heterografts

Summary

Summary: Tissues, cells or organs transplanted between animals of different species.

Top Publications

  1. Humphries B, Wang Z, Li Y, Jhan J, Jiang Y, Yang C. ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA. Cancer Res. 2017;77:4051-4064 pubmed publisher
    ..Taken together, these results define opposing roles for oncogenic ARHGAP18 and tumor suppressive miR-200b in determining TNBC cell migration and metastatic prowess. Cancer Res; 77(15); 4051-64. ©2017 AACR. ..
  2. Pan F, Yang W, Li W, Yang X, Liu S, Li X, et al. Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis. Tumour Biol. 2017;39:1010428317708547 pubmed publisher
    ..Our findings demonstrated recombinant human endostatin-gold nanoparticles might normalize vessels by interfering anterior gradient 2-mediated angiogenesis in metastatic colorectal cancer. ..
  3. Shang Z, Niu Y, Cai Q, Chen J, Tian J, Yeh S, et al. Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation. Tumour Biol. 2014;35:1881-90 pubmed
    ..Together, these results suggested KLK2 might become a new therapeutic target to battle the CRPC and KLK2-siRNA may be developed as an alternative approach to suppress PCa growth. ..
  4. Alatrash G, Garber H, Zhang M, Sukhumalchandra P, Qiu Y, Jakher H, et al. Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target. Leukemia. 2017;31:234-237 pubmed publisher
  5. Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K. Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model. Tokai J Exp Clin Med. 2017;42:41-51 pubmed
  6. Fan Y, Ma X, Li H, Gao Y, Huang Q, Zhang Y, et al. miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. Int J Cancer. 2018;142:547-560 pubmed publisher
    ..Our results suggest an important role of the miR-122/Dicer/miR-200s/EMT pathway in ccRCC metastasis. Furthermore, miR-122 may serve as a biomarker for discriminating ccRCC with metastatic potential. ..
  7. Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, et al. NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression. Mol Cell. 2017;68:224-232.e4 pubmed publisher
    ..These results demonstrate that NRF2 is a major target of p53-independent tumor suppression by ARF and also suggest that the ARF-NRF2 interaction acts as a new checkpoint for oxidative stress responses...
  8. Zhang L, Yang S, Wang Y, Fang Q, Chen X, Lu H, et al. Long Noncoding RNA MIR4697HG Promotes Cell Growth and Metastasis in Human Ovarian Cancer. Anal Cell Pathol (Amst). 2017;2017:8267863 pubmed publisher
    ..These data suggested that MIR4697HG promoted ovarian cancer growth and metastasis. The aggressive role of MIR4697HG in ovarian cancer may be related to the ERK and AKT signaling pathways. ..
  9. Piddock R, Loughran N, Marlein C, Robinson S, Edwards D, Yu S, et al. PI3K? and PI3K? isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment. Blood Cancer J. 2017;7:e539 pubmed publisher
    ..We report that PI3K? and PI3K? isoforms have distinct functions in MM and that combined PI3k?/? isoform inhibition has anti-MM activity. Here we provide a scientific rationale for trials of dual PI3k?/? inhibition in patients with MM...
  10. Barton V, Christenson J, Gordon M, Greene L, Rogers T, Butterfield K, et al. Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer. Cancer Res. 2017;77:3455-3466 pubmed publisher
    ..i>Cancer Res; 77(13); 3455-66. ©2017 AACR. ..

Detail Information

Publications110 found, 100 shown here

  1. Humphries B, Wang Z, Li Y, Jhan J, Jiang Y, Yang C. ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA. Cancer Res. 2017;77:4051-4064 pubmed publisher
    ..Taken together, these results define opposing roles for oncogenic ARHGAP18 and tumor suppressive miR-200b in determining TNBC cell migration and metastatic prowess. Cancer Res; 77(15); 4051-64. ©2017 AACR. ..
  2. Pan F, Yang W, Li W, Yang X, Liu S, Li X, et al. Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis. Tumour Biol. 2017;39:1010428317708547 pubmed publisher
    ..Our findings demonstrated recombinant human endostatin-gold nanoparticles might normalize vessels by interfering anterior gradient 2-mediated angiogenesis in metastatic colorectal cancer. ..
  3. Shang Z, Niu Y, Cai Q, Chen J, Tian J, Yeh S, et al. Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation. Tumour Biol. 2014;35:1881-90 pubmed
    ..Together, these results suggested KLK2 might become a new therapeutic target to battle the CRPC and KLK2-siRNA may be developed as an alternative approach to suppress PCa growth. ..
  4. Alatrash G, Garber H, Zhang M, Sukhumalchandra P, Qiu Y, Jakher H, et al. Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target. Leukemia. 2017;31:234-237 pubmed publisher
  5. Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K. Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model. Tokai J Exp Clin Med. 2017;42:41-51 pubmed
  6. Fan Y, Ma X, Li H, Gao Y, Huang Q, Zhang Y, et al. miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. Int J Cancer. 2018;142:547-560 pubmed publisher
    ..Our results suggest an important role of the miR-122/Dicer/miR-200s/EMT pathway in ccRCC metastasis. Furthermore, miR-122 may serve as a biomarker for discriminating ccRCC with metastatic potential. ..
  7. Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, et al. NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression. Mol Cell. 2017;68:224-232.e4 pubmed publisher
    ..These results demonstrate that NRF2 is a major target of p53-independent tumor suppression by ARF and also suggest that the ARF-NRF2 interaction acts as a new checkpoint for oxidative stress responses...
  8. Zhang L, Yang S, Wang Y, Fang Q, Chen X, Lu H, et al. Long Noncoding RNA MIR4697HG Promotes Cell Growth and Metastasis in Human Ovarian Cancer. Anal Cell Pathol (Amst). 2017;2017:8267863 pubmed publisher
    ..These data suggested that MIR4697HG promoted ovarian cancer growth and metastasis. The aggressive role of MIR4697HG in ovarian cancer may be related to the ERK and AKT signaling pathways. ..
  9. Piddock R, Loughran N, Marlein C, Robinson S, Edwards D, Yu S, et al. PI3K? and PI3K? isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment. Blood Cancer J. 2017;7:e539 pubmed publisher
    ..We report that PI3K? and PI3K? isoforms have distinct functions in MM and that combined PI3k?/? isoform inhibition has anti-MM activity. Here we provide a scientific rationale for trials of dual PI3k?/? inhibition in patients with MM...
  10. Barton V, Christenson J, Gordon M, Greene L, Rogers T, Butterfield K, et al. Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer. Cancer Res. 2017;77:3455-3466 pubmed publisher
    ..i>Cancer Res; 77(13); 3455-66. ©2017 AACR. ..
  11. Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez M, et al. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene. 2017;36:5432-5438 pubmed publisher
    ..Together, our findings demonstrate that stromal lumican restrains PDAC cell growth through mediating cell entry into a quiescent state. ..
  12. Lu J, Wei J, Feng Z, Chen Z, Wang Y, Huang Y, et al. miR-106b-5p promotes renal cell carcinoma aggressiveness and stem-cell-like phenotype by activating Wnt/?-catenin signalling. Oncotarget. 2017;8:21461-21471 pubmed publisher
    ..These findings suggest that miR-106b-5p mediates the constitutive activation of Wnt/?-catenin signalling, likely serving as a potential therapeutic target for ccRCC. ..
  13. Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, et al. Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription. Cancer Res. 2017;77:4228-4237 pubmed publisher
    ..i>Cancer Res; 77(16); 4228-37. ©2017 AACR. ..
  14. Gu Y, Zhang J, Ma X, Kim B, Wang H, Li J, et al. Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma. Cancer Cell. 2017;32:115-128.e7 pubmed publisher
    ..Together, the CAMKIIγ:c-Myc axis critically influences the development and maintenance of TCL and represents a potential therapeutic target for TCL. ..
  15. Stacer A, Nyati S, Moudgil P, Iyengar R, Luker K, Rehemtulla A, et al. NanoLuc reporter for dual luciferase imaging in living animals. Mol Imaging. 2013;12:1-13 pubmed
    ..Our results establish NL as a new reporter for bioluminescence imaging studies in intact cells and living mice that will expand imaging of signal transduction in normal physiology, disease, and drug development. ..
  16. Shui X, Zhou C, Lin W, Yu Y, Feng Y, Kong J. Long non-coding RNA BCAR4 promotes chondrosarcoma cell proliferation and migration through activation of mTOR signaling pathway. Exp Biol Med (Maywood). 2017;242:1044-1050 pubmed publisher
    ..Impact statement LncRNA BCAR4 promoted chondrosarcoma cell proliferation and migration through activation of mTOR signaling pathway, and thus contributed to chondrosarcoma progression. ..
  17. Wang Y, Chu Y, Yue B, Ma X, Zhang G, Xiang H, et al. Adipose-derived mesenchymal stem cells promote osteosarcoma proliferation and metastasis by activating the STAT3 pathway. Oncotarget. 2017;8:23803-23816 pubmed publisher
    ..After the siRNA treatment, the MMP2, MMP9 and Ki67 levels decreased. Based on these data, stromal ADSCs promote osteosarcoma progression by increasing STAT3 signalling-mediated MMP2/9 expression. ..
  18. Liu Q, Yang Y, Tan X, Tao Z, Adah D, Yu S, et al. Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector. Oncotarget. 2017;8:24785-24796 pubmed publisher
    ..More broadly, this strategy supported our hypothesis that Plasmodium parasites, as novel therapeutic antigen vectors, may be applicable to tumor immunotherapy for patients with HCC. ..
  19. Kramer N, Schmöllerl J, Unger C, Nivarthi H, Rudisch A, Unterleuthner D, et al. Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression. Oncogene. 2017;36:5460-5472 pubmed publisher
    ..The identification of the pro-malignant function of stromal derived WNT2 in CRC classifies WNT2 and its receptor as promising stromal targets to confine cancer progression in combination with conventional or targeted therapies. ..
  20. Yang F, Wei J, Zhang S, Zhang X. Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1. Cancer Res. 2017;77:5543-5553 pubmed publisher
    ..Overall, our results illuminated a novel aspect of miRNA-mediated cross-species gene expression and its use in regulating cancer stem-like cells. Cancer Res; 77(20); 5543-53. ©2017 AACR. ..
  21. Powan P, Luanpitpong S, He X, Rojanasakul Y, Chanvorachote P. Detachment-induced E-cadherin expression promotes 3D tumor spheroid formation but inhibits tumor formation and metastasis of lung cancer cells. Am J Physiol Cell Physiol. 2017;313:C556-C566 pubmed publisher
    ..Our data also suggest that agents that restore E-cadherin expression may be used as therapeutic agents for metastatic cancers. ..
  22. Yi Y, Tsai S, Cheng J, Wang E, Anglesio M, Cochrane D, et al. APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner. Gynecol Oncol. 2017;147:663-671 pubmed publisher
    ..APELA plays an essential role in endoderm differentiation and cardiac development during embryogenesis. We investigated whether APELA exerts any functions in cancer progression...
  23. Chiang C, Chao T, Su Y, Hsu C, Chien C, Chiu K, et al. Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-?B signaling. Oncotarget. 2017;8:20706-20718 pubmed publisher
    ..These findings suggest that metformin activates cancer AMPK-NF-?B signaling, a pathway involved in regulating M1/M2 expression and inducing genes for macrophage polarization to anti-tumor phenotype. ..
  24. Xu K, Chen G, Qiu Y, Yuan Z, Li H, Yuan X, et al. miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma. Oncotarget. 2017;8:21719-21732 pubmed publisher
    ..These results indicate that a p53/miR-503-5p/PUMA signaling axis regulates the CRC response to chemotherapy, and suggest that miR-503-5p plays an important role in the development of MDR in CRC by modulating PUMA expression. ..
  25. Herr I, Sähr H, Zhao Z, Yin L, Omlor G, Lehner B, et al. MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. Cancer Lett. 2017;409:49-55 pubmed publisher
    ..7% and 42.7%, while the tumor take rates remained stable. Our results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. ..
  26. Bourdeau R, Lee Gosselin A, Lakshmanan A, Farhadi A, Kumar S, Nety S, et al. Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. Nature. 2018;553:86-90 pubmed publisher
    ..This technology equips microbial cells with a means to be visualized deep inside mammalian hosts, facilitating the study of the mammalian microbiome and the development of diagnostic and therapeutic cellular agents. ..
  27. Zhang D, Zhang G, Hu X, Wu L, Feng Y, He S, et al. Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer. Cancer Res. 2017;77:3745-3757 pubmed publisher
    ..Taken together, our results identify Orilnc1 as a novel, nonprotein mediator of RAS/RAF activation that may serve as a therapeutic target in RAS/RAF-driven cancers. Cancer Res; 77(14); 3745-57. ©2017 AACR. ..
  28. Sharma S, Pourat J, Abdel Atti D, Carlin S, Piersigilli A, Bankovich A, et al. Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer. Cancer Res. 2017;77:3931-3941 pubmed publisher
    ..5 therapy in SCLC patient-derived xenograft models. Cancer Res; 77(14); 3931-41. ©2017 AACR. ..
  29. Lo P, Zhang Y, Yao Y, Wolfson B, Yu J, Han S, et al. Tumor-associated myoepithelial cells promote the invasive progression of ductal carcinoma in situ through activation of TGFβ signaling. J Biol Chem. 2017;292:11466-11484 pubmed publisher
    ..Our findings provide the first experimental evidence to directly support the paradigm that altered DCIS-associated myoepithelial cells promote the invasive progression of DCIS into IDC via TGFβ signaling activation. ..
  30. Winters B, Brown L, Coleman I, Nguyen H, Minas T, Kollath L, et al. Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279. Anticancer Res. 2017;37:3385-3396 pubmed
    ..2 and LuCaP 35 PDX. YK-4-279 decreased ERG+ LuCaP 23.1 tumor growth, but not LuCaP 86.2 and LuCaP 35 ERG+ tumor growth. ..
  31. Lin X, Lin B, Chen X, ZHANG B, Xiao X, Shi J, et al. PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer. Biochem Biophys Res Commun. 2017;493:1464-1470 pubmed publisher
    ..This study intented to clarify the intracellular effect of PAI-1 on Non-small cell lung cancer (NSCLC) metastasis and the precise mechanism involved...
  32. Chen X, Yu T, Zhang J, Li Y, Chen H, Yang G, et al. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. Oncogene. 2017;36:5045-5057 pubmed publisher
    ..In summary, CYP4A in TAMs is crucial for lung pre-metastatic niche formation and metastasis, and may serve as a potential therapeutic target in human cancer...
  33. Lee S, Kim D, Kang J, Kim E, Kim W, Youn H, et al. Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production. Cell Physiol Biochem. 2017;42:1684-1700 pubmed publisher
    ..Our results revealed that down-regulation of SP-B was involved in the radiation-induced metastatic conversion of NSCLC and provided evidence that SP-B acted as a suppressor of NSCLC progression. ..
  34. Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell. 2017;170:548-563.e16 pubmed publisher
    ..Measuring and targeting F. nucleatum and its associated pathway will yield valuable insight into clinical management and may ameliorate colorectal cancer patient outcomes. ..
  35. Yi Y, Chen D, Ao J, Sun S, Wu M, Li X, et al. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability. J Biol Chem. 2017;292:5253-5261 pubmed publisher
  36. Du Z, Cai C, Sims M, Boop F, Davidoff A, Pfeffer L. The effects of type I interferon on glioblastoma cancer stem cells. Biochem Biophys Res Commun. 2017;491:343-348 pubmed publisher
    ..In addition, we show that IFN induces transient STAT3 activation in GSCs, while induction of astrocytic differentiation in GSCs results in sustained STAT3 activation. ..
  37. Murray J, Valli E, Yu D, Truong A, Gifford A, Eden G, et al. Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo. Eur J Cancer. 2017;83:132-141 pubmed publisher
  38. Huang J, Chen M, Chen D, Gao X, Zhu S, Huang H, et al. A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Mol Cell. 2017;68:171-184.e6 pubmed publisher
    ..Our findings uncover a complex regulatory mechanism of cancer metabolism reprogramming orchestrated by a peptide encoded by an lncRNA...
  39. Faubert B, Li K, Cai L, Hensley C, Kim J, Zacharias L, et al. Lactate Metabolism in Human Lung Tumors. Cell. 2017;171:358-371.e9 pubmed publisher
    ..The data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo. ..
  40. Yin H, Meng T, Zhou L, Chen H, Song D. SPC24 is critical for anaplastic thyroid cancer progression. Oncotarget. 2017;8:21884-21891 pubmed publisher
    ..Taken together, our data demonstrates that SPC24 can serve as a promising prognostic biomarker of ATC cells and it is a novel strategy which could be developed by targeting SPC24 in future. ..
  41. Piacente F, Caffa I, Ravera S, Sociali G, Passalacqua M, Vellone V, et al. Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. Cancer Res. 2017;77:3857-3869 pubmed publisher
    ..This knowledge could be used to increase the efficacy of NAMPT inhibitors and chemotherapy. Cancer Res; 77(14); 3857-69. ©2017 AACR. ..
  42. Wawrzyniak R, Wozniak A, Gebreyohannes Y, Dykcik B, Schoffski P, Markuszewski M. Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts. J Breath Res. 2017;11:037101 pubmed publisher
    ..This study constitutes a proof of concept in GISTs and reveals the potential of the metabolomic approach in orphan malignancies. ..
  43. Carretta M, de Boer B, Jaques J, Antonelli A, Horton S, Yuan H, et al. Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models. Exp Hematol. 2017;51:36-46 pubmed publisher
    ..This approach will be useful for functional study of the importance of niche factors in normal and malignant human hematopoiesis. ..
  44. Goto H, Kariya R, Kudo E, Okuno Y, Ueda K, Katano H, et al. Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma. Oncogene. 2017;36:5252-5262 pubmed publisher
    ..Collectively, PU.1 has a role in tumor suppression in PEL and its down-regulation is associated with PEL development. Restoring PU.1 with demethylation agents may be a novel therapeutic approach for PEL. ..
  45. Shukla S, Cyrta J, Murphy D, Walczak E, Ran L, Agrawal P, et al. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell. 2017;32:792-806.e7 pubmed publisher
    ..In HNF4G/HNF1A-double-negative prostate cancer, exogenous expression of HNF4G at physiologic levels recapitulates the gastrointestinal transcriptome, chromatin landscape, and leads to relative castration resistance. ..
  46. Qian Y, Wong C, Xu J, Chen H, Zhang Y, Kang W, et al. Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation. Cancer Res. 2017;77:1968-1982 pubmed publisher
    ..i>Cancer Res; 77(8); 1968-82. ©2017 AACR. ..
  47. Xu Y, Wang X, Chen Y, Chen S, Yang X, Sun Y, et al. Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer. Theranostics. 2017;7:974-986 pubmed publisher
    ..The expression profile of RTKs in breast cancer tissue could be potentially developed as a predictive biomarker for the efficacy of PI3K? inhibitors. ..
  48. Jiang Y, Cao Y, WANG Y, Li W, Liu X, Lv Y, et al. Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. Theranostics. 2017;7:1036-1046 pubmed publisher
    ..Collectively, our data demonstrate that SLC3A1 promotes cysteine uptake and determines cellular response to antioxidant N-acetylcysteine, suggesting SLC3A1 is a potential therapeutic target for breast cancer. ..
  49. Huang B, Yang H, Cheng X, Wang D, Fu S, Shen W, et al. tRF/miR-1280 Suppresses Stem Cell-like Cells and Metastasis in Colorectal Cancer. Cancer Res. 2017;77:3194-3206 pubmed publisher
    ..Furthermore, they provide evidence that functionally active miRNA can be derived from tRNA, offering potential biomarker and therapeutic uses. Cancer Res; 77(12); 3194-206. ©2017 AACR. ..
  50. Grausam K, Dooyema S, Bihannic L, Premathilake H, Morrissy A, Forget A, et al. ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res. 2017;77:3766-3777 pubmed publisher
    ..Our work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities. Cancer Res; 77(14); 3766-77. ©2017 AACR. ..
  51. Wang Z, Zhu Z. [Application and development of patient-derived tumor xenograft model in translational medicine of tumor]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:596-600 pubmed
    ..The methodological issues, salient features, practical applications, and future directions of PDX models will be illustrated. ..
  52. Yoshimi A, Balasis M, Vedder A, Feldman K, Ma Y, Zhang H, et al. Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML. Blood. 2017;130:397-407 pubmed publisher
    ..These data reveal that NSGS mice support the development of CMML and JMML disease-initiating and mature leukemic cells in vivo, allowing creation of genetically accurate preclinical models of these disorders. ..
  53. Kumar B, Kalvala A, Chu S, Rosen S, Forman S, Marcucci G, et al. Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia. Leuk Res. 2017;59:124-135 pubmed publisher
  54. Choo S, Wang P, Newbury R, Roberts W, Yang J. Reactivation of TWIST1 contributes to Ewing sarcoma metastasis. Pediatr Blood Cancer. 2018;65: pubmed publisher
    ..These results suggest that TWIST1 promotes metastasis in Ewing sarcoma and could be used as a prognostic marker for treatment stratification; however, further validation is required in a larger cohort of patients. ..
  55. Bosch A, Bertran S, Lu Y, Garcia A, Jones A, Dawson M, et al. Reversal by RAR? agonist Am580 of c-Myc-induced imbalance in RAR?/RAR? expression during MMTV-Myc tumorigenesis. Breast Cancer Res. 2012;14:R121 pubmed publisher
  56. Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013;123:5231-46 pubmed publisher
    ..These findings uncover an unexpected role for a histone methylation modifier in activating ERK1/2 in lung tumorigenesis and metastasis, suggesting that KDM2A may be a promising therapeutic target in NSCLC. ..
  57. Zhang S, Tang D, Zang W, Yin G, Dai J, Sun Y, et al. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017;37:465-473 pubmed
    ..The present study indicates future clinical potential of combination therapy with AS-IV and curcumin for HCC. ..
  58. Verma M, Clemens J, Burzenski L, Sampson S, Brehm M, Greiner D, et al. A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods. 2017;446:47-53 pubmed publisher
  59. Chaudhry P, Singh M, Triche T, Guzman M, Merchant A. GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML. Blood. 2017;129:3465-3475 pubmed publisher
    ..Furthermore, these data support rational combinations of hypomethylating agents with SMO antagonists in clinical trials. ..
  60. Kametani Y, Katano I, Miyamoto A, Kikuchi Y, Ito R, Muguruma Y, et al. NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination. PLoS ONE. 2017;12:e0179239 pubmed publisher
    ..These results suggest that the human PBMC-transplanted NOG-hIL-4-Tg mouse is an effective tool to evaluate the production of antigen-specific IgG antibodies. ..
  61. Abdul Rahim S, Dirkse A, Oudin A, Schuster A, Bohler J, Barthelemy V, et al. Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A. Br J Cancer. 2017;117:813-825 pubmed publisher
    ..Combination with hypoxia-inducing agents may provide benefit by allowing to decrease the effective dose of autophagy inhibitors. ..
  62. Zhang Z, Zheng F, Yu Z, Hao J, Chen M, Yu W, et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. PLoS ONE. 2017;12:e0186900 pubmed publisher
  63. Zhang S, Fan G, Hao Y, Hammell M, Wilkinson J, Tonks N. Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. Genes Dev. 2017;31:1939-1957 pubmed publisher
    ..Overall, this mechanistic analysis of the tumor-suppressive function of PTPN23 in breast cancer supports the identification of FYN as a therapeutic target for breast tumors with heterozygous or homozygous loss of PTPN23. ..
  64. Knox A, Scaling A, Pinto M, Bliesner B, Haughian J, Abdel Hafiz H, et al. Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease. Breast Cancer Res. 2014;16:418 pubmed publisher
  65. Valdes A, García Cañas V, Pérez Sánchez A, Barrajón Catalán E, Ruiz Torres V, Artemenko K, et al. Shotgun proteomic analysis to study the decrease of xenograft tumor growth after rosemary extract treatment. J Chromatogr A. 2017;1499:90-100 pubmed publisher
  66. Zlitni A, Yin M, Janzen N, Chatterjee S, Lisok A, Gabrielson K, et al. Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry. PLoS ONE. 2017;12:e0176958 pubmed publisher
    ..The results demonstrate both the feasibility of preparing PSMA-targeted MBs and the benefits of using bioorthogonal chemistry to create targeted US probes. ..
  67. Han A, Veeneman B, El Sawy L, Day K, Day M, Tomlins S, et al. Fibulin-3 promotes muscle-invasive bladder cancer. Oncogene. 2017;36:5243-5251 pubmed publisher
    ..This also suggests fibulin-3 and IGFBP5 may have potential as biomarkers of aggressive bladder cancer or therapeutic targets. ..
  68. Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed publisher
    ..This information can be further exploited for research and therapeutic purposes. ..
  69. Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
    ..Overall, our findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer, with potential implications to improve treatment of this disease. Cancer Res; 77(20); 5464-78. ©2017 AACR. ..
  70. Li S, Nishikawa T, Kaneda Y. Inactivated Sendai virus particle upregulates cancer cell expression of intercellular adhesion molecule-1 and enhances natural killer cell sensitivity on cancer cells. Cancer Sci. 2017;108:2333-2341 pubmed publisher
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