uracil nucleotides


Summary: A group of pyrimidine NUCLEOTIDES which contain URACIL.

Top Publications

  1. Pendergast W, Yerxa B, Douglass J, Shaver S, Dougherty R, Redick C, et al. Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg Med Chem Lett. 2001;11:157-60 pubmed
    ..The correlation of phosphate chain length to activities at these receptors is discussed. ..
  2. Tauber J, Davitt W, Bokosky J, Nichols K, Yerxa B, Schaberg A, et al. Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. Cornea. 2004;23:784-92 pubmed
    ..Diquafosol has a favorable risk/benefit profile in a broad spectrum of patients with dry eye disease and is a novel topical treatment of dry eye. ..
  3. Yitzhaki S, Shneyvays V, Jacobson K, Shainberg A. Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. Biochem Pharmacol. 2005;69:1215-23 pubmed
  4. Kamiya K, Nakanishi M, Ishii R, Kobashi H, Igarashi A, Sato N, et al. Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Eye (Lond). 2012;26:1363-8 pubmed publisher
    ..To assess the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome...
  5. Fujihara T, Murakami T, Nagano T, Nakamura M, Nakata K. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 2002;18:363-70 pubmed
    ..INS365 significantly suppressed corneal damage at concentrations of more than 0.1% w/v. These results suggest that this P2Y2 agonist is a good candidate for the treatment of dry eye disease. ..
  6. Yerxa B, Douglass J, Elena P, Caillaud T, Amar T, Edick C, et al. Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits. Adv Exp Med Biol. 2002;506:261-5 pubmed
  7. Brunschweiger A, Muller C. P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13:289-312 pubmed
    ..This article is an updated version of "P2-Pyrimidinergic Receptors and Their Ligands" by C. E. Müller published in Curr. Pharm. Des. 2002, 8, 2353-2369. ..
  8. Ciana P, Fumagalli M, Trincavelli M, Verderio C, Rosa P, Lecca D, et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006;25:4615-27 pubmed
    ..known CysLT and P2Y receptors, with EC(50) values in the nanomolar and micromolar range, for CysLTs and uracil nucleotides, respectively...
  9. Milosevic J, Brandt A, Roemuss U, Arnold A, Wegner F, Schwarz S, et al. Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling. J Neurochem. 2006;99:913-23 pubmed
    ..We conclude that uracil nucleotides exert specific P2 receptor-mediated effects on midbrain-derived human NPCs, and may be used to enhance both ..

More Information

Publications102 found, 100 shown here

  1. Madej M, Alfonzo J, Huttenhofer A. Small ncRNA transcriptome analysis from kinetoplast mitochondria of Leishmania tarentolae. Nucleic Acids Res. 2007;35:1544-54 pubmed
    ..In addition, our screen shows that all kinetoplast-derived RNAs are prone to some degree of uridylation. ..
  2. Nakamura M, Imanaka T, Sakamoto A. Diquafosol ophthalmic solution for dry eye treatment. Adv Ther. 2012;29:579-89 pubmed publisher
    ..Various types of dry eye treatment drugs have been developed. This review summarizes the basic and clinical research carried out in the development of diquafosol for ophthalmic use...
  3. Pesnot T, Tedaldi L, Jambrina P, Rosta E, Wagner G. Exploring the role of the 5-substituent for the intrinsic fluorescence of 5-aryl and 5-heteroaryl uracil nucleotides: a systematic study. Org Biomol Chem. 2013;11:6357-71 pubmed publisher
    ..In this study, we have synthesised a series of derivatives of the uracil nucleotides UMP, UDP and UTP with different aromatic and heteroaromatic substituents in position 5, in order to ..
  4. Fujihara T, Murakami T, Fujita H, Nakamura M, Nakata K. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001;42:96-100 pubmed
    ..These effects suggest that INS365 is a potential therapeutic agent for use in the treatment of dry eye syndrome. ..
  5. Schnaufer A, Ernst N, Palazzo S, O Rear J, Salavati R, Stuart K. Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell. 2003;12:307-19 pubmed
    ..This study provides insight into the molecular architecture of the editosome and supports the existence of separate subcomplexes for deletion and insertion editing. ..
  6. Lecca D, Ceruti S. Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation. Biochem Pharmacol. 2008;75:1869-81 pubmed publisher
    b>Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis...
  7. Ko H, Carter R, Cosyn L, Petrelli R, de Castro S, Besada P, et al. Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008;16:6319-32 pubmed publisher
    The phosphate, uracil, and ribose moieties of uracil nucleotides were varied structurally for evaluation of agonist activity at the human P2Y(2), P2Y(4), and P2Y(6) receptors...
  8. Qi A, Harden T, Nicholas R. Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. J Pharmacol Exp Ther. 2013;347:38-46 pubmed publisher
    ..To determine if GPR17 is activated by uracil nucleotides and leukotrienes, the hemagglutinin-tagged receptor was expressed in five different cell lines and the ..
  9. Ganem D, Miller J, Files J, Platt T, Weber K. Reinitiation of a lac repressor fragment at a codon other than AUG. Proc Natl Acad Sci U S A. 1973;70:3165-9 pubmed
    ..The possibility that a codon other than AUG can act as an initiation codon in vivo is discussed. ..
  10. Morell P, Radin N. Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. Biochemistry. 1969;8:506-12 pubmed
  11. Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt N, et al. The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes. Mol Pharmacol. 2017;91:518-532 pubmed publisher
    ..Herein we report that uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds, ..
  12. Boni I, Isaeva D, Musychenko M, Tzareva N. Ribosome-messenger recognition: mRNA target sites for ribosomal protein S1. Nucleic Acids Res. 1991;19:155-62 pubmed
    ..We propose that S1 binding sites, represented by pyrimidine-rich sequences upstream from the SD region, serve as determinants involved in recognition of mRNA by the ribosome. ..
  13. Kellerman D. P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance. Chest. 2002;121:201S-205S pubmed
    ..This article will review the pharmacology of P2Y(2) receptor agonists, review the clinical studies performed to date, and highlight the challenges inherent in the development of therapies with these pharmacologic properties. ..
  14. Cukier Kahn R, Jacquet M, Gros F. Two heat-resistant, low molecular weight proteins from Escherichia coli that stimulate DNA-directed RNA synthesis. Proc Natl Acad Sci U S A. 1972;69:3643-7 pubmed
  15. Travers A, Cukier Kahn R. Effect of H1 protein on in vitro ribosomal RNA synthesis. FEBS Lett. 1974;43:86-8 pubmed
  16. Vanhooke J, Frey P. Characterization and activation of naturally occurring abortive complexes of UDP-galactose 4-epimerase from Escherichia coli. J Biol Chem. 1994;269:31496-504 pubmed
    ..The activity of the reactivated enzyme approaches that of the most highly active epimerase that has been reported from E. coli. ..
  17. Zimmermann S, Hall L, Riley S, Sørensen J, Amaro R, Schnaufer A. A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases. Nucleic Acids Res. 2016;44:e24 pubmed publisher
    ..We validated the assay by determining kinetic properties of REL1 and by identifying REL1 inhibitors in a library of small, pharmacologically active compounds. ..
  18. Tycowski K, Shu M, Steitz J. A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3. Genes Dev. 1993;7:1176-90 pubmed
    ..The production of a single primary transcript specifying the mRNA for a ribosomal or nucleolar protein and a nucleolar snRNA may constitute a general mechanism for balancing the levels of nucleolar components in vertebrate cells. ..
  19. Van Poecke S, Barrett M, Santhosh Kumar T, Sinnaeve D, Martins J, Jacobson K, et al. Synthesis and P2Yâ‚‚ receptor agonist activities of uridine 5'-phosphonate analogues. Bioorg Med Chem. 2012;20:2304-15 pubmed publisher
    ..These results suggest that these phosphonates bind to an allosteric site of the P2Y(2) receptor. ..
  20. Kunjara S, Sochor M, Ali M, Bennett M, Greenbaum A, McLean P. Uridine and cytidine nucleotide synthesis in renal hypertrophy: biochemical differences in response to the growth stimulus of diabetes and unilateral nephrectomy. Biochem Med Metab Biol. 1992;47:168-80 pubmed
  21. Sheid B, Lerner L, Gaetjens E. Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro. Experientia. 1989;45:729-30 pubmed
    ..The active nucleosides were cytotoxic to the L1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L1210 cells. ..
  22. Grabarkiewicz T, Hoffmann M. Syn- and anti-conformations of 5'-deoxy- and 5'-O-methyl-uridine 2',3'-cyclic monophosphate. J Mol Model. 2006;12:205-12 pubmed
    ..Additionally, the effects of a countercation and protonation on DcUMP were studied, revealing that the syn-structure is also favored over the anti-one for these systems. ..
  23. Lugtenberg E, v Schijndel van Dam A. Temperature-sensitive mutants of Escherichia coli K-12 with low activities of the L-alanine adding enzyme and the D-alanyl-D-alanine adding enzyme. J Bacteriol. 1972;110:35-40 pubmed
    ..A genetic nomenclature for genes concerned with murein synthesis is proposed. ..
  24. Calvori C, Frontali L, Leoni L, Tecce G. Effect of rifamycin on protein synthesis. Nature. 1965;207:417-8 pubmed
  25. Kobata A, Ginsburg V. Uridine diphosphate-N-acetyl-D-galactosamine: D-galactose alpha-3-N-acetyl-D-galactosaminyltransferase, a product of the gene that determines blood type A in man. J Biol Chem. 1970;245:1484-90 pubmed
  26. Bertoli D, Segal S. Developmental aspects and some characteristics of mammalian galactose 1-phosphate uridyltransferase. J Biol Chem. 1966;241:4023-9 pubmed
  27. Poulsen P, Bonekamp F, Jensen K. Structure of the Escherichia coli pyrE operon and control of pyrE expression by a UTP modulated intercistronic attentuation. EMBO J. 1984;3:1783-90 pubmed
    ..From these observations we conclude that pyrE expression is controlled by a UTP modulated intercistronic attentuation. ..
  28. Fumagalli M, Lecca D, Coppolino G, Parravicini C, Abbracchio M. Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine. Adv Exp Med Biol. 2017;1051:169-192 pubmed publisher
    In 2006, cells heterologously expressing the "orphan" receptor GPR17 were shown to acquire responses to both uracil nucleotides and cysteinyl-leukotrienes, two families of signaling molecules accumulating in brain or heart as a result of ..
  29. Murakami T, Fujita H, Fujihara T, Nakamura M, Nakata K. Novel noninvasive sensitive determination of tear volume changes in normal cats. Ophthalmic Res. 2002;34:371-4 pubmed
    ..We demonstrate in cats that changes in conjunctival sac tear volume can be evaluated by measurement of its inferior tear meniscus area. ..
  30. Shibui Nihei A, Ohmori Y, Yoshida K, Imai J, Oosuga I, Iidaka M, et al. The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level. Gene. 2003;311:137-45 pubmed
    ..Many other housekeeping genes, including ribosomal protein genes, are also members of the 5' TOP gene family, and the 5' TOP sequence may be an important core-promoter element of these genes. ..
  31. Cadman E, Benz C, Heimer R, O Shaughnessy J. Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Biochem Pharmacol. 1981;30:2469-72 pubmed
    ..These alterations in de novo purine nucleotide synthesis were associated with enhanced intracellular 5-fluorouracil accumulation and synergistic cytotoxicity...
  32. Hildenbrand K. The SO4-.-induced oxidation of 2'-deoxyuridine-5'-phosphate, uridine-5'-phosphate and thymidine-5'-phosphate. An ESR study in aqueous solution. Z Naturforsch C. 1990;45:47-58 pubmed
    ..In 5'-UMP transfer of the radical site from the base to the sugar moiety competes with intramolecular phosphate addition. ..
  33. Achsel T, Stark H, Luhrmann R. The Sm domain is an ancient RNA-binding motif with oligo(U) specificity. Proc Natl Acad Sci U S A. 2001;98:3685-9 pubmed
  34. Takamura E, Tsubota K, Watanabe H, Ohashi Y. A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol. 2012;96:1310-5 pubmed
    ..Diquafosol has high clinical efficacy and is well tolerated with a good safety profile. ..
  35. Anne A, Blanc B, Moiroux J. Synthesis of the first ferrocene-labeled dideoxynucleotide and its use for 3'-redox end-labeling of 5'-modified single-stranded oligonucleotides. Bioconjug Chem. 2001;12:396-405 pubmed
    ..Enzymatic 3'-ferrocene end-labeling of 5'-phosphorylated oligonucleotides is remarkably efficient, and 3'-ferrocene-labeled oligonucleotides can thus be prepared in sufficient amounts for further use in surface modifications. ..
  36. Jacobson K, Costanzi S, Ohno M, Joshi B, Besada P, Xu B, et al. Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr Top Med Chem. 2004;4:805-19 pubmed
    ..The binding of the negatively-charged phosphate moiety is dependent on positively charged lysine and arginine residues near the exofacial side of TMs 3 and 7. ..
  37. Jankowski V, Tölle M, Vanholder R, Schönfelder G, van der Giet M, Henning L, et al. Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Nat Med. 2005;11:223-7 pubmed
    ..We conclude that Up(4)A is a novel potent nonpeptidic EDCF. Its vasoactive effects, plasma concentrations and its release upon endothelial stimulation strongly suggest that Up(4)A has a functional vasoregulatory role. ..
  38. Rozners E, Smicius R, Uchiyama C. Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs. Chem Commun (Camb). 2005;:5778-80 pubmed
    ..Imidazole modification at C-5 of uridine that is part of tandem G-U wobble base pairs causes slight reduction of thermal stability (DeltaDeltaG(0)(310) < 0.4 kcal mol(-1)) and relatively small change in hydration of short RNA helices. ..
  39. Law J, O Hearn S, Sollner Webb B. In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol. 2007;27:777-87 pubmed
    ..The editing endonucleolytic cleavages being lost when the editing complex becomes fragmented, as upon TbMP18 depletion, should be advantageous to the trypanosome, minimizing broken mRNAs. ..
  40. Hennig S, Ginsburg A. ATP: glutamine synthetase adenylytransferase from Escherichia coli: purification and properties of a low-molecular weight enzyme form. Arch Biochem Biophys. 1971;144:611-27 pubmed
  41. Shirasaka T, Shimamoto Y, Fukushima M. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993;53:4004-9 pubmed
    ..These findings suggest that coadministration of oxonic acid suppresses the GI toxicity of 5-FU and its derivatives without affecting their antitumor activity and thus prolongs the life span of cancer-bearing rats. ..
  42. Gukasyan H, Yerxa B, Pendergast W, Lee V. Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells. Adv Exp Med Biol. 2002;506:255-9 pubmed
  43. Fumagalli M, Daniele S, Lecca D, Lee P, Parravicini C, Fields R, et al. Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J Biol Chem. 2011;286:10593-604 pubmed publisher
    ..pathway, and assess the functional consequences of GPR17 activation by its putative endogenous ligands, uracil nucleotides and cysteinyl leukotrienes (cysLTs)...
  44. Sharbeen G, Yee C, Smith A, Jolly C. Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J Exp Med. 2012;209:965-74 pubmed publisher
    ..Surprisingly, UNG2 does not appear to process U:G base pairs at all in Ig genes outside G1 phase. ..
  45. Schwarz F. Interaction of cytidine 3'-monophosphate and uridine 3'-monophosphate with ribonuclease a at the denaturation temperature. Biochemistry. 1988;27:8429-36 pubmed
    ..5). the denaturation transition cooperativities of the uncomplexed and complexed ribonuclease a were close to unity, indicating that the transition is two state with a stoichiometry of 1.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  46. Lue P, Kaplan J. The aspartate transcarbamylase and carbamoyl phosphate synthetase of yeast: a multi-functional enzyme complex. Biochem Biophys Res Commun. 1969;34:426-33 pubmed
  47. Vigeolas H, van Dongen J, Waldeck P, Huhn D, Geigenberger P. Lipid storage metabolism is limited by the prevailing low oxygen concentrations within developing seeds of oilseed rape. Plant Physiol. 2003;133:2048-60 pubmed
    ..The underlying mechanisms and implications for strategies to increase yield and storage product composition in oilseed crops are discussed. ..
  48. Mazzola A, Amoruso E, Beltrami E, Lecca D, Ferrario S, Cosentino S, et al. Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes. J Cell Mol Med. 2008;12:522-36 pubmed publisher
    ..showed that the human heart expresses all known P2X and P2Y receptors activated by extra-cellular adenine or uracil nucleotides. Despite evidence that, both in humans and rodents, plasma levels of ATP and UTP markedly increase during ..
  49. Rodbell M, Birnbaumer L, Pohl S, Krans H. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem. 1971;246:1877-82 pubmed
  50. Jankowski V, Tölle M, Tran T, van der Giet M, Schuchardt M, Lehmann K, et al. Identification of a potent endothelium-derived angiogenic factor. PLoS ONE. 2013;8:e68575 pubmed publisher
    ..Mean total plasma Up4U concentrations of healthy subjects (N=6) were sufficient to induce angiogenic and proliferative effects (1.34 ± 0.26 nmol L(-1)). In conclusion, Up4U is a novel strong human endothelium-derived angiogenic factor. ..
  51. Peters G, van Groeningen C, Laurensse E, Pinedo H. A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer. 1991;68:1903-9 pubmed
    ..These data suggest a preference of colon tumor over colon mucosa for the conversion of 5-FU to active nucleotides by a direct pathway; a selective antitumor effect of 5-FU may be related to this difference. ..
  52. Redzic Z, Segal M, Gasic J, Markovic I, Vojvodic V, Isakovic A, et al. The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus. Brain Res. 2001;888:66-74 pubmed
  53. Huang Y, Intine R, Mozlin A, Hasson S, Maraia R. Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing. Mol Cell Biol. 2005;25:621-36 pubmed
    ..The data indicate that Rpc11p limits RNA 3'-U length and that this significantly restricts pre-tRNAs to a La-independent pathway of maturation in fission yeast. ..
  54. Ryan C, Kao C, Sleve D, Read L. Biphasic decay of guide RNAs in Trypanosoma brucei. Mol Biochem Parasitol. 2006;146:68-77 pubmed
    ..Overall, these results provide the first evidence for a gRNA-specific decay pathway. ..
  55. Wilusz C, Wilusz J. New ways to meet your (3') end oligouridylation as a step on the path to destruction. Genes Dev. 2008;22:1-7 pubmed publisher
  56. Sakai A, Otani M, Miyamoto A, Yoshida H, Furuya E, Tanigawa N. Identification of phosphorylated serine-15 and -82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics. J Proteomics. 2012;75:806-18 pubmed publisher
    ..The current findings indicate that phosphorylated HSPB1 may play an important role in 5-FU resistance. ..
  57. Kelleher W, Grisebach H. Hydride transfer in the biosynthesis of uridine diphospho-apiose from uridine diphospho-D-glucuronic acid with an enzyme preparation of Lemna minor. Eur J Biochem. 1971;23:136-42 pubmed
  58. Laitinen J, Uri A, Raidaru G, Miettinen R. [(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor. J Neurochem. 2001;77:505-18 pubmed
    ..b>Uracil nucleotides were ineffective but 2-methylthio-ADP activated G proteins approximately 500-fold more potently than ADP, ..
  59. Chow C, Cunningham P, Lee K, Meroueh M, SantaLucia J, Varma S. Photoinduced cleavage by a rhodium complex at G.U mismatches and exposed guanines in large and small RNAs. Biochimie. 2002;84:859-68 pubmed
    ..In general, RNA backbone scission by the metal complex was induced at G.U mismatches and at exposed G residues. The cleavage activity was observed on the three small RNA hairpins as well as on the isolated 1542-nucleotide ribosomal RNA. ..
  61. Guranowski A, de Diego A, Sillero A, Günther Sillero M. Uridine 5'-polyphosphates (p4U and p5U) and uridine(5')polyphospho(5')nucleosides (Up(n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae. FEBS Lett. 2004;561:83-8 pubmed
    ..Occurrence of such dinucleotides in S. cerevisiae and Escherichia coli has been previously reported (Coste et al., J. Biol. Chem. 262 (1987) 12096-12103). ..
  62. Hoefig K, Rath N, Heinz G, Wolf C, Dameris J, Schepers A, et al. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013;20:73-81 pubmed publisher
    ..These data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure. ..
  63. Wotring L, Townsend L. Identification of 6-azauridine triphosphate in L1210 cells and its possible relevance to cytotoxicity. Cancer Res. 1989;49:289-94 pubmed
    ..Therefore, we propose that the inhibition of pyrimidine de novo synthesis and the incorporation into nucleic acid(s) may act in concert to produce the cytotoxic effects of AzUrd...
  64. Min Jou W, Haegeman G, Ysebaert M, Fiers W. Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein. Nature. 1972;237:82-8 pubmed
  65. Zakharenko A, Kolpashchikov D, Khodyreva S, Lavrik O, Menendez Arias L. Investigation of the dNTP-binding site of HIV-1 reverse transcriptase using photoreactive analogs of dNTP. Biochemistry (Mosc). 2001;66:999-1007 pubmed
    ..The use of the sensitizer decreased the number of modification products and increased selective labeling of the catalytic subunit of both the mutant and wild-type RT. ..
  66. Aucagne V, Berteina Raboin S, Guenot P, Agrofoglio L. Palladium-catalyzed synthesis of uridines on polystyrene-based solid supports. J Comb Chem. 2004;6:717-23 pubmed
    ..Except the Suzuki-type reactions, the presented methods exhibit a significant improvement and facilitate the synthetic procedure with respect to purification and yields (determined after filtration over silica gel). ..
  67. Rubini P, Milosevic J, Engelhardt J, Al Khrasani M, Franke H, Heinrich A, et al. Increase of intracellular Ca2+ by adenine and uracil nucleotides in human midbrain-derived neuronal progenitor cells. Cell Calcium. 2009;45:485-98 pubmed publisher
    ..In conclusion, UTP may induce the release of ATP from hmNPCs via P2Y(2) receptor-activation and thereby causes [Ca(2+)](i) transients by stimulating a P2Y(1)-like receptor. ..
  68. Shimazaki Den S, Iseda H, Dogru M, Shimazaki J. Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. Cornea. 2013;32:1120-5 pubmed publisher
    ..Because many patients who have UTF are refractory to conventional treatments, DQS may offer benefits in the treatment of dry eyes. ..
  69. Tanner N, Hanna M, Abelson J. Binding interactions between yeast tRNA ligase and a precursor transfer ribonucleic acid containing two photoreactive uridine analogues. Biochemistry. 1988;27:8852-61 pubmed
    ..On the basis of these data, we present a model for the in vivo splicing reaction of yeast precursor tRNAs. ..
  70. Liguori A, Napoli A, Sindona G. Survey of the proton affinities of adenine, cytosine, thymine and uracil dideoxyribonucleosides, deoxyribonucleosides and ribonucleosides. J Mass Spectrom. 2000;35:139-44 pubmed
    ..The scale extends over a very narrow range of approximately 2 kcal mol(-1), thus demonstrating the sensitivity of the kinetic method in the evaluation of small differences in thermodynamic parameters. ..
  71. Li C, Reches M, Engelberg Kulka H. The bulged nucleotide in the Escherichia coli minimal selenocysteine insertion sequence participates in interaction with SelB: a genetic approach. J Bacteriol. 2000;182:6302-7 pubmed
    ..coli SECIS. Thus, the E. coli SECIS upper stem-loop structure can be considered a "single suppressible unit," suggesting that there is some flexibility to the nature of the interaction between this element and SelB. ..
  72. Borisova O, Romanenkov A, Metelev V, Kubareva E, Zubin E, Timchenko M, et al. [DNA duplexes containing 2'-deoxy-2'-iodoacetamidouridine as reagents for affinity modification of proteins]. Mol Biol (Mosk). 2003;37:534-43 pubmed
  73. Lacenere C, Garg M, Stoltz B, Quake S. Effects of a modified dye-labeled nucleotide spacer arm on incorporation by thermophilic DNA polymerases. Nucleosides Nucleotides Nucleic Acids. 2006;25:9-15 pubmed
    ..Furthermore, some of the assayed polymerases are capable of extending the primer to the full or near full length of 30 nucleotides using dye-labeled nucleotides exclusively. ..
  74. Arita R, Suehiro J, Haraguchi T, Maeda S, Maeda K, Tokoro H, et al. Topical diquafosol for patients with obstructive meibomian gland dysfunction. Br J Ophthalmol. 2013;97:725-9 pubmed publisher
    ..0001). Quantitative image analysis was useful for evaluating the morphological changes of the meibomian glands. Topical diquafosol therapy was effective for patients with obstructive MGD. ..
  75. Kore A, Senthilvelan A, Srinivasan B, Shanmugasundaram M. Facile protection-free one-pot chemical synthesis of nucleoside-5'-tetraphosphates. Nucleosides Nucleotides Nucleic Acids. 2013;32:411-20 pubmed publisher
    ..A plausible mechanism is proposed to account for the formation of product. ..
  76. Gaspar I, Wippich F, Ephrussi A. Enzymatic production of single-molecule FISH and RNA capture probes. RNA. 2017;23:1582-1591 pubmed publisher
  77. Charlier D, Gigot D, Huysveld N, Roovers M, Pierard A, Glansdorff N. Pyrimidine regulation of the Escherichia coli and Salmonella typhimurium carAB operons: CarP and integration host factor (IHF) modulate the methylation status of a GATC site present in the control region. J Mol Biol. 1995;250:383-91 pubmed
  78. Lu Y, Switzer R. Transcriptional attenuation of the Bacillus subtilis pyr operon by the PyrR regulatory protein and uridine nucleotides in vitro. J Bacteriol. 1996;178:7206-11 pubmed
    ..The results strongly support the model for transcriptional regulation of the B. subtilis pyr operon previously proposed by R. J. Turner, Y. Lu, and R. L. Switzer (J. Bacteriol. 176:3708-3722, 1994). ..
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    ..Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes, compared to normal saline in patients with dry eye syndrome. ..
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