    ..reports and biomarkers of stress and placental resistance (measured by Doppler ultrasound of the uterine and umbilical arteries), to determine if restriction of blood flow to the placenta is a mechanism by which stress might affect ..
  46. Haugen G, Helland I. Influence of preeclampsia or maternal intake of omega-3 fatty acids on the vasoactive effect of prostaglandin F-two-alpha in human umbilical arteries. Gynecol Obstet Invest. 2001;52:75-81 pubmed
    The vasoactive effect of prostaglandin F(2alpha) (PGF(2alpha)) was studied in in vitro perfused human umbilical arteries following maternal dietary supplementation with omega-3 fatty acids or in pregnancies complicated by a moderate ..
  47. Viero S, Chaddha V, Alkazaleh F, Simchen M, Malik A, Kelly E, et al. Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries. Placenta. 2004;25:735-41 pubmed
    ..abnormal fetoplacental blood flow (defined by absent or reversed end-diastolic flow velocities [ARED] in the umbilical arteries) before 32 weeks of gestation...
  48. Acharya G, Erkinaro T, Mäkikallio K, Lappalainen T, Rasanen J. Relationships among Doppler-derived umbilical artery absolute velocities, cardiac function, and placental volume blood flow and resistance in fetal sheep. Am J Physiol Heart Circ Physiol. 2004;286:H1266-72 pubmed
    ..In fetal sheep, Doppler-derived UA PI and absolute velocities, except PSV, are closely related to directly measured Q(UA) and R(UA), validating the use of noninvasive Doppler velocimetry in the assessment of placental circulation...
  49. Bhatt A, Tank P, Barmade K, Damania K. Abnormal Doppler flow velocimetry in the growth restricted foetus as a predictor for necrotising enterocolitis. J Postgrad Med. 2002;48:182-5; discussion 185 pubmed
    ..Necrotising Enterocolitis (NEC) results from continued exposure to hostile environment and is an important cause of poor neonatal outcome...
  50. Karsdorp V, van Vugt J, van Geijn H, Kostense P, Arduini D, Montenegro N, et al. Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery. Lancet. 1994;344:1664-8 pubmed
    ..A caesarean section is recommended in all pregnancies complicated by ARED flow if the gestational age and predicted neonatal weight can be handled by the local neonatal intensive care unit...
  51. Reglodi D, Gyarmati J, Ertl T, Borzsei R, Bodis J, Tamas A, et al. Alterations of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in the human plasma during pregnancy and after birth. J Endocrinol Invest. 2010;33:443-5 pubmed
    ..It is unknown whether PACAP has any effect on human pregnancy regarding either utero-maternal or perinatal aspects of the gestation...
  52. El Azreq M, Bourgoin S. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through ?2 integrin activation. Mol Immunol. 2011;48:1408-16 pubmed publisher
    ..We suggest that cytohesin-1 is a key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on ?2 and ?1 integrin activation...
  53. Kalache K, Dückelmann A. Doppler in obstetrics: beyond the umbilical artery. Clin Obstet Gynecol. 2012;55:288-95 pubmed publisher
    ..Early pregnancy uterine artery Doppler reflects the status of the placental vasculature and, as such, is an excellent tool for predicting the risk of preeclampsia or intrauterine growth restriction...