dental cementum

Summary

Summary: The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)

Top Publications

  1. Jager A, Kunert D, Friesen T, Zhang D, Lossdörfer S, Gotz W. Cellular and extracellular factors in early root resorption repair in the rat. Eur J Orthod. 2008;30:336-45 pubmed publisher
    ..Cells with a defined osteoblastic phenotype seemed to be of minor importance in this repair process...
  2. Fujii S, Maeda H, Wada N, Tomokiyo A, Saito M, Akamine A. Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo. J Cell Physiol. 2008;215:743-9 pubmed publisher
    ..These data suggest that cell line 1-11 was derived from a progenitor/stem cell present in the PDL and should be very useful for studying the biology and regeneration of human periodontium...
  3. Cao Z, Zhang H, Zhou X, Han X, Ren Y, Gao T, et al. Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res. 2012;27:1080-92 pubmed publisher
  4. Bozić D, Grgurevic L, Erjavec I, Brkljacic J, Orlic I, Razdorov G, et al. The proteome and gene expression profile of cementoblastic cells treated by bone morphogenetic protein-7 in vitro. J Clin Periodontol. 2012;39:80-90 pubmed publisher
    ..The purpose of this study was to evaluate the effect of BMP7 on early proteome and gene expression profile of cementoblastic OCCM.30 cells in vitro...
  5. Dangaria S, Ito Y, Luan X, Diekwisch T. Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications. Stem Cells Dev. 2011;20:39-52 pubmed publisher
  6. Maxwell E, Caldwell M, Lamoureux D, Budney L. Histology of tooth attachment tissues and plicidentine in Varanus (Reptilia: Squamata), and a discussion of the evolution of amniote tooth attachment. J Morphol. 2011;272:1170-81 pubmed publisher
    ..Varanus is characterized by the presence of both primary and higher-order lamellae, which anastomose to form a honeycomb-like surface that then interacts with the more basal attachment tissues...
  7. Foster B. Methods for studying tooth root cementum by light microscopy. Int J Oral Sci. 2012;4:119-28 pubmed publisher
    ..Histological and immunohistochemical approaches provide insight on developmental biology of cementum...
  8. Kim H, Lee D, Lee J, Kang M, Lee N, Kim H, et al. The effect of odontoblast conditioned media and dentin non-collagenous proteins on the differentiation and mineralization of cementoblasts in vitro. Arch Oral Biol. 2009;54:71-9 pubmed publisher
    ..The purpose of this study was to evaluate the effect of odontoblast conditioned media (CM) and dentin non-collagenous proteins (dNCPs) on the differentiation and mineralization of cementoblastic OCCM-30 cells...
  9. Ho S, Senkyrikova P, Marshall G, Yun W, Wang Y, Karan K, et al. Structure, chemical composition and mechanical properties of coronal cementum in human deciduous molars. Dent Mater. 2009;25:1195-204 pubmed publisher
    ..It was hypothesized that the coronal cementum containing collagen forms a weak junction with enamel unlike the well integrated DEJ and CDJ...

More Information

Publications68

  1. Ho S, Kurylo M, Fong T, Lee S, Wagner H, Ryder M, et al. The biomechanical characteristics of the bone-periodontal ligament-cementum complex. Biomaterials. 2010;31:6635-46 pubmed publisher
    ..2-9.6 GPa) and PDL-cementum (E(r) range for cementum: 1.1-8.3 GPa), which was related to the macro-scale function of the bone-tooth complex...
  2. Hakki S, Foster B, Nagatomo K, Bozkurt S, Hakki E, Somerman M, et al. Bone morphogenetic protein-7 enhances cementoblast function in vitro. J Periodontol. 2010;81:1663-74 pubmed publisher
    ..We hypothesized that BMP-7 would regulate mineralized tissue-associated genes in cementoblasts and influence the expression profile of genes associated with cementoblast extracellular matrix (ECM) and cell adhesion molecules (CAMs)...
  3. Rego E, Inubushi T, Kawazoe A, Miyauchi M, Tanaka E, Takata T, et al. Effect of PGE? induced by compressive and tensile stresses on cementoblast differentiation in vitro. Arch Oral Biol. 2011;56:1238-46 pubmed publisher
    ..The aim of the study was to clarify the mechanisms underlying orthodontically induced root resorption by characterizing the role of PGE(2) induced by compressive stress (CS) and tensile stress (TS) on cementoblast metabolism in vitro...
  4. Bai Y, Bai Y, Matsuzaka K, Hashimoto S, Fukuyama T, Wu L, et al. Cementum- and periodontal ligament-like tissue formation by dental follicle cell sheets co-cultured with Hertwig's epithelial root sheath cells. Bone. 2011;48:1417-26 pubmed publisher
    ..These results indicate that the DFC sheets induced by HERS cells are able to produce periodontal tissues through epithelial-mesenchymal interactions. Therefore, DFC sheets may be useful in the field of periodontium regeneration...
  5. Ye L, Zhang S, Ke H, Bonewald L, Feng J. Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. J Dent Res. 2008;87:624-9 pubmed
    ..We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice...
  6. Lehnen S, Gotz W, Baxmann M, Jager A. Immunohistochemical evidence for sclerostin during cementogenesis in mice. Ann Anat. 2012;194:415-21 pubmed publisher
  7. Nemoto E, Koshikawa Y, Kanaya S, Tsuchiya M, Tamura M, Somerman M, et al. Wnt signaling inhibits cementoblast differentiation and promotes proliferation. Bone. 2009;44:805-12 pubmed publisher
    ..Elucidating the role of Wnt in controlling cementoblast function will provide new tools needed to improve on existing periodontal regeneration therapies...
  8. Kieser J, Tkatchenko T, Dean M, Jones M, Duncan W, Nelson N. Microstructure of dental hard tissues and bone in the Tuatara dentary, Sphenodon punctatus (Diapsida: Lepidosauria: Rhynchocephalia). Front Oral Biol. 2009;13:80-5 pubmed publisher
    ..These were spaced appropriately for monthly lunar growth bands, which would explain the basis of the banding pattern observed in the fast growing basal bone beneath the Meckel's canal...
  9. Fong H, Chu E, Tompkins K, Foster B, Sitara D, Lanske B, et al. Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse. J Periodontol. 2009;80:1348-54 pubmed publisher
    ..Here, we report a developmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum...
  10. Ho S, Yu B, Yun W, Marshall G, Ryder M, Marshall S. Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin. Acta Biomater. 2009;5:707-18 pubmed publisher
    ..5+/-0.7 GPa). The resulting data illustrated that the extensions of observations made from animal models to humans should be justified with substantial and equivalent comparison of data across age ranges (life spans) of mammalian species...
  11. Foster B, Nagatomo K, Nociti F, Fong H, Dunn D, Tran A, et al. Central role of pyrophosphate in acellular cementum formation. PLoS ONE. 2012;7:e38393 pubmed publisher
    ..To elucidate the role of PP(i) in cementum formation, we analyzed root development in knock-out ((-/-)) mice featuring PP(i) dysregulation...
  12. Oka H, Miyauchi M, Sakamoto K, Kitagawa M, Noguchi K, Somerman M, et al. Prostaglandin E2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway. Arch Oral Biol. 2008;53:243-9 pubmed
    ..However, little is known about the effects of PGE(2) on cementoblasts. The aims of this study were to determine the expression of EPs in mature cementoblasts, and to examine the effect of PGE(2) and EPs on their cellular function...
  13. Fong H, Foster B, Sarikaya M, Somerman M. Structure and mechanical properties of Ank/Ank mutant mouse dental tissues--an animal model for studying periodontal regeneration. Arch Oral Biol. 2009;54:570-6 pubmed publisher
    ..In conclusion, these data suggest that this animal model can be utilized for studies focused on defining mechanisms to promote cementum formation without loss of mechanical integrity. ..
  14. Sakuraba H, Fujiwara N, Sasaki Oikawa A, Sakano M, Tabata Y, Otsu K, et al. Hepatocyte growth factor stimulates root growth during the development of mouse molar teeth. J Periodontal Res. 2012;47:81-8 pubmed publisher
    ..As hepatocyte growth factor (HGF) is one of the mediators of epithelial-mesenchymal interactions in rodent tooth, the objective of this study was to examine the effects of HGF on the root development of mouse molars...
  15. Nakano Y, Yamaguchi M, Fujita S, Asano M, Saito K, Kasai K. Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force. Eur J Orthod. 2011;33:335-43 pubmed publisher
    ..Therefore, RANKL/RANK and M-CSF/c-fms systems may be involved in the process of root resorption by heavy orthodontic force...
  16. Jager A, Gotz W, Lossdörfer S, Rath Deschner B. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro. J Periodontal Res. 2010;45:246-54 pubmed publisher
    ..In this study, we investigated the expression of sclerostin in cementocytes in vivo as well as the expression of SOST and sclerostin in periodontal ligament cell cultures following induction of mineralization...
  17. Leong N, Hurng J, Djomehri S, Gansky S, Ryder M, Ho S. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. PLoS ONE. 2012;7:e35980 pubmed publisher
    ..5 to 4 months), growth (4 to 10 months), followed by a senescent phase (10 to 15 months), from which deviations due to experimentally induced perturbations can be effectively investigated. ..
  18. Zhang H, Tompkins K, Garrigues J, Snead M, Gibson C, Somerman M. Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 2010;55:417-25 pubmed publisher
    ..The goal of this study was to determine if LAMP-1 serves as a cell surface binding site for full length amelogenin on tooth root/periodontium associated mesenchymal cells...
  19. Tian Y, Huang L, Guo Y, Cao L, Wang Y, Xu H, et al. Expression of alkaline phosphatase in immortalized murine cementoblasts in response to compression-force. Saudi Med J. 2011;32:1235-40 pubmed
    ..To determine the effect of compression-force on the expression of alkaline phosphatase (ALP), and ALP activity in cementoblasts...
  20. Maxwell E, Caldwell M, Lamoureux D. Tooth histology in the cretaceous ichthyosaur Platypterygius australis, and its significance for the conservation and divergence of mineralized tooth tissues in amniotes. J Morphol. 2011;272:129-35 pubmed publisher
  21. McKee M, Nakano Y, Masica D, Gray J, Lemire I, Heft R, et al. Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia. J Dent Res. 2011;90:470-6 pubmed publisher
  22. Huang X, Chai Y. Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012;4:177-81 pubmed publisher
    ..This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration...
  23. Rodrigues T, Nagatomo K, Foster B, Nociti F, Somerman M. Modulation of phosphate/pyrophosphate metabolism to regenerate the periodontium: a novel in vivo approach. J Periodontol. 2011;82:1757-66 pubmed publisher
    ..We hypothesized that, besides affecting cementum formation, decreased extracellular PP(i) levels in Ank KO mice would also impact cementum regeneration...
  24. Kaipatur N, Murshed M, McKee M. Matrix Gla protein inhibition of tooth mineralization. J Dent Res. 2008;87:839-44 pubmed
    ..Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors...
  25. Bosshardt D, Bergomi M, Vaglio G, Wiskott A. Regional structural characteristics of bovine periodontal ligament samples and their suitability for biomechanical tests. J Anat. 2008;212:319-29 pubmed publisher
    ..The bucco-mesial aspect of the distal root appears to be the most suitable location...
  26. Foster B, Nagatomo K, Bamashmous S, Tompkins K, Fong H, Dunn D, et al. The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition. Cells Tissues Organs. 2011;194:382-405 pubmed publisher
    ..Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type...
  27. Yang Y, Rossi F, Putnins E. Periodontal regeneration using engineered bone marrow mesenchymal stromal cells. Biomaterials. 2010;31:8574-82 pubmed publisher
    ..Finally, donor-derived BM-MSCs were found integrated in newly formed bone, cementum and periodontal ligament, suggesting that they can directly contribute to the regeneration of cells of these tissues...
  28. Jung H, Lee D, Lee J, Park S, Lee G, Seo B, et al. Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells. J Mol Histol. 2011;42:227-35 pubmed publisher
  29. Hurng J, Kurylo M, Marshall G, Webb S, Ryder M, Ho S. Discontinuities in the human bone-PDL-cementum complex. Biomaterials. 2011;32:7106-17 pubmed publisher
    ..The constrictions or narrowed sites within the bone-tooth fibrous joint will become the new "load bearing sites" that eventually could cause direct local fusion of bone with cementum...
  30. van Bezooijen R, Bronckers A, Gortzak R, Hogendoorn P, van der Wee Pals L, Balemans W, et al. Sclerostin in mineralized matrices and van Buchem disease. J Dent Res. 2009;88:569-74 pubmed publisher
    ..In conclusion, sclerostin is expressed by all 3 terminally differentiated cell types embedded within mineralized matrices: osteocytes, cementocytes, and hypertrophic chondrocytes...
  31. Kim T, Lee J, Baek J, Lee J, Yang X, Taketo M, et al. Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun. 2011;412:549-55 pubmed publisher
    ..Local modulation of Wnt/ß-catenin signaling has therapeutic potential to improve the regeneration of dentin and periodontium...
  32. Hakki S, Bozkurt S, Hakki E, Belli S. Effects of mineral trioxide aggregate on cell survival, gene expression associated with mineralized tissues, and biomineralization of cementoblasts. J Endod. 2009;35:513-9 pubmed publisher
    ..02 and 0.002 mg/mL. Based on these results MTA can be considered as a favorable material regarding cell-material interaction...
  33. Bae C, Lee J, Kim T, Baek J, Lee J, Yang X, et al. Excessive Wnt/?-catenin signaling disturbs tooth-root formation. J Periodontal Res. 2013;48:405-10 pubmed publisher
    ..In the present study we analyzed the molar roots of these mice to investigate the role of Wnt/?-catenin signaling in root formation in more detail...
  34. Ponce E, Vilar Fernández J. The cemento-dentino-canal junction, the apical foramen, and the apical constriction: evaluation by optical microscopy. J Endod. 2003;29:214-9 pubmed
    ..Great variability was observed in the measurements of the extension of the cementum into the root canal. AQ: 1. ..
  35. Hakki S, Nohutcu R, Hakki E, Berry J, Akkaya M, Somerman M. Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro. J Periodontol. 2005;76:1550-8 pubmed
    ..Dex and FGF alone and in combination alter cementoblast behavior, but additional studies are required to determine whether these factors have beneficial effects at the clinical level. ..
  36. Nociti F, Berry J, Foster B, Gurley K, Kingsley D, Takata T, et al. Cementum: a phosphate-sensitive tissue. J Dent Res. 2002;81:817-21 pubmed
    ..This information may prove valuable in attempts to design successful therapies for regenerating periodontal tissues...
  37. Bosshardt D. Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?. J Dent Res. 2005;84:390-406 pubmed
    ..The role of enamel matrix proteins in cementoblast and osteoblast differentiation and their potential use for tissue engineering are discussed. ..
  38. Ho S, Balooch M, Goodis H, Marshall G, Marshall S. Ultrastructure and nanomechanical properties of cementum dentin junction. J Biomed Mater Res A. 2004;68:343-51 pubmed
    ..The lower mechanical properties of the CDJ may make it possible for it to redistribute occlusal loads to the alveolar bone. ..
  39. Holliday S, Schneider B, Galang M, Fukui T, Yamane A, Luan X, et al. Bones, teeth, and genes: a genomic homage to Harry Sicher's "Axial Movement of Teeth". World J Orthod. 2005;6:61-70 pubmed
    ..The data indicated significant new formation of bone and cementum in tandem with increased expression of extracellular matrix-related genes. ..
  40. Zhao M, Xiao G, Berry J, Franceschi R, Reddi A, Somerman M. Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002;17:1441-51 pubmed
    ..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved...
  41. Zeichner David M, Oishi K, Su Z, Zakartchenko V, Chen L, Arzate H, et al. Role of Hertwig's epithelial root sheath cells in tooth root development. Dev Dyn. 2003;228:651-63 pubmed
    ..These studies suggest that the acellular and cellular cementum are synthesized by two different types of cells, the first one by HERS-derived cementoblasts and the later by neural crest-derived cementoblasts...
  42. Viswanathan H, Berry J, Foster B, Gibson C, Li Y, Kulkarni A, et al. Amelogenin: a potential regulator of cementum-associated genes. J Periodontol. 2003;74:1423-31 pubmed
    ..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells...
  43. MacNeil R, Berry J, D Errico J, Strayhorn C, Piotrowski B, Somerman M. Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis. Connect Tissue Res. 1995;33:1-7 pubmed
    ..These findings collectively suggest that BSP and OPN are intimately involved in the sequence of cellular and molecular events accompanying cementogenesis...
  44. Boabaid F, Gibson C, Kuehl M, Berry J, Snead M, Nociti F, et al. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol. 2004;75:1126-36 pubmed
    ..Here, we focused on determining whether or not leucine-rich amelogenin peptide (LRAP), translated from an alternatively spliced amelogenin RNA, altered cementoblast behavior...
  45. Van den Bos T, Handoko G, Niehof A, Ryan L, Coburn S, Whyte M, et al. Cementum and dentin in hypophosphatasia. J Dent Res. 2005;84:1021-5 pubmed
    ..Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum...
  46. Nanci A, Bosshardt D. Structure of periodontal tissues in health and disease. Periodontol 2000. 2006;40:11-28 pubmed
  47. Diekwisch T. The developmental biology of cementum. Int J Dev Biol. 2001;45:695-706 pubmed
    ..Our studies in conjunction with our literature review together confirmed the classical theory of cementum as a dental follicle derived connective tissue that forms subsequent to HERS disintegration...
  48. Jayawardena C, Takahashi N, Watanabae E, Takano Y. On the origin of intrinsic matrix of acellular extrinsic fiber cementum: studies on growing cementum pearls of normal and bisphosphonate-affected guinea pig molars. Eur J Oral Sci. 2002;110:261-9 pubmed
  49. Foster B, Popowics T, Fong H, Somerman M. Advances in defining regulators of cementum development and periodontal regeneration. Curr Top Dev Biol. 2007;78:47-126 pubmed
    ..Cells, genes, and proteins regulating root development are reviewed in a question-answer format in order to highlight areas of progress as well as areas of remaining uncertainty that warrant further study...
  50. Ho S, Marshall S, Ryder M, Marshall G. The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials. 2007;28:5238-45 pubmed
    ..Thus, through variations in concentrations of basic constituents, distinct regions with characteristic structures and graded properties allow for attachment and the load bearing characteristics of a tooth...
  51. D Errico J, MacNeil R, Takata T, Berry J, Strayhorn C, Somerman M. Expression of bone associated markers by tooth root lining cells, in situ and in vitro. Bone. 1997;20:117-26 pubmed
    ..These procedures have provided a means to obtain root-lining cells in vitro that can now be cloned and used for studies directed at determining the properties of root-lining cells, or cementoblasts, in vitro...
  52. Van den Bos T, Beertsen W. Alkaline phosphatase activity in human periodontal ligament: age effect and relation to cementum growth rate. J Periodontal Res. 1999;34:1-6 pubmed
    ..The activity of the enzyme in the PDL correlated positively with the yearly cementum thickness increment as calculated from data published previously...
  53. Zeichner David M. Regeneration of periodontal tissues: cementogenesis revisited. Periodontol 2000. 2006;41:196-217 pubmed
  54. Berry J, Zhao M, Jin Q, Foster B, Viswanathan H, Somerman M. Exploring the origins of cementoblasts and their trigger factors. Connect Tissue Res. 2003;44 Suppl 1:97-102 pubmed
    ..Such dissimilarities in responsiveness associated with cell type may need to be considered when designing regenerative therapies...
  55. Ho S, Balooch M, Marshall S, Marshall G. Local properties of a functionally graded interphase between cementum and dentin. J Biomed Mater Res A. 2004;70:480-9 pubmed
    ..Hence, cementum, dentin, and the interphase can be classified as a functionally graded dental tissue within the root of a tooth...
  56. Brezniak N, Wasserstein A. Orthodontically induced inflammatory root resorption. Part I: The basic science aspects. Angle Orthod. 2002;72:175-9 pubmed
    ..This contemporary review is divided into two parts. In Part I, we discuss the basic sciences aspects of OIIRR as a continuation of our previously published work. In Part II, we present the clinical aspects of this subject...
  57. Seo B, Miura M, Gronthos S, Bartold P, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364:149-55 pubmed
    ..We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue...
  58. Beertsen W, Vandenbos T, Everts V. Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation. J Dent Res. 1999;78:1221-9 pubmed
    ..It is concluded that TNAP represents an essential factor in mantle dentin mineralization and in the formation of acellular cementum...
  59. Seo B, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 2005;84:907-12 pubmed