ribose

Summary

Summary: A pentose active in biological systems usually in its D-form.

Top Publications

  1. Wilkinson K, Vasa S, Deigan K, Mortimer S, Giddings M, Weeks K. Influence of nucleotide identity on ribose 2'-hydroxyl reactivity in RNA. RNA. 2009;15:1314-21 pubmed publisher
    ..anhydride (1M7), are broadly useful for RNA structure analysis because they react preferentially with the ribose 2'-OH group at conformationally unconstrained or flexible nucleotides...
  2. Kun E, Kirsten E, Hakam A, Bauer P, Mendeleyev J. Dependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1. FEBS Lett. 2008;582:2709-13 pubmed publisher
    The H-bonded complex of ATP with Arg 34 of Zn2+ finger I of poly-ADP-ribose polymerase-1 (PARP-1) determines trans-oligo-ADP-ribosylation from NAD+ to proteins other than PARP-1...
  3. Dunne L, Worley S, Macknin M. Ribose versus dextrose supplementation, association with rowing performance: a double-blind study. Clin J Sport Med. 2006;16:68-71 pubmed
    It has been hypothesized that ribose supplementation rapidly replenishes adenosine triphosphate stores and thereby improves exercise performance. We compared the effects of ribose versus dextrose on rowing performance...
  4. Cuzic S, Heidemann K, Wöhnert J, Hartmann R. Escherichia coli RNase P RNA: substrate ribose modifications at G+1, but not nucleotide -1/+73 base pairing, affect the transition state for cleavage chemistry. J Mol Biol. 2008;379:1-8 pubmed publisher
    ..We show, for the first time, that these ribose modifications at nucleotide +1 increase the activation energy and alter the activation parameters for the ..
  5. Seifert J, Subudhi A, Fu M, Riska K, John J, Shecterle L, et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009;12:690-3 pubmed publisher
    ..We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production ..
  6. Griffiths J, Borzelleca J, St Cyr J. Sub-chronic (13-week) oral toxicity study with D-ribose in Wistar rats. Food Chem Toxicol. 2007;45:144-52 pubmed
    The present study evaluated the toxicity from sub-chronic administration of D-ribose (DR) to male and female albino Wistar rats...
  7. Kerksick C, Rasmussen C, Bowden R, Leutholtz B, Harvey T, Earnest C, et al. Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers. Int J Sport Nutr Exerc Metab. 2005;15:653-64 pubmed
    This study examined whether ribose supplementation before and during intense anaerobic exercise impacts anaerobic capacity and metabolic markers. Twelve moderately trained male cyclists (22.3 +/- 2.2 y; 181 +/- 6 cm, 74...
  8. Han C, Lu Y, Wei Y, Liu Y, He R. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS ONE. 2011;6:e24623 pubmed publisher
    D-ribose, an important reducing monosaccharide, is highly active in the glycation of proteins, and results in the rapid production of advanced glycation end products (AGEs) in vitro...
  9. Cramer J, Housh T, Johnson G, Coburn J, Stout J. Effects of a carbohydrate-, protein-, and ribose-containing repletion drink during 8 weeks of endurance training on aerobic capacity, endurance performance, and body composition. J Strength Cond Res. 2012;26:2234-42 pubmed publisher
    This study compared a carbohydrate-, protein-, and ribose-containing repletion drink vs. carbohydrates alone during 8 weeks of aerobic training...

More Information

Publications62

  1. Belanger F, Stepinski J, Darzynkiewicz E, Pelletier J. Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. J Biol Chem. 2010;285:33037-44 pubmed publisher
    ..yeast mRNAs have no additional modifications to the cap, called cap0, higher eukaryotes are methylated at the 2'-O-ribose of the first or the first and second transcribed nucleotides, called cap1 and cap2, respectively...
  2. Shecterle L, Terry K, St Cyr J. The patented uses of D-ribose in cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 2010;5:138-42 pubmed
    ..However, D-ribose, a natural occurring carbohydrate, has demonstrated significant enhancing abilities in replenishing deficient ..
  3. Hamm S, Latz E, Hangel D, Muller T, Yu P, Golenbock D, et al. Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology. 2010;215:559-69 pubmed publisher
    ..Selective 2'-O-ribose methylation of sense or antisense strand can abolish the immunostimulatory potential, however, no universal ..
  4. Teitelbaum J, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006;12:857-62 pubmed
    ..As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, this open-label uncontrolled ..
  5. Herrick J, Shecterle L, St Cyr J. D-ribose--an additive with caffeine. Med Hypotheses. 2009;72:499-500 pubmed publisher
    ..The results of these investigations have produced no positive consensus. However, D-ribose, an important pentose carbohydrate in the energy molecule of adenosine triphosphate, as well as our genetic code ..
  6. Pitaru S, Noff M, Blok L, Nir E, Pitaru S, Goldlust A, et al. Long-term efficacy of a novel ribose-cross-linked collagen dermal filler: a histologic and histomorphometric study in an animal model. Dermatol Surg. 2007;33:1045-54; discussion 1054 pubmed
    ..This study assessed the functional longevity of a new ribose-cross-linked collagen filler during 24 months in an animal model...
  7. Hassa P, Hottiger M. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2008;13:3046-82 pubmed
    Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes, such as maintenance of genomic stability, transcriptional regulation, energy metabolism and cell death...
  8. Zust R, Cervantes Barragan L, Habjan M, Maier R, Neuman B, Ziebuhr J, et al. Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol. 2011;12:137-43 pubmed publisher
    The 5' cap structures of higher eukaryote mRNAs have ribose 2'-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2'-O-methyltransferases to autonomously modify their mRNAs...
  9. Chen K, Lu C, Cheng H, Chen S, Hu C, Wu A. A pyrenyl-appended triazole-based ribose as a fluorescent sensor for Hg2+ ion. Carbohydr Res. 2010;345:2557-61 pubmed publisher
    For the efficient detection of toxic trace metal ions, two pyrenyl-appended triazole-based d-ribose fluorescent chemosensors 6 and 7 were prepared and their fluoroionophoric properties toward transition metal ions were investigated...
  10. Yoon R, Yeom S, Kim H, Oh D. Novel substrates of a ribose-5-phosphate isomerase from Clostridium thermocellum. J Biotechnol. 2009;139:26-32 pubmed publisher
    A substrate specificity study of the recombinant D-ribose-5-phosphate isomerase (RpiB) from Clostridium thermocellum was performed...
  11. Suardiaz R, Sahakyan A, Vendruscolo M. A geometrical parametrization of C1'-C5' RNA ribose chemical shifts calculated by density functional theory. J Chem Phys. 2013;139:034101 pubmed publisher
    ..nucleic acids, we present an equation that relates the structural parameters and the (13)C chemical shifts of the ribose group...
  12. Esguerra J, Warringer J, Blomberg A. Functional importance of individual rRNA 2'-O-ribose methylations revealed by high-resolution phenotyping. RNA. 2008;14:649-56 pubmed publisher
    ..Despite their evolutionary conservation, the functional role of individual 2'-O-ribose methylations in rRNA is not known...
  13. Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, et al. Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition. 2008;24:233-8 pubmed publisher
    We examined the effects of administering two different candidate antifatigue substances, caffeine and D-ribose, on mental fatigue...
  14. Fatima S, Jairajpuri D, Saleemuddin M. A procedure for the rapid screening of Maillard reaction inhibitors. J Biochem Biophys Methods. 2008;70:958-65 pubmed
    ..order to speed up glycation, the reaction was carried out at 60 degrees C using a thermostable protein RNase and ribose, a sugar that is known to react rapidly than glucose in the glycation reaction...
  15. Feinberg J, Joseph S. Ribose 2'-hydroxyl groups in the 5' strand of the acceptor arm of P-site tRNA are not essential for EF-G catalyzed translocation. RNA. 2006;12:580-8 pubmed
    ..This suggests that either these 2'-hydroxyl groups are not important for translocation or they are redundant and the three-dimensional shape of the P-site tRNA is more important for translocation. ..
  16. Lin J, Lai S, Jia R, Xu A, Zhang L, Lu J, et al. Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. Nature. 2011;469:559-63 pubmed publisher
    ..binds to an undistorted A-form structure of the guide-substrate duplex and specifically loads the target ribose into the active site...
  17. Kasinskas R, Forbes N. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 2007;67:3201-9 pubmed
    ..the aspartate receptor initiated chemotaxis toward cylindroids, the serine receptor initiated penetration, and the ribose/galactose receptor directed S. typhimurium toward necrosis...
  18. Jain R, Shuman S. Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase. RNA. 2011;17:429-38 pubmed publisher
    ..Clostridium thermocellum Hen1 (CthHen1) is a manganese-dependent RNA ribose 2'O-methyltransferase that marks the 3' terminal nucleoside of broken RNAs and protects repair junctions from ..
  19. Thakur C, Sama J, Jackson M, Chen B, Dayie T. Selective 13C labeling of nucleotides for large RNA NMR spectroscopy using an E. coli strain disabled in the TCA cycle. J Biomol NMR. 2010;48:179-92 pubmed publisher
    ..For DL323 E. coli grown in (13)C-2-glycerol without labeled formate, all the ribose carbon atoms are labeled except the C3' and C5' carbon positions...
  20. Yan H, Harding J. Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate. Mol Vis. 2006;12:205-14 pubmed
    ..alphaL-crystallin was incubated with different concentrations of fructose 6-phosphate (F6P) and ribose with or without carnosine for different times...
  21. Nakamura A, Sasaki F, Watanabe K, Ojima T, Ahn D, Saeki H. Changes in allergenicity and digestibility of squid tropomyosin during the Maillard reaction with ribose. J Agric Food Chem. 2006;54:9529-34 pubmed
    ..When TM was reacted with ribose (TM-ribose), its human-specific IgE-binding ability decreased markedly and alpha-chymotryptic digestibility of TM ..
  22. Peacock H, Fucini R, Jayalath P, Ibarra Soza J, Haringsma H, Flanagan W, et al. Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc. 2011;133:9200-3 pubmed publisher
    ..Here, we address this problem in the context of a mimic of microRNA-122 by employing novel nucleobase and known 2'-ribose modifications...
  23. Frolov A, Hoffmann P, Hoffmann R. Fragmentation behavior of glycated peptides derived from D-glucose, D-fructose and D-ribose in tandem mass spectrometry. J Mass Spectrom. 2006;41:1459-69 pubmed
    ..Here, the fragmentation behavior of D-glucose and D-ribose-derived Amadori peptides as well as D-fructose-derived Heynes peptides were studied by collision-induced ..
  24. Yeom S, Ji J, Kim N, Park C, Oh D. Substrate specificity of a mannose-6-phosphate isomerase from Bacillus subtilis and its application in the production of L-ribose. Appl Environ Microbiol. 2009;75:4705-10 pubmed publisher
    ..hydroxyl groups oriented in the same direction at the C-2 and C-3 positions, such as the d and l forms of ribose, lyxose, talose, mannose, and allose...
  25. Moreau C, Ashamu G, Bailey V, Galione A, Guse A, Potter B. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org Biomol Chem. 2011;9:278-90 pubmed publisher
    ..base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (..
  26. Wei C, Pohorille A. Permeation of membranes by ribose and its diastereomers. J Am Chem Soc. 2009;131:10237-45 pubmed publisher
    It was recently found that ribose permeates membranes an order of magnitude faster than its diastereomers arabinose and xylose (Sacerdote, M. G.; Szostak, J. W. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 6004)...
  27. Kominsky D, Klawitter J, Brown J, Boros L, Melo J, Eckhardt S, et al. Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res. 2009;15:3442-50 pubmed publisher
    ..mass spectrometry to assess (13)C glucose uptake and metabolism (glycolysis, TCA cycle, and nucleic acid ribose synthesis) during imatinib treatment in CML cell lines with different sensitivities to imatinib...
  28. Nentwich S, Brinkrolf K, Gaigalat L, Hüser A, Rey D, Mohrbach T, et al. Characterization of the LacI-type transcriptional repressor RbsR controlling ribose transport in Corynebacterium glutamicum ATCC 13032. Microbiology. 2009;155:150-64 pubmed publisher
    The gene products of the rbsRACBD (rbs) operon of C. glutamicum (cg1410-cg1414) encode a ribose-specific ATP-binding cassette (ABC) transport system and its corresponding regulatory protein (RbsR)...
  29. Malladi V, Sobczak A, Meyer T, Pei D, Wnuk S. Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. Bioorg Med Chem. 2011;19:5507-19 pubmed publisher
    ..5 ?M). The structure-activity relationship of the designed inhibitors highlights the importance of both the homocysteine and ribose moieties for high-affinity binding to LuxS active site.
  30. Tozzi M, Camici M, Mascia L, Sgarrella F, Ipata P. Pentose phosphates in nucleoside interconversion and catabolism. FEBS J. 2006;273:1089-101 pubmed
    b>Ribose phosphates are either synthesized through the oxidative branch of the pentose phosphate pathway, or are supplied by nucleoside phosphorylases...
  31. Eleswarapu S, Chen J, Athanasiou K. Temporal assessment of ribose treatment on self-assembled articular cartilage constructs. Biochem Biophys Res Commun. 2011;414:431-6 pubmed publisher
    ..The objectives of this study were (1) to determine whether continuous application of ribose would enhance biochemical and biomechanical properties of self-assembled articular cartilage constructs, and (2) ..
  32. Johnson J, Julien K, Hoogstraten C. Alternate-site isotopic labeling of ribonucleotides for NMR studies of ribose conformational dynamics in RNA. J Biomol NMR. 2006;35:261-74 pubmed
    ..Due to strong 13C-13C magnetic interactions within the ribose ring, however, these studies have thus far largely been limited to (13)C and (15)N resonances on the nucleotide ..
  33. James D, Shao H, Lamont R, Demuth D. The Actinobacillus actinomycetemcomitans ribose binding protein RbsB interacts with cognate and heterologous autoinducer 2 signals. Infect Immun. 2006;74:4021-9 pubmed
    ..harveyi AI-2. RbsB-mediated inhibition of V. harveyi bioluminescence was reversed by the addition of 50 mM ribose, suggesting that A. actinomycetemcomitans AI-2 and ribose bind at the same site of RbsB...
  34. Ohlenschläger O, Haumann S, Ramachandran R, Görlach M. Conformational signatures of 13C chemical shifts in RNA ribose. J Biomol NMR. 2008;42:139-42 pubmed publisher
    ..Results derived support the applicability of the canonical coordinates approach of Rossi and Harbison (J Magn Reson 151:1-8, 2001) in liquid-state NMR to assess the sugar pucker of ribose units in RNA.
  35. Benner S, Kim H, Carrigan M. Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA. Acc Chem Res. 2012;45:2025-34 pubmed publisher
    ..aquifers generated by serpentinizing rocks, these substances were undoubtedly converted to carbohydrates including ribose. Likewise, atmospherically generated HCN was undoubtedly converted in these aquifers to formamide and ammonium ..
  36. Narins R, Brandt F, Lorenc Z, Maas C, Monheit G, Smith S. Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler. Dermatol Surg. 2008;34 Suppl 1:S31-9 pubmed publisher
    ..No unexpected, severe, or serious injection-related adverse events were experienced. The effectiveness of Dermicol-P35 appears to be maintained for up to 1 year after achieving an OCR, both for touch-up and for non-touch-up subjects. ..
  37. Pokusaeva K, Neves A, Zomer A, O Connell Motherway M, Macsharry J, Curley P, et al. Ribose utilization by the human commensal Bifidobacterium breve UCC2003. Microb Biotechnol. 2010;3:311-23 pubmed publisher
    Growth of Bifidobacterium breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster...
  38. Yi Brunozzi H, Brabazon D, Lener D, Le Grice S, Marino J. A ribose sugar conformational switch in the LTR-retrotransposon Ty3 polypurine tract-containing RNA/DNA hybrid. J Am Chem Soc. 2005;127:16344-5 pubmed
    ..hybrid adopts an overall A-form-like helical geometry, an unexpected sugar pucker switch has been detected for the ribose at position +1, relative to the cleavage site, on the RNA strand...
  39. Ha J, Shinsky S, Loh S. Stepwise conversion of a binding protein to a fluorescent switch: application to Thermoanaerobacter tengcongensis ribose binding protein. Biochemistry. 2013;52:600-12 pubmed publisher
    ..Here, we apply the AFF mechanism to create several ribose-sensing proteins derived from Thermoanaerobacter tengcongensis ribose binding protein...
  40. Akhter F, Salman Khan M, Shahab U, Moinuddin -, Ahmad S. Bio-physical characterization of ribose induced glycation: a mechanistic study on DNA perturbations. Int J Biol Macromol. 2013;58:206-10 pubmed publisher
    ..previously demonstrated, however no extensive studies have been performed to assess the glycation of DNA using D-ribose as glycating agent...
  41. Banfalvi G. Why ribose was selected as the sugar component of nucleic acids. DNA Cell Biol. 2006;25:189-96 pubmed
    During evolution ribose was selected as the exclusive sugar component of nucleic acids...
  42. Chen L, Wei Y, Wang X, He R. D-Ribosylated Tau forms globular aggregates with high cytotoxicity. Cell Mol Life Sci. 2009;66:2559-71 pubmed publisher
    ..filament formation in Alzheimer's disease has been widely studied, little attention has been paid to the role of D-ribose in the glycation of Tau...
  43. Wei Y, Chen L, Chen J, Ge L, He R. Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. BMC Cell Biol. 2009;10:10 pubmed publisher
    D-ribose in cells and human serum participates in glycation of proteins resulting in advanced glycation end products (AGEs) that affect cell metabolism and induce cell death...
  44. Koch M, Huang Y, Sprinzl M. Peptide-bond synthesis on the ribosome: no free vicinal hydroxy group required on the terminal ribose residue of peptidyl-tRNA. Angew Chem Int Ed Engl. 2008;47:7242-5 pubmed publisher
  45. Faria M, Ulrich H. Sugar boost: when ribose modifications improve oligonucleotide performance. Curr Opin Mol Ther. 2008;10:168-75 pubmed
    ..Modifications to improve the activity of oligonucleotides by 2'-O-modification of the ribose sugar, and the systematic approaches used to evaluate the potential of mixed oligonucleotides, are discussed in ..
  46. Peveler W, Bishop P, Whitehorn E. Effects of ribose as an ergogenic aid. J Strength Cond Res. 2006;20:519-22 pubmed
    ..b>Ribose, a naturally occurring pentose sugar, helps resynthesize ATP for use in muscles...
  47. Martinková M, Gonda J, Pomikalová K, Kozisek J, Kuchár J. A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose. Carbohydr Res. 2011;346:1728-38 pubmed publisher
    ..The Overman rearrangement of allylic trichloroacetimidates derived from the known ribose derivative 7 has been used as the key step...
  48. Kong F, Cheng W, Chen J, Liang Y. d-Ribose glycates ?(2)-microglobulin to form aggregates with high cytotoxicity through a ROS-mediated pathway. Chem Biol Interact. 2011;194:69-78 pubmed publisher
    ..We find that the glycating agent d-ribose interacts with human ?(2)M to generate AGEs that form aggregates in a time-dependent manner...
  49. Bielski R, Tencer M. A possible path to the RNA world: enantioselective and diastereoselective purification of ribose. Orig Life Evol Biosph. 2007;37:167-75 pubmed
    A theoretical mechanism resulting in the prebiotic appearance of enantiopure ribose, which would be needed for the origin of RNA and the "RNA world" is proposed...
  50. Wei Y, Han C, Zhou J, Liu Y, Chen L, He R. D-ribose in glycation and protein aggregation. Biochim Biophys Acta. 2012;1820:488-94 pubmed publisher
    D-ribose is a naturally occurring pentose monosaccharide present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways...
  51. Vercillo N, Herald K, Fox J, Der B, Dattelbaum J. Analysis of ligand binding to a ribose biosensor using site-directed mutagenesis and fluorescence spectroscopy. Protein Sci. 2007;16:362-8 pubmed
    ..In this work, we investigated the outcome of site-directed mutagenesis on the Escherichia coli ribose binding protein (RBP), which is frequently used as a design scaffold for computational searches...
  52. Mansy S, Schrum J, Krishnamurthy M, Tobé S, Treco D, Szostak J. Template-directed synthesis of a genetic polymer in a model protocell. Nature. 2008;454:122-5 pubmed publisher
  53. Autieri S, Lins J, Leatham M, Laux D, Conway T, Cohen P. L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium. Infect Immun. 2007;75:5465-75 pubmed
    ..To determine the roles of L-fucose and D-ribose, an E. coli MG1655 DeltafucAO mutant and an E...