Summary: An antineoplastic agent derived from BLEOMYCIN.

Top Publications

  1. Hagiwara A, Takahashi T, Kojima O, Kitamura K, Sakakura C, Shoubayashi S, et al. Endoscopic local injection of a new drug-delivery format of peplomycin for superficial esophageal cancer: a pilot study. Gastroenterology. 1993;104:1037-43 pubmed
    A new drug-delivery format comprising activated carbon particles adsorbing peplomycin (PEP-CH) was developed for the treatment of superficial esophageal cancer...
  2. Yoshimura K, Yamauchi T, Maeda H, Kawai T. Cisplatin, vincristine, methotrexate, peplomycin, etoposide (COMPE) therapy for disseminated germ cell testicular tumors. Int J Urol. 1997;4:47-51 pubmed
    ..COMPE is an effective chemotherapy regimen in patients with disseminated germ cell testicular tumors. Complications arising from this therapy are mild. ..
  3. Ikeda S, Ozaki K. Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II). Biochem Biophys Res Commun. 1997;235:291-4 pubmed
    ..Treatment of DNA with L-ascorbic acid or peplomycin, that introduces single-strand breaks through active oxygen radicals, greatly enhanced the susceptibility to ..
  4. Ueta E, Yoneda K, Yamamoto T, Osaki T. Manganese superoxide dismutase negatively regulates the induction of apoptosis by 5-fluorouracil, peplomycin and gamma-rays in squamous cell carcinoma cells. Jpn J Cancer Res. 1999;90:555-64 pubmed
    ..The Mn-SOD activity was increased by treatments with 5-fluorouracil (5-FU), peplomycin and 137Cs, reaching plateau levels at 12 h after treatment and then decreasing gradually...
  5. Umebayashi Y, Enomoto H, Ogasawara M. Drug eruption due to peplomycin: an unusual form of Stevens-Johnson syndrome with pustules. J Dermatol. 2004;31:802-5 pubmed
    A rare case of Stevens-Johnson syndrome (SJS) due to peplomycin in a 48-year-old man is described. The patient had squamous cell carcinoma on the scalp and underwent preoperative neoadjuvant chemotherapy with peplomycin...
  6. Liu T, Shimada H, Ochiai T, Shiratori T, Lin S, Kitagawa M, et al. Enhancement of chemosensitivity toward peplomycin by calpastatin-stabilized NF-kappaB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism. Apoptosis. 2006;11:1025-37 pubmed
    ..Tn and YES-6 cells. T.Tn cells were more resistant than YES-6 cells to peplomycin (PEP) but not to the other anticancer drugs such as camptothecin, mitomycin C and cytosine arabinoside...
  7. Chisholm R, Dixon A, Williams M, Oliver R. Bleomycin lung: the effect of different chemotherapeutic regimens. Cancer Chemother Pharmacol. 1992;30:158-60 pubmed
    ..63, P less than 0.01). Nevertheless, in view of continuing reports of mortality resulting from bleomycin-induced pulmonary fibrosis in patients receiving the drug by i.v. bolus, further exploration of these results is clearly justified. ..
  8. Hirai M. [Thermochemotherapy of prostatic cancer]. Hinyokika Kiyo. 1991;37:833-6 pubmed
    We performed hyperthermia concomitantly with the use of anticancer agents (etoposide and peplomycin) for the treatment of 13 patients with prostatic cancer. Seven of them were new cases and the others were recurrent ones...
  9. Nishio M, Kagami Y, Narimatsu N, Asano K, Sanbe S, Somekawa Y. [Treatment of squamous cell carcinoma of the head and neck with multi-drug chemotherapy and radiotherapy]. Gan To Kagaku Ryoho. 1989;16:3111-8 pubmed
    ..4% in recurrent or metastatic patients. Problems of chemotherapy combined with radiotherapy and future direction of clinical study in locally advanced or recurrent head and neck cancer are discussed. ..

More Information

Publications103 found, 100 shown here

  1. Mall G, Burkhardt A. Pulmonary toxicity of the combination of bleomycin and peplomycin--an experimental study in rats. Cancer Chemother Pharmacol. 1991;28:357-60 pubmed
    Combination of the two drugs bleomycin (BLM) and peplomycin (PEP) may enhance their antineoplastic effects; however, it is not known as to whether this enhancement is accompanied by a concomitant increase in toxicity, especially toxic ..
  2. Yasui Y, Suzumori K, Yagami Y. [Pharmacokinetic and therapeutic studies of the administration of peplomycin by continuous subcutaneous infusion]. Gan No Rinsho. 1988;34:1975-8 pubmed
    A continuous subcutaneous infusion of peplomycin was performed on 15 patients with cervical cancer. Eight patients received 5 mg of peplomycin a day and 7 patients received 2.5 mg a day...
  3. Iiyama T, Chikira M, Oyoshi T, Sugiyama H. Deglyco-peplomycin metal complexes on DNA fibers: a role of the sugar moiety for the stability and the orientation of the complexes. J Biol Inorg Chem. 2003;8:135-40 pubmed
    Binding structures of metal complexes of deglyco-peplomycin (dPEP) on DNA were investigated by comparing dPEP complexes with those of bleomycin (BLM) using DNA fiber EPR spectroscopy...
  4. Hirao E, Saito T, Kuwahara A, Shigemitsu Y, Kinoshita T, Shimoda K, et al. [Unresectable stage 4-cancer of the esophagus well responded to combined chemoradiotherapy--a case report]. Nihon Gan Chiryo Gakkai Shi. 1990;25:1497-501 pubmed
    ..4 esophageal carcinoma well responded to chemoradiotherapy of combination of cisplatin (C), vindesine (V) and peplomycin (P) with radiotherapy (R)...
  5. Fujieda S, Tanaka N, Sunaga H, Noda I, Sugimoto C, Tsuzuki H, et al. Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma. Cancer Lett. 1998;132:37-44 pubmed
    ..Among five anticancer drugs (cisplatin (CDDP), 5-FU, peplomycin, mitomycin C and doxorubicin), only for CDDP was sensitivity to cytotoxicity correlated with the hMSH2 positive ..
  6. Sunagawa M, Suzuki T, Ito K, Endo M. Subrenal capsule assay as a chemosensitivity test for primary esophageal squamous cell carcinoma. J Surg Oncol. 1991;46:71-6 pubmed
    ..5-FU administration produced a response in 8/21 cases (38.1%), VDS in 8/21 (38.1%), and CDDP in 3/21 (14.3%). Used in combination, CDDP + VDS was effective in 7/18 cases (38.9%) and CDDP + BLM in 6/18 cases (33.3%). ..
  7. Masaki N, Ikeda H, Matayoshi Y, Murayama S, Fujita M, Kozuka T, et al. [The role of radiation therapy in treatment with preservation of shape and function in intraoral cancer]. Gan To Kagaku Ryoho. 1989;16:3105-10 pubmed
    ..The use of bleomycin or peplomycin in simultaneous combination with external radiation therapy provides a good chance of local control without ..
  8. Suh D, Povirk L. Mapping of the cleavage-associated bleomycin binding site on DNA with a new method based on site-specific blockage of the minor groove with N2-isobutyrylguanine. Biochemistry. 1997;36:4248-57 pubmed
    ..Thus, it is proposed that site-specific incorporation of N2-isobutyrylguanine may provide a general method for mapping binding sites of minor groove-binding ligands on DNA. ..
  9. Sasaki M, Okamura M, Ideo A, Shimada J, Suzuki F, Ishihara M, et al. Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin. Anticancer Res. 2006;26:3373-80 pubmed
    Three antitumor antibiotics, mitomycin C, bleomycin sulfate and peplomycin sulfate, were compared for their tumor-specific cytotoxicity, using human oral squamous cell lines (HSC-2, HSC-3, HSC-4, Ca9-22 and NA), human promyelocytic ..
  10. Sato Y, Tohma H, Shikama T. [Chemotherapy for advanced and recurrent cancer patients--the effect of combination chemotherapy using cisplatin, peplomycin, mitomycin C, adriamycin, and 5-fluorouracil]. Nihon Gan Chiryo Gakkai Shi. 1990;25:1565-70 pubmed
  11. Ikeda S, Suzuki T, Kiyohara Y, Kuramochi A. [Squamous cell carcinoma, basal cell carcinoma]. Gan To Kagaku Ryoho. 1993;20:1293-301 pubmed
    In Japan the regimen with peplomycin has been mainly used for the treatment of squamous cell carcinoma (SCC)...
  12. Kumazawa H, Wada Y, Tachikawa T, Kakimoto S, Yamashita T, Kawamoto K. [Mechanism of cisplatin and peplomycin therapy on head and neck carcinoma]. Hum Cell. 1996;9:69-74 pubmed
    ..are now improving owing to the development of concomitant use of chemotherapeutic agents such as cisplatin or peplomycin. Concomitant use of the two agents has been favored clinically...
  13. Aoki Y, Higashino M, Ishii S, Tanaka K. Yolk sac tumor of the ovary during pregnancy: a case report. Gynecol Oncol. 2005;99:497-9 pubmed
    ..induced, delivering a healthy baby, and received seven complete chemotherapy courses (cisplatin, etoposide, and peplomycin). Currently, the mother (39 months after last chemotherapy) and child are doing well...
  14. Konami T, Wakabayashi Y, Kim T, Ishida A, Arai Y, Konishi T, et al. [Sequential combination chemotherapy consisting of vincristine, peplomycin, methotrexate, cis-diamminedichloroplatinum (II) and adriamycin in urothelial cancer]. Hinyokika Kiyo. 1989;35:231-7 pubmed
    The VPM-CisA (vincristine (VCR), peplomycin (PLM), methotrexate (MTX), cisplatin (CDDP) and doxorubicin (ADM), regimen was used to treat 33 patients with urothelial tract tumors...
  15. Hoffman M, Roberts W, Cavanagh D, Praphat H, Solomon P, Lyman G. Treatment of recurrent and metastatic endometrial cancer with cisplatin, doxorubicin, cyclophosphamide, and megestrol acetate. Gynecol Oncol. 1989;35:75-7 pubmed
    ..The combination of cisplatin, doxorubicin, cyclophosphamide, and megestrol acetate has modest effectiveness in the treatment of metastatic or recurrent carcinoma of the endometrium. ..
  16. Ikeda R, Chikazawa I, Kobayashi Y, Shiroma K, Nakade T, Suga K, et al. [Prophylaxis of recurrence in superficial bladder carcinoma by intravesical chemotherapy--comparative study between instillation of combined double anticancer agents and single anticancer agent]. Gan To Kagaku Ryoho. 1999;26:509-14 pubmed
    ..Of these cases, 42 were treated with intravesical adriamycin (ADR) and peplomycin (PEP), 56 with ADR, PEP, epirubicin (epi-ADR) or pirarubicin (THP) only, and the remaining 29 with TUR only...
  17. Suzuki T, Kohda K, Kawazoe Y. Potentiation of bleomycin cytotoxicity in cultured mammalian cells by high molecular weight polyacrylic acid. Anticancer Res. 1990;10:1001-4 pubmed
    ..A decisive lethal event occurred in the cell during vortex-stirring with BLM and polyacrylate. It is possible that a unique mechanism might operate in this synergistic cell killing. ..
  18. Hagiwara A, Takahashi T, Ueda T, Iwamoto A, Yamashita H, Maeda T. Enhanced therapeutic efficacy on lymph node metastasis by the use of peplomycin adsorbed on small activated carbon particles. Anticancer Res. 1988;8:287-9 pubmed
    ..25 mg/mouse of peplomycin in the form of PEP-CH (peplomycin adsorbed on activated carbon particles) or peplomycin aqueous solution into ..
  19. Ueta E, Osaki T, Yoneda K, Yamamoto T. Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts. Cancer Chemother Pharmacol. 1995;35:230-6 pubmed
    The influence of peplomycin (PLM) and azelastine hydrochloride (Azeptin) on reactive oxygen (RO) and cytokine generation was examined in human peripheral blood mononuclear leukocytes, polymorphonuclear leukocytes (PMN), and rabbit ..
  20. Sato K, Kato T. [Arterial chemoembolization using microencapsulated anticancer drugs]. Gan To Kagaku Ryoho. 1990;17:1105-10 pubmed
    ..These results suggested that microcapsule chemoembolization can be successfully applied to a variety of tumors with low morbidity and mortality, and also combined with other treatments in multidisciplinary therapy. ..
  21. Ichinose Y, Hara N, Ohta M, Motohiro A, Kuda T, Aso H. Postoperative adjuvant chemotherapy in non-small cell lung cancer: prognostic value of DNA ploidy and post-recurrent survival. J Surg Oncol. 1991;46:15-20 pubmed
    ..Furthermore, analysis of postrecurrent survival in the adjuvant chemotherapy trial, as well as that of overall and disease-free survivals should be done. ..
  22. Ikeda R, Kawamura K, Yamaguchi C, Miyazawa K, Sasagawa M, Taniguchi T, et al. [Prophylaxis of recurrence of superficial bladder tumor by intravesical chemotherapy]. Hinyokika Kiyo. 1989;35:1135-9 pubmed
    ..Of these 70 cases, 30 were treated with intravesical adriamycin (ADR) and peplomycin (PEP), 13 with ADR only and one case with PEP and remaining 26 with TUR and hydrostatic pressure technique...
  23. Uchida D, Kawamata H, Omotehara F, Miwa Y, Hino S, Begum N, et al. Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line. Lab Invest. 2000;80:955-63 pubmed
    ..the sensitivity of the transfectants to several anticancer drugs (5-fluorouracil, cis-diaminedichloroplatinum, peplomycin), and (c) induction of apoptotic cell death in the transfectants by 5-fluorouracil treatment...
  24. Hirai M. [Basic and clinical studies of local hyperthermia for prostatic cancer]. Nihon Hinyokika Gakkai Zasshi. 1992;83:597-604 pubmed
    ..However, these side effects were mild, and did not interrupt the treatment. Local hyperthermia of the prostate after systemic chemotherapy could be carried out safely and effectively in patients with prostatic cancer. ..
  25. Asai T, Baba K. [Experience with multidrug chemotherapy for patients with head and neck malignant tumors--comparison between CP therapy and PTP therapy]. Gan To Kagaku Ryoho. 1994;21:975-9 pubmed
    A combined chemotherapy regimen (CP chemotherapy) consisting of cisplatin (CDDP) and peplomycin (PEP) was employed to treat patients with head and neck malignant tumors...
  26. Follett S, Ingersoll A, Murray S, Reilly T, Lehmann T. Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5'-GT-3' binding site in comparison with the 5'-GC-3' binding site studied by NMR spectroscopy. J Biol Inorg Chem. 2017;22:1039-1054 pubmed publisher
    ..This region has been shown to closely interact with DNA. We examined the binding of Zn(II)peplomycin and Zn(II)bleomycin-A2 to a DNA hairpin of sequence 5'-CCAGTATTTTTACTGG-3', containing the binding ..
  27. Munakata H, Kayada Y, Kawahara M, Sakamoto T, Yoshiga K, Takada K. A biochemical evaluation of oral squamous cell carcinoma growth by measurement of specific activity of succinate dehydrogenase in the subrenal capsule assay. Int J Oral Maxillofac Surg. 1995;24:216-20 pubmed
    ..chemosensitivity of tumors, derived from six xenograft lines originating from oral squamous cell carcinomas, to peplomycin (PEP), cisplatin (CDDP), and 5-fluorouracil (5-FU) were evaluated by the SRCA and the nude mouse assay (NMA)...
  28. Caceres Cortes J, Sugiyama H, Ikudome K, Saito I, Wang A. Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies. Eur J Biochem. 1997;244:818-28 pubmed
    ..e., the metal-binding domain) and the C-terminus of CoPEP and CodPEP have similar patterns, suggesting that they both adopt compact structures with the bithiazole group folded back over the N-terminus. ..
  29. Ando T, Yokomori T, Taniguchi T, Iesato H, Takeyoshi I, Saito A, et al. [Intra-arterial infusion chemotherapy for recurrent cervical lymph nodes after surgery in esophageal cancer]. Gan To Kagaku Ryoho. 1992;19:2411-3 pubmed
    ..Intra-arterial infusion chemotherapy (75 mg of cisplatin and 5 mg of peplomycin) was performed using a reservoir system connected with a catheter inserted into the left subclavian artery, ..
  30. Sarashina H, Todoroki T, Orii K, Ohara K, Otsu H, Iwasaki Y. Effects of preoperative radiotherapy on rectal cancer. Preliminary report on combining radiation with intratumor injections of peplomycin and bromodeoxyuridine. Dis Colon Rectum. 1990;33:1017-25 pubmed
    ..0 Gy/fr x 4/week) delivered to the primary tumor. Of 36 patients, 21 were administered intratumor injections of peplomycin and bromodeoxyuridine at the time of boost radiation and 15 were treated without intratumor injections...
  31. Machida T, Takeuchi S, Kano H, Hyouchi N, Tanizawa A, Kamata S, et al. [Surgery for bone metastasis of testicular tumor: a case report]. Hinyokika Kiyo. 1996;42:539-41 pubmed
    ..lung metastasis and L2 vertebral body metastasis, right high orchiectomy and three courses of chemotherapy (peplomycin, etoposide, CDDP) were performed. Histological diagnosis was teratocarcinoma...
  32. Inuyama Y, Fujii M, Tanaka J, Takaoka T, Hosoda H, Kawaura M, et al. [Combined radiotherapy and chemotherapy for head and neck cancer]. Gan To Kagaku Ryoho. 1988;15:1621-7 pubmed
    ..For future perspectives, new trials of alternating radiotherapy and chemotherapy based upon Looney's hypothesis seem necessary. ..
  33. Hiraku Y, Oikawa S, Kuroki K, Sugiyama H, Saito I, Kawanishi S. Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide. Biochem Pharmacol. 2001;61:351-6 pubmed
    ..b>Peplomycin, a bleomycin analog, plus Fe(II) caused DNA cleavage at the 5'-GC-3' and 5'-GT-3' sequences (damaged bases are ..
  34. Yamamoto T, Nishioka K. Flagellate erythema. Int J Dermatol. 2006;45:627-31 pubmed
  35. Liu Y, Sakagami H, Amano O, Kikuchi H, Nakamura Y, Ishihara M, et al. Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines. Anticancer Res. 2008;28:2197-204 pubmed
    The antitumor antibiotic peplomycin showed higher cytostatic antiproliferative effect on five cultured human oral squamous cell carcinoma (OSCC) cell lines (HSC-2, HSC-3, HSC-4, Ca9-22 and NA), as compared with three human oral normal ..
  36. Iwanari O, Date Y, Nakayama S, Miyako J, Kijima S, Moriyama M, et al. [Studies of intra-arterial hypertensive chemotherapy with cisplatin and peplomycin in advanced cancer of the uterine cervix--suitable dose of angiotensin II determined by intra-arterial digital subtraction angiography]. Nihon Sanka Fujinka Gakkai Zasshi. 1988;40:835-40 pubmed
    We have been treating advanced cancer of the cervix uteri with intra-arterial cisplatin (CDDP) and peplomycin (PEP) (injected into the bilateral internal iliac artery), combined with radiotherapy and hysterectomy...
  37. Uchibayashi T, Nakajima K, Hisazumi H, Nishino A, Miyoshi N. Hyperthermic intravesical peplomycin perfusion treatment for bladder cancer. Br J Urol. 1993;72:65-7 pubmed
    ..Physiological saline solution containing 40 micrograms/ml peplomycin with/without 2% ethanol was used as a perfusate...
  38. Kawanishi S, Oikawa S, Kawanishi M, Sugiyama H, Saito I, Strekowski L, et al. Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations. Biochemistry. 2000;39:13210-5 pubmed
    ..The present study on amplifiers of anticancer agents shows a novel approach to the potentially effective anticancer therapy. ..
  39. Kawamoto K, Wada Y, Kumazawa H, Yamashita T, Kumazawa T, Matsumura H. Experimental and clinical evaluation by flow cytometry for the mechanism of combination therapy (cisplatin and peplomycin). Cytometry. 1992;13:307-13 pubmed
    Pharmacologic effects of cisplatin (CDDP) and peplomycin (PEP) on tumor cell kinetics were studied both in vitro and in vivo with the aid of flow cytometry (FCM)...
  40. Lin S. [Study on chemosensitivity test (in vitro) of cultured human urogenital carcinoma cell lines by MTT assay]. Nihon Ika Daigaku Zasshi. 1990;57:127-36 pubmed
    ..Therefore, MTT assay was concluded as a useful method for chemosensitivity test, although the problem of normal cell contamination was left to be solved for clinical use. ..
  41. Hibi G, Okui K, Abe A, Murai T, Sugiura N, Yamauchi T, et al. [Feasibility and radicality of PEP-chemoradiation therapy in oral squamous cell carcinoma]. Gan To Kagaku Ryoho. 1990;17:1692-5 pubmed
    ..6 mg/d peplomycin (PEP). Twenty of these 26 patients did not undergo resection of the primary sites during initial hospitalization...
  42. Moriyama Gonda N, Mizutani M, Ehara S, Usui T, Ishibe T. Inhibitory effects of vincristine, ifosfamide and peplomycin on hormone-independent human prostatic carcinoma cell line. Exp Pathol. 1988;35:141-8 pubmed
    ..The anticancer drugs used were vincristine sulfate (VCR), peplomycin sulfate (PLM) and 4-hydroperoxyisophosphamide (4-HIF), i.e., an form of ifosfamide (IFOS) in vivo...
  43. Kawahara K, Kano E, Ueda K. Effect of peplomycin or camptothecin-11 on X-ray skin injuries of ICR hairless mice. J Dermatol. 1994;21:465-73 pubmed
    ..In the present experiment, the possible modifying effects of Peplomycin (PEP, 30 mg/kg body weight) and Camptothecin-11, an inhibitor of DNA topoisomerase I (CPT-11, 15 and 50 mg/kg ..
  44. Hamakawa H, Bao Y, Takarada M, Tanioka H. Histological effects and predictive biomarkers of TPP induction chemotherapy for oral carcinoma. J Oral Pathol Med. 1998;27:87-94 pubmed
    The effects of an induction chemotherapy with THP-adriamycin, cisplatin, and peplomycin (TPP) were studied in 32 patients with operable oral cancer...
  45. Kodama J, Ikuhashi H, Hongo A, Mizutani Y, Miyagi Y, Yoshinouchi M, et al. [Neoadjuvant chemotherapy for advanced cervical cancer]. Gan To Kagaku Ryoho. 1999;26:89-92 pubmed
    ..There was no correlation between tumor size and response to NAC. NAC therapy may be useful therapy in advanced cervical cancers, especially squamous cell carcinomas. ..
  46. Kanazawa T, Nishino H, Ishikawa K, Miyata M, Morita M, Kitamura K. [A clinical study of inoperable head and neck cancers]. Nihon Jibiinkoka Gakkai Kaiho. 1999;102:1296-9 pubmed
    ..Moreover, high QOL was obtained longer in the combined therapy. Therefore, we conclude that radiotherapy should be combined with chemotherapy for cases with inoperable head and neck cancer. ..
  47. Okada E, Kamizaki H. Primary squamous cell carcinoma of the prostate. Int J Urol. 2000;7:347-50 pubmed
    ..The patient was treated with pelvic irradiation and systemic administration of cis-platinum and peplomycin, which resulted in shrinkage of the cancer. No evidence of recurrence has been seen for 18 months.
  48. Yaguma K, Matsumoto O, Guan L, Kawano Y, Kamiya N, Tsujimoto G, et al. Crystallization and preliminary X-ray diffraction studies of DNA decamer d(CCAGGCCTGG) complexed with cobalt(III)-pepleomycin. Acta Crystallogr D Biol Crystallogr. 2004;60:144-5 pubmed
    ..An X-ray diffraction data set was collected to 2.8 A at 100 K. The crystal belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 34.52, b = 59.88, c = 72.93 A. ..
  49. Moriyama Gonda N, Sumi H, Yokogi H, Ishibe T. [Short-term incubation study on inhibitory effect of chemohyperthermia against hormone-independent human prostatic carcinoma cell line (PC-3)]. Gan To Kagaku Ryoho. 1992;19:2201-5 pubmed
    ..The anticancer drugs used here were vincristine sulfate (VCR), peplomycin sulfate (PLM) and cis-diamminedichloroplatinum (CDDP)...
  50. Kamidono S. [Cancer of the penis and its treatment]. Nihon Hinyokika Gakkai Zasshi. 1992;83:1-15 pubmed
    ..I really wish a certain form of group study to be completed and the results from this study utilized to overcome the present problems for the treatment of carcinoma of the penis. ..
  51. Iwanari O, Date Y, Yoshino N, Miyako J, Ryuhkoh K, Moriyama M, et al. [Studies on renal dysfunction after intra-arterial hypertensive chemotherapy (CDDP, PEP) for advanced cancer of the uterine cervix--serum.urinary alpha 1-microglobulin, beta 2-microglobulin and urinary lysozyme, albumin]. Nihon Sanka Fujinka Gakkai Zasshi. 1990;42:115-20 pubmed
  52. Suzuki T, Kohda K, Kawazoe Y. Potentiation of bleomycin cytotoxicity by polyhydric alcohols. Anticancer Res. 1990;10:97-103 pubmed
    ..The synergistic effect of glycerol emerged in combinations with BLM analogs (peplomycin and libromycin) as well, but not with other cytotoxic drugs such as adriamycin, neocarzinostatin, paraquat, ..
  53. Asakawa M, Yasumoto R, Sakamoto W, Yoshihara H, Iseki T, Nakatani T, et al. [Instillation of a new anticancer preparation for the treatment of superficial bladder cancer: comparison of clinical efficacy between peplomycin emulsion in hydroxypropylcellulosum and peplomycin in saline solution on tumor reduction]. Nihon Gan Chiryo Gakkai Shi. 1990;25:2579-83 pubmed
    Clinical efficacy of a new preparation of peplomycin emulsion in hydroxypropylcellulosum (HPC-PEP) was studied in 26 patients to compared with that in 14 patients administered with 60 mg of PEP in 20 ml saline (S-PEP)...
  54. Minagawa Y, Kanamori Y, Ishihara H, Morishita K, Kigawa J, Ito T, et al. Solitary metastatic ovarian carcinoma of the spleen: a case report. Asia Oceania J Obstet Gynaecol. 1991;17:45-8 pubmed
    ..In this paper we report a case of a solitary metastatic lesion of the spleen arising from a serous cystadenocarcinoma of the ovary 5 years after the initial operation. A splenectomy was performed followed by smooth postoperative course. ..
  55. Okamoto K, Okuno H, Fukuyama T, Itoyama M, Okamoto E. [A case of squamous cell carcinoma of the urinary bladder effectively responsive to combination chemotherapy]. Hinyokika Kiyo. 1991;37:1045-8 pubmed
    ..Clinical staging of the tumor was T3b. We used combination chemotherapy with methotrexate, peplomycin and cis-platinum (MBD regimen) before radical cystectomy...
  56. Wolf M, Havemann K, Holle R, Harms V, Drings P, Hans K, et al. The prognostic value of response to the first cycle of chemotherapy in small cell lung cancer. Results of a multicenter German trial. Eur J Cancer Clin Oncol. 1987;23:1197-205 pubmed
    ..In this treatment modality no change in tumor size after the first cycle indicates poor prognosis, and improvement of the patients' outcome may be achieved by a switch to a second non-cross resistant drug combination. ..
  57. Hashiba M, Yamashita M, Murakami K, Nishikawa H. [Modification of the cytotoxic effect of peplomycin by cepharanthine]. Gan To Kagaku Ryoho. 1987;14:3245-51 pubmed
    The cytotoxicity of peplomycin modified by cepharanthine, was studied on in vitro cultured Chinese Hamster V-79 cells. Cepharanthine alone showed almost no cytotoxicity on this tumor system...
  58. Ebihara K, Nishikawa K, Shibasaki C, Takahashi K, Matsuda A. [Antitumor activity of peplomycin against 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors]. Jpn J Antibiot. 1987;40:1566-70 pubmed
    Antitumor activity of peplomycin (PEP) against 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors was compared with activities of bleomycin (BLM) and doxorubicin (adriamycin, ADM)...
  59. Ozawa S, Suzuki H, Yamaki H, Nishimura T, Tanaka N. A peplomycin-supersensitive cell line lacking activation of poly(adenosine diphosphate ribose) synthetase by peplomycin. Biochem Biophys Res Commun. 1988;151:1305-11 pubmed
    In peplomycin-supersensitive Chinese hamster lung cells, the increase in poly(ADP-ribose) synthesizing activity following peplomycin treatment was significantly reduced as compared with the parental lung cells, suggesting that peplomycin-..
  60. Hagiwara A, Takahashi T, Kondoh S, Iwamoto A, Sawai K. [Targeting chemotherapy with activated carbon particles adsorbing anti-cancer drugs]. Gan To Kagaku Ryoho. 1988;15:1038-42 pubmed
    ..Fifty-one of the 81 patients responded well. Activated carbon particles adsorbing peplomycin (PEP-CH) were prepared for chemotherapy against lymphatic metastasis...
  61. Takashi M, Murase T, Aota Y, Nagai T, Kinjo T, Sabashi M, et al. [Multivariate evaluation of survival factors and postoperative adjuvant chemotherapy in patients with bladder cancer treated by radical cystectomy]. Hinyokika Kiyo. 1988;34:1377-81 pubmed
    ..negative). Postoperative adjuvant chemotherapy consisting of cisplatin, peplomycin and mitomycin C (PPM therapy) seemed to improve survival, when the influence of the major prognostic factors ..
  62. Kanazawa H, Takahashi K, Hanazawa Y, Uchiyama S, Takahara T, Takahara M, et al. [Continuous subcutaneous infusion of peplomycin in oral squamous carcinoma]. Gan To Kagaku Ryoho. 1989;16:775-80 pubmed
    To determine the effect of continuous subcutaneous infusion of peplomycin on both antitumor activity and pulmonary toxicity, thirty-two patients with previously untreated oral squamous carcinoma were given peplomycin via osmotic ..
  63. Pirtoli L, Bellezza A, Tucci E, Pepi F, Crociani M, Crastolla A, et al. [Radiotherapy of limited pulmonary microcytoma in current clinical practice]. Radiol Med. 1994;88:863-8 pubmed
    ..Some guidelines are here considered, which could make this combination reliable also for current clinical use. ..
  64. Hagiwara A, Takahashi T, Sawai K, Shoubayashi S, Sakakura C, Muranishi S. Reduced toxicity of a new formulation--peplomycin adsorbed on activated carbon particles--in mice. Anticancer Drugs. 1994;5:31-4 pubmed
    We studied the acute toxicity and pathological effects of peplomycin adsorbed on fine activated carbon particles (PEP-CH) injected subcutaneously in mice. The 50% lethal dose value was 41.2 mg/kg in terms of peplomycin, which was 1...
  65. Tohnai I, Goto Y, Hayashi Y, Ueda M, Kobayashi T, Matsui M. Preoperative thermochemotherapy of oral cancer using magnetic induction hyperthermia (Implant Heating System: IHS). Int J Hyperthermia. 1996;12:37-47 pubmed
    ..two courses of chemotherapy, which included intra-arterial infusion of 100 mg of cisplatin (CDDP) and 25 mg of peplomycin (PEP) via the superficial temporal artery...
  66. Ohtsubo T, Saito H, Matsumoto H, Hayashi S, Shioura H, Kitai R, et al. In vitro effects of hyperthermia combined with cisplatin or peplomycin on the human maxillary carcinoma cell line IMC-2. Int J Hyperthermia. 1997;13:59-67 pubmed
    We examined the interactive effects of hyperthermia combined with cisplatin (CDDP) (0.5 micrograms/ml) or peplomycin (PEP) (1.0 microgram/ml) on surviving fractions of human maxillary carcinoma IMC-2 cells...
  67. Osaki T, Yoneda K, Tatemoto Y, Yamamoto T, Yokoyama T, Enzan H. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001;82:231-41 pubmed
    To analyse the mechanism by which a bleomycin derivative, peplomycin (PLM) induces pulmonary fibrosis, we investigated differentiation of rat pulmonary fibroblasts to myofibroblasts (MF)...
  68. Yamamoto T, Satake H, Ueta E, Kimura T, Doi S, Osaki T. [Influence of peplomycin on pulmonary function (PaO2, %DLco) in patients with oral carcinoma]. Gan To Kagaku Ryoho. 2001;28:1251-6 pubmed
    The pathogenesis of pulmonary fibrosis (PF) induced by bleomycin and its derivative, peplomycin (PEP), is insufficiently understood...
  69. Minagawa Y, Onohara Y, Takahashi H, Tsudo T. Blood flow after intraarterial infusion chemotherapy in a patient with advanced cervical cancer. Gynecol Obstet Invest. 2001;52:278-80 pubmed
    ..Blood flow change assessed by Doppler ultrasound may be a limited but useful parameter for the efficacy of neoadjuvant chemotherapy in patients with cervical cancer. ..
  70. Morshed S, Tokunaga T, Otsuki S, Takayama F, Satoh T, Hashimoto K, et al. Effect of antitumor agents on cytotoxicity induction by sodium fluoride. Anticancer Res. 2003;23:4729-36 pubmed
    ..Cytotoxic concentrations of cisplatin, etoposide, doxorubicin or peplomycin (tentatively termed as Group I compounds), but not methotrexate and 5-FU (tentatively termed as Group II ..
  71. Tsujino S, Yamauchi T, Kokuho M, Kobayashi T, Tachibana Y, Sawano S, et al. [Intra-arterial COMPA chemotherapy for invasive bladder cancer]. Nihon Hinyokika Gakkai Zasshi. 1992;83:1640-6 pubmed
    ..6 mg/M2 on days 1 and 2; methotrexate: 5 mg/M2 on days 2 and 3; peplomycin: 5 mg/body on days 1, 2 and 3; and adriamycin: 10 mg/M2 on day 4...
  72. Miyao N, Kumamoto Y, Tsukamoto T, Ohmura K, Yamazaki K, Iwasawa M. [Clinical study of penile cancer]. Nihon Hinyokika Gakkai Zasshi. 1990;81:1550-4 pubmed
    ..Ten of the 14 patients were initially treated for the primary lesion with a combination of peplomycin (PEP) or bleomycin (BLM) and radiation therapy...
  73. Komiyama S, Masuda A, Tomita K, Kuratomi Y, Zingu K. [Clinical evaluation of hypopharyngeal cancer]. Gan To Kagaku Ryoho. 1991;18:2090-4 pubmed
    ..We used FAR therapy since 1972, and preoperative chemotherapy (CDDP and Peplomycin) in addition to FAR therapy since 1984...
  74. Robson C, Hall A, Harris A, Hickson I. Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: genetic analysis and cross-resistance to neocarzinostatin. Mutat Res. 1988;193:157-65 pubmed
    ..112 (1983) 313-319]. These results indicate that at least 3 gene products are involved in cellular protection against bleomycin toxicity in mammalian cells. ..
  75. Villani F, Pizzini L, Rossi A. Evaluation of pulmonary toxicity induced by pepleomycin. Tumori. 1988;74:429-32 pubmed
    ..These preliminary results suggest that, in the absence of risk factors, pepleomycin, may have no significant pulmonary toxicity at least up to the cumulative dose of 200 mg. ..
  76. Irisawa C, Kakizaki H, Kaneko H, Hirano J, Ishii N, Numasawa K. [Bilateral testicular tumors of germ cell origin: a case report--a review of 136 cases in Japanese literature]. Hinyokika Kiyo. 1989;35:1795-800 pubmed
    ..Postoperative chemotherapy was performed with CDDP, VP-16 and peplomycin, and postoperative course was uneventful with no distant metastasis or local recurrence...
  77. Wada T, Harada M, Morita N, Oomata T, Koizumi T, Kawashima T, et al. Chemotherapy administered using two-route infusion of cisplatin and sodium thiosulfate and intravenous infusion of vinblastine and peplomycin in patients with oral cancer. Clin Ther. 1995;17:280-9 pubmed
    ..infusion of cisplatin and its antidote, sodium thiosulfate, and intravenous infusion of vinblastine and peplomycin were studied in 22 patients with previously untreated squamous cell carcinoma of the oral cavity or maxillary ..
  78. Onishi Y, Hatae M, Hokanishi H. [Long time survival after combination chemotherapy with cisplatin, vinblastine and peplomycin for cervical cancer]. Nihon Sanka Fujinka Gakkai Zasshi. 1993;45:657-64 pubmed
    ..patients with cervical cancer were treated with PVP therapy including cisplatin 50mg/m2, vinblastine 4mg/m2 and peplomycin 15mg/body during the period from 1984 to 1989. Fourteen patients had a primary lesion...
  79. Tsukuda M, Mochimatsu I, Kokatsu T, Furukawa S, Yuyama S, Enomoto H, et al. Induction chemotherapy in advanced head and neck cancer. Auris Nasus Larynx. 1994;21:186-92 pubmed
    ..pharynx, patients received two different induction chemotherapy regimens: cisplatin, vincristine (Oncovin) plus peplomycin (COP), and cisplatin plus continuous 120-hr 5-fluorouracil (5-FU) infusion (CF) for two courses...
  80. Morikawa N, Mori T, Takeyama M, Hori S. Pharmacokinetics of intra-arterially administered pirarubicin in plasma and cerebrospinal fluid of patients with glioma. Biol Pharm Bull. 1998;21:297-9 pubmed
    ..with astrocytoma received a course of HODBBB and intra-arterial combination chemotherapy with THP, methotrexate, peplomycin, and vindesine...
  81. Osaku M, Ueda M, Miyakawa T, Toyoda H, Uesato K, Yamada Y, et al. Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Oncol Rep. 2001;8:855-60 pubmed
    ..The cytotoxicity of peplomycin (PEP) was correlated with the number of the EGF receptors expressed on the cancer cells, but no correlations ..
  82. Kawashiri S, Kojima K, Kumagai S, Nakagawa K, Yamamoto E. Effects of chemotherapy on invasion and metastasis of oral cavity cancer in mice. Head Neck. 2001;23:764-71 pubmed
    ..oral squamous cell carcinoma cell line, OSC-19, was implanted into the oral floor of nude mice, and cisplatin or peplomycin was administered to the mice 7 or 14 days after implantation...
  83. Wang Y, Sun Y, Zhang J, Liu X. [Clinical practice of 99mTc-peplimycin imaging and radio guided surgery for lung neoplasms]. Ai Zheng. 2003;22:749-52 pubmed was preliminary clinical practice of tumor imaging and radioimmunoguided surgery (RGS) using (99m)Tc-PPM (peplomycin) as a tumor tracer. Thirty-seven patients were administered with injection of (99m)Tc-PPM...
  84. Sudoh M, Kishimoto Y, Marumoto A, Inoue M, Sano A, Miura N, et al. A new animal model of continuous catheterization for investigating mechanisms of arteritis associated with chemotherapy. Life Sci. 2004;74:3025-32 pubmed
    ..Chemotherapeutic agents (fluorouracil (5-FU) or peplomycin (PEP)) were continuously administered for 7 days into the abdominal aorta of male Sprague-Dawley rats through a ..
  85. Asano Y, Ihn H, Shikada J, Kadono T, Kikuchi K, Tamaki K. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004;150:1213-4 pubmed
  86. Hagiwara A, Takahashi T, Ueda T, Iwamoto A, Torii T. Activated carbon particles as anti-cancer drug carrier into regional lymph nodes. Anticancer Drug Des. 1987;1:313-21 pubmed
    ..05-0.01), and a concentration in blood that was significantly lower (PEP-CH, about 1/2 times in 2 h; MMC-CH, 1/10-1/5 times in 1 h; p less than 0.05). ..
  87. Saitoh M, Kondo A, Sakakibara T, Takashi M, Sahashi M, Kanai S, et al. [Female urethral carcinoma: results of irradiation in 2 patients]. Hinyokika Kiyo. 1988;34:1231-4 pubmed
    ..1, a 73-year-old female with squamous cell carcinoma was successfully treated with irradiation of 4,000 rad and peplomycin of 60 mg intravenously given. She has been free from the disease for the past 43 months...
  88. Sakura H, Fujii T, Ohashi T, Tsuruta S. Occurrence of an anti-peplomycin IgE antibody cross-reacting with bleomycin in a patient with cervical uterine cancer. Cancer Chemother Pharmacol. 1989;23:333-6 pubmed
    An allergic reaction to peplomycin was observed in a patient with cervical uterine cancer who had previously been treated with peplomycin...
  89. Sugimori H, Iwasaka T, Fukuda K, Hayashi Y, Hachisuga T. Treatment of advanced cervical cancer by a combination of peplomycin, vincristine, mitomycin-C, and cisplatin. Gynecol Oncol. 1989;34:180-2 pubmed
    Eighteen patients with advanced or recurrent carcinoma of the cervix were treated with a combination of peplomycin, vincristine, mitomycin-C, and cisplatin (POMP)...
  90. Nasu T, Nakane H, Kamata S, Mitsui H, Hayashida S. [The long-term effect and outcome of preoperative chemotherapy combined with radiation therapy for bladder cancer]. Nihon Hinyokika Gakkai Zasshi. 1996;87:857-64 pubmed
    ..of radiation to the small pelvic cavity and a chemotherapy combination of adriamycin, cis-platinum, tegaful, and peplomycin. The average observation time after the therapy was 83 month, with the maximum being 146 months. (RESULTS)...
  91. Yoneda K, Yamamoto T, Ueta E, Osaki T. Azelastine hydrochloride (Azeptin) inhibits peplomycin (PLM)-induced pulmonary fibrosis by contradicting the up-regulation of signal transduction. Anticancer Drug Des. 1997;12:577-90 pubmed
    Inhibition of peplomycin (PLM)-induced pulmonary fibrosis by azelastine hydrochloride (Azeptin) was examined using ICR mice, and the effects of both drugs on signal transduction were investigated...
  92. Aoki Y, Tomita M, Sato T, Watanabe M, Kase H, Fujita K, et al. Neoadjuvant chemotherapy for patients younger than 50 years with high-risk squamous cell carcinoma of the cervix. Gynecol Oncol. 2001;83:263-7 pubmed
    ..The NAC consisted of cisplatin (60 mg/m(2)) on day 1, vinblastine (4 mg/m(2)/day) on days 1 and 2, and peplomycin (10 mg/day) on days 1, 8, and 15 (PVP). Treatment was repeated every 3 weeks for a total of two cycles...