Genomes and Genes
Summary: Sucrose present in the diet. It is added to food and drinks as a sweetener.
- Zou M, Arentson E, Teegarden D, Koser S, Onyskow L, Donkin S. Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats. Nutr Res. 2012;32:588-98 pubmed publisher..The data demonstrate a unique physiological status response to diet resulting in the development of gestational diabetes coupled with hepatic steatosis in FR-fed dams, which is more severe than an LP diet. ..
- Qi Q, Chu A, Kang J, Jensen M, Curhan G, Pasquale L, et al. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med. 2012;367:1387-96 pubmed publisher..03 to 4.92), respectively (P=0.007 for interaction). The genetic association with adiposity appeared to be more pronounced with greater intake of sugar-sweetened beverages. (Funded by the National Institutes of Health and others.). ..
- Ebbeling C, Feldman H, Chomitz V, Antonelli T, Gortmaker S, Osganian S, et al. A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med. 2012;367:1407-16 pubmed publisher..Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; ClinicalTrials.gov number, NCT00381160.). ..
- de Ruyter J, Olthof M, Seidell J, Katan M. A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med. 2012;367:1397-406 pubmed publisher..However, data are lacking to show that the replacement of sugar-containing beverages with noncaloric beverages diminishes weight gain...
- Bray G. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Adv Nutr. 2013;4:220-5 pubmed publisher..By worsening blood lipids, contributing to obesity, diabetes, fatty liver, and gout, fructose in the amounts currently consumed is hazardous to the health of some people. ..
- Tappy L, Mittendorfer B. Fructose toxicity: is the science ready for public health actions?. Curr Opin Clin Nutr Metab Care. 2012;15:357-61 pubmed publisher..Public health is almost certainly to benefit more from policies that are aimed at promoting what is known to be good than from policies that are prohibiting what is not (yet) known to be bad. ..
- Garber A, Lustig R. Is fast food addictive?. Curr Drug Abuse Rev. 2011;4:146-62 pubmed..While the concept of fast food addiction remains to be proven, these findings support the role of fast food as a potentially addictive substance that is most likely to create dependence in vulnerable populations. ..
- Johnson R, Appel L, Brands M, Howard B, Lefevre M, Lustig R, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009;120:1011-20 pubmed publisher..A prudent upper limit of intake is half of the discretionary calorie allowance, which for most American women is no more than 100 calories per day and for most American men is no more than 150 calories per day from added sugars. ..
- Dus M, Min S, Keene A, Lee G, Suh G. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011;108:11644-9 pubmed publisher..Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway...
- Herbst A, Diethelm K, Cheng G, Alexy U, Icks A, Buyken A. Direction of associations between added sugar intake in early childhood and body mass index at age 7 years may depend on intake levels. J Nutr. 2011;141:1348-54 pubmed publisher..However, detrimental effects on BMI development may emerge when added sugar intakes are increased to higher levels. ..
- Welsh J, Sharma A, Cunningham S, Vos M. Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation. 2011;123:249-57 pubmed publisher..004). Consumption of added sugars among US adolescents is positively associated with multiple measures known to increase cardiovascular disease risk. ..
- Ruxton C, Gardner E, McNulty H. Is sugar consumption detrimental to health? A review of the evidence 1995-2006. Crit Rev Food Sci Nutr. 2010;50:1-19 pubmed publisher..Overall, the available evidence did not support a single quantitative sugar guideline covering all health issues. ..
- Odegaard A, Koh W, Arakawa K, Yu M, Pereira M. Soft drink and juice consumption and risk of physician-diagnosed incident type 2 diabetes: the Singapore Chinese Health Study. Am J Epidemiol. 2010;171:701-8 pubmed publisher..34, 2.16) compared with those who gained less weight (RR = 1.20, 95% CI: 1.03, 1.41). Relatively frequent intake of soft drinks and juice is associated with an increased risk for development of type 2 diabetes in Chinese men and women. ..
- Malik V, Popkin B, Bray G, Despres J, Willett W, Hu F. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 2010;33:2477-83 pubmed publisher..These data provide empirical evidence that intake of SSBs should be limited to reduce obesity-related risk of chronic metabolic diseases. ..
- Reedy J, Krebs Smith S. Dietary sources of energy, solid fats, and added sugars among children and adolescents in the United States. J Am Diet Assoc. 2010;110:1477-84 pubmed publisher..However, product reformulation alone is not sufficient-the flow of empty calories into the food supply must be reduced. ..
- Dolan L, Potter S, Burdock G. Evidence-based review on the effect of normal dietary consumption of fructose on development of hyperlipidemia and obesity in healthy, normal weight individuals. Crit Rev Food Sci Nutr. 2010;50:53-84 pubmed publisher..The results of the analysis indicate that fructose does not cause biologically relevant changes in TG or body weight when consumed at levels approaching 95th percentile estimates of intake. ..
- Block J, Chandra A, McManus K, Willett W. Point-of-purchase price and education intervention to reduce consumption of sugary soft drinks. Am J Public Health. 2010;100:1427-33 pubmed publisher..A price increase may be an effective policy mechanism to decrease sales of regular soda. Further multisite studies in varied populations are warranted to confirm these results. ..
- Brown I, Stamler J, Van Horn L, Robertson C, Chan Q, Dyer A, et al. Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure. Hypertension. 2011;57:695-701 pubmed publisher..These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced. ..
- Cohen D, Sturm R, Scott M, Farley T, Bluthenthal R. Not enough fruit and vegetables or too many cookies, candies, salty snacks, and soft drinks?. Public Health Rep. 2010;125:88-95 pubmed..It may be politically more expedient to promote an increase in consumption of healthy items rather than a decrease in consumption of unhealthy items, but it may be far less effective. ..
- Chapman M, Fraser R, Matthews G, Russo A, Bellon M, Besanko L, et al. Glucose absorption and gastric emptying in critical illness. Crit Care. 2009;13:R140 pubmed publisher..The aim of this study was to quantify glucose absorption and the relationships between GE, glucose absorption and glycaemia in critically ill patients...
- Guido J, Martinez Mier E, Soto A, Eggertsson H, Sanders B, Jones J, et al. Caries prevalence and its association with brushing habits, water availability, and the intake of sugared beverages. Int J Paediatr Dent. 2011;21:432-40 pubmed publisher..CONCLUSIONS. Drinking sugared beverages, poor oral hygiene habits, and lack of access to tap water were identified as risk factor for caries in this sample of residents of rural Mexico. ..
- Pomeranz J. Advanced policy options to regulate sugar-sweetened beverages to support public health. J Public Health Policy. 2012;33:75-88 pubmed publisher..Our review describes recent international initiatives and classifies options available in the United States by jurisdiction (federal, state, and local) based on legal viability. ..
- Cox C, Stanhope K, Schwarz J, Graham J, Hatcher B, Griffen S, et al. Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women. Eur J Clin Nutr. 2012;66:201-8 pubmed publisher..In addition, we report that REE is reduced compared with baseline values in subjects consuming fructose-sweetened beverages for 10 weeks. ..
- Welsh J, Sharma A, Abramson J, Vaccarino V, Gillespie C, Vos M. Caloric sweetener consumption and dyslipidemia among US adults. JAMA. 2010;303:1490-7 pubmed publisher..In this study, there was a statistically significant correlation between dietary added sugars and blood lipid levels among US adults. ..
- Larson N, Neumark Sztainer D, Laska M, Story M. Young adults and eating away from home: associations with dietary intake patterns and weight status differ by choice of restaurant. J Am Diet Assoc. 2011;111:1696-703 pubmed publisher..There may be a need for interventions to promote healthier food choices among young adults who report frequent burger-and-fries restaurant use. ..
- Collison K, Zaidi M, Subhani S, Al Rubeaan K, Shoukri M, Al Mohanna F. Sugar-sweetened carbonated beverage consumption correlates with BMI, waist circumference, and poor dietary choices in school children. BMC Public Health. 2010;10:234 pubmed publisher..A higher intake of SSCB is associated with poor dietary choices. Male SSCB intake correlates with a higher W_C and BMI. Limiting exposure to SSCB could therefore have a large public health impact. ..
- Marriott B, Olsho L, Hadden L, Connor P. Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003-2006. Crit Rev Food Sci Nutr. 2010;50:228-58 pubmed publisher..With over 80% of the population at risk for select nutrient inadequacy, guidance may need to focus on targeted healthful diet communication to reach the highest risk demographic groups for specific life stage nutrient inadequacies. ..
- McNeill G, Masson L, Craig L, Macdiarmid J, Holmes B, Nelson M, et al. Sugar and fat intake among children in Scotland: what is needed to reach the dietary targets?. Public Health Nutr. 2010;13:1286-94 pubmed publisher..Major changes in the intake of many food groups will be required to bring the NMES and saturated fat intake in line with current dietary recommendations. ..
- Welsh J, Cunningham S. The role of added sugars in pediatric obesity. Pediatr Clin North Am. 2011;58:1455-66, xi pubmed publisher..Primary health care providers play an important role in assessing the added sugar intake of their patients and in providing nutrition and behavior change counselling to high-risk children and their families. ..
- Chen L, Caballero B, Mitchell D, Loria C, Lin P, Champagne C, et al. Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults. Circulation. 2010;121:2398-406 pubmed publisher..Reduced consumption of SSB and sugars was significantly associated with reduced BP. Reducing SSB and sugar consumption may be an important dietary strategy to lower BP. URL: http://clinicaltrials.gov. Unique identifier: NCT00000616. ..
- Andreyeva T, Chaloupka F, Brownell K. Estimating the potential of taxes on sugar-sweetened beverages to reduce consumption and generate revenue. Prev Med. 2011;52:413-6 pubmed publisher..To the extent that at least some of the tax revenues get invested in obesity prevention programs, the public health benefits could be even more pronounced. ..
- Finkelstein E, Zhen C, Nonnemaker J, Todd J. Impact of targeted beverage taxes on higher- and lower-income households. Arch Intern Med. 2010;170:2028-34 pubmed publisher..These taxes would also generate substantial revenue that could be used to fund obesity prevention programs or for other causes. ..
- Lomba A, Milagro F, Garcia Diaz D, Campion J, Marzo F, Martinez J. A high-sucrose isocaloric pair-fed model induces obesity and impairs NDUFB6 gene function in rat adipose tissue. J Nutrigenet Nutrigenomics. 2009;2:267-72 pubmed publisher..These results suggest, apparently for the first time, that high-sugar diets appear to induce mitochondrial dysfunction in adipose tissue, which may be related to greater weight gain and metabolic impairment. ..
- Vigne P, Frelin C. Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila. Exp Gerontol. 2010;45:113-8 pubmed publisher..We conclude that flies sense and respond to specific nutrients and that food presentation is a major factor which determines the sensitivity of flies to dietary restriction. ..
- Sato A, Kawano H, Notsu T, Ohta M, Nakakuki M, Mizuguchi K, et al. Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis. Diabetes. 2010;59:2495-504 pubmed publisher..Because the metabolic syndrome is often associated with hepatic lipogenesis and steatosis, the data suggest that EPA is suited for treatment of the metabolic syndrome. ..
- Farley T, Baker E, Futrell L, Rice J. The ubiquity of energy-dense snack foods: a national multicity study. Am J Public Health. 2010;100:306-11 pubmed publisher..The ubiquity of these products may contribute to excess energy consumption in the United States. ..
- Benton D. The plausibility of sugar addiction and its role in obesity and eating disorders. Clin Nutr. 2010;29:288-303 pubmed publisher..There is no support from the human literature for the hypothesis that sucrose may be physically addictive or that addiction to sugar plays a role in eating disorders. ..
- Reid M, Hammersley R, Duffy M. Effects of sucrose drinks on macronutrient intake, body weight, and mood state in overweight women over 4 weeks. Appetite. 2010;55:130-6 pubmed publisher..Alternative explanations for the correlation between sugary soft drink intake and weight gain are discussed. ..
- Hoppu U, Lehtisalo J, Kujala J, Keso T, Garam S, Tapanainen H, et al. The diet of adolescents can be improved by school intervention. Public Health Nutr. 2010;13:973-9 pubmed publisher..It is the responsibility of the adults working in schools to create a healthy environment and to make healthy choices easy for pupils. ..
- Duffey K, Huybrechts I, Mouratidou T, Libuda L, Kersting M, de Vriendt T, et al. Beverage consumption among European adolescents in the HELENA study. Eur J Clin Nutr. 2012;66:244-52 pubmed publisher..Beverages provide 1609?kJ/day, of which 30.4%, 20.7% and 18.1% comes from SSBs, sweetened milk and fruit juice, respectively. ..
- Pasco M, Leopold P. High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo. PLoS ONE. 2012;7:e36583 pubmed publisher..These results indicate that insulin resistance shares common molecular mechanisms in flies and human and that Drosophila could emerge as a powerful genetic system to study some aspects of this complex syndrome. ..
- Maersk M, Belza A, Stødkilde Jørgensen H, Ringgaard S, Chabanova E, Thomsen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95:283-9 pubmed publisher..Thus, daily intake of SSSDs is likely to enhance the risk of cardiovascular and metabolic diseases. This trial is registered at clinicaltrials.gov as NCT00777647. ..
- Johnson D, Bruemmer B, Lund A, Evens C, MAR C. Impact of school district sugar-sweetened beverage policies on student beverage exposure and consumption in middle schools. J Adolesc Health. 2009;45:S30-7 pubmed publisher..School district SSB policies and exposure to SSB in middle schools are associated with student SSB consumption. Interventions to improve policies and their implementation may offer opportunities to improve the diets of adolescents. ..
- Smutzer G, Patel J, Stull J, Abarintos R, Khan N, Park K. A preference test for sweet taste that uses edible strips. Appetite. 2014;73:132-9 pubmed publisher..This test should also be useful for identifying sweet taste preferences outside of the lab or clinic. Finally, edible strips should be useful for developing preference tests for other primary taste stimuli and for taste mixtures. ..
- Chen Z, Chen J, Zhang W, Zhang T, Guang C, Mu W. Recent research on the physiological functions, applications, and biotechnological production of D-allose. Appl Microbiol Biotechnol. 2018;102:4269-4278 pubmed publisher..To date, very little information is available on the molecular modification and food-grade expression of D-allose-producing enzymes, representing a very large research space yet to be explored. ..
- Schneider S, Jerusalem M, Mente J, De Bock F. Sweets consumption of preschool children--extent, context, and consumption patterns. Clin Oral Investig. 2013;17:1301-9 pubmed publisher..Particular attention is to be paid to children of Turkish and Arabic decent, as they have been shown to consume above-average amounts of sweets. ..
- Arvidsson L, Birkhed D, Hunsberger M, Lanfer A, Lissner L, Mehlig K, et al. BMI, eating habits and sleep in relation to salivary counts of mutans streptococci in children - the IDEFICS Sweden study. Public Health Nutr. 2016;19:1088-92 pubmed publisher..Promoting adequate sleep duration and limiting the intake frequency of sugar-rich foods and beverages could provide multiple benefits in public health interventions aimed at reducing dental caries and childhood overweight. ..
- Barrio Lopez M, Martinez Gonzalez M, Fernández Montero A, Beunza J, Zazpe I, Bes Rastrollo M. Prospective study of changes in sugar-sweetened beverage consumption and the incidence of the metabolic syndrome and its components: the SUN cohort. Br J Nutr. 2013;110:1722-31 pubmed publisher..In conclusion, an increase in SSB consumption was associated with a higher risk of developing the MetS and other metabolic disorders after 6 years of follow-up in a Mediterranean cohort of university graduates. ..
- Richelsen B. Sugar-sweetened beverages and cardio-metabolic disease risks. Curr Opin Clin Nutr Metab Care. 2013;16:478-84 pubmed publisher..A so-called 'well tolerated' intake of SSB is not determined. Accordingly, intake of SSB should generally be reduced as much as possible to improve the health of the population. ..
- Stice E, Burger K, Yokum S. Relative ability of fat and sugar tastes to activate reward, gustatory, and somatosensory regions. Am J Clin Nutr. 2013;98:1377-84 pubmed publisher..This trial was registered at clinicaltrials.gov as DK092468. ..
- Lieske J, Turner S, Edeh S, Ware E, Kardia S, Smith J. Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships. J Nephrol. 2016;29:45-51 pubmed publisher..Significant genetic correlations were observed among dietary protein, dietary sucrose, and dietary calcium intakes (pÂ <Â 0.001)...
- Colucci A, Cesar C, Marchioni D, Fisberg R. Factors associated with added sugars intake among adolescents living in São Paulo, Brazil. J Am Coll Nutr. 2012;31:259-67 pubmed..Socioeconomic condition (represented by the head of the household's education level) and macronutrient intake were shown to be determinants of sugars intake. ..
- Ma C, Sun Z, Chen C, Zhang L, Zhu S. Simultaneous separation and determination of fructose, sorbitol, glucose and sucrose in fruits by HPLC-ELSD. Food Chem. 2014;145:784-8 pubmed publisher..70-19.13 mg g?¹) were only found in peach, apple and cherry fruits, and sucrose (15.82-106.39 mg g?¹) were in peach, apple and watermelon. There was not detectable sorbitol in watermelon and sucrose in cherry fruits, respectively. ..