periodontium

Summary

Summary: The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.

Top Publications

  1. Luan X, Dangaria S, Ito Y, Walker C, Jin T, Schmidt M, et al. Neural crest lineage segregation: a blueprint for periodontal regeneration. J Dent Res. 2009;88:781-91 pubmed publisher
    ..We propose that the developmental history of a tissue is a highly instructive design template for the discovery of novel bioengineering tools and approaches...
  2. Shirakata Y, Taniyama K, Yoshimoto T, Miyamoto M, Takeuchi N, Matsuyama T, et al. Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs. J Clin Periodontol. 2010;37:374-81 pubmed publisher
    ..The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs...
  3. Xu C, Lei C, Meng L, Wang C, Song Y. Chitosan as a barrier membrane material in periodontal tissue regeneration. J Biomed Mater Res B Appl Biomater. 2012;100:1435-43 pubmed publisher
  4. Fujita Y, Ito H, Sekino S, Numabe Y. Correlations between pentraxin 3 or cytokine levels in gingival crevicular fluid and clinical parameters of chronic periodontitis. Odontology. 2012;100:215-21 pubmed publisher
    ..01) than in healthy sites. There were strong correlations between PTX3 or IL-1? and periodontal status. These results suggest that GCF PTX3 levels might be useful as a diagnostic marker for periodontal disease...
  5. Signat B, Roques C, Poulet P, Duffaut D. Fusobacterium nucleatum in periodontal health and disease. Curr Issues Mol Biol. 2011;13:25-36 pubmed
    ..nucleatum. We are looking for how the presence of F. nucleatum induces secretion of peptides which have an impact on host cells and modulate immune response...
  6. Han W, Ji T, Wang L, Yan L, Wang H, Luo Z, et al. Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice. Mol Cell Biochem. 2011;347:13-20 pubmed publisher
    ..These findings suggest that inflammation in the dKO brain could expand to the periphery, including the oral tissue, which could ultimately induce abnormalities in the periodontal and salivary tissues...
  7. Saxlin T, Suominen Taipale L, Knuuttila M, Alha P, Ylöstalo P. Dual effect of statin medication on the periodontium. J Clin Periodontol. 2009;36:997-1003 pubmed publisher
    ..The aim of this study was to investigate the association between statin medication and periodontal infection in an adult population...
  8. Qian L, Todo M, Morita Y, Matsushita Y, Koyano K. Deformation analysis of the periodontium considering the viscoelasticity of the periodontal ligament. Dent Mater. 2009;25:1285-92 pubmed publisher
    ..means of a combined experimental and numerical approach, to investigate the full-field distributions of displacement, stress and strain, and their evolution with loading in the entire fresh periodontium under an externally applied force.
  9. Avlund K, Schultz Larsen K, Krustrup U, Christiansen N, Holm Pedersen P. Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up. J Am Geriatr Soc. 2009;57:1206-12 pubmed publisher
    To analyze whether inflammatory processes in the periodontium in early old age are related to subsequent mortality during 21 years of follow-up in a nondisabled 70-year-old population.

More Information

Publications70

  1. Dangaria S, Ito Y, Luan X, Diekwisch T. Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications. Stem Cells Dev. 2011;20:39-52 pubmed publisher
  2. Pradeep A, Kathariya R, Raghavendra N, Sharma A. Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease. J Periodontol. 2011;82:734-41 pubmed publisher
    ..Although a classic pentraxin, C-reactive protein, and its association with various systemic diseases is well documented in the periodontal literature, there is no data on PTX3 to our knowledge...
  3. Scardina G, Pisano T, Cacioppo A, Messina P. Periodontal alteration of the microcirculation and hypercholesterolemia: a possible correlation?. South Med J. 2011;104:116-20 pubmed publisher
    ..We evaluated the morphological and parametric characteristics of the periodontal microcirculation in patients diagnosed as having hypercholesterolemia and high levels of low-density lipoprotein (LDL)...
  4. San Miguel S, Fatahi M, Li H, Igwe J, Aguila H, Kalajzic I. Defining a visual marker of osteoprogenitor cells within the periodontium. J Periodontal Res. 2010;45:60-70 pubmed publisher
    ..To identify an osteoprogenitor population, this study utilized a transgenic model in which an alpha-smooth muscle actin (alphaSMA) promoter directed green fluorescent protein (GFP) expression...
  5. Luan X, Walker C, Dangaria S, Ito Y, Druzinsky R, Jarosius K, et al. The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium. Evol Dev. 2009;11:247-59 pubmed publisher
    ..We propose that the mineralization status of the periodontal ligament is a dynamic feature in vertebrate evolution subject to functional adaptation...
  6. Yang Y, Rossi F, Putnins E. Periodontal regeneration using engineered bone marrow mesenchymal stromal cells. Biomaterials. 2010;31:8574-82 pubmed publisher
    Regeneration of lost periodontium is a challenge in that both hard (alveolar bone, cementum) and soft (periodontal ligament) connective tissues need to be restored to their original architecture...
  7. Carneiro L, Venuleo C, Oppenheim F, Salih E. Proteome data set of human gingival crevicular fluid from healthy periodontium sites by multidimensional protein separation and mass spectrometry. J Periodontal Res. 2012;47:248-62 pubmed publisher
    ..In this report, we present a proteome data set of gingival crevicular fluid from healthy periodontium sites.
  8. Hajishengallis G, Liang S, Payne M, Hashim A, Jotwani R, Eskan M, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10:497-506 pubmed publisher
    ..The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology...
  9. Nesse W, Westra J, van der Wal J, Abbas F, Nicholas A, Vissink A, et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol. 2012;39:599-607 pubmed publisher
    ..To determine the presence and location (stroma versus epithelium) of citrullinated proteins in periodontitis tissue as compared to non-periodontitis tissue and synovial tissue of RA patients...
  10. Păunică S, Dumitriu A, Mogoş M, Georgescu O, Mogoş I. The evaluation of the periodontium in patients with leukemia using thermographic imaging. Hematology. 2009;14:341-6 pubmed publisher
    ..There are many systemic conditions with unvarying manifestations at the level of the gums and deep periodontium; leukemias have varying rates of development, and in most cases a reserved prognosis...
  11. Gibson M, Zhu Q, Liu Q, D Souza R, Feng J, Qin C. Loss of dentin sialophosphoprotein leads to periodontal diseases in mice. J Periodontal Res. 2013;48:221-7 pubmed publisher
    ..indicating that this molecule may play an important role in the formation and maintenance of a healthy periodontium, and its deletion may cause increased susceptibility to periodontal diseases...
  12. Zhang J, Dong Z, Chu L. Hydrogen sulfide induces apoptosis in human periodontium cells. J Periodontal Res. 2010;45:71-8 pubmed publisher
    ..This study was designed to examine the cytotoxicity of H(2)S in periodontium cells, including human periodontal ligament (PDL) cells and human gingival fibroblasts (HGFs), as well as the ..
  13. Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Kasuyama K, et al. Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium. Lipids Health Dis. 2013;12:1 pubmed publisher
    ..The purpose of this study was to investigate the effects of dyslipidemia on osteoclast differentiation associated with TLR2 and TLR4 in periodontal tissues using a rat dyslipidemia (apolipoprotein E deficient) model...
  14. Haffajee A, Yaskell T, Torresyap G, Teles R, Socransky S. Comparison between polymerase chain reaction-based and checkerboard DNA hybridization techniques for microbial assessment of subgingival plaque samples. J Clin Periodontol. 2009;36:642-9 pubmed publisher
    ..To compare polymerase chain reaction (PCR) with subsequent reverse hybridization (micro-IDent test) and checkerboard DNA-DNA hybridization for the identification of 13 bacterial species in subgingival plaque samples...
  15. Palomo L, Liu J, Bissada N. Skeletal bone diseases impact the periodontium: a review of bisphosphonate therapy. Expert Opin Pharmacother. 2007;8:309-15 pubmed
    Healthcare professionals should be aware that systemic bone conditions impact the periodontium. Bisphosphonate drugs used for systemic bone loss affect the maxilla and mandible...
  16. Lin N, Menicanin D, Mrozik K, Gronthos S, Bartold P. Putative stem cells in regenerating human periodontium. J Periodontal Res. 2008;43:514-23 pubmed publisher
    Human postnatal stem cells have been identified in periodontal ligament, with the potential to regenerate the periodontium in vivo. However, it is unclear if periodontal ligament stem cells are present in regenerating periodontal tissues...
  17. McCulloch C. Proteomics for the periodontium: current strategies and future promise. Periodontol 2000. 2006;40:173-83 pubmed
  18. Güncü G, Tözüm T, Caglayan F. Effects of endogenous sex hormones on the periodontium--review of literature. Aust Dent J. 2005;50:138-45 pubmed
    ..This review focuses on the effects of endogenous sex hormones on the periodontium and the goal was to inform and update practitioners' knowledge about the impact of these hormones on ..
  19. Song A, Shu R, Xie Y, Song Z, Li H, Liu X, et al. A study of enamel matrix proteins on differentiation of porcine bone marrow stromal cells into cementoblasts. Cell Prolif. 2007;40:381-96 pubmed
    ..Histological analysis demonstrated new cellular cementum-like tissue formed along EMP-treated root slices. Our work has indicated for the first time, differentiation of BMSCs into cementoblasts using an EMP-based protocol. ..
  20. Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H. Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res. 2004;83:920-5 pubmed
    ..We hypothesized that local OPG gene transfer to the periodontium would neutralize the RANKL activity induced by mechanical compressive force, thereby inhibiting ..
  21. Hu B, Nadiri A, Kuchler Bopp S, Perrin Schmitt F, Peters H, Lesot H. Tissue engineering of tooth crown, root, and periodontium. Tissue Eng. 2006;12:2069-75 pubmed
    ..Based on these results, we propose a refined strategy for tooth tissue engineering that may help to eventually generate morphologically defined teeth...
  22. Zhang Y, Wang Y, Shi B, Cheng X. A platelet-derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering. Biomaterials. 2007;28:1515-22 pubmed
    ..This study demonstrated the potential of coral scaffold combined PDGFB gene as a good substrate candidate in periodontal tissue regeneration. ..
  23. Ioannidou E, Kao D, Chang N, Burleson J, Dongari Bagtzoglou A. Elevated serum interleukin-6 (IL-6) in solid-organ transplant recipients is positively associated with tissue destruction and IL-6 gene expression in the periodontium. J Periodontol. 2006;77:1871-8 pubmed
  24. Everts V, Niehof A, Jansen D, Beertsen W. Type VI collagen is associated with microfibrils and oxytalan fibers in the extracellular matrix of periodontium, mesenterium and periosteum. J Periodontal Res. 1998;33:118-25 pubmed
    ..Our observations indicate that the structural organization of type VI collagen varies from small microfibrillar structures associated with the collagen and elastin fibre systems to highly ordered parallel arrays of oxytalan bundles...
  25. Baba O, Qin C, Brunn J, Jones J, Wygant J, McIntyre B, et al. Detection of dentin sialoprotein in rat periodontium. Eur J Oral Sci. 2004;112:163-70 pubmed
    ..Together, these observations suggest that DSP is involved in formation of the periodontium as well as tooth structures.
  26. Mealey B, Moritz A. Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontol 2000. 2003;32:59-81 pubmed
  27. Yeo Y, Jeon D, Kim C, Choi S, Cho K, Lee Y, et al. Effects of chitosan nonwoven membrane on periodontal healing of surgically created one-wall intrabony defects in beagle dogs. J Biomed Mater Res B Appl Biomater. 2005;72:86-93 pubmed
    ..The chitosan nonwoven membrane has the potential to support the cementum and bone regeneration, possibly by providing the conditions needed for guided tissue regeneration in the one-wall intrabony periodontal defects of beagle dogs...
  28. Warhonowicz M, Staszyk C, Rohn K, Gasse H. The equine periodontium as a continuously remodeling system: morphometrical analysis of cell proliferation. Arch Oral Biol. 2006;51:1141-9 pubmed
    ..Tooth eruption is inevitably associated with a remodeling of the periodontium. One major process of remodeling in the PDL is cell proliferation...
  29. Dixon D, Bainbridge B, Darveau R. Modulation of the innate immune response within the periodontium. Periodontol 2000. 2004;35:53-74 pubmed
  30. Bender J, Thang H, Glogauer M. Novel rinse assay for the quantification of oral neutrophils and the monitoring of chronic periodontal disease. J Periodontal Res. 2006;41:214-20 pubmed
    ..Previous studies have relied on time-consuming serial rinses and cumbersome counting techniques for the collection and quantification of oral neutrophils...
  31. Perez J, Smukler H, Nunn M. Clinical dimensions of the supraosseous gingivae in healthy periodontium. J Periodontol. 2008;79:2267-72 pubmed
    ..The main purpose of this investigation was to determine the clinical SOG dimensions around molar, premolar, canine, and incisor teeth in upper and lower jaws...
  32. Demmer R, Behle J, Wolf D, Handfield M, Kebschull M, Celenti R, et al. Transcriptomes in healthy and diseased gingival tissues. J Periodontol. 2008;79:2112-24 pubmed
    ..We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobiology of periodontitis and would inform the design of future studies...
  33. Pietruska M, Paniczko A, Waszkiel D, Pietruski J, Bernaczyk A. Efficacy of local treatment with chlorhexidine gluconate drugs on the clinical status of periodontium in chronic periodontitis patients. Adv Med Sci. 2006;51 Suppl 1:162-5 pubmed
    ..The aim of the study was the clinical evaluation of periodontium after treatment with one of the drugs containing chlorhexidine gluconate (Corsodyl) as compared to professional ..
  34. Tobita M, Uysal A, Ogawa R, Hyakusoku H, Mizuno H. Periodontal tissue regeneration with adipose-derived stem cells. Tissue Eng Part A. 2008;14:945-53 pubmed publisher
    ..Because large amounts of human lipoaspirates are readily available, and their procurement induces only low morbidity, ASCs may be useful in future clinical cell-based therapy for periodontal disease...
  35. Luan X, Ito Y, Dangaria S, Diekwisch T. Dental follicle progenitor cell heterogeneity in the developing mouse periodontium. Stem Cells Dev. 2006;15:595-608 pubmed
    ..progenitor cells were compared with follicle components in tissue sections of the postnatal developing periodontium. The presence of heterogeneous cell populations in the DF mirrors individual developmental pathways in the ..
  36. Ramseier C, Abramson Z, Jin Q, Giannobile W. Gene therapeutics for periodontal regenerative medicine. Dent Clin North Am. 2006;50:245-63, ix pubmed
    ..Ongoing investigations in ex vivo and in vivo gene transfer to periodontia seek to examine the extent of the potential effects in stimulating periodontal tissue engineering...
  37. Teng Y. Protective and destructive immunity in the periodontium: Part 2--T-cell-mediated immunity in the periodontium. J Dent Res. 2006;85:209-19 pubmed
  38. Kaku M, Motokawa M, Tohma Y, Tsuka N, Koseki H, Sunagawa H, et al. VEGF and M-CSF levels in periodontal tissue during tooth movement. Biomed Res. 2008;29:181-7 pubmed
    ..These results suggest that orthodontic tooth movement causes an increase in VEGF and M-CSF levels. These factors may induce bone remodeling via osteoclastic bone resorption...
  39. Laxman V, Annaji S. Tobacco use and its effects on the periodontium and periodontal therapy. J Contemp Dent Pract. 2008;9:97-107 pubmed
    ..The purpose of this article is to present a review of the potential biological mechanisms underlying the effects of tobacco smoking on periodontal health and periodontal therapy...
  40. Kawamoto S, Ejiri S, Nagaoka E, Ozawa H. Effects of oestrogen deficiency on osteoclastogenesis in the rat periodontium. Arch Oral Biol. 2002;47:67-73 pubmed
    This study was designed to investigate quantitative changes in osteoclast generation in rat periodontium following ovariectomy. Wistar rats, aged 9 weeks, were subjected to either ovariectomy (OVX) or sham surgery...
  41. Mascarenhas P, Gapski R, Al Shammari K, Wang H. Influence of sex hormones on the periodontium. J Clin Periodontol. 2003;30:671-81 pubmed
    ..The objectives of this review article are to (1) address the link between sex hormones and the periodontium, (2) analyse how these hormones influence the periodontium at different life times and (3) discuss the effects ..
  42. van Winkelhoff A, Loos B, van der Reijden W, Van der Velden U. Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol. 2002;29:1023-8 pubmed
    ..The aim of the present study was to compare prevalence and proportions of a number of periodontal bacteria in periodontitis patients and control subjects...
  43. Foster B, Somerman M. Regenerating the periodontium: is there a magic formula?. Orthod Craniofac Res. 2005;8:285-91 pubmed
    ..Critical to improving the predictability of regenerative therapies is targeting studies toward enhancing our understanding of the cellular and molecular events required to restore periodontal tissues...
  44. Machtei E, Mahler D, Sanduri H, Peled M. The effect of menstrual cycle on periodontal health. J Periodontol. 2004;75:408-12 pubmed
    Fluctuation in estrogen/progesterone levels has been shown to affect the periodontium. The effects of pregnancy, prepuberty, and oral contraceptives on gingival health has been studied extensively, with gingival scores reported to be ..
  45. Matias M, Li H, Young W, Bartold P. Immunohistochemical localisation of extracellular matrix proteins in the periodontium during cementogenesis in the rat molar. Arch Oral Biol. 2003;48:709-16 pubmed
    The development of the periodontium involves the coordinated expression of numerous extracellular matrix (ECM) macromolecules and their receptors (integrins)...
  46. Gibson C. The amelogenin "enamel proteins" and cells in the periodontium. Crit Rev Eukaryot Gene Expr. 2008;18:345-60 pubmed
  47. Kohno T, Matsumoto Y, Kanno Z, Warita H, Soma K. Experimental tooth movement under light orthodontic forces: rates of tooth movement and changes of the periodontium. J Orthod. 2002;29:129-35 pubmed
    ..To investigate light forces for experimental tooth movement...
  48. Kemoun P, Laurencin Dalicieux S, Rue J, Vaysse F, Romeas A, Arzate H, et al. Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium. Tissue Cell. 2007;39:257-66 pubmed
    ..of mesenchymal progenitor cells and several members of the BMP pathway during the development of mouse molar periodontium, from the post-natal days 6 to 23 (D6 to D23)...
  49. Ho S, Marshall S, Ryder M, Marshall G. The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials. 2007;28:5238-45 pubmed
    ..structure, chemical composition and mechanical properties of collagen fibers at three regions within a human periodontium, has enabled us to define a novel tooth attachment mechanism...
  50. Keles G, Acikgoz G, Ayas B, Sakallioglu E, Firatli E. Determination of systemically & locally induced periodontal defects in rats. Indian J Med Res. 2005;121:176-84 pubmed
  51. Qian H, Fan M, Xiao Y, Bartold P. [Immunohistochemical localization and expression of fibromodulin in the periodontium]. Zhonghua Yi Xue Za Zhi. 2003;83:1682-5 pubmed
    To study the distribution and expression of fibromodulin in normal periodontium, so as to understand its role in periodontal tissue homeostasis.
  52. Perinetti G, Serra E, Paolantonio M, Brue C, Meo S, Filippi M, et al. Lactate dehydrogenase activity in human gingival crevicular fluid during orthodontic treatment: a controlled, short-term longitudinal study. J Periodontol. 2005;76:411-7 pubmed
  53. Teng Y. Protective and destructive immunity in the periodontium: Part 1--innate and humoral immunity and the periodontium. J Dent Res. 2006;85:198-208 pubmed
  54. Gotz W, Kunert D, Zhang D, Kawarizadeh A, Lossdörfer S, Jager A. Insulin-like growth factor system components in the periodontium during tooth root resorption and early repair processes in the rat. Eur J Oral Sci. 2006;114:318-27 pubmed
    ..g. IGF-II, IGFBP-5 or -6) within lacunae and in cementoblasts showed an involvement in the resorption-repair sequence, which is considered to be a coupling process as known from bone...
  55. McIntosh J, Anderton X, Flores De Jacoby L, Carlson D, Shuler C, Diekwisch T. Caiman periodontium as an intermediate between basal vertebrate ankylosis-type attachment and mammalian "true" periodontium. Microsc Res Tech. 2002;59:449-59 pubmed
    ..The purpose of the present study was to compare several key features of the crocodilian periodontium with those of the mammalian and noncrocodilian reptile periodontium...
  56. Roberts F, Darveau R. Beneficial bacteria of the periodontium. Periodontol 2000. 2002;30:40-50 pubmed
  57. Tomokiyo A, Maeda H, Fujii S, Wada N, Shima K, Akamine A. Development of a multipotent clonal human periodontal ligament cell line. Differentiation. 2008;76:337-47 pubmed
    ..These results suggest that cell line 1-17 is a PDL-committed stem cell line and that bFGF exerts dualistic (i.e., promoting and inhibitory) effects on the osteoblastic differentiation of cell line 1-17 based on its differentiation stage...
  58. Soory M. Targets for steroid hormone mediated actions of periodontal pathogens, cytokines and therapeutic agents: some implications on tissue turnover in the periodontium. Curr Drug Targets. 2000;1:309-25 pubmed
    ..of glucocorticoids, androgens, oestrogen and progesterone on connective tissue and bone, are applicable to the periodontium, being target tissue...
  59. Nevins M, Camelo M, Nevins M, King C, Oringer R, Schenk R, et al. Human histologic evaluation of bioactive ceramic in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent. 2000;20:458-67 pubmed
  60. Qian H, Xiao Y, Bartold P. Immunohistochemical localization and expression of fibromodulin in adult rat periodontium and inflamed human gingiva. Oral Dis. 2004;10:233-9 pubmed
    ..The aim of this study was to determine the distribution and expression of fibromodulin in adult rat periodontal tissues and inflamed human gingiva...
  61. Sringkarnboriboon S, Matsumoto Y, Soma K. Root resorption related to hypofunctional periodontium in experimental tooth movement. J Dent Res. 2003;82:486-90 pubmed
    ..These teeth present with a histologically altered periodontium and are considered to be hypofunctional...