cerebrosides

Summary

Summary: Neutral glycosphingolipids that contain a monosaccharide, normally glucose or galactose, in 1-ortho-beta-glycosidic linkage with the primary alcohol of an N-acyl sphingoid (ceramide). In plants the monosaccharide is normally glucose and the sphingoid usually phytosphingosine. In animals, the monosaccharide is usually galactose, though this may vary with the tissue and the sphingoid is usually sphingosine or dihydrosphingosine. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1st ed)

Top Publications

  1. Tan R, Chen J. The cerebrosides. Nat Prod Rep. 2003;20:509-34 pubmed
    This review covers distribution, structural determination, syntheses and biological activities of the cerebrosides reported so far. Those with absolute stereochemistry assigned are marked herein with '*'...
  2. Barreto Bergter E, Pinto M, Rodrigues M. Structure and biological functions of fungal cerebrosides. An Acad Bras Cienc. 2004;76:67-84 pubmed
    Ceramide monohexosides (CMHs, cerebrosides) are glycosphingolipids composed of a hydrophobic ceramide linked to one sugar unit...
  3. Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T. Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells. Biosci Biotechnol Biochem. 2006;70:2906-12 pubmed
    ..We show here the sphingoid base composition of cerebrosides prepared from sea cucumber and the cytotoxicity against human colon cancer cell lines...
  4. Kang S, Kim J, Son K, Kim H, Chang H. Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. Chem Pharm Bull (Tokyo). 2001;49:321-3 pubmed
    A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix (Phytolaccaceae) and characterized as 1-O-beta-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S,..
  5. Ishii T, Okino T, Mino Y. A ceramide and cerebroside from the starfish asterias amurensis Lütken and their plant-growth promotion activities. J Nat Prod. 2006;69:1080-2 pubmed
    ..ceramide asteriaceramide A (1) and glucocerebroside asteriacerebroside G (2), together with two known cerebrosides, asteriacerebrosides A and B, were isolated from lipophilic fractions of the whole bodies of the Northern ..
  6. Wang J, Zheng L, Tan R. Involvement of nitric oxide in cerebroside-induced defense responses and taxol production in Taxus yunnanensis suspension cells. Appl Microbiol Biotechnol. 2007;75:1183-90 pubmed
    ..These results are suggestive of a role for NO as a new signal component for activating the cerebroside-induced defense responses and secondary metabolism activities of plant cells...
  7. Shu R, Wang F, Yang Y, Liu Y, Tan R. Antibacterial and xanthine oxidase inhibitory cerebrosides from Fusarium sp. IFB-121, an endophytic fungus in Quercus variabilis. Lipids. 2004;39:667-73 pubmed
    Two antibacterial and xanthine oxidase inhibitory cerebrosides, one of which is chemically new, were characterized from the chloroform-methanol (1:1) extract of Fusarium sp. IFB-121, an endophytic fungus in Quercus variabilis...
  8. Umemura K, Ogawa N, Yamauchi T, Iwata M, Shimura M, Koga J. Cerebroside elicitors found in diverse phytopathogens activate defense responses in rice plants. Plant Cell Physiol. 2000;41:676-83 pubmed
    b>Cerebrosides A and C, compounds categorized as glycosphingolipids, were isolated in our previous study from the rice blast fungus (Magnaporthe grisea) as novel elicitors which induce the synthesis of rice phytoalexins...
  9. Sakaki T, Zahringer U, Warnecke D, Fahl A, Knogge W, Heinz E. Sterol glycosides and cerebrosides accumulate in Pichia pastoris, Rhynchosporium secalis and other fungi under normal conditions or under heat shock and ethanol stress. Yeast. 2001;18:679-95 pubmed
    The occurrence of glycolipids such as sterol glycosides, acylated sterol glycosides, cerebrosides and glycosyldiacylglycerols was examined in the three yeast species Candida albicans, Pichia pastoris and Pichia anomala, as well as in the ..

More Information

Publications94

  1. Xu X, Bittman R, Duportail G, Heissler D, Vilcheze C, London E. Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, an. J Biol Chem. 2001;276:33540-6 pubmed
    ..formation by sphingomyelin and dipalmitoylphosphatidylcholine but only a weak influence on the ability of cerebrosides to form domains...
  2. Wicklow D, Joshi B, Gamble W, Gloer J, Dowd P. Antifungal metabolites (monorden, monocillin IV, and cerebrosides) from Humicola fuscoatra traaen NRRL 22980, a mycoparasite of Aspergillus flavus sclerotia. Appl Environ Microbiol. 1998;64:4482-4 pubmed
    ..flavus mycelium extension (MIC > 28 microg/ml) as monocillin IV (MIC > 56 microg/ml). Cerebrosides C and D, metabolites known to potentiate the activity of cell wall-active antibiotics, were separated from the ..
  3. Batrakov S, Konova I, Sheichenko V, Esipov S, Galanina L, Istratova L. Unusual fatty acid composition of cerebrosides from the filamentous soil fungus Mortierella alpina. Chem Phys Lipids. 2002;117:45-51 pubmed
    The cerebrosides produced by the soil filamentous fungus Mortierella alpina strain KG-1/95 account for about 13% of the total polar lipids extractable from lyophilised cells with chloroform/methanol mixtures...
  4. Black F, Kocienski P. Synthesis of phalluside-1 and Sch II using 1,2-metallate rearrangements. Org Biomol Chem. 2010;8:1188-93 pubmed publisher
    ..By an analogous route, (4E,8E)-9-methyl-4,8-sphingadiene was synthesised and converted to Sch II, a cerebroside that induces fruiting body formation in the basidiomycete Schizophyllum commune...
  5. Levery S, Momany M, Lindsey R, Toledo M, Shayman J, Fuller M, et al. Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth. FEBS Lett. 2002;525:59-64 pubmed
    ..fumigatus cultured in the presence of these inhibitors displayed a significantly reduced GlcCer/GalCer ratio. These results suggest that synthesis of GlcCer is essential for normal development of A. fumigatus and A. nidulans. ..
  6. Cheng S, Wen Z, Chiou S, Tsai C, Wang S, Hsu C, et al. Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi. J Nat Prod. 2009;72:465-8 pubmed publisher
    ..collected at the Dongsha Islands, Taiwan, has led to the isolation of a known ceramide (1) and two new cerebrosides, sarcoehrenosides A (2) and B (4), along with three known cerebrosides (3, 5, and 6)...
  7. Qi J, Ojika M, Sakagami Y. Neuritogenic cerebrosides from an edible Chinese mushroom. Part 2: Structures of two additional termitomycesphins and activity enhancement of an inactive cerebroside by hydroxylation. Bioorg Med Chem. 2001;9:2171-7 pubmed
    Termitomycesphins E and F, novel cerebrosides that are hydroxylated around the middle of the long-chain base (LCB), have been isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Heim...
  8. Wang W, Wang Y, Tao H, Peng X, Liu P, Zhu W. Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field. J Nat Prod. 2009;72:1695-8 pubmed publisher
    ..From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known ..
  9. Tuntiwachwuttikul P, Pootaeng on Y, Phansa P, Taylor W. Cerebrosides and a monoacylmonogalactosylglycerol from Clinacanthus nutans. Chem Pharm Bull (Tokyo). 2004;52:27-32 pubmed
    A mixture of nine cerebrosides and a monoacylmonogalactosylglycerol were separated from the leaves of Clinacanthus nutans...
  10. Toledo M, Levery S, Suzuki E, Straus A, Takahashi H. Characterization of cerebrosides from the thermally dimorphic mycopathogen Histoplasma capsulatum: expression of 2-hydroxy fatty N-acyl (E)-Delta(3)-unsaturation correlates with the yeast-mycelium phase transition. Glycobiology. 2001;11:113-24 pubmed
    ..capsulatum and other dimorphic fungi are discussed. ..
  11. Wang J, Zheng L, Zhang B, Zou T. Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots. Appl Microbiol Biotechnol. 2009;85:285-92 pubmed publisher
    ..4 mg/l, a 2.3-fold increase over the control. These results suggest that cerebroside plays as a novel elicitor and the involvement of NO in the signaling pathway of the elicitor activity for artemisinin biosynthesis. ..
  12. Mansoor T, Shinde P, Luo X, Hong J, Lee C, Sim C, et al. Renierosides, cerebrosides from a marine sponge Haliclona (Reniera) sp. J Nat Prod. 2007;70:1481-6 pubmed
    Guided by the brine shrimp lethality assay, eight new cerebrosides (1-8) have been isolated from an extract of the marine sponge Haliclona (Reniera) sp...
  13. Gao Z, Zhou X, Hu X, Xue C, Xu J, Wang Y. [Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose metabolism in obese mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012;41:60-4 pubmed
    ..To investigate the effect of sea cucumber cerebroside(SCC) and its long-chain base(LCB) on lipid and glucose metabolism in obese mice...
  14. Mbosso E, Ngouela S, Nguedia J, Penlap V, Rohmer M, Tsamo E. Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata. Nat Prod Res. 2008;22:296-304 pubmed publisher
    ..The antibacterial activity of the isolated compounds against a wide range of microorganisms was examined. They inhibited significantly the growth of some gram-positive and -negative bacteria. ..
  15. Cateni F, Zilic J, Zacchigna M, Procida G. Cerebrosides with antiproliferative activity from Euphorbia peplis L. Fitoterapia. 2010;81:97-103 pubmed publisher
    Two new cerebrosides have been isolated from the whole plants of Euphorbia peplis L. The structures were established by FT-IR spectroscopy, FAB MS, EI-MS, ESI-MS, 1D and 2D NMR spectroscopy...
  16. Tian X, Tang H, Li Y, Lin H, Ma N, Zhang W, et al. Ceramides and cerebrosides from the marine bryozoan Bugula neritina inhabiting South China Sea. J Asian Nat Prod Res. 2009;11:1005-12 pubmed publisher
    ..6), together with one known ceramide (2) and three known cerebrosides (3, 4, and 5), were isolated...
  17. Peng X, Wang Y, Sun K, Liu P, Yin X, Zhu W. Cerebrosides and 2-pyridone alkaloids from the halotolerant fungus Penicillium chrysogenum grown in a hypersaline medium. J Nat Prod. 2011;74:1298-302 pubmed publisher
    Five new cerebrosides, chrysogesides A-E (1-5), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline ..
  18. Emura C, Higuchi R, Miyamoto T, van Soest R. Amphimelibiosides A-F, six new ceramide dihexosides isolated from a Japanese marine sponge Amphimedon sp. J Org Chem. 2005;70:3031-8 pubmed
    ..The structures of the other constituents were elucidated by a combination of mass spectra, (1)H NMR, and GC-MS analysis. ..
  19. Subathra M, Korrapati M, Howell L, Arthur J, Shayman J, Schnellmann R, et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015;309:F204-15 pubmed publisher
    ..We used 9- and 17-wk-old nondiabetic db/m and diabetic db/db mice to examine the role of GSLs in DN. Cerebrosides or monoglycosylated GSLs [hexosylceramides (HexCers); glucosyl- and galactosylceramides] and lactosylceramide (..
  20. Benjamins J, Hadden T, Skoff R. Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain. J Neurochem. 1982;38:233-41 pubmed
    ..Our results show a more highly localized distribution of sulfatide synthesis than of galactocerebroside synthesis, probably in Golgi membranes or oligodendroglia-related membranes with similar properties. ..
  21. Jurevics H, Largent C, Hostettler J, Sammond D, Matsushima G, Kleindienst A, et al. Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination. J Neurochem. 2002;82:126-36 pubmed
    ..The ability to correlate gene expression with known pathophysiological events should help in elucidating further function of such genes as related to demyelination/remyelination. ..
  22. Yu C, Sun Y, Chen G. A new phenylethanoid glucoside from Plantago depressa Willd. Nat Prod Res. 2013;27:609-12 pubmed publisher
    ..These five compounds (1-5) were isolated from the family Plantaginaceae for the first time; the chemotaxonomic significance of cerebrosides was also discussed.
  23. Li L, Yang R, Sun K, Bai Y, Zhang Z, Zhou L, et al. Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²? influx of NMDA receptors. Int J Neuropsychopharmacol. 2012;15:497-507 pubmed publisher
    ..These findings indicate that treatment with CS-A after stroke exerts potent neuroprotection through prevention of excessive glutamate release and reduction of Ca²? influx through NMDARs. ..
  24. Takakuwa N, Kinoshita M, Oda Y, Ohnishi M. Existence of cerebroside in Saccharomyces kluyveri and its related species. FEMS Yeast Res. 2002;2:533-8 pubmed
    ..in the genera Saccharomyces, Torulaspora, Zygosaccharomyces, and Kluyveromyces were analyzed for sphingolipids, cerebrosides were found in S. kluyveri, Z. cidri, Z. fermentati, K. lactis, K. thermotolerans, and K. waltii...
  25. Boger D, Sato H, Lerner A, Hedrick M, Fecik R, Miyauchi H, et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci U S A. 2000;97:5044-9 pubmed
  26. Park T, Mansoor T, Shinde P, Bao B, Hong J, Jung J. New cerebrosides from a marine sponge Haliclona (Reniera) sp. Chem Pharm Bull (Tokyo). 2009;57:106-11 pubmed
    ..collected off the coast of Ulleung Island, Korea, led to the isolation of thirteen new cerebrosides (1--3, 5--14), along with a known analogue (4)...
  27. Chludil H, Seldes A, Maier M. Anasterocerebroside A, a new glucosylceramide from the Patagonian starfish Anasterias minuta. Z Naturforsch C. 2003;58:433-40 pubmed
    ..The structures of 1 and 7 were established by spectroscopic and chemical methods. ..
  28. Shaiq Ali M, Ahmed W, Saleem M, Ashfaq Ali M. Longifoside-A and -B: two new cerebrosides from Mentha longifolia (Lamiaceae). Nat Prod Res. 2006;20:715-23 pubmed
    Two new N-acyl-glycosphingosines (cerebrosides) named longifoside-A {6'-tetracosenamide, N-[3,4-dihydroxy-1-(hydroxymethyl)-2-(beta-D-glucopyranosyl) heptadecyl]-(6'E)} and B {6'-tetracosenamide, N-[3-hydroxy-1-(hydroxymethyl)-2-(beta-D-..
  29. Jurevics H, Hostettler J, Muse E, Sammond D, Matsushima G, Toews A, et al. Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain. J Neurochem. 2001;77:1067-76 pubmed
    ..We propose this experimental design, and the reproducible cuprizone model, as appropriate for studies of how to promote remyelination. ..
  30. Ben Hamo M, Muñoz Garcia A, Larraín P, Pinshow B, Korine C, Williams J. The cutaneous lipid composition of bat wing and tail membranes: a case of convergent evolution with birds. Proc Biol Sci. 2016;283: pubmed publisher
    ..b>Cerebrosides are not present in the mammalian SC; their pathological accumulation occurs in Gaucher's disease, which leads ..
  31. Ma B, Ruan Y, Liu J. [Chemical study on fruiting bodies of Boletus vioaceo-fuscus]. Zhongguo Zhong Yao Za Zhi. 2007;32:1766-7 pubmed
    ..All the Compounds were obtained from the fruiting bodies of Boletus vioaceo-fiscus for the first time. ..
  32. Dennis M, Downey C, Brufatto N, Nesheim M, Stevenson K, Toh C. Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein. Thromb Haemost. 2004;91:522-30 pubmed
    ..As the CRP-VLDL complex exists in vivo, it could have a pathogenic role in disseminating the process of intravascular coagulation. ..
  33. Weintraub H, Abramovici A, Sandbank U, Pentchev P, Brady R, Sekine M, et al. Neurological mutation characterized by dysmyelination in NCTR-Balb/C mouse with lysosomal lipid storage disease. J Neurochem. 1985;45:665-72 pubmed
    ..deficit in the proportion of long-chain fatty acids (C24), notable in both normal and alpha-hydroxy acids of cerebrosides from affected white matter, was measured...
  34. Fleischer B, Zambrano F. Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney. Biochem Biophys Res Commun. 1973;52:951-8 pubmed
  35. Ikeda Y, Inagaki M, Yamada K, Miyamoto T, Higuchi R, Shibata O. Langmur monolayers of cerebroside with different head groups originated from sea cucumber: binary systems with dipalmitoylphosphatidylcholine (DPPC). Colloids Surf B Biointerfaces. 2009;72:272-83 pubmed publisher
    Surface properties (Langmuir monolayer) of two different cerebrosides which are extracted from the sea cucumber (Bohadschia argus) were investigated...
  36. Boiron Sargueil F, Heape A, Garbay B, Cassagne C. Cerebroside formation in the peripheral nervous system of normal and Trembler mice. Neurosci Lett. 1995;186:21-4 pubmed
    The formation of cerebrosides by the galactosylation of ceramides was investigated in a microsomal fraction prepared from sciatic nerves of normal and Trembler mice...
  37. Nakahara H, Nakamura S, Nakamura K, Inagaki M, Aso M, Higuchi R, et al. Cerebroside Langmuir monolayers originated from the echinoderms: II. Binary systems of cerebrosides and steroids. Colloids Surf B Biointerfaces. 2005;42:175-85 pubmed
    ..5M sodium chloride solution were investigated for two different cerebrosides (LMC-1 and LMC-2) with steroids of cholesterol (Ch) and cholesteryl sodium sulfate (Ch-S); i.e...
  38. Jurevics H, Hostettler J, Sammond D, Nave K, Toews A, Morell P. Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein. J Neurosci Res. 2003;71:826-34 pubmed
    ..Metabolic tracer experiments showed this was not the case. We conclude that PLP(null) myelin is physically less stable and/or less dense than wt myelin. ..
  39. Holm H. Gangliosides of the optic pathway: biosynthesis and biodegradation studied in vivo. J Neurochem. 1972;19:623-9 pubmed
  40. Gupta P, Yadav D, Siripurapu K, Palit G, Maurya R. Constituents of Ocimum sanctum with antistress activity. J Nat Prod. 2007;70:1410-6 pubmed
    ..luteolin-5-O-beta-D-glucopyranoside, and 4-allyl-1-O-beta-D-glucopyronosyl-2-hydroxybenzene (5), and two known cerebrosides. The structures of the new compounds were determined on the basis of extensive 1D and 2D NMR spectroscopic ..
  41. Hu Y, Ye W, Yin Z, Zhao S. [Chemical constituents from flos Sesamum indicum L]. Yao Xue Xue Bao. 2007;42:286-91 pubmed
    ..Among them, 4 is a new compound, and others were isolated from the flowers of the plant for the first time. Compounds 2 to 4 belong to cerebroside, which is rare to be found in land plants and was proved to possess many bioactivities...
  42. Du L, Yang Y, Xu J, Wang Y, Xue C, Kurihara H, et al. Transport and uptake effects of marine complex lipid liposomes in small intestinal epithelial cell models. Food Funct. 2016;7:1904-14 pubmed publisher
    Nowadays, marine complex lipids, including starfish phospholipids (SFP) and cerebrosides (SFC) separated from Asterias amurensis as well as sea cucumber phospholipids (SCP) and cerebrosides (SCC) isolated from Cucumaria frondosa, have ..
  43. Nakahara H, Nakamura S, Nakamura K, Inagaki M, Aso M, Higuchi R, et al. Cerebroside Langmuir monolayers originated from the echinoderms I. Binary systems of cerebrosides and phospholipids. Colloids Surf B Biointerfaces. 2005;42:157-74 pubmed
    ..the dipole moment (mu( perpendicular))-A isotherms were obtained for two-component monolayers of two different cerebrosides (LMC-1 and LMC-2) with phospholipids of dipalmitoylphosphatidylcholine (DPPC) and with ..
  44. Liu C, Xia X, Qi J, Zhang Y, Yuan W, Meng X, et al. [The secondary metabolites of the HS-3 Alternaria sp. fungus associated with holothurians]. Zhong Yao Cai. 2010;33:1875-7 pubmed
    ..All of this provides scientific data for further study of holothurians, and the four coumpouns are isolated from the microbe associated with holothurians for the first time. ..
  45. Hakomori S. A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE. J Biochem. 1964;55:205-8 pubmed
  46. Siminovitch D, Ruocco M, Olejniczak E, Das Gupta S, Griffin R. Anisotropic 2H-nuclear magnetic resonance spin-lattice relaxation in cerebroside- and phospholipid-cholesterol bilayer membranes. Biophys J. 1988;54:373-81 pubmed
    ..Furthermore, from the observed orientation dependence of the 2H spin-lattice relaxation rates, we conclude that order director fluctuations cannot provide the dominant relaxation pathway for acyl chain deuterons. ..
  47. Coulter Mackie M, Applegarth D, Toone J, Gagnier L, Anzarut A, Hendson G. Isolated peripheral neuropathy in atypical metachromatic leukodystrophy: a recurrent mutation. Can J Neurol Sci. 2002;29:159-63 pubmed
    ..A homozygous mutation, thr286pro, found in her arylsulfatase A gene, decreased enzyme activity to a level consistent with a late onset form of MLD. ..
  48. Wang R, Wu X, Geng D. Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotective effect. Molecules. 2013;18:1181-7 pubmed publisher
    Two cerebrosides named 1-O-b-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (1) and soya-cerebroside I (2) were isolated from the seeds of Sterculia lychnophora for the first time...
  49. Sicard R, Landgraf R. High-Performance Chromatographic Separation of Cerebrosides. Methods Mol Biol. 2017;1609:57-63 pubmed publisher
    ..This technique can be used for quantitation purposes but also with small modification for subsequent mass spectrum analyses for structural determination. ..
  50. Abul Milh M, Barnett Foster D, Lingwood C. In vitro binding of Helicobacter pylori to monohexosylceramides. Glycoconj J. 2001;18:253-60 pubmed
    ..pylori clinical isolates and cultured strains commonly used to study host-cell adhesion. ..
  51. Yu R, Lee S. In vitro biosynthesis of sialosylgalactosylceramide (G7) by mouse brain microsomes. J Biol Chem. 1976;251:198-203 pubmed
    ..Liver appeared to have the highest activity for G7 synthesis (as well as of hematoside), followed by brain. The synthesis of B7 by mouse brain microsomes in vitro demonstrates a new pathway for brain ganglioside synthesis. ..
  52. Fluharty A, Meek W, Katona Z, Tsay K. The cerebroside sulfate activator from pig kidney: derivitization, cerebroside sulfate binding, and metabolic correction. Biochem Med Metab Biol. 1992;47:86-96 pubmed
    ..The pig kidney protein was taken up more efficiently by the cells and resulted in a better metabolic correction than material from human liver, but was somewhat less effective than a preparation from human urine. ..
  53. Holtschmidt H, Sandhoff K, Furst W, Kwon H, Schnabel D, Suzuki K. The organization of the gene for the human cerebroside sulfate activator protein. FEBS Lett. 1991;280:267-70 pubmed
    ..All exons and exon/intron splice junctions and five introns were sequenced. Exon 8 consists of only 9 bp and is involved in alternative splicing which generates three different mRNAs of cerebroside sulfate activator precursor. ..
  54. Yao J, Bourre J. Metabolic alterations of endoneurial lipids in developing trembler nerve. Brain Res. 1985;325:21-7 pubmed
    ..In 3 and 6 day-old trembler mice, proportionately less [14C]acetate was incorporated into phospholipids and cerebrosides and more was incorporated into cholesterol...
  55. Xu J, Wang Y, Feng T, Zhang B, Sugawara T, Xue C. Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides. Biosci Biotechnol Biochem. 2011;75:1466-71 pubmed
    b>Cerebrosides are a kind of important bioactive substance in sea cucumber. A novel cerebroside, AMC-2, was purified from the less-polar lipid fraction of the sea cucumber Acaudina molpadioides by repeated column chromatography...
  56. Muse E, Jurevics H, Toews A, Matsushima G, Morell P. Parameters related to lipid metabolism as markers of myelination in mouse brain. J Neurochem. 2001;76:77-86 pubmed
    ..This approach may be useful as an additional parameter for examining the effects of environmental or genetic alterations on the rate of myelination. ..
  57. Xu H, Qi J, Wang G, Deng H, Qi Z. The effect of single cerebroside compounds on activation of BKCa channels. Mol Membr Biol. 2011;28:145-54 pubmed publisher
    We have previously shown that a mixture of cerebrosides obtained from dried tubers of herb Typhonium giganteum Engl. plays a neuroprotective role in the ischemic brain through its effect on activation of BK(Ca) channels...
  58. Bankeu J, Mustafa S, Gojayev A, Lenta B, Tchamo Noungoué D, Ngouela S, et al. Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae). Chem Pharm Bull (Tokyo). 2010;58:1661-5 pubmed
    ..Structures of compounds 1 and 2 were elucidated by spectroscopic analysis and chemical methods. ..
  59. Jackson S, Ugarov M, Egan T, Post J, Langlais D, Albert Schultz J, et al. MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J Mass Spectrom. 2007;42:1093-8 pubmed
    ..Furthermore, the use of gold nanoparticles as a matrix enables detection of cerebrosides, which although highly concentrated in brain tissue, are not easily observed as positive ions because of ..
  60. Longo M, Blanchette C. Imaging cerebroside-rich domains for phase and shape characterization in binary and ternary mixtures. Biochim Biophys Acta. 2010;1798:1357-67 pubmed publisher
    ..to this review we review briefly the molecular structure, phase behavior, and intermolecular interactions of cerebrosides, in comparison to ceramides and sphingomyelins and in some binary and biological systems...
  61. Dicko A, Heng Y, Boggs J. Interactions between glucosylceramide and galactosylceramide I(3) sulfate and microstructures formed. Biochim Biophys Acta. 2003;1613:87-100 pubmed
    ..Furthermore, conversion of NFA-GluC to the stable state was inhibited, although it reached the intermediate state, suggesting that some degree of trans interaction between these two lipids occurred. ..
  62. Han X, Cheng H. Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics. J Lipid Res. 2005;46:163-75 pubmed
    ..This method was demonstrated to have a greater than 1,000-fold linear dynamic range in the low concentration region; therefore, it should have a wide range of applications in studies of the cellular sphingolipid lipidome. ..
  63. da Silva A, Rodrigues M, Farias S, Almeida I, Pinto M, Barreto Bergter E. Glucosylceramides in Colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelial cells. FEBS Lett. 2004;561:137-43 pubmed
    ..Since GlcCer is present in several plant pathogens, the inhibitory activity of external ligands recognizing these structures may be applicable in other models of fungal infections. ..
  64. Maruta T, Hoda K, Inagaki M, Higuchi R, Shibata O. Langmuir monolayers of cerebroside originated from Linckia laevigata: binary systems of cerebrosides and phospholipid. Colloids Surf B Biointerfaces. 2005;44:123-42 pubmed
    ..the surface potential (DeltaV)-A and the dipole moment (mu( perpendicular))-A isotherms were obtained for six cerebrosides of LLC-2, LLC-2-1, LLC-2-8, LLC-2-10, LLC-2-12, and LLC-2-15, which were isolated from Linckia laevigata, and ..
  65. Beier U, Görögh T. Implications of galactocerebrosidase and galactosylcerebroside metabolism in cancer cells. Int J Cancer. 2005;115:6-10 pubmed
    ..The resulting accumulation of galactosylcerebroside promotes a reduction of cellular adhesion and inhibits apoptosis, leading to increased cellular growth, migration and prolonged cell survival contributing to carcinogenesis. ..
  66. Farokhi F, Wielgosz Collin G, Clement M, Kornprobst J, Barnathan G. Cytotoxicity on human cancer cells of ophidiacerebrosides isolated from the African starfish Narcissia canariensis. Mar Drugs. 2010;8:2988-98 pubmed publisher
    ..We found that F13-3 displayed an interesting cytotoxic activity over 24 hours on various adherent human cancerous cell lines (multiple myeloma, colorectal adenocarcinoma and glioblastoma multiforme) with an IC(50) of around 20 ?M...
  67. Dabrowski J, Dabrowski U, Kordowicz M, Hanfland P. Structure elucidation of the blood group B like and blood group I active octaantennary ceramide tetracontasaccharide from rabbit erythrocyte membranes by two-dimensional 1H NMR spectroscopy at 600 MHz. Biochemistry. 1988;27:5149-55 pubmed
    ..This analysis has shown 1 to be the highest homologue of the multiantennary neolactoglycosphingolipids of the following general formula with n = 7: (Formula: see text). ..
  68. Champagne A, Munoz Garcia A, Shtayyeh T, Tieleman B, Hegemann A, Clement M, et al. Lipid composition of the stratum corneum and cutaneous water loss in birds along an aridity gradient. J Exp Biol. 2012;215:4299-307 pubmed publisher
    ..The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher disease...
  69. Wu X, Wu X, Guo W, Luo Q, Gu Y, Shen Y, et al. Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes. Toxicol Appl Pharmacol. 2012;263:296-302 pubmed publisher
    ..These results showed multiple effects of cerebroside D against activated T cells for a novel approach to treatment of colonic inflammation. ..
  70. Broderick P. Studies of oxidative stress mechanisms using a morphine / ascorbate animal model and novel N-stearoyl cerebroside and laurate sensors. J Neural Transm (Vienna). 2008;115:7-17 pubmed
    ..Thus, oxidative stress mechanisms and novel N-stearoyl cerebroside and laurate sensors, which selectively detect and separate neuromolecules involved in these mechanisms, may be potentially clinically relevant. ..
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    ..The isolation of a new cerebroside, 1-O-beta-d-glucopyranosyl-(2S,3S,4R,11E)-2-[(2'R)-2'-hydroxypalmitoylamino]-11-octadecene-1,3,4-triol (polygalacerebroside) (1), from the aerial part of Polygala japonica is reported. ..
  72. Fluharty C, Johnson J, Whitelegge J, Faull K, Fluharty A. Comparative lipid binding study on the cerebroside sulfate activator (saposin B). J Neurosci Res. 2001;63:82-9 pubmed
    ..No simple "binding rule" can be ascertained from these data, but ligands with longer and/or more complex lipoidal and polar adducts appear to be favored. ..
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    ..subjunquillea led to the isolation of four ergosterols, two cerebrosides and four cyclopeptides...
  74. Hisaki H, Okazaki T, Kubota M, Nakane M, Fujimaki T, Nakayama H, et al. L-PDMP improves glucosylceramide synthesis and behavior in rats with focal ischemia. Neurol Res. 2008;30:979-84 pubmed publisher
    ..and thereafter, the levels of GSLs and their effects on behavioral changes were examined Methods: The levels of cerebrosides, sphingomyelin (SM) and ceramide in the ischemic cortex were measured by gas-liquid chromatography (GLC) after ..
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    ..Sumatranoside (2) exhibited proteasome inhibitory activity with an IC(50) value of 30 microM. ..
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    ..Compound 1 was elucidated as 1-O-3-D-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2'R)-2'-hyd roxylignocenoyl-amino]-8-octadecene-1, 3, 4-triol. Compound 2 was an analogue of 1. The two compounds are new cerebrosides.
  78. Zhou X, Tang L, Liu Y. An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids. 2009;44:759-63 pubmed publisher
    An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f...
  79. Liu X, Wang L, Wang Q, Qiu B. [Chemical constituents from root of Psammosilene tunicoides]. Zhongguo Zhong Yao Za Zhi. 2007;32:921-3 pubmed
    ..Compounds 2-7 were obtained from genus Psammosilene for the first time. ..
  80. Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, et al. Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem. 2005;280:36815-23 pubmed
    ..We have identified 3 groups of lipids that stimulate proteolytic activity of BACE: 1) neutral glycosphingolipids (cerebrosides), 2) anionic glycerophospholipids, and 3) sterols (cholesterol).
  81. Gately C, Podbielska M, Counihan T, Hennessy M, Leahy T, Moran A, et al. Invariant Natural Killer T-cell anergy to endogenous myelin acetyl-glycolipids in multiple sclerosis. J Neuroimmunol. 2013;259:1-7 pubmed publisher
    ..glycolipids that are poly-acetylated derivatives of ?-galactosylceramide designated as fast-migrating cerebrosides (FMC) by thin-layer chromatography...
  82. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, et al. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 1997;278:1626-9 pubmed
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells. ..
  83. Bouhours D, Liaigre J, Richard C, Oriol R, Bouhours J. Forssman penta- and tetraglycosylceramide are xenoantigens of ostrich kidney and liver. Glycobiology. 1999;9:875-86 pubmed
    ..Its localization in the vascular endothelium and connective tissue makes ostrich an unpromising organ or cell donor for xenotransplantation to man. ..
  84. Quartacci M, Glisić O, Stevanovic B, Navari Izzo F. Plasma membrane lipids in the resurrection plant Ramonda serbica following dehydration and rehydration. J Exp Bot. 2002;53:2159-66 pubmed
    ..Smaller amounts of cerebrosides, acylated steryl glycosides and steryl glycosides were also detected...
  85. Tan J, Dong Z, Liu J. New cerebrosides from the basidiomycete Cortinarius tenuipes. Lipids. 2003;38:81-4 pubmed
    Five cerebrosides (1-5), including three new ones named cortenuamide A (1), cortenuamide B (2), and cortenuamide C (3), were isolated from the fruiting bodies of the basidiomycete Cortinarius tenuipes...