group vi phospholipases a2


Summary: A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodeling and homeostasis by controling the levels of PHOSPHATIDYLCHOLINE in mammalian cell membranes.

Top Publications

  1. Atsumi G, Murakami M, Kojima K, Hadano A, Tajima M, Kudo I. Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2alpha inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+-indep. J Biol Chem. 2000;275:18248-58 pubmed
  2. Mallat Z, Lambeau G, Tedgui A. Lipoprotein-associated and secreted phospholipases A? in cardiovascular disease: roles as biological effectors and biomarkers. Circulation. 2010;122:2183-200 pubmed publisher
  3. Kerr D, Talib L, Yamamoto V, Ferreira A, Zanetti M, Serpa M, et al. Antipsychotic drugs decrease iPLA2 gene expression in schizophrenia. Schizophr Res. 2013;147:203-204 pubmed publisher
  4. Liu G, Moon S, Jenkins C, Li M, Sims H, Guan S, et al. The phospholipase iPLA2? is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling. J Biol Chem. 2017;292:10672-10684 pubmed publisher
    ..Collectively, these results demonstrate the integrated roles of CL and iPLA2? in lipid second-messenger production and mitochondrial bioenergetics during oxidative stress. ..
  5. Dastsooz H, Nemati H, Fard M, Fardaei M, Faghihi M. Novel mutations in PANK2 and PLA2G6 genes in patients with neurodegenerative disorders: two case reports. BMC Med Genet. 2017;18:87 pubmed publisher