cytosine nucleotides

Summary

Summary: A group of pyrimidine NUCLEOTIDES which contain CYTOSINE.

Top Publications

  1. Neumann M, Seduk F, Iobbi Nivol C, Leimkuhler S. Molybdopterin dinucleotide biosynthesis in Escherichia coli: identification of amino acid residues of molybdopterin dinucleotide transferases that determine specificity for binding of guanine or cytosine nucleotides. J Biol Chem. 2011;286:1400-8 pubmed publisher
    ..Analysis of protein-protein interactions showed that the C-terminal domain of either MocA or MobA determines the specific binding to the respective acceptor protein. ..
  2. Jacobsen J, Perkins C, Callahan J, Sambamurti K, Humayun M. Mechanisms of mutagenesis by chloroacetaldehyde. Genetics. 1989;121:213-22 pubmed
    ..Paradoxically, ethenoadenines are efficiently bypassed by a mechanism which appears to be largely nonmutagenic. ..
  3. Liguori A, Napoli A, Sindona G. Survey of the proton affinities of adenine, cytosine, thymine and uracil dideoxyribonucleosides, deoxyribonucleosides and ribonucleosides. J Mass Spectrom. 2000;35:139-44 pubmed
    ..The scale extends over a very narrow range of approximately 2 kcal mol(-1), thus demonstrating the sensitivity of the kinetic method in the evaluation of small differences in thermodynamic parameters. ..
  4. Pan H, Lin H, Ku W, Li T, Li S, Lin C, et al. Haplotype analysis of the myotonic dystrophy type 1 (DM1) locus in Taiwan: implications for low prevalence and founder mutations of Taiwanese myotonic dystrophy type 1. Eur J Hum Genet. 2001;9:638-41 pubmed
    ..These findings support the notion that the out-of-Africa DM1 alleles were originated by stepwise expansion from a pool of large-sized normal chromosomes with haplotype A. ..
  5. Schlosser K, Li Y. DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides. Nucleic Acids Res. 2009;37:413-20 pubmed publisher
    ..The demonstration of a catalytic DNA molecule made from a binary nucleotide alphabet broadens our understanding of the fundamental limits of nucleic-acid-mediated catalysis. ..
  6. Newell J, Markby D, Schachman H. Cooperative binding of the bisubstrate analog N-(phosphonacetyl)-L-aspartate to aspartate transcarbamoylase and the heterotropic effects of ATP and CTP. J Biol Chem. 1989;264:2476-81 pubmed
    ..Ligation of the regulatory subunits by either of the allosteric effectors leads to a change in the effect of PALA on the association-dissociation equilibrium. ..
  7. Ulvik A, Ueland P, Fredriksen A, Meyer K, Vollset S, Hoff G, et al. Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study. Hum Genet. 2007;121:57-64 pubmed
    ..In conclusion, this report demonstrates functional inference of the MTHFR 677 C > T and 1,298 A > C polymorphisms from a large-scale epidemiological study. ..
  8. Taha H, Dove S, Geduhn J, Konig B, Shen Y, Tang W, et al. Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:57-68 pubmed publisher
    ..These data provide a basis for future studies aiming at the development of potent EF inhibitors with high selectivity relative to mammalian ACs...
  9. Kang G, Cooney D, Moyer J, Kelley J, Kim H, Marquez V, et al. Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase. J Biol Chem. 1989;264:713-8 pubmed
    ..The Hill coefficient was calculated to be 3.2. ..

More Information

Publications103 found, 100 shown here

  1. Kausar J, Ohyama Y, Terato H, Ide H, Yamamoto O. 16S rRNA gene sequence of Rubrobacter radiotolerans and its phylogenetic alignment with members of the genus Arthrobacter, gram-positive bacteria, and members of the family Deinococcaceae. Int J Syst Bacteriol. 1997;47:684-6 pubmed
    ..Moreover, although it is radioresistant and has a high G+C content, R. radiotolerans is more closely related to the gram-positive bacteria with high G+C contents than to the radioresistant members of the Deinococcaceae. ..
  2. Rahmani T, Azad M, Chahardouli B, Nasiri H, Vatanmakanian M, Kaviani S. Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia. Int J Hematol Oncol Stem Cell Res. 2017;11:172-177 pubmed
    ..According to this method, un-methylated cytosine nucleotides are converted to uracil by sodium bisulfite and the proliferation of methylated and un-methylated regions ..
  3. Lindahl T, Nyberg B. Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry. 1974;13:3405-10 pubmed
  4. Park J, Han H, Kang M, Nakamura Y. Presymptomatic diagnosis of familial adenomatous polyposis coli. Dis Colon Rectum. 1994;37:700-7 pubmed
  5. Lissak A, Sharon A, Fruchter O, Kassel A, Sanderovitz J, Abramovici H. Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss. Am J Obstet Gynecol. 1999;181:126-30 pubmed
  6. Shao X, O Neill K, Zhao Z, Anderson S, Malik A, Lee M. Analysis of nucleotide pools in human lymphoma cells by capillary electrophoresis. J Chromatogr A. 1994;680:463-8 pubmed
    ..The whole capillary electrophoretic separation time was only 35 min. These results demonstrate that capillary electrophoresis provides a useful and easy way to analyze nucleotide pools in cells. ..
  7. Monaco H, Crawford J, Lipscomb W. Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate. Proc Natl Acad Sci U S A. 1978;75:5276-80 pubmed
    ..The active site is at or near the interface between adjacent C chains within the trimers. Probably each active center involves amino acid residues from adjacent C chains. ..
  8. Zielenski J, Markiewicz D, Rininsland F, Rommens J, Tsui L. A cluster of highly polymorphic dinucleotide repeats in intron 17b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Am J Hum Genet. 1991;49:1256-62 pubmed
    ..These dinucleotide repeats should be useful in genetic linkage studies, in counseling for CF families with unknown mutations, and in tracing the origins of the various mutant CF alleles. ..
  9. Tsukamoto K, Yoshida H, Watanabe S, Suzuki T, Miyao M, Hosoi T, et al. Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenopausal Japanese women. J Hum Genet. 1999;44:148-51 pubmed
    ..294 +/- 0.064 vs 0.312 +/- 0.061 g/cm2; P = 0.0221). This result suggests that genetic variation at the IL-6 gene locus is associated with some determinants of BMD in postmenopausal women. ..
  10. Rakocevic Stojanovic V, Savic D, Pavlovic S, Lavrnic D, Romac S, Apostolski S. Correlation between cardiac involvement and CTG repeat amplification in myotonic dystrophy type 1. Acta Myol. 2003;22:26-7 pubmed
  11. Crauste C, Perigaud C, Peyrottes S. Insights into the soluble PEG-supported synthesis of cytosine-containing nucleoside 5'-mono-, di-, and triphosphates. J Org Chem. 2009;74:9165-72 pubmed publisher
    ..Applied to natural and synthetic cytosine containing nucleosides, this methodology allowed the preparation of various phosphorylated forms in high yields and good purity. ..
  12. Herzig M, Rodriguez K, Trevino A, Dziegielewski J, Arnett B, Hurley L, et al. The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level. Biochemistry. 2002;41:1545-55 pubmed
    ..This study underscores the significance of the genome factor in a drug's potential for region-specific DNA damage, by showing that it can take precedence over drug binding preferences at the nucleotide level. ..
  13. Gremer L, Meyer O. Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of a molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor. Eur J Biochem. 1996;238:862-6 pubmed
    ..atypica had a heterotrimeric subunit structure and a single [2Fe-2S] cluster. In addition, the enzyme indicates the presence of a molybdopterin dinucleotide as a constituent of a xanthine dehydrogenase molybdenum cofactor...
  14. Koo D, Han F, Birchler J, Jiang J. Distinct DNA methylation patterns associated with active and inactive centromeres of the maize B chromosome. Genome Res. 2011;21:908-14 pubmed publisher
    ..In contrast, an inactive version of this same centromere exhibits hypermethylation, indicating that the inactive centromere was modified into a different epigenetic state at the DNA level. ..
  15. Fazaeli S, Ashouri S, Kheirollahi M, Mohammadi M, Fazilati M. A Novel Mutation in SLC7A9 Gene in Cystinuria. Iran J Kidney Dis. 2017;11:138-141 pubmed
    ..in exon 4 of the SLC7A9 gene was identified, which was insertion of 1 adenine nucleotide between 2 cytosine nucleotides in position c.213-214insA...
  16. Ben Hattar J, Jiricny J. Methylation of single CpG dinucleotides within a promoter element of the Herpes simplex virus tk gene reduces its transcription in vivo. Gene. 1988;65:219-27 pubmed
    ..2-kb vector, our results demonstrate that the presence of a single mCpG dinucleotide within the promoter region is sufficient for transcriptional inactivation of the tk gene. The possible mechanisms of this downregulation are discussed. ..
  17. Chan P, Henig I, Tredway D. Regulation of mouse trophoblast giant cell nucleus development in hatched mouse blastocysts by cyclic cytidine 3',5'-monophosphate (cCMP). Experientia. 1988;44:774-5 pubmed
    ..The result suggests that cCMP has a trophic effect on embryonic development, specifically by altering the size of the trophoblast cell nucleus but does not enhance trophoblast cell proliferation processes. ..
  18. Riegger G, Elsner D, Kromer E, Daffner C, Forssmann W, Muders F, et al. Atrial natriuretic peptide in congestive heart failure in the dog: plasma levels, cyclic guanosine monophosphate, ultrastructure of atrial myoendocrine cells, and hemodynamic, hormonal, and renal effects. Circulation. 1988;77:398-406 pubmed
    ..This suggests an intracellular defect that prevents the mediation of the hormonal signal into biological action in the presence of heart failure. ..
  19. Ghalambor M, Heath E. The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase. J Biol Chem. 1966;241:3216-21 pubmed
  20. Williams P, Etcheverry S, Baran E. A spectrophotometric study of the interaction of VO2+ with cytosine in nucleotides. J Inorg Biochem. 1996;61:285-9 pubmed
    ..Similar spectroscopic measurements with the systems VO2+/PO(3-)4, VO2+/P2O(4-)7, and VO2+/D-ribose were also performed in order to complement the analysis of the experimental results. ..
  21. Hiraide A, Hiroishi K, Eguchi J, Ishii S, Doi H, Imawari M. Dendritic cells stimulated with cytidine-phosphate-guanosine oligodeoxynucleotides and interferon-alpha-expressing tumor cells effectively reduce outgrowth of established tumors in vivo. Cancer Sci. 2008;99:1663-9 pubmed publisher
    ..As DC-based immunotherapy with CpG ODN and IFN-alpha-expressing tumor cells induces a potent antitumor immune response, it should be considered for clinical application. ..
  22. Colicchio J, Miura F, Kelly J, Ito T, Hileman L. DNA methylation and gene expression in Mimulus guttatus. BMC Genomics. 2015;16:507 pubmed publisher
    The presence of methyl groups on cytosine nucleotides across an organism's genome (methylation) is a major regulator of genome stability, crossing over, and gene regulation...
  23. Mages F, Macovschi O, Prigent A, Fonlupt P. Increased methylation of chloroform extractable products and CTP: cholinephosphate cytidylyltransferase in brain membrane preparations from triethyltin-intoxicated rats. Pharmacol Toxicol. 1989;65:302-5 pubmed
    ..This increase might be a compensatory mechanism for counteracting the membrane damages induced by triethyltin. ..
  24. Novotny L, Vachalkova A. Polarographic study of cytosine nucleosides. Neoplasma. 1993;40:369-72 pubmed
  25. Lin J, Tu C, Mou C, Chen X, Yang Q. CpG DNA facilitate the inactivated transmissible gastroenteritis virus in enhancing the local and systemic immune response of pigs via oral administration. Vet Immunol Immunopathol. 2016;172:1-8 pubmed publisher
    ..05). Taken together, these data suggest that oral immunization of ITGEV plus CpG DNA elicits a local immune response. Further studies are required to determine whether this immunity provides protection against TGEV in pigs. ..
  26. Carter J. Cytidine triphosphate: phosphatidic acid cytidyltransferase in Escherichia coli. J Lipid Res. 1968;9:748-54 pubmed
    ..The apparent K(m) for CTP is 7 x 10(-4)M and for phosphatidic acid, 2 x 10(-3)M. The reaction rate falls off rapidly with time and ceases entirely after 1 hr as the result of inactivation of the system by Mg(++). ..
  27. Behringer M, Hall D. Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation. G3 (Bethesda). 2015;6:149-60 pubmed publisher
    ..pombe exhibits a stronger insertion bias. Intriguingly, we observed an increased mutation rate at cytosine nucleotides, specifically CpG nucleotides, which is also seen in S. cerevisiae...
  28. Subramanian D, Griffith J. Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events. Biochemistry. 2005;44:2536-44 pubmed
    ..In all cases, phosphorylation of serine 392 occurs; however, reactivation also involves other residues. Together, the results show that p53 DNA binding activity is strongly regulated by the phosphorylation state of the protein. ..
  29. García B, Garcia Tojal J, Ruiz R, Gil García R, Ibeas S, Donnadieu B, et al. Interaction of the DNA bases and their mononucleotides with pyridine-2-carbaldehyde thiosemicarbazonecopper(II) complexes. Structure of the cytosine derivative. J Inorg Biochem. 2008;102:1892-900 pubmed publisher
    ..A pseudocoordination to the cytosine O12 site (=O2) can also be considered. ..
  30. Thompson R. The formation of CDP-diglyceride by isolated neuronal nuclei. J Neurochem. 1975;25:811-23 pubmed
  31. Quigley F, Brinkmann H, Martin W, Cerff R. Strong functional GC pressure in a light-regulated maize gene encoding subunit GAPA of chloroplast glyceraldehyde-3-phosphate dehydrogenase: implications for the evolution of GAPA pseudogenes. J Mol Evol. 1989;29:412-21 pubmed
    ..A speculative model is presented explaining these observations in terms of a homologous recombination of genes with their reverse-transcribed pre-mRNAs. ..
  32. Wu R, Taylor E. Nucleotide sequence analysis of DNA. II. Complete nucleotide sequence of the cohesive ends of bacteriophage lambda DNA. J Mol Biol. 1971;57:491-511 pubmed
  33. Shapiro R, Agarwal S. Reaction of ninhydrin with cytosine derivatives. J Am Chem Soc. 1968;90:474-8 pubmed
  34. Bezdek M, Koukalova B, Kuhrova V, Vyskot B. Differential sensitivity of CG and CCG DNA sequences to ethionine-induced hypomethylation of the Nicotiana tabacum genome. FEBS Lett. 1992;300:268-70 pubmed
  35. Yoshida Y, Yamada J, Watanabe T, Suga T, Takayama H. Participation of the peroxisomal beta-oxidation system in the chain-shortening of PCA16, a metabolite of the cytosine arabinoside prodrug, YNKO1, in rat liver. Biochem Pharmacol. 1990;39:1505-12 pubmed
    ..These results indicate that peroxisomal beta-oxidation participates in the shortening of the alkyl-side chain of PCA16 and plays an important role in the formation of antileukemic cytosine arabinoside from YNKO1. ..
  36. Howlin B, Harris G, Moss D, Palmer R. X-ray refinement study on the binding of cytidylic acid (2'-CMP) to ribonuclease A. J Mol Biol. 1987;196:159-64 pubmed
    ..Phe120 is much closer to the inhibitor than in the cytidine N(3)-oxide 2'-phosphate structure. ..
  37. Min Jou W, Haegeman G, Ysebaert M, Fiers W. Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein. Nature. 1972;237:82-8 pubmed
  38. Galimberti D, Fenoglio C, Clerici R, Comi C, De Riz M, Rottoli M, et al. E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. J Neuroimmunol. 2005;165:201-5 pubmed
    ..The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS. ..
  39. Yanagida M, Gohda E, Yamamoto I. Dibutyrylcytidine 3',5'-cyclic monophosphate stimulates neurite outgrowth in rat pheochromocytoma PC12. Neurosci Lett. 1990;114:323-8 pubmed
    ..Staurosporine inhibited the neurite outgrowth induced by NGF, but not that by Bt2cCMP. These results suggest that Bt2cCMP stimulates neuronal differentiation by a mechanism different from that by NGF. ..
  40. Ishida T, Ueda H, Segawa K, Doi M, Inoue M. Prominent stacking interaction with aromatic amino acid by N-quarternization of nucleic acid base: X-ray crystallographic characteristics and biological implications. Arch Biochem Biophys. 1990;278:217-27 pubmed
  41. Beres J, Bentrude W, Otvos L, Balzarini J, De Clercq E. Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates. J Med Chem. 1989;32:224-8 pubmed
    ..A drug design rationale for utilization of 5-alkylcytidines based on their potential conversion to biologically active 5-alkyl-2'-deoxyuridines is not supported by these experimental findings. ..
  42. O Donovan G, Herlick S, Beck D, Dutta P. UTP/CTP ratio, an important regulatory parameter for ATCase expression. Arch Microbiol. 1989;153:19-25 pubmed
    ..This applied to all conditions in the present work as well as to all conditions in work hitherto reported by others. The ratio of UTP/CTP is proposed as a key regulatory parameter for pyr enzyme expression. ..
  43. Lepers A, Shaw L, Cacan R, Schauer R, Montreuil J, Verbert A. Transport of CMP-N-glycoloylneuraminic acid into mouse liver Golgi vesicles. FEBS Lett. 1989;250:245-50 pubmed
    ..This transport system for CMP-Neu5Gc involves both CMP and CMP-Neu5Gc since intravesicular CMP induced the entry of external CMP-Neu5Gc. ..
  44. Chan S, Orenberg J, Lahav N. Soluble minerals in chemical evolution. II. Characterization of the adsorption of 5'-AMP and 5'-CMP on a variety of soluble mineral salts. Orig Life Evol Biosph. 1987;17:121-34 pubmed
    ..The implications of the results of the study are discussed in terms of the importance of soluble mineral salts as adsorption sites in the characterization of the adsorption reactions of an adsorbed template in biogeochemical cycles. ..
  45. Vitols E, Bauer V, Stanbrough E. Ribonucleotide reductase from Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1970;41:71-7 pubmed
  46. Zhang Y, Kantrowitz E. Lysine-60 in the regulatory chain of Escherichia coli aspartate transcarbamoylase is important for the discrimination between CTP and ATP. Biochemistry. 1989;28:7313-8 pubmed
    ..For the mutant enzyme, CTP affinity is reduced approximately 100-fold, while ATP affinity is increased by 5-fold.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  47. Wild J, Loughrey Chen S, Corder T. In the presence of CTP, UTP becomes an allosteric inhibitor of aspartate transcarbamoylase. Proc Natl Acad Sci U S A. 1989;86:46-50 pubmed
    ..The synergistic inhibition of ATCase by both CTP and UTP provides a satisfying logic for ensuring a balance of endogenous pyrimidine nucleotide pools. ..
  48. Szkopinska A, Nowak L, Swiezewska E, Palamarczyk G. CTP-dependent lipid kinases of yeast. Arch Biochem Biophys. 1988;266:124-31 pubmed
    ..This result points to the specific role of CTP as a gamma-phosphate donor for the synthesis of phosphatidate and dolichyl phosphates in the yeast system. ..
  49. Rodbell M, Birnbaumer L, Pohl S, Krans H. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. J Biol Chem. 1971;246:1877-82 pubmed
  50. Kristal A, Price D, Till C, Schenk J, Neuhouser M, Ockers S, et al. Androgen receptor CAG repeat length is not associated with the risk of incident symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial. Prostate. 2010;70:584-90 pubmed publisher
    ..There were no associations of AR CAG repeat length and BPH risk. Knowledge of AR CAG repeat length provides no clinical useful information for the prevention of symptomatic BPH. ..
  51. Johnson J, Rajagopalan K, Meyer O. Isolation and characterization of a second molybdopterin dinucleotide: molybdopterin cytosine dinucleotide. Arch Biochem Biophys. 1990;283:542-5 pubmed
  52. Stuhne Sekalec L, Stanacev N. Modification of the biosynthesis and composition of polyglycerophosphatides in outer and inner mitochondrial membranes by cytidine liponucleotides. Membr Biochem. 1989;8:165-75 pubmed
    ..The formation of [3H]cardiolipin from [3H]phosphatidylglycerol in the presence of CDP-didecanoin and Mn2+ was found in both the outer and inner mitochondrial membranes. ..
  53. Damron D, Dorman R. [3H]arachidonic acid metabolism in rat brain minces: effects of nucleotide triphosphates, CDPcholine and CMP. Neurochem Res. 1988;13:777-83 pubmed
  54. Eisbruch A, Shewach D, Bradford C, Littles J, Teknos T, Chepeha D, et al. Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study. J Clin Oncol. 2001;19:792-9 pubmed
    ..Different regimens of combined radiation and gemcitabine should be evaluated, based on newer preclinical data promising an improved therapeutic ratio. ..
  55. Sachelaru P, Schiltz E, Brandsch R. A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans. Appl Environ Microbiol. 2006;72:5126-31 pubmed publisher
    ..A mobA gene responsible for the formation of MCD could be identified and its function shown to be required for assembly of the heterotrimeric molybdenum enzymes...
  56. Spaniel F, Horacek J, Tintera J, Ibrahim I, Novak T, Cermak J, et al. Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients. Neurosci Lett. 2011;493:131-5 pubmed publisher
    ..Our data suggest that GMC reductions in schizophrenia may be driven by C allele carriers of the FOXP2 gene variant. ..
  57. Lavia P, Macleod D, Bird A. Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse. EMBO J. 1987;6:2773-9 pubmed
    ..The results support the view that HTF islands often mark genes, and they suggest that bidirectional transcription may be a common feature of island promoters. ..
  58. Kodama K, Morozumi M, Saitoh K, Kuninaka A, Yoshino H, Saneyoshi M. Antitumor activity and pharmacology of 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate: an orally active derivative of 1-beta-D-arabinofuranosylcytosine. Jpn J Cancer Res. 1989;80:679-85 pubmed
    ..These results indicate that C18PCA administered per orally is absorbed intact through the gastrointestinal tract and area-C is released of long period of time. C18PCA is regarded as an orally active depot form of ara-C. ..
  59. Grem J, Geoffroy F, Politi P, Cuddy D, Ross D, Nguyen D, et al. Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells. Mol Pharmacol. 1995;48:305-15 pubmed
    ..5%, 19%, and 21% with 0.1, 1, and 10 microM AraC DNA content, magnitude of nascent DNA damage, duration of DNA synthetic inhibition, and induction of double-stranded DNA fragmentation appeared to be the crucial determinants of lethality. ..
  60. Saha T, Usdin K. Tetraplex formation by the progressive myoclonus epilepsy type-1 repeat: implications for instability in the repeat expansion diseases. FEBS Lett. 2001;491:184-7 pubmed
    ..However, EPM1 is unique in that tetraplexes are the only structures likely to form in long unpaired repeat tracts under physiological conditions. ..
  61. Kappen L, Chen C, Goldberg I. Atypical abasic sites generated by neocarzinostatin at sequence-specific cytidylate residues in oligodeoxynucleotides. Biochemistry. 1988;27:4331-40 pubmed
    ..Each type of lesion may exist on the complementary strands of the same DNA molecule, forming a double-stranded lesion. ..
  62. Kubin T, Yanagida M, Mori S, Hayashi Y, Gohda E, Yamamoto I. Inhibition of DNA synthesis of adult rat hepatocytes in primary culture by dibutyrylcytidine 3', 5'-cyclic monophosphate. Cell Biol Int Rep. 1989;13:907-17 pubmed
    ..When added at the onset of DNA synthesis, Bt2cAMP was much less effective, but Bt2cCMP was still effective. Thus Bt2cCMP is able to inhibit growth factor-stimulated hepatocyte proliferation. ..
  63. Subramaniam R, Wang Y, Mathews C, Santi D. On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2'-deoxycytidine 5'-monophosphate. Arch Biochem Biophys. 1989;275:11-5 pubmed
    ..We conclude that FdCMP is not a mechanism-based inhibitor of dCMP hydroxymethylase. ..
  64. Chiba P, Cory J. CTP: CMP phosphotransferase activity in L1210 cells. Cancer Biochem Biophys. 1988;9:353-8 pubmed
    ..Monitoring of nucleoside diphosphate substrate level is, therefore, mandatory for obtaining accurate measurements of CDP reductase activity in crude cell extracts. ..
  65. Noguchi T, Shiba T. Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis. Biosci Biotechnol Biochem. 1998;62:1594-6 pubmed
    ..It was confirmed that the PPK efficiently catalyzed the UTP regeneration in the cyclic system of N-acetyllactosamine synthesis. This novel activity of PPK enables us to perform the practical synthesis of oligosaccharides. ..
  66. Javaux F, Bertaux F, Donda A, Francis Lang H, Vassart G, DiLauro R, et al. Functional role of TTF-1 binding sites in bovine thyroglobulin promoter. FEBS Lett. 1992;300:222-6 pubmed
    ..As in the rat, sites A and C only are critical for promoter activity, these results suggest that full occupancy of the B site is required for thyroglobulin promoter activity in the cow only. ..
  67. Sheffield L. Cyclic cytidine monophosphate stimulates DNA synthesis by bovine mammary tissue in vitro. Cell Biol Int Rep. 1987;11:557-62 pubmed
    ..With 1 micrograms/ml insulin, dbcCMP increased DNA synthesis. Higher levels of dbcCMP reduced DNA synthesis relative to 10(-6)M dbcCMP, as did sodium butyrate. Thus cCMP is capable of stimulating mammary growth. ..
  68. Kanada S, Nakano N, Potaczek D, Maeda K, Shimokawa N, Niwa Y, et al. Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T. J Immunol. 2008;180:8204-10 pubmed
    ..The findings demonstrate that a -315 SNP significantly affects human FcepsilonRI alpha-chain promoter activity and expression level of FcepsilonRI on basophils by binding different transcription factors to the SNP site. ..
  69. Hughes A, Rando O. Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?. J Biol. 2009;8:96 pubmed publisher
    ..Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442. ..
  70. Richardson L, Richardson J. Cytosine nucleoside inhibition of the ATPase of Escherichia coli termination factor rho: evidence for a base specific interaction between rho and RNA. Nucleic Acids Res. 1992;20:5383-7 pubmed
    ..Although BrCMP could form Michaelis inhibition complexes, it did not activate rho. Rho thus lacks a diagnostic property of enzymes that make specific covalent addition complexes with pyrimidines. ..
  71. Nagahata T, Shibasaki C, Ishii T, Uchida T, Arakawa M, Kusama K, et al. [Antitumor activity of a novel analog of cytarabine, 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone 5'-(sodium octadecyl phosphate) monohydrate (YNK01)]. Gan To Kagaku Ryoho. 1990;17:1437-45 pubmed
    ..The metabolite exhibited activity against L1210 leukemia in mice after i.p. administration. These results suggest that YNK01 is a clinically useful drug with p.o. administration for cancers as well as Ara-C. ..
  72. Honzatko R, Crawford J, Monaco H, Ladner J, Ewards B, Evans D, et al. Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli. J Mol Biol. 1982;160:219-63 pubmed
  73. Morita Y, Daimon M, Kashiwaba M, Yamatani K, Igarashi M, Fukase N, et al. A point mutation, C to T, in exon 8 of the porphobilinogen deaminase gene in a Japanese family with acute intermittent porphyria. Jpn J Hum Genet. 1995;40:207-13 pubmed
    ..This mutation resulted in an Arg116 to Trp substitution. Four carriers in the family were successfully diagnosed by detecting the mutation using restriction analysis of PCR products. ..
  74. Neschastnova A, Gasanova V, Belitskiĭ G, Iakubovskaia M, Dolinnaia N. [Chemical cleavage of DNA with single base mismatches for detection of mutations of unknown localization]. Mol Biol (Mosk). 2007;41:535-43 pubmed
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