dental sac

Summary

Summary: Dense fibrous layer formed from mesodermal tissue that surrounds the epithelial enamel organ. The cells eventually migrate to the external surface of the newly formed root dentin and give rise to the cementoblasts that deposit cementum on the developing root, fibroblasts of the developing periodontal ligament, and osteoblasts of the developing alveolar bone.

Top Publications

  1. Jeon B, Kang E, Kumar B, Maeng G, Ock S, Kwack D, et al. Comparative analysis of telomere length, telomerase and reverse transcriptase activity in human dental stem cells. Cell Transplant. 2011;20:1693-705 pubmed publisher
  2. Jin Z, Zhang Y, Sun H, Lin Z, Bi Y, Duan Y, et al. Osteogenic-related gene expression profiles of human dental follicle cells induced by dexamethasone. Acta Pharmacol Sin. 2008;29:1013-20 pubmed publisher
    ..The present study aimed to validate the osteogenic induction of hDFC by dexamethasone (DEX) and to explore the changes of related genes responsible for the osteogenic differentiation process...
  3. Stathopoulos P, Mezitis M, Kappatos C, Titsinides S, Stylogianni E. Cysts and tumors associated with impacted third molars: is prophylactic removal justified?. J Oral Maxillofac Surg. 2011;69:405-8 pubmed publisher
    ..The aim of this retrospective analysis was to determine the frequency and type of cysts and tumors related to impacted third molars (ITMs) in Greek patients. Indications, complications, risks, and benefits of ITM removal are also discussed...
  4. Wise G, Yao S. Regional differences of expression of bone morphogenetic protein-2 and RANKL in the rat dental follicle. Eur J Oral Sci. 2006;114:512-6 pubmed
  5. Yokoi T, Saito M, Kiyono T, Iseki S, Kosaka K, Nishida E, et al. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res. 2007;327:301-11 pubmed
    ..Our findings suggest that MDF( E6-EGFP ) cells can act as PDL progenitors, and that these cells may be a useful research tool for studying PDL formation and for developing regeneration therapies...
  6. Saravana G, Subhashraj K. Cystic changes in dental follicle associated with radiographically normal impacted mandibular third molar. Br J Oral Maxillofac Surg. 2008;46:552-3 pubmed publisher
    ..The incidence of cystic changes in the dental follicle was 46%. There was a high incidence in the right side and in men. We recommend histopathological evaluation and radiographic diagnosis in the management of impacted third molars...
  7. Guo W, Chen L, Gong K, Ding B, Duan Y, Jin Y. Heterogeneous dental follicle cells and the regeneration of complex periodontal tissues. Tissue Eng Part A. 2012;18:459-70 pubmed publisher
    ..Moreover, our results demonstrate the potential for this treatment approach to address periodontal defects that result from periodontitis, or for the regeneration of teeth...
  8. Li R, Guo W, Yang B, Guo L, Sheng L, Chen G, et al. Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration. Biomaterials. 2011;32:4525-38 pubmed publisher
    ..In conclusion, hTDM is indicated as an ideal biomaterial for human dentin regeneration...
  9. Rakprasitkul S. Pathologic changes in the pericoronal tissues of unerupted third molars. Quintessence Int. 2001;32:633-8 pubmed
    ..The purpose of this study was to determine whether the incidence of pathologic conditions affecting the pericoronal tissue of unerupted third molars justifies their routine removal...

More Information

Publications82

  1. Liu D, Yao S, Pan F, Wise G. Chronology and regulation of gene expression of RANKL in the rat dental follicle. Eur J Oral Sci. 2005;113:404-9 pubmed
    ..Bone morphogenetic protein-2 acts to down-regulate RANKL expression in vitro and, in vivo, may promote alveolar bone growth in the basal region of the tooth...
  2. Morsczeck C, Gotz W, Schierholz J, Zeilhofer F, Kuhn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155-65 pubmed
    ..Therefore, our results demonstrate that cultured PCs are unique undifferentiated lineage committed cells residing in the periodontium prior or during tooth eruption...
  3. Cabbar F, Guler N, Comunoglu N, Sencift K, Cöloğlu S. Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars. J Oral Maxillofac Surg. 2008;66:2004-11 pubmed publisher
  4. Wise G, Ren Y, Yao S. Regulation of osteoprotegerin gene expression in dental follicle cells. J Dent Res. 2003;82:298-302 pubmed
    ..The PKC-alpha isoform may be critical in OPG regulation because PKC-alpha gene expression is enhanced by PMA and reduced by either CSF-1 or PTHrP...
  5. Assael L. Impacted teeth: reflections on Curran, Kugelberg, and Rood. J Oral Maxillofac Surg. 2002;60:611-2 pubmed
  6. Curran A, Damm D, Drummond J. Pathologically significant pericoronal lesions in adults: Histopathologic evaluation. J Oral Maxillofac Surg. 2002;60:613-7; discussion 618 pubmed
    ..This study reports the histopathologic diagnoses of a large series of pericoronal lesions in adults submitted to an oral and maxillofacial pathology biopsy service...
  7. Kemoun P, Laurencin Dalicieux S, Rue J, Farges J, Gennero I, Conte Auriol F, et al. Human dental follicle cells acquire cementoblast features under stimulation by BMP-2/-7 and enamel matrix derivatives (EMD) in vitro. Cell Tissue Res. 2007;329:283-94 pubmed
    ..Thus, EMD may activate HDFC toward the cementoblastic phenotype, an effect mainly (but not exclusively) involving both exogenous and endogenous BMP-dependent pathways...
  8. Huang X, Bringas P, Slavkin H, Chai Y. Fate of HERS during tooth root development. Dev Biol. 2009;334:22-30 pubmed publisher
    ..Furthermore, HERS cells interact with cranial neural crest derived mesenchyme to guide root development. Taken together, the network of HERS cells is crucial for tooth root development...
  9. Honda M, Imaizumi M, Tsuchiya S, Morsczeck C. Dental follicle stem cells and tissue engineering. J Oral Sci. 2010;52:541-52 pubmed
    ..This review describes current knowledge and recent developments in dental follicle stem cells and their application...
  10. Kemoun P, Laurencin Dalicieux S, Rue J, Vaysse F, Romeas A, Arzate H, et al. Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium. Tissue Cell. 2007;39:257-66 pubmed
    ..These results suggest that STRO-1 positive DF cells may be target of BMPs secreted by HERS. BMP-3 might be involved in the arrest of this process by inhibiting the signaling provided by cementogenic and osteogenic BMPs...
  11. Morsczeck C, Ernst W, Florian C, Reichert T, Proff P, Bauer R, et al. Gene expression of nestin, collagen type I and type III in human dental follicle cells after cultivation in serum-free medium. Oral Maxillofac Surg. 2008;12:89-92 pubmed publisher
    ..In the age of bovine spongiform encephalopathy (BSE), a serum-free cell culture system for dental follicle cells are recommended, if these cells will be applied in dentistry...
  12. Wise G, Ding D, Yao S. Regulation of secretion of osteoprotegerin in rat dental follicle cells. Eur J Oral Sci. 2004;112:439-44 pubmed
    ..Thus, a reduction in secretion of the OPG protein at defined times may promote the osteoclastogenesis and alveolar bone resorption needed for eruption, and enhancement of OPG secretion at other times may promote alveolar bone formation...
  13. Huang G, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009;88:792-806 pubmed publisher
    ..Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed...
  14. D Aquino R, Tirino V, Desiderio V, Studer M, De Angelis G, Laino L, et al. Human neural crest-derived postnatal cells exhibit remarkable embryonic attributes either in vitro or in vivo. Eur Cell Mater. 2011;21:304-16 pubmed
    ..Our results demonstrate that these cells represent a very easy accessible and extraordinary source of pluripotent cells and point out the fact that they own the cardinal feature of embryonic stem cells...
  15. Guo W, Gong K, Shi H, Zhu G, He Y, Ding B, et al. Dental follicle cells and treated dentin matrix scaffold for tissue engineering the tooth root. Biomaterials. 2012;33:1291-302 pubmed publisher
    ..This strategy could be a promising approach for the treatment of clinical tooth loss and provides a perspective with potential applications to regeneration of other tissues and organs...
  16. Liu D, Yao S, Wise G. Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle. Eur J Oral Sci. 2006;114:42-9 pubmed
    ..In these knockdowns, RANKL expression was increased and OPG expression was decreased. All of these results suggest that IL-10 inhibits bone resorption by up-regulating OPG expression while down-regulating expression of RANKL and CSF-1...
  17. Wu J, Jin F, Tang L, Yu J, Xu L, Yang Z, et al. Dentin non-collagenous proteins (dNCPs) can stimulate dental follicle cells to differentiate into cementoblast lineages. Biol Cell. 2008;100:291-302 pubmed
    ..In the present study, we hypothesized that dNCPs (dentin non-collagenous proteins) extracted from dentin could stimulate DFCs to differentiate into cementoblast lineages...
  18. Chen X, Qian H, Wu J, Ma X, Gu Z, Sun H, et al. Expression of vascular endothelial growth factor in cultured human dental follicle cells and its biological roles. Acta Pharmacol Sin. 2007;28:985-93 pubmed
    ..To investigate the expression of vascular endothelial growth factor (VEGF) in cultured human dental follicle cells (HDFC), and to examine the roles of VEGF in the proliferation, differentiation, and apoptosis of HDFC in vitro...
  19. Farah C, Savage N. Pericoronal radiolucencies and the significance of early detection. Aust Dent J. 2002;47:262-5 pubmed
    ..In this report we present four cases of large pericoronal radiolucencies associated with unerupted teeth, and highlight the importance of early detection and management of such lesions...
  20. Yao S, Pan F, Prpic V, Wise G. Differentiation of stem cells in the dental follicle. J Dent Res. 2008;87:767-71 pubmed
    ..Treating the DF cell population with doxorubicin, followed by incubation in an adipogenesis medium, suggested that the adipocytes originated from stem cells. Thus, a possibly puripotent stem cell population is present in the rat DF...
  21. Guo W, He Y, Zhang X, Lu W, Wang C, Yu H, et al. The use of dentin matrix scaffold and dental follicle cells for dentin regeneration. Biomaterials. 2009;30:6708-23 pubmed publisher
    ..The combination of TDM and DFCs may constitute a promising approach for future clinical dentin regeneration...
  22. Matsumoto M, Filho H, Jorge F, Salvadori D, Marques M, Ribeiro D. Expression of cell cycle regulatory proteins in epithelial components of dental follicles. J Mol Histol. 2006;37:127-31 pubmed
    ..However, the biological behavior of dental follicles during the late stage of dental eruptive process may not be associated with deregulation of death and/or cell proliferation...
  23. Yao S, Pan F, Wise G. Chronological gene expression of parathyroid hormone-related protein (PTHrP) in the stellate reticulum of the rat: implications for tooth eruption. Arch Oral Biol. 2007;52:228-32 pubmed
  24. Luan X, Ito Y, Dangaria S, Diekwisch T. Dental follicle progenitor cell heterogeneity in the developing mouse periodontium. Stem Cells Dev. 2006;15:595-608 pubmed
  25. Yao S, Ring S, Henk W, Wise G. In vivo expression of RANKL in the rat dental follicle as determined by laser capture microdissection. Arch Oral Biol. 2004;49:451-6 pubmed
    ..Thus, RANKL has now been shown to be expressed in the follicle and it is probable that interactions between it, CSF-1 and OPG regulate locally the osteoclastogenesis needed for tooth eruption...
  26. Zhou J, Liu T, Zheng H, Song J, Deng F. [Immortalization of the SD rats' dental follicle cell with simian virus 40 large tumor antigen gene]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2012;47:631-6 pubmed publisher
    ..To construct SD rat immortalized dental follicle cells (rDFC) induced by simian virus 40 large tumor antigen (SV40Tag) gene to provide a reliable cell source for periodontal tissue engineering research...
  27. Yang B, Chen G, Li J, Zou Q, Xie D, Chen Y, et al. Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold. Biomaterials. 2012;33:2449-61 pubmed publisher
    ..Therefore, DFCSs combined with TDM may prove to be a better strategy for the construction of tooth root, and is a prospective approach that could be utilized for the treatment of root or tooth defect or loss in future...
  28. Tomic S, Djokic J, Vasilijic S, Vucevic D, Todorovic V, Supic G, et al. Immunomodulatory properties of mesenchymal stem cells derived from dental pulp and dental follicle are susceptible to activation by toll-like receptor agonists. Stem Cells Dev. 2011;20:695-708 pubmed publisher
    ..In conclusion, our results suggest that dental MSCs are functionally different and each of these functions should be further explored in vivo before their specific biomedical applications...
  29. Morsczeck C, Moehl C, Gotz W, Heredia A, Schäffer T, Eckstein N, et al. In vitro differentiation of human dental follicle cells with dexamethasone and insulin. Cell Biol Int. 2005;29:567-75 pubmed
    ..Our work demonstrates differentiation of dental follicle cells with an insulin-based protocol for the first time...
  30. Völlner F, Ernst W, Driemel O, Morsczeck C. A two-step strategy for neuronal differentiation in vitro of human dental follicle cells. Differentiation. 2009;77:433-41 pubmed publisher
    ..In conclusion, we demonstrated the differentiation of human DFCs into neuron-like cells after a two-step strategy for neuronal differentiation...
  31. Zhao M, Xiao G, Berry J, Franceschi R, Reddi A, Somerman M. Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002;17:1441-51 pubmed
    ..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved...
  32. Wise G, Frazier Bowers S, D Souza R. Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13:323-34 pubmed
    ..Cbfa1 is also expressed at high levels by the dental follicle cells. This review concludes with a discussion of the several human conditions that result in a failure of or delay in tooth eruption...
  33. Sohn W, Choi M, Yamamoto H, Lee S, Lee Y, Jung J, et al. Contribution of mesenchymal proliferation in tooth root morphogenesis. J Dent Res. 2014;93:78-83 pubmed publisher
    ..Immunolocalization and three-dimensional reconstruction results confirmed these mesenchymal cellular events, with higher proliferation in MRF in multi-rooted tooth formation. ..
  34. Felthaus O, Ernst W, Driemel O, Reichert T, Schmalz G, Morsczeck C. TGF-beta stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs). Neurosci Lett. 2010;471:179-84 pubmed publisher
    ..In contrast gene expression of neural cell markers was not regulated. In conclusion, TGF-beta improved glial-like, but not neural-like, differentiation of mDFPCs. ..
  35. Wise G, Yao S. Expression of vascular endothelial growth factor in the dental follicle. Crit Rev Eukaryot Gene Expr. 2003;13:173-80 pubmed
    ..Treatment with PMA also increased the protein level of VEGF. Thus, VEGF may be involved in promoting the secondary burst of osteoclastogenesis, and activation of PKC may upregulate its expression. ..
  36. Dangaria S, Ito Y, Luan X, Diekwisch T. Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications. Stem Cells Dev. 2011;20:39-52 pubmed publisher
  37. da Costa N, Fialho A, Proietti C, da Silva Kataoka M, Jaeger R, de Alves Júnior S, et al. Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, hypoxia-inducible factor 1α, a disintegrin and metalloproteinase 12, and heparin-binding epidermal growth factor. Histopathology. 2016;69:99-106 pubmed publisher
    ..05). AME showed an increased presence of proteins associated with tumour invasiveness, which indicates a possible role of these proteins in the biological behaviour of this tumour. ..
  38. Martínez González J, Cortés Bretón Brinkmann J, Calvo Guirado J, Arias Irimia O, Barona Dorado C. Clinical epidemiological analysis of 173 supernumerary molars. Acta Odontol Scand. 2012;70:398-404 pubmed publisher
    ..2% of the sample. Supernumerary molars are usually diagnosed as a coincidental radiological finding without any associated pathology. However a higher percentage of comorbidity was found than initially expected. ..
  39. Xiong J, Gronthos S, Bartold P. Role of the epithelial cell rests of Malassez in the development, maintenance and regeneration of periodontal ligament tissues. Periodontol 2000. 2013;63:217-33 pubmed publisher
    ..Therefore, the epithelial cell rests of Malassez, rather than being 'cell rests', as indicated by their name, are an important source of stem cells that might play a pivotal role in periodontal regeneration. ..
  40. Holan G. Development of clinical and radiographic signs associated with dark discolored primary incisors following traumatic injuries: a prospective controlled study. Dent Traumatol. 2004;20:276-87 pubmed
    ..There is still a dilemma: which treatment is better for dark discolored primary incisors: early endodontic treatment or follow-up with the risk of development of infection and root resorption that may require extraction? ..
  41. Walker L, Enciso R, Mah J. Three-dimensional localization of maxillary canines with cone-beam computed tomography. Am J Orthod Dentofacial Orthop. 2005;128:418-23 pubmed
    ..In short, 3D imaging is clearly advantageous in the management of impacted canines. ..
  42. Zhang J, Tu Q, Grosschedl R, Kim M, Griffin T, Drissi H, et al. Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Eng Part A. 2011;17:1767-76 pubmed publisher
    ..The application of SATB2 in bone tissue engineering gives rise to a higher bone forming capacity as a result of multiple-level amplification of regulatory activity. ..
  43. Mori G, Ballini A, Carbone C, Oranger A, Brunetti G, Di Benedetto A, et al. Osteogenic differentiation of dental follicle stem cells. Int J Med Sci. 2012;9:480-7 pubmed publisher
    ..This study suggests that DFSCs may provide a cell source for tissue engineering of bone. ..
  44. Morsczeck C, Gresser J, Ettl T. The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation. Mol Cell Biochem. 2016;417:1-6 pubmed publisher
    ..In conclusion, we showed that a prolonged cell culture induces cellular senescence and inhibits the osteogenic differentiation in DFCs. ..
  45. Hendek M, Senses F, Kisa U, Aksoy N, Tekin U. Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronitis a True Marker of Oxidative Stress?. J Oral Maxillofac Surg. 2017;75:2058-2062 pubmed publisher
    ..05). Results of this study showed that NO might be used as an indicator of oxidative stress and the necessity to remove impacted mandibular third molars with a history of recurrent pericoronitis. ..
  46. Heng B, Gong T, Wang S, Lim L, Wu W, Zhang C. Decellularized Matrix Derived from Neural Differentiation of Embryonic Stem Cells Enhances the Neurogenic Potential of Dental Follicle Stem Cells. J Endod. 2017;43:409-416 pubmed publisher
    ..DECM derived from neurogenesis of hESCs can enhance the neurogenic potential of DFSCs. ..
  47. Wise G, Huang H, Que B. Gene expression of potential tooth eruption molecules in the dental follicle of the mouse. Eur J Oral Sci. 1999;107:482-6 pubmed
    ..These results provide a standard for future studies on eruption in the mouse molar and extends the number of species in which putative eruption molecules are expressed at a critical time of eruption. ..
  48. da Silva Baumgart C, da Silva Lauxen I, Filho M, de Quadros O. Epidermal growth factor receptor distribution in pericoronal follicles: relationship with the origin of odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:240-5 pubmed
    ..Investigate the distribution of epidermal growth factor receptor (EGFR) in pericoronal follicles as a predictor of progression to odontogenic cysts and tumors...
  49. Bennett J, Hunt P, Thorogood P. Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995;40:847-54 pubmed
    ..These results support the role of BMP-2 and -4 as regulators of orofacial development and demonstrates different fields of BMP-2 expression in developing oral mucosal epithelium. ..
  50. Wise G. Cellular and molecular basis of tooth eruption. Orthod Craniofac Res. 2009;12:67-73 pubmed publisher
    ..Conclusion - The osteoclastogenesis and osteogenesis needed for eruption are regulated by differential gene expression in the DF both chronologically and spatially. ..
  51. Rajasuo A, Peltola J, Ventä I, Murtomaa H. Radiographic findings on 3rd molars removed in 20-year-old men. Acta Odontol Scand. 2003;61:263-7 pubmed
    ..001). We conclude that there are some typical 3rd-molar findings in rotational panoramic radiographs that show a need for surgical extraction. ..
  52. Nickolaychuk B, McNicol A, Gilchrist J, Birek C. Evidence for a role of mitogen-activated protein kinases in proliferating and differentiating odontogenic epithelia of inflammatory and developmental cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:720-9 pubmed
  53. Becker A, Casap N, Chaushu S. Conventional wisdom and the surgical exposure of impacted teeth. Orthod Craniofac Res. 2009;12:82-93 pubmed publisher
    ..To provide evidence against the notion that direct contact between the crown of an impacted tooth and alveolar bone is an impediment to orthodontically assisted eruption of teeth...
  54. Guven E, Yalvac M, Sahin F, Yazici M, Rizvanov A, Bayirli G. Effect of dental materials calcium hydroxide-containing cement, mineral trioxide aggregate, and enamel matrix derivative on proliferation and differentiation of human tooth germ stem cells. J Endod. 2011;37:650-6 pubmed publisher
  55. Nivedhitha Sundaram M, Sowmya S, Deepthi S, Bumgardener J, Jayakumar R. Bilayered construct for simultaneous regeneration of alveolar bone and periodontal ligament. J Biomed Mater Res B Appl Biomater. 2016;104:761-70 pubmed publisher
    ..Overall these results show that the developed bilayered construct might serve as a good candidate for the simultaneous regeneration of the alveolar bone and PDL...
  56. Hermann N, Zargham M, Darvann T, Christensen I, Kreiborg S. Early postnatal development of the mandibular permanent first molar in infants with isolated cleft palate. Int J Paediatr Dent. 2012;22:280-5 pubmed publisher
  57. Khojasteh A, Khodayari A, Rahimi F, Ghaderian M, Jafarian M, Nayebi A, et al. Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles. J Oral Maxillofac Surg. 2013;71:62-5 pubmed publisher
    ..The present study investigated the possible methylation of the p16 tumor in ameloblastic carcinoma, ameloblastoma, and dental follicles...
  58. Ureles S, Chrzan J, Norton L, Rossomando E. A role for TNF in bone resorption of deciduous molars in human beings. Am J Orthod Dentofacial Orthop. 2000;118:196-202 pubmed
    ..05. The results of this study suggest tumor necrosis-alpha values are elevated in the gingival crevice of deciduous molars with ankylosis and where the permanent tooth bud is congenitally missing...
  59. Becktor K, Bangstrup M, Rølling S, Kjaer I. Unilateral primary or secondary retention of permanent teeth, and dental malformations. Eur J Orthod. 2002;24:205-14 pubmed
    ..A connection between unilateral retained permanent teeth and temporary or permanent disruption of the nerve supply to the affected region is suggested...
  60. Guo L, Li J, Qiao X, Yu M, Tang W, Wang H, et al. Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells. PLoS ONE. 2013;8:e62332 pubmed publisher
    ..This study expands our understanding on tooth development, and provides direct evidence for the use of alternative cell sources in tooth regeneration...
  61. Gopinathan G, Kolokythas A, Luan X, Diekwisch T. Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations. Stem Cells Dev. 2013;22:1763-78 pubmed publisher
    ..Findings presented here highlight the crucial role of epigenetic regulatory mechanisms in the terminal differentiation of odontogenic neural crest lineages...
  62. Shibata Y, Asaumi J, Yanagi Y, Kawai N, Hisatomi M, Matsuzaki H, et al. Radiographic examination of dentigerous cysts in the transitional dentition. Dentomaxillofac Radiol. 2004;33:17-20 pubmed
    ..To examine radiographically the relationship between the deciduous tooth and dentigerous cyst of the permanent successor during the transitional dentition...
  63. Matsumoto A, Harada H, Saito M, Taniguchi A. Induction of enamel matrix protein expression in an ameloblast cell line co-cultured with a mesenchymal cell line in vitro. In Vitro Cell Dev Biol Anim. 2011;47:39-44 pubmed publisher
    ..Our culture system should be a useful method for investigation of epithelial-mesenchymal interactions...
  64. Morsczeck C, Schmalz G. Transcriptomes and proteomes of dental follicle cells. J Dent Res. 2010;89:445-56 pubmed publisher
    ..This review describes the transcriptomes and proteomes of dental follicle cells before and after differentiation, and compares them with differentially expressed populations from dental tissue or bone marrow...
  65. Gomes J, Omar N, Dos Santos Neves J, Narvaes E, Novaes P. Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure. J Mol Histol. 2011;42:153-9 pubmed publisher
  66. Du Y, Gu H, Gong Q, Yang F, Ling J. HSP25 affects the proliferation and differentiation of rat dental follicle cells. Int J Oral Sci. 2009;1:72-80 pubmed publisher
    ..To detect the expression of HSP25 in rat dental follicles both in vivo and vitro, and explore the underlying mechanism of HSP25 on the proliferation and differentiation of rat dental follicle cells (DFCs)...
  67. Jung H, Lee D, Lee J, Park S, Lee G, Seo B, et al. Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells. J Mol Histol. 2011;42:227-35 pubmed publisher
  68. Krauss E, Rauthe S, Gattenlohner S, Reuther T, Kochel M, Kriegebaum U, et al. MAGE-A antigens in lesions of the oral mucosa. Clin Oral Investig. 2011;15:315-20 pubmed publisher
    ..The staining rate of dysplastic precancerous lesions or malignant lesions ranged from 33% to 65%. The MAGE-A antigens might facilitate better differentiation between precancerous and cancerous lesions of the oral mucosa...
  69. Johnston N, Riordan P. Tooth follicle extirpation and uvulectomy. Aust Dent J. 2005;50:267-72 pubmed
    ..With improved understanding between Western health teams and local, traditional people, an improved system may develop whereby the two systems can work together in providing improved health outcomes for the people...
  70. Bsoul S, Terezhalmy G, Abboud H, Woodruff K, Abboud S. PDGF BB and bFGF stimulate DNA synthesis and upregulate CSF-1 and MCP-1 gene expression in dental follicle cells. Arch Oral Biol. 2003;48:459-65 pubmed
    ..Further understanding of the molecular mechanisms by which cytokines regulate CSF-1 and MCP-1 may lead to more effective treatment regimens for disorders associated with abnormal tooth eruption...
  71. Feller L, Kramer B, Raubenheimer E, Lemmer J. Enamel dysplasia with hamartomatous atypical follicular hyperplasia (EDHFH) syndrome: suggested pathogenic mechanisms. SADJ. 2008;63:102-5 pubmed
    ..Thus, alterations in the function of enamel matrix protein function, may be the common denominator responsible for the development of the EDHFH phenotype...
  72. Viale Bouroncle S, Völlner F, Möhl C, Küpper K, Brockhoff G, Reichert T, et al. Soft matrix supports osteogenic differentiation of human dental follicle cells. Biochem Biophys Res Commun. 2011;410:587-92 pubmed publisher
    ..In conclusion, different to bone marrow derived MSCs, soft ECMs have a superior capacity to support the osteogenic differentiation of DFCs...
  73. Khanna Jain R, Vuorinen A, Sandor G, Suuronen R, Miettinen S. Vitamin D(3) metabolites induce osteogenic differentiation in human dental pulp and human dental follicle cells. J Steroid Biochem Mol Biol. 2010;122:133-41 pubmed publisher
    ..Furthermore, our findings strengthen our knowledge about the role of hDPCs and hDFCs as vitamin D(3) target cells...