Genomes and Genes
Summary: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
- Schott M, Rasineni K, Weller S, Schulze R, Sletten A, Casey C, et al. ?-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure. J Biol Chem. 2017;292:11815-11828 pubmed publisher..In summary, these findings suggest that ?-AR stimulation mobilizes cytosolic lipases for LD breakdown in hepatocytes, and perturbation of this pathway could be a major consequence of chronic EtOH insult leading to fatty liver. ..
- Tuohetahuntila M, Molenaar M, Spee B, Brouwers J, Wubbolts R, Houweling M, et al. Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. J Biol Chem. 2017;292:12436-12448 pubmed publisher..Our data suggest that LAL/Lipa is involved in the degradation of a specific preexisting pool of LDs and that inhibition of this pathway attenuates HSC activation. ..
- Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Terayama K, Nagaoka N, et al. Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor. Bioorg Med Chem. 2017;25:4817-4828 pubmed publisher..o., which indicated that this novel compound is the most potent orally active HSL inhibitor. Moreover, compound 25a did not show bioactivation liability. ..
- Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher..The reduction in TAG content following Zn addition was attributable to reduced lipogenesis and increased lipolysis, and similar regulatory mechanisms were observed between the fore- and mid-intestine. ..