sterol esterase

Summary

Summary: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.

Top Publications

  1. Amor Salamanca A, Castillo S, Gonzalez Vioque E, Dominguez F, Quintana L, Lluís Ganella C, et al. Genetically Confirmed Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome. J Am Coll Cardiol. 2017;70:1732-1740 pubmed publisher
    ..FH clinical algorithms do not accurately classify patients with FH. Genetic testing should be advocated in young patients with ACS and high LDL-C levels to allow prompt identification of patients with FH and relatives at risk. ..
  2. Smith T, McNamara J. Regulation of bovine adipose tissue metabolism during lactation. 6. Cellularity and hormone-sensitive lipase activity as affected by genetic merit and energy intake. J Dairy Sci. 1990;73:772-83 pubmed
    ..Activity per cell and per milligram cytoplasm protein increased in all groups in early lactation and were highest in high line animals fed the low energy ration. ..
  3. Poinsot P, Collardeau Frachon S, Restier L, Serusclat A, Di Filippo M, Charriere S, et al. Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases. J Clin Lipidol. 2017;11:167-177.e3 pubmed publisher
    ..43 mm). Late-onset LALD is a rare metabolic disease with a larger impact than liver disease. Our work shows the importance of having a global metabolic view and to evaluate the cardiovascular impact of the new enzymatic treatment. ..
  4. Wu J, Preuss C, Wang S, Yang H, Ji B, Carter G, et al. Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice. PLoS Genet. 2017;13:e1006716 pubmed publisher
    ..DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset malignant disease. ..
  5. Gopakumar K, Thankamony P, Nampoothiri S, Bali D, Raj J, A Vasudevan J, et al. Wolman Disease: A Mimic of Infant Leukemia. J Pediatr Hematol Oncol. 2017;39:e489-e492 pubmed publisher
    ..1180_1184del" in the last exon (exon 10) of the lipase A (LIPA) gene. Hepatosplenomegaly and pallor resulting from nutritional deficiency or bone marrow involvement in Wolman disease can mimic infant leukemia. ..
  6. Zhang H, Shi J, Hachet M, Xue C, Bauer R, Jiang H, et al. CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:2156-2160 pubmed publisher
    ..CRISPR/Cas9 and IPSDM provide important tools to study human macrophage biology and more broadly for future studies of disease-associated LIPA genetic variation in human macrophages. ..
  7. Morris G, Braund P, Moore J, Samani N, Codd V, Webb T. Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes. Arterioscler Thromb Vasc Biol. 2017;37:1050-1057 pubmed publisher
  8. Bergan Roller H, Ickstadt A, Kittilson J, Sheridan M. Insulin and insulin-like growth factor-1 modulate the lipolytic action of growth hormone by altering signal pathway linkages. Gen Comp Endocrinol. 2017;248:40-48 pubmed publisher
    ..g., nutritional), developmental, or other conditions. ..
  9. Demine S, Tejerina S, Bihin B, Thiry M, Reddy N, Renard P, et al. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. J Cell Physiol. 2018;233:1247-1265 pubmed publisher
    ..This new mechanism of triacylglycerol breakdown in adipocytes exposed to mild uncoupling provides new insights on the biology of adipocytes dealing with mitochondria forced to dissipate energy. ..

More Information

Publications13

  1. Schott M, Rasineni K, Weller S, Schulze R, Sletten A, Casey C, et al. ?-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure. J Biol Chem. 2017;292:11815-11828 pubmed publisher
    ..In summary, these findings suggest that ?-AR stimulation mobilizes cytosolic lipases for LD breakdown in hepatocytes, and perturbation of this pathway could be a major consequence of chronic EtOH insult leading to fatty liver. ..
  2. Tuohetahuntila M, Molenaar M, Spee B, Brouwers J, Wubbolts R, Houweling M, et al. Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. J Biol Chem. 2017;292:12436-12448 pubmed publisher
    ..Our data suggest that LAL/Lipa is involved in the degradation of a specific preexisting pool of LDs and that inhibition of this pathway attenuates HSC activation. ..
  3. Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Terayama K, Nagaoka N, et al. Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor. Bioorg Med Chem. 2017;25:4817-4828 pubmed publisher
    ..o., which indicated that this novel compound is the most potent orally active HSL inhibitor. Moreover, compound 25a did not show bioactivation liability. ..
  4. Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher
    ..The reduction in TAG content following Zn addition was attributable to reduced lipogenesis and increased lipolysis, and similar regulatory mechanisms were observed between the fore- and mid-intestine. ..