sphenoid sinus


Summary: One of the paired air spaces located in the body of the SPHENOID BONE behind the ETHMOID BONE in the middle of the skull. Sphenoid sinus communicates with the posterosuperior part of NASAL CAVITY on the same side.

Top Publications

  1. Felisati G, Lozza P, Chiapasco M, Borloni R. Endoscopic removal of an unusual foreign body in the sphenoid sinus: an oral implant. Clin Oral Implants Res. 2007;18:776-80 pubmed
    Migration of oral implants displaced in the maxillary sinus toward the sphenoid sinus is an extremely rare event...
  2. Tabaee A, Anand V, Cappabianca P, Stamm A, Esposito F, Schwartz T. Endoscopic management of spontaneous meningoencephalocele of the lateral sphenoid sinus. J Neurosurg. 2010;112:1070-7 pubmed publisher
    Spontaneous meningoencephaloceles of the lateral sphenoid sinus are rare lesions that are hypothesized to result from persistence of the lateral craniopharyngeal canal...
  3. Demetri C, Shoukri K, Taylor S, Silva J. Postpartum granulomatous hypophysitis with sphenoid sinus involvement: a case study. Endocr Pract. 2010;16:264-9 pubmed publisher
    To report an unusual case of granulomatous hypophysitis with sphenoid sinus involvement in a woman presenting with headaches and visual field deficits approximately 2 weeks after a normal delivery.
  4. Unlu A, Meco C, Ugur H, Comert A, Ozdemir M, Elhan A. Endoscopic anatomy of sphenoid sinus for pituitary surgery. Clin Anat. 2008;21:627-32 pubmed publisher
    ..This facilitated exact evaluation for variations, which could result in more effective and safe surgery. However, these variations again emphasize the necessity of preoperative radiological evaluation in each case...
  5. Socher J, Cassano M, Filheiro C, Cassano P, Felippu A. Diagnosis and treatment of isolated sphenoid sinus disease: a review of 109 cases. Acta Otolaryngol. 2008;128:1004-10 pubmed publisher
    Endoscopic transethmoidal sphenoidotomy performed mainly in the early stages of the pathology and by expert hands is [WX1]very effective in treating isolated sphenoid sinus disease.
  6. Hatipoglu H, Cetin M, Selvi A, Yuksel E. Role of magnetic resonance imaging in evaluating sphenoid sinus and internal carotid artery. J Laryngol Otol. 2009;123:1331-7 pubmed publisher
    This study aimed to determine whether magnetic resonance imaging has a role in the evaluation of the sphenoid sinus and internal carotid artery...
  7. Forer B, Sethi D. Endoscopic repair of cerebrospinal fluid leaks in the lateral sphenoid sinus recess. J Neurosurg. 2010;112:444-8 pubmed publisher
    ..The authors present their experience with repairs of 10 CSF leaks that were confined to the lateral sphenoid recess and were treated at the Singapore General Hospital...
  8. Ciobanu I, Motoc A, Jianu A, Cergan R, Banu M, Rusu M. The maxillary recess of the sphenoid sinus. Rom J Morphol Embryol. 2009;50:487-9 pubmed
    The most studied recess of the sphenoid sinus seems to be the lateral one, which is highly variable. Less attention seems to be paid to the maxillary recess, extending anterior, inferior and lateral towards the maxillary sinus...
  9. Truong M, Kamat U, Liebsch N, Curry W, Lin D, Barker F, et al. Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck. 2009;31:1297-308 pubmed publisher
    The purpose of this study was to determine treatment outcome and prognostic factors in patients with locally advanced primary sphenoid sinus malignancy treated with proton radiation therapy.

More Information


  1. Struffert T, Buhk J, Buchfelder M, Rohde V, Doerfler A, Knauth M. Coil migration after endovascular coil occlusion of internal carotid artery pseudoaneurysms within the sphenoid sinus. Minim Invasive Neurosurg. 2009;52:89-92 pubmed publisher
    We report two cases of coil migration after endovascular treatment of pseudoaneurysm of the internal carotid artery within the sphenoid sinus with coils and noncovered stents.
  2. Seno S, Arikata M, Sakurai H, Owaki S, Fukui J, Suzuki M, et al. Endoscopic ligation of the sphenopalatine artery and the maxillary artery for the treatment of intractable posterior epistaxis. Am J Rhinol Allergy. 2009;23:197-9 pubmed publisher
    ..This investigation evaluates the effectiveness and complications of endoscopic ligation of the sphenopalatine or maxillary artery for the treatment of intractable posterior epistaxis...
  3. Chan L, Wang L, Tai C, Wu C, Kuo W. Huge sphenoid sinus olfactory neuroblastoma: a case report. Kaohsiung J Med Sci. 2009;25:87-92 pubmed publisher
    ..However, the origin and isolation of olfactory neuroblastomas to the sphenoid sinus is exceedingly rare...
  4. Gu X, Eskandari F, Fowler M. Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature. Head Neck Pathol. 2011;5:81-5 pubmed publisher
    ..In this report, we present a case of a female patient with a sphenoid sinus mass. Clinically, the patient had progressively decreasing vision and headache...
  5. Zada G, Agarwalla P, Mukundan S, Dunn I, Golby A, Laws E. The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery. J Neurosurg. 2011;114:1319-30 pubmed publisher
    A considerable degree of variability exists in the anatomy of the sphenoid sinus, sella turcica, and surrounding skull base structures...
  6. Pagella F, Pusateri A, Matti E, Giourgos G, Cavanna C, De Bernardi F, et al. Sphenoid sinus fungus ball: our experience. Am J Rhinol Allergy. 2011;25:276-80 pubmed publisher
    ..b>Sphenoid sinus is an uncommon localization of this disease, as reported in the literature...
  7. Petersson F, Hui T, Loke D, Putti T. Metastasis of occult prostatic carcinoma to the sphenoid sinus: report of a rare case and a review of the literature. Head Neck Pathol. 2012;6:258-63 pubmed publisher
    We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease...
  8. Leunig A, Betz C, Sommer B, Sommer F. [Anatomic variations of the sinuses; multiplanar CT-analysis in 641 patients]. Laryngorhinootologie. 2008;87:482-9 pubmed publisher
    ..Axial and sagittal views are often not available, yet they can provide important additional information...
  9. Dogan M, Kahraman A, Firat C, Kahraman B, Karatas E, Kizilay A. Intraosseous lipoma presenting as a sphenoid sinus mass. Eur Rev Med Pharmacol Sci. 2011;15:1339-42 pubmed
    ..We present a case of lipoma in the body of the sphenoid bone mimicking sphenoid sinus tumor...
  10. Güldner C, Pistorius S, Diogo I, Bien S, Sesterhenn A, Werner J. Analysis of pneumatization and neurovascular structures of the sphenoid sinus using cone-beam tomography (CBT). Acta Radiol. 2012;53:214-9 pubmed publisher
    The sphenoid sinus is a frequent target of paranasal sinus surgery. Because of the high risk of injuring the surrounding structures (e.g. internal carotid artery, optical nerve) a preoperative imaging is absolutely necessary.
  11. King A, Ahuja A, Leung S, Abrigo J, Wong J, Poon W, et al. MR imaging of nonmalignant polyps and masses of the nasopharynx and sphenoid sinus after radiotherapy for nasopharyngeal carcinoma. AJNR Am J Neuroradiol. 2008;29:1209-14 pubmed publisher
    ..The purpose of this study was to document the MR appearance of unusual nonmalignant polyps or masses (NMPMs) in the nasopharynx and sphenoid sinus arising after radiation treatment of nasopharyngeal carcinoma.
  12. Schmidt R, Choudhry O, Raviv J, Baredes S, Casiano R, Eloy J, et al. Surgical nuances for the endoscopic endonasal transpterygoid approach to lateral sphenoid sinus encephaloceles. Neurosurg Focus. 2012;32:E5 pubmed publisher
    ..this report, the authors review the endoscopic endonasal transpterygoid approach to the lateral recess of the sphenoid sinus for repair of temporal lobe encephaloceles, including an overview of the surgical anatomy from an endoscopic ..
  13. Filho B, Pinheiro Neto C, Neto C, Weber R, Voegels R. Sphenoid sinus symmetry and differences between sexes. Rhinology. 2008;46:195-9 pubmed
    To evaluate the anatomic variations of neurovascular structures adjacent to the sphenoid sinus and their agreement between right and left sides as well as differences between sexes.
  14. Kwon S, Kim S, Yoon J. Anterior clinoid mucocele coexisting with sphenoid sinus mucocele. Auris Nasus Larynx. 2009;36:598-600 pubmed publisher
    ..Interestingly, the anterior clinoid mucocele coexisted with a sphenoid sinus mucocele...
  15. Kurowska M, Tarach J, Zgliczynski W, Malicka J, Zielinski G, Janczarek M. Acromegaly in a patient with normal pituitary gland and somatotropic adenoma located in the sphenoid sinus. Endokrynol Pol. 2008;59:348-51 pubmed
    ..Even rarer are ectopic pituitary adenomas located in the sphenoid sinus or nasopharynx that originate from pituitary remnants in the craniopharyngeal duct...
  16. Cho H, Kim J, Kim K, Kim Y, Lee J, Yoon J. Endoscopic surgery for inverted papilloma originating from the sphenoid sinus and related clinical characteristics. Acta Otolaryngol. 2008;128:1120-5 pubmed publisher
    ..Because the lateral wall and floor of the sphenoid sinus are the most common origin and recurrence sites, the anterior wall of the sphenoid sinus should be opened as ..
  17. Yang B, Chong V, Wang Z, Xian J, Chen Q. Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings. Br J Radiol. 2010;83:218-24 pubmed publisher
    ..The purpose of this study was to describe the CT and MRI features of sphenoid sinus EPAs...
  18. Enomoto K, Inohara H, Hamada K, Tamura M, Tomita Y, Kubo T, et al. FDG PET imaging of myxofibrosarcoma on the sphenoid sinus. Clin Nucl Med. 2008;33:421-2 pubmed publisher
  19. Stamm A, Pignatari S, Vellutini E, Harvey R, Nogueira J. A novel approach allowing binostril work to the sphenoid sinus. Otolaryngol Head Neck Surg. 2008;138:531-2 pubmed publisher
  20. Soon S, Lim C, Singh H, Sethi D. Sphenoid sinus mucocele: 10 cases and literature review. J Laryngol Otol. 2010;124:44-7 pubmed publisher
    b>Sphenoid sinus mucoceles represent only 1-2 per cent of all paranasal sinus mucoceles. Patients may present with a myriad of symptoms...
  21. Thompson L, Seethala R, Muller S. Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the english literature. Head Neck Pathol. 2012;6:75-100 pubmed publisher
    Ectopic sphenoid sinus pituitary adenoma (ESSPA) may arise from a remnant of Rathke's pouch...
  22. Tomazic P, Stammberger H. Spontaneous CSF-leaks and meningoencephaloceles in sphenoid sinus by persisting Sternberg's canal. Rhinology. 2009;47:369-74 pubmed publisher
    ..A congenital bony defect in the lateral wall of sphenoid sinus called Sternberg's canal could be the origin of these lesions...
  23. Bahadir O, Arslan S, Arslan E, Turk A, Ural A. Sphenoid sinus mucocele presenting with unilateral visual loss: a case report. B-ENT. 2011;7:65-8 pubmed
    Mucoceles of the sphenoid sinus are rare and may remain undiagnosed until symptoms arise due to the compression of surrounding structures...
  24. Muscatello L, Lenzi R, Dallan I, Seccia V, Marchetti M, Sellari Franceschini S. Endoscopic transnasal management of cerebrospinal fluid leaks of the sphenoid sinus. J Craniomaxillofac Surg. 2010;38:396-402 pubmed publisher
    The authors reviewed the medical records of patients who had undergone endoscopic management of sphenoid sinus (SS) cerebrospinal fluid (CSF) leaks in our department between 2005 and 2007...
  25. Wang J, Bidari S, Inoue K, Yang H, Rhoton A. Extensions of the sphenoid sinus: a new classification. Neurosurgery. 2010;66:797-816 pubmed publisher
    ..been extended in recent years from tumors of the sellar region to lesions involving other areas bordering the sphenoid sinus including the cavernous sinus, Meckel's cave, middle cranial fossa, planum sphenoidal, suprasellar region, and ..
  26. Wang S, Xue L, Jing J, Wang R. Virtual reality surgical anatomy of the sphenoid sinus and adjacent structures by the transnasal approach. J Craniomaxillofac Surg. 2012;40:494-9 pubmed publisher
    To examine the three-dimensional virtual anatomical features of the sphenoid sinus and adjacent structures during virtual surgery and explore their relevance to actual transsphenoidal surgery.
  27. Vandist V, Deridder F, Waelput W, Parizel P, Van de Heyning P, Van Laer C. A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. B-ENT. 2010;6:147-51 pubmed
    It is rare for neuroendocrine tumours to originate in the sphenoid sinus and the nasopharynx. Neuroendocrine tumours can be classified into typical carcinoids, atypical carcinoids and small cell neuroendocrine carcinomas...
  28. Vedrine P, Thariat J, Merrot O, Percodani J, Dufour X, Choussy O, et al. Primary cancer of the sphenoid sinus--a GETTEC study. Head Neck. 2009;31:388-97 pubmed publisher
    Primary involvement of the sphenoid sinus occurs in 2% of all paranasal sinus tumors and is associated with dismal prognosis. Optimal management remains debatable.
  29. Citardi M, Gallivan R, Batra P, Maurer C, Rohlfing T, Roh H, et al. Quantitative computer-aided computed tomography analysis of sphenoid sinus anatomical relationships. Am J Rhinol. 2004;18:173-8 pubmed
    ..a novel computer-generated anatomic symmetry plane as a framework for the quantitative description of sphenoid sinus anatomy...
  30. Kingdom T, DelGaudio J. Endoscopic approach to lesions of the sphenoid sinus, orbital apex, and clivus. Am J Otolaryngol. 2003;24:317-22 pubmed
    ..In this report, we review our experience approaching lesions of the sphenoid sinus, orbital apex, and clivus via a transnasal endoscopic technique...
  31. Shetty P, Shroff M, Fatterpekar G, Sahani D, Kirtane M. A retrospective analysis of spontaneous sphenoid sinus fistula: MR and CT findings. AJNR Am J Neuroradiol. 2000;21:337-42 pubmed
    The sphenoid sinus is rarely implicated as a site of spontaneous CSF fistula. We undertook this study to evaluate the potential etiopathogenesis of spontaneous CSF fistula involving the sphenoid sinus and to review the imaging findings...
  32. Pasquini E, Sciarretta V, Farneti G, Mazzatenta D, Modugno G, Frank G. Endoscopic treatment of encephaloceles of the lateral wall of the sphenoid sinus. Minim Invasive Neurosurg. 2004;47:209-13 pubmed
    ..the endoscopic approach was a useful tool for the treatment of encephaloceles of the lateral wall of the sphenoid sinus. In skilled hands, this technique permits both the resection of the encephalocele and the subsequent ..
  33. Sharma S, Reddy C, Srinivasan S, Rawal A, Singh D. Isolated esthesioneuroblastoma of sphenoid sinus. Am J Otolaryngol. 2002;23:287-9 pubmed
    ..In this report, we present an interesting case of isolated sphenoid sinus esthesioneuroblastoma, which is the first case to be reported in the literature, and discuss the pathology, ..
  34. Takeshita T, Tanaka H, Harasawa A, Kaminaga T, Imamura T, Furui S. Brown tumor of the sphenoid sinus in a patient with secondary hyperparathyroidism: CT and MR imaging findings. Radiat Med. 2004;22:265-8 pubmed
    We present a case of brown tumor of the sphenoid sinus in a patient with secondary hyperparathyroidism. CT showed an expansile soft-tissue attenuation mass centered in the sphenoid sinus...
  35. Eisen M, Buchmann L, Litman R, Kennedy D. Inverted papilloma of the sphenoid sinus presenting with auditory symptoms: a report of two cases. Laryngoscope. 2002;112:1197-200 pubmed
    The report aims to inform the reader of cases of inverted papilloma involving the sphenoid sinus presenting with auditory symptoms.
  36. Akhaddar A, Abouchadi A, Jidal M, Gazzaz M, Elmostarchid B, Naama O, et al. Metallic foreign body in the sphenoid sinus after ballistic injury: a case report. J Neuroradiol. 2008;35:125-8 pubmed
    ..Among them, penetrating maxillofacial injuries to the sphenoid sinus and skull base remain rare...
  37. Vaphiades M, Roberson G. Sphenoid sinus mucocele presenting as a third cranial nerve palsy. J Neuroophthalmol. 2005;25:293-4 pubmed
    A 90-year-old woman developed an acute left third cranial nerve palsy. Brain imaging revealed a left sphenoid sinus mucocele. Endoscopic marsupialization of the mucocele led to complete resolution of the third cranial nerve palsy.
  38. Connor S, Deasy N. MRI appearances of the sphenoid sinus at the late follow-up of trans-sphenoidal surgery for pituitary macroadenoma. Australas Radiol. 2002;46:33-40 pubmed
    We aimed to demonstrate the appearances of the sphenoid sinus on MRI performed later than 2 years post- transsphenoidal surgery (TSS)...
  39. Nishio S, Samoto K, Takeshita I, Matsumoto K, Matsushima T, Fukui M. Inverting papilloma of the sphenoid sinus: report of two cases. J Clin Neurosci. 2001;8:168-70 pubmed
    Two patients with sphenoid sinus inverting papilloma who were treated either by transcranial or sublabial trans-septal approach are reported. Inverting papillomas arising from the sphenoid sinus are exceedingly rare...
  40. Hadar T, Shvero J, Nageris B, Yaniv E. [The endoscopic approach to isolated sphenoid sinus disease]. Harefuah. 2002;141:670-2, 764 pubmed
    We reviewed the records of 38 patients aged 16 to 76 years with isolated sphenoid sinus disease who were treated by intranasal endoscopic sphenoidotomy at our hospital during the period 1992-1997...
  41. Alba J, Armengot M, Diaz A, Perez A, Rausell N, Basterra J. Inverted papilloma of the sphenoid sinus. Acta Otorhinolaryngol Belg. 2002;56:399-402 pubmed
    ..order of frequency being the lateral wall of the nasal fossa, ethmoid sinus, and maxillary sinus; the sphenoid sinus is only rarely affected...
  42. Bowman J, Panizza B, Gandhi M. Sphenoid sinus fungal balls. Ann Otol Rhinol Laryngol. 2007;116:514-9 pubmed
    We sought to examine the nature of fungal balls of the sphenoid sinus, in particular the exposure of adjacent skull base structures and the potential for surgical morbidity...
  43. Liess B, Horst J, Zitsch R. Sphenoid sinus paraganglioma: first reported case. Am J Otolaryngol. 2007;28:347-9 pubmed
    ..Rarely, this benign tumor may occur in the nose and paranasal sinus. We report a case of paraganglioma involving the sphenoid sinus, discuss histologic characteristics, and review this tumor.
  44. Suzuki J, Otsuka F, Ogura T, Kishida M, Takeda M, Tamiya T, et al. An aberrant ACTH-producing ectopic pituitary adenoma in the sphenoid sinus. Endocr J. 2004;51:97-103 pubmed
    ..Although EAPA is clinically rare in parasellar disorders, the presence of ectopic pituitary adenoma should be considered in such cases showing ACTH hypersecretion without typical Cushingoid features. ..
  45. Gandour Edwards R, Kapadia S, Janecka I, Martinez A, Barnes L. Biologic markers of invasive pituitary adenomas involving the sphenoid sinus. Mod Pathol. 1995;8:160-4 pubmed
    ..Utilizing immunohistochemistry on tissue sections, we examined 10 invasive pituitary adenomas involving the sphenoid sinus with a panel of cellular and molecular markers and compared the results with 10 noninvasive pituitary adenomas ..
  46. Lin J, Lin S, Chang Y, Lo S, Chuang F, Lin S. Sphenoid sinus mucocoele presenting with optic neuropathy and abducens palsy: a late complication of radiotherapy to the head and neck. Eye (Lond). 2005;19:697-9 pubmed
  47. Lam P, Trendell Smith N, Li J, Fan Y, Yuen A. Myxofibrosarcoma of the sphenoid sinus. J Laryngol Otol. 2002;116:464-6 pubmed
    ..Close collaboration between surgeon, radiologist, histopathologist and clinical oncologist in makng accurate diagnosis and appropriate management of this rare tumour are emphasized. ..
  48. Pinzer T, Reiss M, Bourquain H, Krishnan K, Schackert G. Primary aspergillosis of the sphenoid sinus with pituitary invasion - a rare differential diagnosis of sellar lesions. Acta Neurochir (Wien). 2006;148:1085-90; discussion 1090 pubmed
    ..Isolated aspergillosis of the sphenoid sinus or the clivus is a difficult diagnosis, since the often misleading clinical manifestations of this rare ..
  49. Cappabianca P, Alfieri A, de Divitiis E. Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS). Minim Invasive Neurosurg. 1998;41:66-73 pubmed
  50. Wong K, Fenton R. Endoscopic resection of isolated inverted papilloma of the sphenoid sinus. J Otolaryngol. 2004;33:125-8 pubmed
  51. Metellus P, Fuentes S, Figarella Branger D, Dufour H, Grisoli F. [Sphenoid sinus lymphoma. Case report and review of the literature]. Neurochirurgie. 2002;48:522-6 pubmed
    ..Neuroradiological investigation showed a sphenoid sinus mass involving the sella and the clivus...
  52. Martin T, Smith T, Smith M, Loehrl T. Evaluation and surgical management of isolated sphenoid sinus disease. Arch Otolaryngol Head Neck Surg. 2002;128:1413-9 pubmed
    To evaluate the pathologic conditions, preoperative evaluation, treatment, and clinical outcomes associated with sphenoid sinus disease.
  53. Vernon S, Casiano R. Sphenoid sinus chondromyxoid fibroma mimicking a mucocele. Am J Otolaryngol. 2006;27:406-8 pubmed
    We report the case of a 44-year-old man who presented with a chondromyxoid fibroma (CMF) of the sphenoid sinus, which filled the sinus and clinically and radiologically resembled a mucocele...
  54. Levy J, Monos T, Puterman M. Bilateral consecutive blindness due to sphenoid sinus mucocele with unilateral partial recovery. Can J Ophthalmol. 2005;40:506-8 pubmed
    We present an interventional case report of a rare occurrence of sphenoid sinus mucocele causing bilateral consecutive blindness with unilateral partial recovery after endoscopic surgery.
  55. Prepageran N, Subramaniam K, Krishnan G, Raman R. Ocular presentation of sphenoid mucocele. Orbit. 2004;23:45-7 pubmed
    ..It can present initially to the ophthalmologist with ocular complaints. In the present paper, the authors present two cases of sphenoid mucocele, one with an isolated third and one with an isolated sixth cranial nerve palsy. ..
  56. Cappabianca P, Cavallo L, Colao A, de Divitiis E. Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg. 2002;97:293-8 pubmed
  57. Chopra H, Dua K, Malhotra V, Gupta R, Puri H. Invasive fungal sinusitis of isolated sphenoid sinus in immunocompetent subjects. Mycoses. 2006;49:30-6 pubmed
    ..Isolated involvement of any paranasal sinus, particularly sphenoid sinus is rare...
  58. Nouraei S, Maani T, Hajioff D, Saleh H, Mackay I. Outcome of endoscopic sphenopalatine artery occlusion for intractable epistaxis: a 10-year experience. Laryngoscope. 2007;117:1452-6 pubmed
    ..To evaluate the efficacy of surgical sphenopalatine artery occlusion (SAO) for treating intractable epistaxis, and identify factors associated with long-term success or failure of this procedure...
  59. Petrick M, Honegger J, Daschner F, Feuerhake F, Zentner J. Fungal granuloma of the sphenoid sinus and clivus in a patient presenting with cranial nerve III paresis: case report rand review of the literature. Neurosurgery. 2003;52:955-8; discussion 958-9 pubmed
    Isolated fungal granulomas originating within the sphenoid sinus are extremely rare in immunocompetent patients. In their symptoms and morphological appearance, these lesions may be mistaken for pituitary tumors...
  60. Gondim J, Schops M, Ferreira E, Bulcão T, Mota J, Silveira C. Acromegaly due to an ectopic pituitary adenoma in the sphenoid sinus. Acta Radiol. 2004;45:689-91 pubmed
    An ectopic pituitary adenoma, exclusively involving the sphenoid sinus, associated with a normal size pituitary gland and an empty sella is a rare clinical entity. Only four cases have been found in the literature...
  61. Park Y, Cho J, Cho J, Huh J, Ahn J. Non-Hodgkin's lymphoma of the sphenoid sinus presenting as isolated oculomotor nerve palsy. World J Surg Oncol. 2007;5:86 pubmed
    Solitary involvement of the sphenoid sinus has rarely been reported in non-Hodgkin's lymphoma. Isolated oculomotor nerve palsy is uncommon as an initial presentation of malignant tumors of the sphenoid sinus.
  62. Cakmak O, Ergin N, Aydin M. Isolated sphenoid sinus adenocarcinoma: a case report. Eur Arch Otorhinolaryngol. 2002;259:266-8 pubmed
    While solitary sphenoid sinus disease is uncommon, primary isolated sphenoid sinus carcinoma is extremely rare. We describe a case of isolated sphenoid sinus adenocarcinoma in a 68-year-old man...
  63. DeMonte F, Ginsberg L, Clayman G. Primary malignant tumors of the sphenoidal sinus. Neurosurgery. 2000;46:1084-91; discussion 1091-2 pubmed
    ..Primary involvement of the sphenoidal sinus has been reported to occur in only 1 to 2% of all paranasal sinus tumors. Tumors at this site commonly present with cranial neuropathies and require multidisciplinary treatment...
  64. Castelnuovo P, Pagella F, Semino L, De Bernardi F, Delù G. Endoscopic treatment of the isolated sphenoid sinus lesions. Eur Arch Otorhinolaryngol. 2005;262:142-7 pubmed
    Presenting symptoms of the isolated sphenoid sinus lesion are often vague and non-specific. Diagnostic nasal endoscopy procedures and imaging techniques are of great value for an early and precise diagnosis...
  65. Avanzini F, Bigoni A, Nicoletti G. [A rare case of isolated aspergilloma of the sphenoid sinus]. Acta Otorhinolaryngol Ital. 1991;11:483-9 pubmed
    The authors report an interesting case of an isolated pathology of the sphenoid sinus (more precisely, in this case a mycotic infection of this paranasal sinus), up to a few years ago an extremely rare disease and still today an ..
  66. Morris L, Govindaraj S, Genden E. Primary sphenoid sinus esthesioneuroblastoma. Am J Otolaryngol. 2004;25:350-3 pubmed
    ..We report a rare case of a primary sphenoid sinus esthesioneuroblastoma and discuss the pathogenesis, clinical presentation, and treatment of this rare entity.
  67. Miller T, Stevens E, Orlandi R. Economic analysis of the treatment of posterior epistaxis. Am J Rhinol. 2005;19:79-82 pubmed
    ..The aim of this study was to compare the economic impact of controlling posterior epistaxis by transnasal endoscopic sphenopalatine artery ligation (TESPAL) and endovascular embolization...
  68. Sani S, Smith A, Leppla D, Ilangovan S, Glick R. Epidermoid cyst of the sphenoid sinus with extension into the sella turcica presenting as pituitary apoplexy: case report. Surg Neurol. 2005;63:394-7; discussion 397 pubmed
    ..We report here a rare case of an epidermoid arising from the sphenoid sinus with extension into the sella and adjacent structures with acute onset of neurological deficit...
  69. Kazkayasi M, Karadeniz Y, Arikan O. Anatomic variations of the sphenoid sinus on computed tomography. Rhinology. 2005;43:109-14 pubmed
    Anatomic variations of the vital structures adjacent to the sphenoid sinus can be jeopardized during functional endoscopic sinus surgery (FESS)...
  70. Unal B, Bademci G, Bilgili Y, Batay F, Avci E. Risky anatomic variations of sphenoid sinus for surgery. Surg Radiol Anat. 2006;28:195-201 pubmed
    We searched for the surgically risky anatomic variations of sphenoid sinus and aimed to compare axial and coronal tomography in detection of these variations...
  71. Righini C, Darouassi Y, Boubagra K, Schmerber S, Reyt E. [Sphenoid sinus mucocele of unusual aetiology and location]. Rev Laryngol Otol Rhinol (Bord). 2006;127:165-70 pubmed
    ..Mucoceles of the sphenoid sinnus are rare. 140 cases have been reported in the literature...
  72. Weiland D, Aygun N. An unusual presentation of a cholesterol granuloma in a pneumatized pterygoid process of the sphenoid sinus. Otolaryngol Head Neck Surg. 2007;136:153-4 pubmed
  73. Eloy J, Bederson J, Smouha E. Petrous apex aspergillosis as a long-term complication of cholesterol granuloma. Laryngoscope. 2007;117:1199-201 pubmed
    ..Because of the potential lethal nature of this condition, aggressive surgical therapy should be considered early in this illness and may provide the best chance for survival...
  74. Lee L, Huang C, Lee T. Prolonged visual disturbance secondary to isolated sphenoid sinus disease. Laryngoscope. 2004;114:986-90 pubmed
    The objective was to evaluate the efficacy of endoscopic sinus surgery in patients with isolated sphenoid sinus disease with visual disturbances of more than 72 hours' duration.
  75. Lee J, Bhuta S, Lufkin R, Castro D. Isolated inverting papilloma of the sphenoid sinus. Laryngoscope. 2003;113:41-4 pubmed
    Primary inverting papilloma of the sphenoid sinus is rare...
  76. Friedman A, Batra P, Fakhri S, Citardi M, Lanza D. Isolated sphenoid sinus disease: etiology and management. Otolaryngol Head Neck Surg. 2005;133:544-50 pubmed
    To evaluate the diagnosis and management of isolated sphenoid sinus disease by using the current rhinologic standard of care.
  77. Lai S, Kennedy D, Bolger W. Sphenoid encephaloceles: disease management and identification of lesions within the lateral recess of the sphenoid sinus. Laryngoscope. 2002;112:1800-5 pubmed
    ..Encephaloceles can also result from temporal lobe herniation through a middle fossa defect into the sphenoid sinus. Within the sphenoid, encephaloceles are thought to occur most commonly in the central or midline aspect of ..
  78. Mra Z, Roach J, Brook A. Infectious and neoplastic diseases of the sphenoid sinus--a report of 10 cases. Rhinology. 2002;40:34-40 pubmed
    ..When evaluating hospitalized patients with sphenoid sinus disease, a thorough history and a bedside nasal endoscopy should be performed...
  79. Hori E, Akai T, Kurimoto M, Hirashima Y, Endo S. Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. J Clin Neurosci. 2002;9:196-9 pubmed
    We present a case of growth hormone (GH)-secreting ectopic pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. It has been well known that acromegaly is sometimes associated with an empty sella...
  80. Enatsu K, Takasaki K, Kase K, Jinnouchi S, Kumagami H, Nakamura T, et al. Surgical anatomy of the sphenoid sinus on the CT using multiplanar reconstruction technique. Otolaryngol Head Neck Surg. 2008;138:182-6 pubmed publisher
    To clarify the three-dimensional anatomical features of the sphenoid sinus and its surrounding structures as are relevant to performing an endoscopic sphenoidotomy.