dental papilla

Summary

Summary: Mesodermal tissue enclosed in the invaginated portion of the epithelial enamel organ and giving rise to the dentin and pulp.

Top Publications

  1. Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takagi Y, Takano Y. The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements. Arch Histol Cytol. 2004;67:65-77 pubmed
    ..The whole or minced human dental papilla was reconstructed with human- or mouse molar enamel epithelium, and transplanted in the dorsal aspect of C...
  2. Rothova M, Feng J, Sharpe P, Peterkova R, Tucker A. Contribution of mesoderm to the developing dental papilla. Int J Dev Biol. 2011;55:59-64 pubmed publisher
    ..The majority of the dental papilla of the tooth has been demonstrated to be of neural crest origin...
  3. Kwon S, Kim S, Yoon J, Ahn S. Transforming growth factor beta1-induced heat shock protein 27 activation promotes migration of mouse dental papilla-derived MDPC-23 cells. J Endod. 2010;36:1332-5 pubmed publisher
    ..The TGFbeta1 signal transduction pathways are mostly undefined in mouse dental papilla-derived MDPC-23 cells...
  4. Kikuchi H, Suzuki K, Sakai N, Yamada S. Odontoblasts induced from mesenchymal cells of murine dental papillae in three-dimensional cell culture. Cell Tissue Res. 2004;317:173-85 pubmed
    ..2002), we examined whether dental papilla cells in rat mandibular incisors could differentiate into tubular dentine-forming cells...
  5. Huang G, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009;88:792-806 pubmed publisher
    ..Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed...
  6. Liu J, Zhou H, Fan W, Dong W, Fu S, He H, et al. Melatonin influences proliferation and differentiation of rat dental papilla cells in vitro and dentine formation in vivo by altering mitochondrial activity. J Pineal Res. 2013;54:170-8 pubmed publisher
    ..This study investigated the effects of melatonin on the proliferation and differentiation of rat dental papilla cells (rDPCs) in vitro and dentine formation in vivo...
  7. Thesleff I, Keranen S, Jernvall J. Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. Adv Dent Res. 2001;15:14-8 pubmed
    Odontoblasts differentiate from the cells of the dental papilla, and it has been well-established that their differentiation in developing teeth is induced by the dental epithelium...
  8. Ikeda E, Hirose M, Kotobuki N, Shimaoka H, Tadokoro M, Maeda M, et al. Osteogenic differentiation of human dental papilla mesenchymal cells. Biochem Biophys Res Commun. 2006;342:1257-62 pubmed
    We isolated dental papilla from impacted human molar and proliferated adherent fibroblastic cells after collagenase treatment of the papilla...
  9. Park J, Kwon S, Yoon H, Kim S, Ahn S, Yoon J. Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. Int J Mol Med. 2011;27:277-81 pubmed publisher
    ..These findings indicate that LPS, an immune activator from Gram-negative bacteria, can promote the adhesion and migration ability of MDPC-23 cells via TLR4...

More Information

Publications89

  1. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS ONE. 2006;1:e79 pubmed
    ..This hybridized tissue engineering approach led to recovery of tooth strength and appearance...
  2. Li R, Peng L, Ren L, Tan H, Ye L. Hepatocyte growth factor exerts promoting functions on murine dental papilla cells. J Endod. 2009;35:382-8 pubmed publisher
    ..of this study was to determine whether HGF could stimulate proliferation and/or differentiation of murine dental papilla cells (MDPCs)...
  3. Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z. Establishment and characterization of a tamoxifen-mediated reversible immortalized mouse dental papilla cell line. In Vitro Cell Dev Biol Anim. 2013;49:114-21 pubmed publisher
    ..Mouse dental papilla cells (mDPCs), which can differentiate into odontoblast-like cells in vitro, have a limited life span...
  4. Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z. KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1. J Cell Physiol. 2013;228:2076-85 pubmed publisher
    Odontoblasts, which derive from dental papilla, are a type of terminally differentiated matrix-secreting cells. Previous studies have identified various transcription factors involved in the differentiation process of odontoblasts...
  5. Zhao Z, Tang L, Deng Z, Wen L, Jin Y. Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs). Histochem Cell Biol. 2008;130:1015-25 pubmed publisher
    b>Dental papilla mesenchymal cells (DPMCs) have been supposed to possess the relatively independent and critical role for tooth development and morphogenesis...
  6. Tziafas D, Kodonas K. Differentiation potential of dental papilla, dental pulp, and apical papilla progenitor cells. J Endod. 2010;36:781-9 pubmed publisher
    ..Regenerative endodontic procedures use the differentiation potential of embryonic and adult pulp progenitor cell populations to reconstitute dental structures...
  7. Wu L, Feng J, Wang L, Mu Y, Baker A, Donly K, et al. Immortalized mouse floxed Bmp2 dental papilla mesenchymal cell lines preserve odontoblastic phenotype and respond to BMP2. J Cell Physiol. 2010;225:132-9 pubmed publisher
    ..In this study, we established and characterized immortalized mouse floxed Bmp2 dental papilla mesenchymal cell lines, which were isolated from 1st mouse mandibular molars at postnatal day 1 and ..
  8. Thonemann B, Schmalz G. Immortalization of bovine dental papilla cells with simian virus 40 large t antigen. Arch Oral Biol. 2000;45:857-69 pubmed
    Primary cultures of dental papilla-derived cells have a limited lifespan in vitro and can be maintained only up to passage 7-9 before showing senescence, but in vitro investigations often require a large number of cells showing phenotypic ..
  9. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, et al. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS ONE. 2012;7:e50090 pubmed publisher
    ..expression of miRNAs during cytodifferentiation in the human tooth germ and studied miR-34a as a regulator of dental papilla cell differentiation...
  10. Yagyuu T, Ikeda E, Ohgushi H, Tadokoro M, Hirose M, Maeda M, et al. Hard tissue-forming potential of stem/progenitor cells in human dental follicle and dental papilla. Arch Oral Biol. 2010;55:68-76 pubmed publisher
    ..The purpose of this study was to investigate these cells in human dental follicles and dental papillae at the crown-forming stage and compare their potential for hard tissue formation...
  11. Thonemann B, Schmalz G, Hiller K, Schweikl H. Responses of L929 mouse fibroblasts, primary and immortalized bovine dental papilla-derived cell lines to dental resin components. Dent Mater. 2002;18:318-23 pubmed
    ..In the present study, the responses in primary bovine dental papilla-derived cells (pulp cells) were compared with those in transformed dental papilla-derived cell lines and L929 ..
  12. Thonemann B, Schmalz G. Bovine dental papilla-derived cells immortalized with HPV 18 E6/E7. Eur J Oral Sci. 2000;108:432-41 pubmed
    ..The purpose of our study was to establish and preliminary characterize an immortalized bovine dental papilla-derived cell line by transfection with HPV 18 E6/E7 for future use in biocompatibility testing of dental ..
  13. Rothova M, Peterkova R, Tucker A. Fate map of the dental mesenchyme: dynamic development of the dental papilla and follicle. Dev Biol. 2012;366:244-54 pubmed publisher
    ..cervical loops grow and appear to wrap around the condensed mesenchyme, enclosing the cells of the forming dental papilla. We have fate mapped the dental mesenchyme, using in vitro tissue culture combined with vital cell labelling ..
  14. Jeon B, Kumar B, Kang E, Maeng G, Lee Y, Hah Y, et al. Differential cytotoxic effects of sodium meta-arsenite on human cancer cells, dental papilla stem cells and somatic cells correlate with telomeric properties and gene expression. Anticancer Res. 2011;31:4315-28 pubmed
    ..the effects of sodium meta-arsenite (NaAsO(2)) on human cancer cells (MDA-MB-231, MCF-7 and U-87 MG), dental papilla tissue stem cells (DPSCs) and somatic cells [MRC-5 fetal fibroblasts and adult muscle cells (MCs)] by ..
  15. Peng L, Ren L, Dong G, Wang C, Xu P, Ye L, et al. Wnt5a promotes differentiation of human dental papilla cells. Int Endod J. 2010;43:404-12 pubmed publisher
    To investigate the role of Wnt5a in the process of differentiation of human dental papilla cells (HDPCs).
  16. Tete S, Nargi E, Mastrangelo F, Zizzari V, D Apolito G, Traini T, et al. Changes in matrix extracellular phosphoglycoprotein expression before and during in vitro osteogenic differentiation of human dental papilla mesenchymal cells. Int J Immunopathol Pharmacol. 2008;21:309-18 pubmed
    ..of matrix extracellular phosphoglycoprotein (MEPE) in cultured mesenchymal cells isolated from human dental papilla (PaMCs) of impacted third molars either before or during differentiation of these cells into osteo/..
  17. Peng L, Ye L, Dong G, Ren L, Wang C, Xu P, et al. WNT5A inhibits human dental papilla cell proliferation and migration. Biochem Biophys Res Commun. 2009;390:1072-8 pubmed publisher
    ..In this study, WNT5A was localized to human dental papilla tissue and human dental papilla cells (HDPCs) cultured in vitro, using immunochemistry and RT-PCR...
  18. Guo L, Li J, Qiao X, Yu M, Tang W, Wang H, et al. Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells. PLoS ONE. 2013;8:e62332 pubmed publisher
    Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor cells of odontoblasts, which are responsible for dentin development...
  19. Wang C, Ren L, Peng L, Xu P, Dong G, Ye L. Effect of Wnt6 on human dental papilla cells in vitro. J Endod. 2010;36:238-43 pubmed publisher
    ..Wnt6 in tooth development was still unknown, the purpose of this study was to investigate the role of Wnt6 in tooth morphogenesis and dental tissue mineralization by elucidating its effect on human dental papilla cells (hDPCs) in vitro.
  20. Huang G, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod. 2008;34:645-51 pubmed publisher
  21. Kikuchi H, Amano H, Yamada S. Putative role of basement membrane for dentinogenesis in the mesenchyme of murine dental papillae in vitro. Cell Tissue Res. 2001;303:93-107 pubmed
    ..The BM therefore serves as a structural meshwork that acts as a foothold for cell immobilisation; its components act as ligands for RGD-dependent cell adhesion and it stores TGF-beta1, which regulates ECM production...
  22. Jernvall J, Kettunen P, Karavanova I, Martin L, Thesleff I. Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int J Dev Biol. 1994;38:463-9 pubmed
    ..Based on these results, we suggest that the enamel knot may control tooth morphogenesis by concurrently stimulating cusp growth (via FGF-4 synthesis) and by directing folding of cusp slopes (by not proliferating itself). ..
  23. Chen Z, Gao B, Zhou X. Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development. In Vitro Cell Dev Biol Anim. 2012;48:61-8 pubmed publisher
    ..were used to investigate the inner enamel epithelium, stellate reticulum, outer enamel epithelium, and dental papilla between E18.5 and E19.5. P300 had a presence in nearly every region of the tooth germ from E11.5 to E19.5...
  24. Zmijewska C, Surdyk Zasada J, Zabel M. Development of innervation in primary incisors in the foetal period. Arch Oral Biol. 2003;48:745-52 pubmed
    ..Their presence in the dental papilla was confirmed in the 18th week when the first layers of dentine and enamel were deposited...
  25. Touati B. Significant perfection. Pract Proced Aesthet Dent. 2004;16:258 pubmed
  26. Lei G, Yan M, Wang Z, Yu Y, Tang C, Wang Z, et al. Dentinogenic capacity: immature root papilla stem cells versus mature root pulp stem cells. Biol Cell. 2011;103:185-96 pubmed publisher
    Immature dental papilla stem cells and mature dental pulp stem cells are capable of performing the dentinogenesis under suitable circumstances...
  27. Smith A, Lesot H. Induction and regulation of crown dentinogenesis: embryonic events as a template for dental tissue repair?. Crit Rev Oral Biol Med. 2001;12:425-37 pubmed
    ..Some dental papilla cells achieve commitment and specific competence, allowing them to respond to epithelially derived inductive ..
  28. Kumamoto H, Ohki K, Ooya K. Association between vascular endothelial growth factor (VEGF) expression and tumor angiogenesis in ameloblastomas. J Oral Pathol Med. 2002;31:28-34 pubmed
    ..VEGF was considered to be an important mediator of angiogenesis in these epithelial odontogenic tumors, and up-regulation of VEGF might be associated with neoplastic or malignant changes of odontogenic epithelial cells. ..
  29. Xiong J, Gronthos S, Bartold P. Role of the epithelial cell rests of Malassez in the development, maintenance and regeneration of periodontal ligament tissues. Periodontol 2000. 2013;63:217-33 pubmed publisher
    ..root development, the Hertwig's epithelial root sheath is not only a barrier between the dental follicle and dental papilla cells but is also involved in determining the shape, size and number of roots and in the development of dentin ..
  30. Matalová E, Buchtová M, Tucker A, Bender T, Janečková E, Lungová V, et al. Expression and characterization of c-Myb in prenatal odontogenesis. Dev Growth Differ. 2011;53:793-803 pubmed publisher
    ..At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation...
  31. Liu J, Zou X, Chen X, Chen Y, Yue L. [Effect of lipopolysaccharide on the stromal cell-derived factor-1 expression in human stem cells from apical papilla]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2015;50:346-51 pubmed
    ..SCAP were isolated from dental papilla of human immature third molars. The expression of SDF-1 was evaluated by reverse transcription-PCR (RT-PCR)...
  32. Canullo L, Rasperini G. Preservation of peri-implant soft and hard tissues using platform switching of implants placed in immediate extraction sockets: a proof-of-concept study with 12- to 36-month follow-up. Int J Oral Maxillofac Implants. 2007;22:995-1000 pubmed
    ..25 mm. This proof-of-concept study suggests that immediate loading with platform switching can provide peri-implant hard tissue stability with soft tissue and papilla preservation. (Case Series) ..
  33. Duncan H, Smith A, Fleming G, Partridge N, Shimizu E, Moran G, et al. The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity. J Cell Physiol. 2016;231:798-816 pubmed publisher
    ..Pharmacological inhibition of HDAC and MMP may provide novel insights into pulpal repair processes with significant translational benefit. J. Cell. Physiol. 231: 798-816, 2016. © 2015 Wiley Periodicals, Inc. ..
  34. Canullo L, Iurlaro G, Iannello G. Double-blind randomized controlled trial study on post-extraction immediately restored implants using the switching platform concept: soft tissue response. Preliminary report. Clin Oral Implants Res. 2009;20:414-20 pubmed publisher
    ..This study suggests that, in a limited time period of 2 years, immediately placed implants with subsequent platform switching can provide peri-implant tissue stability. ..
  35. Chen K, Xiong H, Huang Y, Liu C. Comparative analysis of in vitro periodontal characteristics of stem cells from apical papilla (SCAP) and periodontal ligament stem cells (PDLSCs). Arch Oral Biol. 2013;58:997-1006 pubmed publisher
    ..The aim of this study was to compare the in vitro periodontal properties of stem cells from apical papilla (SCAP) and periodontal ligament stem cells (PDLSCs)...
  36. Sahlberg C, Aukhil I, Thesleff I. Tenascin-C in developing mouse teeth: expression of splice variants and stimulation by TGFbeta and FGF. Eur J Oral Sci. 2001;109:114-24 pubmed
    ..expressed during epithelial budding in the condensed dental mesenchyme, and that it reappears later in the dental papilla mesenchyme where it persists in the dental pulp but is downregulated in odontoblasts...
  37. Unda F, Martin A, Hernandez C, Perez Nanclares G, Hilario E, Arechaga J. FGFs-1 and -2, and TGF beta 1 as inductive signals modulating in vitro odontoblast differentiation. Adv Dent Res. 2001;15:34-7 pubmed
    ..In contrast, FGF2 may regulate the effect of TGF beta 1, permitting cell polarization but restraining pre-odontoblast functions. ..
  38. Tonetti M, Fourmousis I, Suvan J, Cortellini P, Bragger U, Lang N. Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. J Clin Periodontol. 2004;31:1092-8 pubmed
    ..Earlier gains in soft-tissue density were observed following application of EMD. In terms of patient-centered outcomes, however, both procedures performed in a similar manner. ..
  39. Helder M, Karg H, Bervoets T, Vukicevic S, Burger E, D Souza R, et al. Bone morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth development. J Dent Res. 1998;77:545-54 pubmed
    ..With advancing differentiation of odontoblasts, BMP-7 protein staining in the dental papilla became restricted to the layer of fully functional odontoblasts in the process of depositing (pre)dentin...
  40. Al Harbi S. Nonsurgical management of interdental papilla associated with multiple maxillary anterior implants: a clinical report. J Prosthet Dent. 2005;93:212-6 pubmed
    ..The use of 1 implant instead of multiple implants to support a cantilivered fixed partial denture with an ovate pontic successfully enhanced the soft tissue contours to satisfy the patients esthetic needs and desires. ..
  41. Yang J, Zhao Y, Wang W, Jia W, Ge L. [Isolation, culture and biological characterization of Beagle stem cells from apical papilla]. Beijing Da Xue Xue Bao Yi Xue Ban. 2012;44:921-6 pubmed
    ..There are stem cells from the apical papilla which have high proliferation ability and multilineage differentiation potential existing in the Beagle's apical papilla. ..
  42. Ohazama A, Courtney J, Sharpe P. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. J Dent Res. 2004;83:241-4 pubmed
    ..of Opg and Rank was observed in both the internal and the external enamel epithelium as well as in the dental papilla mesenchyme...
  43. Kumasaka S, Shimozuma M, Kawamoto T, Mishima K, Tokuyama R, Kamiya Y, et al. Possible involvement of melatonin in tooth development: expression of melatonin 1a receptor in human and mouse tooth germs. Histochem Cell Biol. 2010;133:577-84 pubmed publisher
    ..These results strongly suggest that melatonin may play a physiological role in tooth development/growth by regulating the cellular function of odontogenic cells in tooth germs...
  44. D Souza R, Litz M. Analysis of tooth development in mice bearing a TGF-beta 1 null mutation. Connect Tissue Res. 1995;32:41-6 pubmed
    ..Using antibodies against TGF-beta 1, we observed immunoreactive TGF-beta 1 in tissues from null mice suggesting that maternally-derived TGF-beta 1 may be involved in the rescue of several developmental events in TGF-beta 1 knockout mice...
  45. Waszkiewicz N, Zalewska Szajda B, Zalewska A, Waszkiewicz M, Szajda S, Repka B, et al. Salivary lysozyme in smoking alcohol dependent persons. Folia Histochem Cytobiol. 2012;50:609-12 pubmed publisher
    ..In conclusion, persons addicted to alcohol and nicotine have a poorer periodontal status than non-smoking social drinkers, which may partially be due to the diminished protective effects of lysozyme present in the saliva. ..
  46. Ulmer F, Winkel A, Kohorst P, Stiesch M. Stem cells--prospects in dentistry. Schweiz Monatsschr Zahnmed. 2010;120:860-83 pubmed
    ..from the dental pulp, exfoliated deciduous teeth, the periodontal ligament, the dental follicle and the dental papilla. Stem cell markers such as STRO-1 were used for the characterization and isolation of stem cells...
  47. Nonaka C, Augusto Vianna Goulart Filho J, Cristina da Costa Miguel M, Batista de Souza L, Pereira Pinto L. Immunohistochemical expression of matrix metalloproteinases 1, 2, and 9 in odontogenic myxoma and dental germ papilla. Pathol Res Pract. 2009;205:458-65 pubmed publisher
    ..Taken together, our results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas. ..
  48. Kim D, Park H, Yeom J, Seo J, Ryu G, Park K, et al. Long-term follow-ups of revascularized immature necrotic teeth: three case reports. Int J Oral Sci. 2012;4:109-13 pubmed
    ..At 48-month(in case 2) and 42-month (in case 3) follow-ups, loss of periapical radiolucencies and increases in the root wall thickness were also observed. ..
  49. Jiang B, Yokohama Tamaki T, Wang Z, Obara N, Shibata S. Expression, localisation and synthesis of versican by the enamel organ of developing mouse molar tooth germ: an in vivo and in vitro study. Arch Oral Biol. 2010;55:995-1006 pubmed publisher
    ..In dental tissue, versican expression occurs primarily in mesenchymal tissue but rarely in epithelial tissue. We investigated the expression, localisation and synthesis of versican in the enamel organ of the developing tooth germ...
  50. Wang J, Dai J, Liu B, Gu S, Cheng L, Liang J. Porphyromonas gingivalis lipopolysaccharide activates canonical Wnt/?-catenin and p38 MAPK signalling in stem cells from the apical papilla. Inflammation. 2013;36:1393-402 pubmed publisher
    ..Our results suggest that the p38 MAPK and canonical Wnt/?-catenin signalling pathways are activated by P. gingivalis LPS in SCAP, but we have no evidence that p38 MAPK is upstream of GSK-3? in the Wnt/?-catenin signalling pathway...
  51. Yu J, Shi J, Deng Z, Zhuang H, Nie X, Wang R, et al. Cell pellets from dental papillae can reexhibit dental morphogenesis and dentinogenesis. Biochem Biophys Res Commun. 2006;346:116-24 pubmed
    We isolated dental papilla mesenchymal cells (DPMCs) from different rat incisor germs at the late bell stage and incubated them as cell pellets in polypropylene tubes...
  52. Wu Y, Tu Y, Huang S, Chan C. The influence of the distance from the contact point to the crest of bone on the presence of the interproximal dental papilla. Chang Gung Med J. 2003;26:822-8 pubmed
    Loss of the interproximal dental papilla may cause functional and, especially in the maxillary anterior region, phonetic and severe esthetic problems...
  53. Inocencio F, Sandhu H. Interdental papilla reconstruction combining periodontal and orthodontic therapy in adult periodontal patients: a case report. J Can Dent Assoc. 2008;74:531-5 pubmed
    ..This approach resulted in stable periodontium and an esthetically pleasing appearance of the maxillary anterior area...
  54. Ida Yonemochi H, Ohshiro K, Swelam W, Metwaly H, Saku T. Perlecan, a basement membrane-type heparan sulfate proteoglycan, in the enamel organ: its intraepithelial localization in the stellate reticulum. J Histochem Cytochem. 2005;53:763-72 pubmed
    ..by using murine molars in neonatal and postnatal stages and primary cultured cells of the enamel organ and dental papilla to demonstrate the role of perlecan in normal odontogenesis...
  55. Bae C, Lee J, Kim T, Baek J, Lee J, Yang X, et al. Excessive Wnt/?-catenin signaling disturbs tooth-root formation. J Periodontal Res. 2013;48:405-10 pubmed publisher
    ..In the present study we analyzed the molar roots of these mice to investigate the role of Wnt/?-catenin signaling in root formation in more detail...
  56. Scardina G, Carini F, Messina P. Vasodilatation of human gingiva and neurogenic inflammation. Clin Hemorheol Microcirc. 2005;32:279-85 pubmed
    ..The aim of this study is to evaluate the effects of topical capsaicin application on human periodontal mucosa and to assess if NI might have a role in the pathogenesis of periodontal diseases...
  57. Sedgley C, Botero T. Dental stem cells and their sources. Dent Clin North Am. 2012;56:549-61 pubmed publisher
    ..In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues...
  58. Hayman A, Bune A, Cox T. Widespread expression of tartrate-resistant acid phosphatase (Acp 5) in the mouse embryo. J Anat. 2000;196 ( Pt 3):433-41 pubmed
  59. Kamata N, Fujimoto R, Tomonari M, Taki M, Nagayama M, Yasumoto S. Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase. J Oral Pathol Med. 2004;33:417-23 pubmed
    ..Human telomerase reverse transcriptase (hTERT) is catalytic subunit of human telomerase...
  60. Almushayt A, Narayanan K, Zaki A, George A. Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts. Gene Ther. 2006;13:611-20 pubmed
    Odontoblasts are postmitotic cells that differentiate from the dental papilla. These cells are responsible for producing the calcified dentin matrix...
  61. Obara N, Suzuki Y, Nagai Y, Nishiyama H, Mizoguchi I, Takeda M. Expression of neural cell-adhesion molecule mRNA during mouse molar tooth development. Arch Oral Biol. 2002;47:805-13 pubmed
    ..In the mesenchyme at the cap stage, expression was weak in the dental papilla and strong in the follicle...
  62. Sumita Y, Honda M, Ueda M, Asahina I, Kagami H. Differential effects of growth differentiation factor-5 on porcine dental papilla- and follicle-derived cells. Growth Factors. 2010;28:56-65 pubmed publisher
    ..this study, the effect of growth differentiation factor-5 (GDF-5) on the growth and differentiation of porcine dental papilla- and follicle-derived cells was investigated. Furthermore, the effect was compared with that of BMP-2...
  63. Sakai H, Mori T, Iida T, Tokuma Y, Maruo K, Masegi T. Immunohistochemical features of proliferative marker and basement membrane components of two feline inductive odontogenic tumours. J Feline Med Surg. 2008;10:296-9 pubmed
    ..Type IV collagen and laminin were constantly positive around the foci of epithelial cells, and Ki-67 positive indices were extremely low; therefore, these findings consistent with the benign clinical presentation of FIOT...
  64. Donohue D, Garcia Godoy F, King D, Barnwell G. Evaluation of mandibular infiltration versus block anesthesia in pediatric dentistry. ASDC J Dent Child. 1993;60:104-6 pubmed
    ..The paired t-test indicated no significant difference between the two techniques for any of the factors evaluated...
  65. Dong R, Yao R, Du J, Wang S, Fan Z. Depletion of histone demethylase KDM2A enhanced the adipogenic and chondrogenic differentiation potentials of stem cells from apical papilla. Exp Cell Res. 2013;319:2874-82 pubmed publisher
  66. Speranza L, Pesce M, Franceschelli S, Mastrangelo F, Patruno A, De Lutiis M, et al. The role of inducible nitric oxide synthase and haem oxygenase 1 in growth and development of dental tissue'. Cell Biochem Funct. 2012;30:217-23 pubmed publisher
    ..activity of the antioxidant enzyme network was assessed spectrophotometrically in samples of dental pulp and dental papilla taken from third-molar gem extracts...
  67. Zhu F, Nie R, Wu L, Liu L, Tang W, Tian W. [Spontaneous odontogenic differentiation and critical gene expression of mouse dental papilla mesenchymal cell in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:286-9, 297 pubmed
    To observe the spontaneous odontogenic differentiation of mouse dental papilla mesenchymal cells in blood serum medium...
  68. Kettunen P, Furmanek T, Chaulagain R, Kvinnsland I, Luukko K. Developmentally regulated expression of intracellular Fgf11-13, hormone-like Fgf15 and canonical Fgf16, -17 and -20 mRNAs in the developing mouse molar tooth. Acta Odontol Scand. 2011;69:360-6 pubmed publisher
    ..To investigate and compare the cellular expression of non-secreted Fgf11-14 and secreted Fgf15-18 and -20 mRNAs during tooth formation...
  69. Chang H, Chang M, Wu I, Huang G, Huang W, Wang Y, et al. Role of ALK5/Smad2/3 and MEK1/ERK Signaling in Transforming Growth Factor Beta 1-modulated Growth, Collagen Turnover, and Differentiation of Stem Cells from Apical Papilla of Human Tooth. J Endod. 2015;41:1272-80 pubmed publisher
    ..These results highlight the future use of TGF-β1 and SCAP for engineering of pulpal regeneration and apexogenesis. ..
  70. Diao S, Yang D, Dong R, Wang L, Wang J, Du J, et al. Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla. J Endod. 2015;41:205-11 pubmed publisher
    ..These results indicate that WDR63 is a positive enhancer for SCAP osteogenic differentiation and suggest that activation of WDR63 signaling might improve tissue regeneration mediated by MSCs of dental origin. ..
  71. Ye L, Le T, Zhu L, Butcher K, Schneider R, Li W, et al. Amelogenins in human developing and mature dental pulp. J Dent Res. 2006;85:814-8 pubmed
    ..These studies suggest that odontoblasts actively synthesize and secrete amelogenin protein during human tooth development, and that low-molecular-weight amelogenins can enhance pulp cell proliferation...
  72. Zhao Z, Wang Y, Wang D, Liu H. The regulatory role of a disintegrin and metalloproteinase 28 on the biologic property of human periodontal ligament stem cells. J Periodontol. 2010;81:934-44 pubmed publisher
    ..This study evaluates the influence of ADAM28 on the biologic property of human PDLSCs (HPDLSCs) and to postulate the possible mechanism of this influence...
  73. Liu F, Dangaria S, Andl T, Zhang Y, Wright A, Damek Poprawa M, et al. beta-Catenin initiates tooth neogenesis in adult rodent incisors. J Dent Res. 2010;89:909-14 pubmed publisher
    ..Thus, forced activation of beta-catenin signaling can initiate an embryonic-like program of tooth development in adult rodent incisor teeth. ..
  74. Lee M, Lee S, Lee K, Kang H, Jung H, Kim J. Expression patterns of the Fam83h gene during murine tooth development. Arch Oral Biol. 2009;54:846-50 pubmed publisher
    ..Little is known about this novel gene, and so we investigated the expression pattern of Fam83h in murine tooth development using serial sectional in situ hybridisation...
  75. Hanks C, Fang D, Sun Z, Edwards C, Butler W. Dentin-specific proteins in MDPC-23 cell line. Eur J Oral Sci. 1998;106 Suppl 1:260-6 pubmed
    ..In addition, these cultures were characterized by phase microscopy and scanning and transmission electron microscopy. These findings suggest that MDPC-23 cells are of the odontoblast lineage...
  76. Gomes J, Omar N, Dos Santos Neves J, Narvaes E, Novaes P. Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure. J Mol Histol. 2011;42:153-9 pubmed publisher
  77. Hoffmann M, Olson K, Cavender A, Pasqualini R, Gaikwad J, D Souza R. Gene expression in a pure population of odontoblasts isolated by laser-capture microdissection. J Dent Res. 2001;80:1963-7 pubmed
    ..The use of LCM is thus a valuable means of retrieving quality RNA from discrete populations of odontoblasts at different stages of dentinogenesis...
  78. Su Y, Xie W, Wang C, Peng L, Zhou X, Ye L. JNK/P38 mitogen-activated protein kinase used for hepatocyte growth factor-induced proliferation, differentiation, and migration in human dental papilla cells. J Endod. 2012;38:1207-13 pubmed publisher
    ..have been reported, and our previous study also demonstrated that HGF exerts promoting functions on murine dental papilla cells. However, the potential mechanisms involved are not yet clearly understood...
  79. Waszkiewicz N, Zalewska Szajda B, Zalewska A, Waszkiewicz M, Szajda S, Repka B, et al. Decrease in salivary lactoferrin output in chronically intoxicated alcohol-dependent patients. Folia Histochem Cytobiol. 2012;50:248-54 pubmed
    ..The poorer periodontal state in alcohol dependent persons compared to controls may be a result of lower salivary flow and decreased protection of the oral cavity by lactoferrin...
  80. Scardina G, Messina P. Microvascular characteristics of the human filiform papillae: a videocapillaroscopic study. Ann Anat. 2006;188:183-6 pubmed
    ..This method could also be applied to the study of microcirculation in pathologies which strictly pertain to the dental stomatological field...