iridoid glucosides


Summary: A subclass of iridoid compounds that include a glucoside moiety, usually found at the C-1 position.

Top Publications

  1. Wang J, Li Y, Huang W, Zeng X, Li X, Li J, et al. The Protective Effect of Aucubin from Eucommia ulmoides Against Status Epilepticus by Inducing Autophagy and Inhibiting Necroptosis. Am J Chin Med. 2017;45:557-573 pubmed publisher
    ..These original findings might provide an important basis for the further investigation of the therapeutic role of aucubin in treatment or prevention of epilepsy-related neuronal damages. ..
  2. He J, Ye X, Wang X, Yang Y, Zhang P, Ma B, et al. Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis. Fitoterapia. 2017;120:136-141 pubmed publisher
    Four new and rare iridoid glucosides, cornusfuroside A-D (1-4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis...
  3. Park K, Suh W, Subedi L, Kim S, Choi S, Lee K. Secoiridoid Glucosides from the Twigs of Syringa oblata var. dilatata and Their Neuroprotective and Cytotoxic Activities. Chem Pharm Bull (Tokyo). 2017;65:359-364 pubmed publisher
    ..Compounds 5, 7, 8, 10, and 14 were found to induce upregulation of NGF secretion without causing significant cell toxicity. ..
  4. Andoh T, Uta D, Kato M, Toume K, Komatsu K, Kuraishi Y. Prophylactic Administration of Aucubin Inhibits Paclitaxel-Induced Mechanical Allodynia via the Inhibition of Endoplasmic Reticulum Stress in Peripheral Schwann Cells. Biol Pharm Bull. 2017;40:473-478 pubmed publisher
    ..These results suggest that aucubin inhibits paclitaxel-induced mechanical allodynia through the inhibition of ER stress in peripheral Schwann cells. ..
  5. Zhai L, Liu M, Wang T, Zhang H, Li S, Guo Y. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS ONE. 2017;12:e0174414 pubmed publisher
  6. Zhang Y, Xiong H, Bi J, Zhao G, Yang Y, Chen X, et al. An HPLC method for simultaneous quantitative determination of seven secoiridoid glucosides separated from the roots of Ilex pubescens. Biomed Chromatogr. 2017;31: pubmed publisher
    ..4 and 1.9%, respectively. The established method was successfully applied to simultaneous determination of seven secoiridoid glucosides in 11 batches of samples collected from different habitats in China. ..
  7. Kim J, Hwang D, Moon J, Lee Y, Yoo J, Shin D, et al. Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations. Molecules. 2017;22: pubmed publisher
    ..Based on these results, the pharmacokinetics of verproside may be affected by the co-administration of relevant UGT and SULT inhibitors or inducers. ..
  8. Chen L, Yang Y, Zhang L, Li C, Coffie J, Geng X, et al. Aucubin promotes angiogenesis via estrogen receptor beta in a mouse model of hindlimb ischemia. J Steroid Biochem Mol Biol. 2017;172:149-159 pubmed publisher
    ..It might provide insight into the ER? regulating neovascularisation in hindlimb ischemia and identify AU as a potent new compound used for the treatment of peripheral vascular disease. ..
  9. Kil Y, Kim S, Kang U, Chung H, Seo E. Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata. J Nat Prod. 2017;80:2240-2251 pubmed publisher
    ..In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 ?M. ..

More Information


  1. Yang Y, Yin B, Lv L, Wang Z, He J, Chen Z, et al. Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice. Life Sci. 2017;189:44-51 pubmed publisher
    ..Furthermore, aucubin enhanced gastric mucosal protection by up-regulation of HSP-70 level and normalization of EGF, VEGF and COX-1 levels. ..
  2. Xiong K, Gao T, Zhang T, Wang Z, Han H. Simultaneous determination of gentiopicroside and its two active metabolites in rat plasma by LC-MS/MS and its application in pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1065-1066:1-7 pubmed publisher
    ..The pharmacokinetic differences between gentiopicroside and its two metabolites were identified.Results provided the evidence for in vivo metabolism-based activation of gentiopicroside. ..
  3. Young I, Chuang S, Hsu C, Sun Y, Liu H, Chen Y, et al. Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus. BMC Complement Altern Med. 2017;17:91 pubmed publisher
    ..These results indicated that aucubin has protective effects in an osteoarthritic chondrocyte model induced by H2O2 and mechanical stimulus. ..
  4. Yang T, Zheng Q, Wang S, Fang L, Liu L, Zhao H, et al. Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice. BMC Complement Altern Med. 2017;17:240 pubmed publisher
    ..These data demonstrated that Catalpol had a strong neuroprotective effect on EAE mice. Catalpol also plays a role in remyelination by promoting the expressions of Olig1 and Olig2 transcription factors. ..
  5. Kroll Møller P, Pedersen K, Gousiadou C, Kokubun T, Albach D, Taskova R, et al. Iridoid glucosides in the genus Veronica (Plantaginaceae) from New Zealand. Phytochemistry. 2017;140:174-180 pubmed publisher
    Four simple iridoid glucosides, three known esters of catalpol, seven esters of aucubin, and two phenylethanoids were isolated from Veronica hookeri (syn. Hebe ciliolata; Plantaginaceae)...