Summary: Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale, The Extra Pharmacopoeia, 30th ed, p670)

Top Publications

  1. Kang M, Kim M, Kim W, Um J, Shin Y, Song J, et al. Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair. Oncotarget. 2016;7:6074-87 pubmed publisher
    ..Thus, lanatoside C could be a potential molecule for anti-cancer drugs and radiosensitizing agents. ..
  2. Xie L, van der Donk W. Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol. 2004;8:498-507 pubmed
    ..In addition to these developments in understanding their biosynthesis, studies on the mode of action of several lantibiotics have shown a unique mechanism of binding to lipid II, an intermediate in cell wall biosynthesis. ..
  3. Santos P, Souza S, Freire Maia L, Almeida A. Effects of crotoxin on the isolated guinea pig heart. Toxicon. 1990;28:215-24 pubmed
    ..It is suggested that the reduction of contractile force evoked by crotoxin is due probably to release of free fatty acids and lysophospholipids (initial effect) and to a cellular lesion (late effect). ..
  4. Sechser T, PETRASEK R, Stika L, Modr Z, Elis J, Maly J. Contribution of clinical pharmacology to a rational use of cardiac glycosides in Czechoslovakia. Pol J Pharmacol Pharm. 1989;41:527-32 pubmed
  5. Cristodorescu R, Deutsch G, Dragan S. Clinical utility of plasma digoxin measurements. Med Interne. 1989;27:25-32 pubmed
    ..As the method is not widely available, it has to be used in patients with borderline renal function, in aged subjects and in patients with rapid atrial fibrillation who require higher digitalis doses for heart rate control. ..
  6. Ikeda Y, Fujii Y, Nakaya I, Yamazaki M. Quantitative HPLC analysis of cardiac glycosides in Digitalis purpurea leaves. J Nat Prod. 1995;58:897-901 pubmed
    ..Quantitation was carried out by the incorporation of lanatoside A as an internal standard. The present method is sufficiently precise and relatively simple...
  7. Roscani M, Zanati S, Magalhães C, Borges V, Matsubara B. Digitalis-like induced arrhythmia in a patient with rheumatic mitral regurgitation complicated by preeclampsia. Hypertens Pregnancy. 2010;29:148-52 pubmed publisher
    ..This case calls attention to the need for further studies analysing the security of digoxin use in preeclampsia. ..
  8. Kesim Y, Marangoz C, Ayyildiz M, Tasci N, Agar E, Sahinoglu H. The effects of the purinergic system on digitalis-induced epileptiform activity. J Basic Clin Physiol Pharmacol. 1994;5:167-78 pubmed
    ..These results indicate that the purinergic system may be involved in the mechanism of action of digitalis glycosides. ..
  9. Tracqui A, Kintz P, Ludes B, Mangin P. High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma. J Chromatogr B Biomed Sci Appl. 1997;692:101-9 pubmed
    ..The lower limits of detection in single ion monitoring mode range from 0.15 ng/ml (alpha- and beta-acetyldigitoxin) to 0.60 ng/ml (lanatoside C), making the method less sensitive than radioimmunoassay, whereas it is much more specific. ..

More Information


  1. Klys M, Gross A. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990;45:231-8 pubmed
    ..Deslanoside in antemortem plasma was determined by FPIA and the analysis was done by HPLC in the postmortem tissue samples. The analytical results and methods used in the examinations are discussed in the following paper. ..
  2. Ueda Y, Mishiro K, Yoshida K, Furuta T, Kawabata T. Regioselective diversification of a cardiac glycoside, lanatoside C, by organocatalysis. J Org Chem. 2012;77:7850-7 pubmed
    ..Thus, diverse regioselective introduction of acyl groups among eight free hydroxy groups of lanatoside C was achieved. ..
  3. Shi H, Lindemann P. Expression of recombinant Digitalis lanata EHRH. cardenolide 16'-O-glucohydrolase in Cucumis sativus L. hairy roots. Plant Cell Rep. 2006;25:1193-8 pubmed
    ..Therefore, the cgh I transformed cucumber hairy roots may provide a valuable model for biotransformation of natural compounds by recombinant enzymes. ..
  4. Chen D, Cao J, Zhu B. Drug therapy of paroxysmal atrial fibrillation in the elderly over 75 years old. Chin Med Sci J. 2006;21:16-9 pubmed
    ..Amiodarone and cedilanid may be the proper drugs for the treatment of paroxysmal atrial fibrillation in the elderly. The above antiarrhythmics in each therapeutic group were relatively safe and effective. ..
  5. Zamotaev I, Kremnev I, Podshibiakin S. [Cardiac glycosides in complex treatment of patients with heart failure and supraventricular arrhythmias]. Klin Med (Mosk). 2005;83:59-63 pubmed
    ..The combination celanide + enalapril + indapamide in individual doses was effective in FC II-III HF with supraventricular arrhythmias. The cost of treatment with celanid is lower. ..
  6. Kessler C. The digoxigenin:anti-digoxigenin (DIG) technology--a survey on the concept and realization of a novel bioanalytical indicator system. Mol Cell Probes. 1991;5:161-205 pubmed
    ..It is also shown that with these applications alternative reaction formats are used which are partly characterized by additional amplification steps. ..
  7. Guillarme D, Grata E, Glauser G, Wolfender J, Veuthey J, Rudaz S. Some solutions to obtain very efficient separations in isocratic and gradient modes using small particles size and ultra-high pressure. J Chromatogr A. 2009;1216:3232-43 pubmed publisher
    ..Compared to 30 degrees C, peak capacities were increased by about 20-30% for a constant gradient length at 90 degrees C and gradient time decreased by 2-fold for an identical peak capacity. ..
  8. Qiao D. [A study on the hemodynamic effect of cedilanid in the treatment of acute myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi. 1993;21:83-4, 122 pubmed
    ..From the hemodynamic studies, the beneficial effect of cedilanid is greater than its adverse effect. It is concluded that digitalis can be safely and effectively used in the treatment of AMI. ..
  9. Badr C, Wurdinger T, Nilsson J, Niers J, Whalen M, Degterev A, et al. Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. Neuro Oncol. 2011;13:1213-24 pubmed publisher
    ..Activation of such mechanism may be a useful strategy to counter resistance of cancer cells to apoptosis. ..
  10. Lembo G, Rendina V, Iaccarino G, De Luca N, Ricciardelli B, Volpe M, et al. Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy. J Hypertens. 1993;11:1395-402 pubmed
    ..Therefore, impairment of this reflex response seems to be related to functional rather than to structural abnormalities of the hypertrophied ventricle. ..
  11. Crommentuijn M, Maguire C, Niers J, Vandertop W, Badr C, Würdinger T, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2016;10:625-34 pubmed publisher
    ..In summary, AAV-sTRAIL combined with lanatoside C induced cell death in U87 glioma cells and patient-derived GBM neural spheres in culture and in vivo leading to an increased in overall mice survival. ..
  12. Shi H, Mao X, Zhong Y, Liu Y, Zhao X, Yu K, et al. Lanatoside C Promotes Foam Cell Formation and Atherosclerosis. Sci Rep. 2016;6:20154 pubmed publisher
    ..Overall, our data demonstrate that lanatoside C aggravates the development of atherosclerosis by inducing PPARβ/δ expression, which mediates upregulation of SR-A and CD36, and promotes oxLDL uptake and foam-cell formation. ..