cardiovascular diseases

DESCRIPTION (provided by applicant): Among cardiovascular diseases, coronary artery disease (CAD) is the leading cause of death in the United States, and South Asians (people whose ancestral origin is in the Indian subcontinent i.e...

..focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is ..

..focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is ..

..of biological variables and by usingas outcomes the age-specific incidence of critical diseases (cardiovascular diseases, dementia, fractures etc...

..it may aid future development of specific therapeutic strategies against hypercholesterolemia and related cardiovascular diseases. PUBLIC HEALTH RELEVANCE: Bile acids play an invaluable role in the intestinal absorption of food-derived ..

..that oxidative stress, a state of excessive reactive oxygen species (ROS) activity, is associated with cardiovascular diseases, such as hypertension...

..disrupts these regulatory mechanisms, and is a potential factor in the development of a number of cardiovascular diseases including pulmonary hypertension...

..Abnormalities of vascular tone are a hallmark of atherosclerotic cardiovascular diseases and hypertension...

..epidemic proportions in the United States and is closely linked to type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD)...

..Abnormalities of vascular tone are a hallmark of atherosclerotic cardiovascular diseases and hypertension...

..Overall, more than 6 million hospitalizations occur each year for treatment of cardiovascular diseases. Consequently, the economic impact of cardiovascular diseases on our nation's health care system ..

..Depressive symptoms, hostility, and stressful conditions are associated with cardiovascular diseases (CVD), but systematic investigation of these factors in relation to stroke incidence and mortality has ..

..Depressive symptoms, hostility, and stressful conditions are associated with cardiovascular diseases (CVD), but systematic investigation of these factors in relation to stroke incidence and mortality has ..

..oxide (NO) of endothelial nitric oxide synthase (eNOS), such as peroxynitrite (ONOO-), are important in cardiovascular diseases including diabetes...

DESCRIPTION (provided by applicant): Hypertension remains as a major risk factor for a multitude of cardiovascular diseases, and as such it is responsible for significant morbidity and mortality...

..provided by applicant): Patients with type 2 diabetes mellitus (T2DM) are more likely to die from cardiovascular diseases (CVD) than people without diabetes...

..these variants promise to illuminate the pathophysiologic basis of diabetes and diabetes related cardiovascular diseases, accelerate the development of chemopreventive agents, and facilitate the conduct of prevention trials by ..

..This cohort is ideally suited for investigating a) genetic risk factors underlying a wide spectrum of cardiovascular diseases, and b) the relationship between DMA variants and well defined environmental and life style variables...

..This cohort is ideally suited for investigating a) genetic risk factors underlying a wide spectrum of cardiovascular diseases, and b) the relationship between DMA variants and well defined environmental and life style variables...

DESCRIPTION (provided by applicant): Cardiovascular diseases, which result from thrombosis of critically situated blood vessels, are a leading cause of deaths...

..widely used in research studies, as well as in clinical practice to diagnose both cardiovascular and non-cardiovascular diseases to track its progression and to assess the efficacy of therapies...

DESCRIPTION (provided by applicant): Cardiovascular diseases, which result from thrombosis of critically situated blood vessels, are a leading cause of deaths...

..Most cardiovascular diseases, notably hypertension, involve pathogenic dysfunction of the autonomic nervous system...

..widely used in research studies, as well as in clinical practice to diagnose both cardiovascular and non-cardiovascular diseases to track its progression and to assess the efficacy of therapies...

..is the medical term for the process of pathologic blood clot formation, the key mechanism behind many cardiovascular diseases. For example, deep vein thrombosis (DVT) is a condition which affects nearly two million Americans ..

..Most cardiovascular diseases, notably hypertension, involve pathogenic dysfunction of the autonomic nervous system...

DESCRIPTION (provided by applicant): Project Summary This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, M.D...

..These studies will yield potential targets for the development of new drug therapies. Public Health Relevance: This Public Health Relevance is not available...

..where iron deficiency causes anemia, while an excess of iron results in hemochromatosis, both serious cardiovascular diseases. In Saccharomyces cerevisiae, genes encoding iron transporters and iron uptake facilitators are activated ..

Smooth muscle contractile state determines vascular tone, and ischemic and hypertensive cardiovascular diseases arise in part from abnormalities in smooth muscle cell function...

..Altered NE transport is documented in cardiovascular diseases and brain disorders...

..Altered NE transport is documented in cardiovascular diseases and brain disorders...

Heart failure represents the results of a variety of cardiovascular diseases in which the initial insult to the myocardium may either be identifiable, such as a myocardial infarction, or unknown, such as in dilated cardiomyopathy...

..Elevated levels of homocysteine constitute a risk factor for cardiovascular diseases, certain neurodegenerative diseases (viz...

DESCRIPTION (provided by applicant): Project Summary This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, M.D...

DESCRIPTION (provided by applicant): Cardiovascular diseases (CVD) are the major causes of morbidity and mortality in the US and their risks are determined by non-modifiable (i.e., genetic) and modifiable factors (i.e...

..Elevated levels of homocysteine constitute a risk factor for cardiovascular diseases, certain neurodegenerative diseases (viz...

..of reactive oxygen species that are implicated in the etiology of multiple and complex diseases such as cardiovascular diseases, Alzheimer's disease, Parkinson's disease, arthritis, certain cancers as well as in aging and apoptosis...

..Dysregulation of bile acid metabolism causes dyslipidemia, gallstone, liver, and cardiovascular diseases, and diabetes...

..Dysregulation of bile acid metabolism causes dyslipidemia, gallstone, liver, and cardiovascular diseases, and diabetes...

..Bile acids are involved in liver, biliary, intestinal, and cardiovascular diseases. FXR is a bile-acid activated nuclear receptor and is essential in maintaining bile-acid homeostasis...

DESCRIPTION (provided by applicant): Cardiovascular diseases remain the major cause of morbidity and mortality in United States. It is estimated that 12...

..interest in CAM education has been accelerated by the work of the NIH-funded CAM Research Center for Cardiovascular Diseases. Strong collaborative relationships have developed within the Medical School, between the Medical School ..

..to be a common thread connecting the etiologies of various complex and multifactorial diseases, such as cardiovascular diseases, Parkinson's disease, Alzheimer's disease, arthritis and some cancers...

..to be a common thread connecting the etiologies of various complex and multifactorial diseases, such as cardiovascular diseases, Parkinson's disease, Alzheimer's disease, arthritis and some cancers...

DESCRIPTION (provided by applicant): Cardiovascular diseases (CVD) are the major causes of morbidity and mortality in the US and their risks are determined by non-modifiable (i.e., genetic) and modifiable factors (i.e...

..control systems, and 2) it focuses mainly on long-term control of the circulation because many cardiovascular diseases, such as hypertension, are manifestations of abnormal control mechanisms that develop slowly over long ..

..Our focus is on the genetics and genomics of vascular remodeling during common, complex cardiovascular diseases and during premature aging syndromes...

..a critical problem in an increasing number of diseases lacking effective treatments, including cancer and cardiovascular diseases. Before logically designing effective preventive and therapeutic strategies targeting unregulated NO ..

..Elastin degeneration and calcification occurs in a number of cardiovascular diseases including arteriosclerosis, calcific aortic stenosis, bioprosthetic heart valve calcification, human ..

..Statins are a class of cholesterol-lowering drugs that have been used successfully to prevent cardiovascular diseases. Recently, retrospective studies have shown an apparent reduction of risk for Alzheimer's disease in ..

..Elastin degeneration and calcification occurs in a number of cardiovascular diseases including arteriosclerosis, calcific aortic stenosis, bioprosthetic heart valve calcification, human ..

..by which fetal adaptations to maternal obesity and/or being born LGA increase the risk for developing cardiovascular diseases. Our global hypothesis is that the offspring of obese mothers have permanent alterations in adipose ..

..Perturbations of these signaling pathways have been implicated in a number of prevalent human cardiovascular diseases including congenital cardiac malformations, pathologic cardiac hypertrophy, and dilated cardiomyopathy...

..risk factor for markers of cardiovascular disease risk (Jakes et al, 2003) and the development of cardiovascular diseases (Sidney et al, 1996)...

..risk factor for markers of cardiovascular disease risk (Jakes et al, 2003) and the development of cardiovascular diseases (Sidney et al, 1996)...

..agents has dramatically increased due to the presumed beneficial effects of phytoestrogens in preventing cardiovascular diseases and cancer...

..the Molecular Cardiology Research Institute (MCRI) at the Tufts-New England Medical Center are studying cardiovascular diseases with the goal of identifying new diagnostic tools and treatments that can be used to improve the ..

..In addition, they have been shown to be associated with other health complications such as cardiovascular diseases, diabetes, and preterm low birth weight babies. Both P. gingivalis and Prev...

..In addition, they have been shown to be associated with other health complications such as cardiovascular diseases, diabetes, and preterm low birth weight babies. Both P. gingivalis and Prev...

..68-3.17) and 3.48 (95% CI: 2.52-4.81), respectively. CONCLUSIONS: Blood pressure, when not optimal, is the predominant predictor of hypertension. The metabolic syndrome contributes to the risk, especially when blood pressure is optimal...

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..The metabolic syndrome is common in patients receiving lipid-lowering therapy in an office-based setting. Three recent definitions resulted in similar estimates of its prevalence...

..Greater cardiovascular risk factor expression in overweight males 11 years and older may explain the earlier appearance of cardiovascular disease end points in overweight men...

..CONCLUSIONS: There are some indications that WHtR or WC may predict prevalent cardiovascular risk better than BMI or WHR, even though the differences are small...

..These finding suggest that these risk factors do cluster and obesity and insulin resistance were suggested to be linked with metabolic syndrome more than hypertension or high triglyceride...

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..6%). CONCLUSIONS: The prevalence of cardiovascular risk factors was high in Morocco and it is necessary to increase action against the cardiovascular diseases and their risk factors.

..Other predictors of abnormal albuminuria included diabetes, blood pressure, and triglyceride level. CONCLUSION: Results of this study suggest that HT is associated with a reduction in urinary albumin excretion in postmenopausal women...

..Clinical depression can be a manifestation of obesity. An overview of the prevalence and non-conservative clinical management is given...

..85 (95%CI 1.19-2.89) and 2.59 (95%CI 1.41-4.74), respectively). CONCLUSIONS: For most elderly with diabetes cardiovascular risk factor management continues to be not in line with recommendations...

..These findings can help design health policy for the early detection of chronic disease in different ethnic Chinese groups...

..CONCLUSION: Increasing snoring frequency was associated with an increasing prevalence of risk factors and self-reported vascular disease. Snoring may a useful marker for increased risk of vascular disease...

..Despite the significant associations of CRP and carotid atherosclerosis with CVD, these measures modestly improve the prediction of CVD outcomes after one accounts for the conventional risk factors...

..OW and HT are by far most common and are likely to aggregate with each other. A small modification of these two factors would reduce the incidence of stroke and myocardial infarction significantly...

..Additionally, women on the lower end of the socioeconomic spectrum were less likely to return for repeat visits, suggesting that further investigation is needed to understand why these women fail to return for screening services...

..The RIAHD study emphasizes the importance of performing a more extended RF assessment in hypertensive patients with as well as without diabetes and/or micro/macroalbuminuria in order to expose the full RF profile...

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..Various economic analyses indicate that global CMR should be reduced to control costs in this population. Newer antihyperglycemic agents with a favorable overall metabolic profile may offer a cost-effective approach to managing diabetes...

..Our data support using lower BMI and WC levels to define obesity and its associated health risks rather than using the criteria established from Caucasians who generally have larger body frames...

..CONCLUSION: These data demonstrate that numerous baseline characteristics are associated with suboptimal control of these cardiovascular risk factors among overweight and obese adults with diabetes...

..We would propose that light to moderate alcohol consumption should not be discouraged in the severely obese...

..Additional therapeutic agents are currently being developed specifically to improve INS sensitivity and other CVD risk factors that are components of the cardiometabolic syndrome...

..S. independent of the cost of cardiovascular disease. Individuals, private insurers, Medicare, Medicaid, the Veterans Administration, and other payers all share this burden...

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..The atherogenic mixed dyslipidaemic profile associated with the metabolic syndrome is an important target for intervention to reduce the risk of type 2 diabetes and premature cardiovascular disease...

..While pharmacotherapy appears promising, additional evidence is needed, especially with respect to the long-term impact, before it becomes a widespread treatment option in the pediatric population...

..The most recent updates in the area of medical management, as well as updates of recommendations for lifestyle changes, including physical activity and dietary recommendations for older persons at risk, are presented in this article...

..This review focuses on the controversy surrounding the potential relationship between cardiovascular disease outcomes and polycystic ovary syndrome...

..It may also be a feasible, non-invasive method for the detection and prevention of the macrovascular complications of diabetes...

..A cluster of metabolic abnormalities attributable to insulin resistance appears more likely to contribute to cataract formation than any individual cardiovascular risk factor alone...

..This review recommends a framework for the assessment, monitoring and management of patients with schizophrenia in the UK clinical setting...

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..This study has shown that ED is associated with low bioavailable and free testosterone levels, age, visceral adiposity and hypertension in type 2 diabetic men...

..mass index was related to increased prevalence of HT and close associations were observed between HT and cardiovascular diseases. Our data also show a linear upward trend in blood pressure from normal glucose metabolism to diabetes ..

..However, none of them alone was a good screening tool for CVD risk factors. Therefore, how to apply AI prudently to screen elderly for CVD risk factors needs further research...

..Thus, these women are at increased risk of diabetes mellitus and cardiovascular disease...

..Given the difficulty of using age-adjusted associations in the clinical setting, these results suggest that given appropriate cut-off points, WHR is the most useful measure of obesity to use to identify individuals with CVD risk factors...

..Additional cultural and demographic variables need to be considered to improve adherence to lifestyle measures...

..Waist circumference, a practical tool that had a higher discriminant ability than BMI in identifying presence or absence of all these risk factors, appears as the best screening tool in this population...

..The findings emphasise the scale of the CVD epidemic in Ireland and the need for ongoing monitoring of risk factors at the population level and the need to develop preventive strategies at both the clinical and societal level...

..These results emphasize the need to develop an urgent public program to improve the detection, prevention, and treatment of diabetes...

..Only a stricter adherence to the existing guidelines and a much stronger attention to the attainment of the desired therapeutic goals will allow a decrease in morbidity and mortality as well as in the costs related to diabetes...

..Weight loss intervention for obese patients, including patient education or referral to weight loss programs, might be effective for prevention of pre-hypertension and thus should be considered as a potential quality indicator...

..Increasing adjusted waist circumference was associated with increased risk of hypertension and diabetes in Chinese and dyslipidemia in women only...

..In conclusion, secular trends in many obesity-related health indicators among 70-year old Swedish cohorts were dependent on both gender and socio-economic factors...