bruch membrane

Summary

Summary: The inner layer of CHOROID, also called the lamina basalis choroideae, located adjacent to the RETINAL PIGMENT EPITHELIUM; (RPE) of the EYE. It is a membrane composed of the basement membranes of the choriocapillaris ENDOTHELIUM and that of the RPE. The membrane stops at the OPTIC NERVE, as does the RPE.

Top Publications

  1. Ebrahem Q, Renganathan K, Sears J, Vasanji A, Gu X, Lu L, et al. Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A. 2006;103:13480-4 pubmed
    ..Overall, these results suggest that CEP-induced angiogenesis utilizes VEGF-independent pathways and that anti-CEP therapeutic modalities might be of value in limiting CNV in AMD...
  2. Booij J, Baas D, Beisekeeva J, Gorgels T, Bergen A. The dynamic nature of Bruch's membrane. Prog Retin Eye Res. 2010;29:1-18 pubmed publisher
    ..Our review may shed light on the complex involvement of BM in retinal pathology, notably age-related macular degeneration...
  3. Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008;283:26684-93 pubmed publisher
    ..These findings provide direct evidence that aberrant production of toxic condensation byproducts of the visual cycle in mice can lead to rapid, progressive retinal degeneration...
  4. Dithmar S, Sharara N, Curcio C, Le N, Zhang Y, Brown S, et al. Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane. Arch Ophthalmol. 2001;119:1643-9 pubmed
    To examine the histologic, histochemical, and ultrastructural changes in Bruch membrane in mice on a high-fat diet with and without laser photochemical injury.
  5. Hussain A, Lee Y, Zhang J, Marshall J. Disturbed matrix metalloproteinase activity of Bruch's membrane in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:4459-66 pubmed publisher
    ..To evaluate the potential role of the matrix metalloproteinase (MMP) system of Bruch's membrane in the pathology of age-related macular degeneration...
  6. Hollyfield J, Bonilha V, Rayborn M, Yang X, Shadrach K, Lu L, et al. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med. 2008;14:194-8 pubmed publisher
    ..This new model provides a platform for dissecting the molecular pathology of oxidative damage in the outer retina and the immune response contributing to AMD...
  7. Espinosa Heidmann D, Sall J, Hernandez E, Cousins S. Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. Invest Ophthalmol Vis Sci. 2004;45:260-6 pubmed
  8. Zarbin M. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004;122:598-614 pubmed
    ..To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD)...
  9. Cai H, Del Priore L. Bruch membrane aging alters the gene expression profile of human retinal pigment epithelium. Curr Eye Res. 2006;31:181-9 pubmed
    We investigated the effects of age-related changes within the Bruch membrane on the gene expression profile of the RPE...

More Information

Publications62

  1. Triviño A, Ramírez A, Salazar J, De Hoz R, Rojas B, Padilla E, et al. A cholesterol-enriched diet induces ultrastructural changes in retinal and macroglial rabbit cells. Exp Eye Res. 2006;83:357-66 pubmed
    ..Excess cholesterol induces ultrastructural changes in the rabbit retina similar to those in human AMD. Given that lipid intake is most dependent on food composition, dietary regimen could help induce or prevent retinal disease...
  2. Uno K, Bhutto I, McLeod D, Merges C, Lutty G. Impaired expression of thrombospondin-1 in eyes with age related macular degeneration. Br J Ophthalmol. 2006;90:48-54 pubmed
    ..This study investigated the expression and localisation of thrombospondin-1 (TSP-1), a known anti-angiogenic extracellular matrix protein, in normal aged control human eyes and eyes with age related macular degeneration (AMD)...
  3. Li C, Chung B, Presley J, Malek G, Zhang X, Dashti N, et al. Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization. Invest Ophthalmol Vis Sci. 2005;46:2576-86 pubmed
    ..To isolate and characterize cholesteryl ester-containing, lipoprotein-like particles (LLPs) from normal aged human Bruch's membrane (BrM)/choroid (Ch)...
  4. Gottsch J, Bynoe L, Harlan J, Rencs E, Green W. Light-induced deposits in Bruch's membrane of protoporphyric mice. Arch Ophthalmol. 1993;111:126-9 pubmed
  5. Chong N, Keonin J, Luthert P, Frennesson C, Weingeist D, Wolf R, et al. Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration. Am J Pathol. 2005;166:241-51 pubmed
    ..These structural properties of the macular EL correspond spatially to the distribution of macular lesions associated with AMD and may help to explain why the macula is more susceptible to degenerative events that occur in this disease...
  6. Rudolf M, Ivandic B, Winkler J, Schmidt Erfurth U. [Accumulation of lipid particles in Bruch's membrane of LDL receptor knockout mice as a model of age-related macular degeneration]. Ophthalmologe. 2004;101:715-9 pubmed
    ..Atherosclerosis is a suspected risk factor for the development of neovascular age-related macular degeneration (AMD)...
  7. Huang J, Curcio C, Johnson M. Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membrane. Invest Ophthalmol Vis Sci. 2008;49:2721-7 pubmed publisher
    ..To determine the size and regional distribution of lipoprotein-like particles (LLPs) that accumulate with age in Bruch's membrane (BrM)...
  8. Guymer R, Bird A, Hageman G. Cytoarchitecture of choroidal capillary endothelial cells. Invest Ophthalmol Vis Sci. 2004;45:1660-6 pubmed
    ..To describe the cytoarchitecture of the choroidal capillary endothelial cells, especially as it relates to cellular processes that protrude through the basal lamina into Bruch's membrane (BM)...
  9. Hirabayashi Y, Fujimori O, Shimizu S. Bruch's membrane of the brachymorphic mouse. Med Electron Microsc. 2003;36:139-46 pubmed
    ..These findings suggest that the formation of the collagenous layer, regulated with acidic glycoconjugates such as decorin, is important in the development of Bruch's membrane...
  10. Curcio C, Millican C, Bailey T, Kruth H. Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci. 2001;42:265-74 pubmed
    ..To determine the cholesterol composition of normal human Bruch's membrane and choroid as a function of age and retinal location...
  11. Na J, Moon B, Sung K, Lee Y, Kook M. Characterization of peripapillary atrophy using spectral domain optical coherence tomography. Korean J Ophthalmol. 2010;24:353-9 pubmed publisher
    ..To characterize the features of peripapillary atrophy (PPA), as imaged by spectral-domain optical coherence tomography (SD-OCT)...
  12. Miceli M, Newsome D, Tate D, Sarphie T. Pathologic changes in the retinal pigment epithelium and Bruch's membrane of fat-fed atherogenic mice. Curr Eye Res. 2000;20:8-16 pubmed
  13. Handa J, Verzijl N, Matsunaga H, Aotaki Keen A, Lutty G, te Koppele J, et al. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. Invest Ophthalmol Vis Sci. 1999;40:775-9 pubmed
  14. Hu Y, Zhang T, Wu J, Li Y, Lu X, Qian F, et al. Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit. Invest Ophthalmol Vis Sci. 2008;49:3185-92 pubmed publisher
    ..An improved translocation technique for autologous retinal pigment epithelium (RPE) transplantation is presented. The graft consists of a sheet of a partial-thickness choroid with RPE attached...
  15. van Soest S, de Wit G, Essing A, ten Brink J, Kamphuis W, De Jong P, et al. Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane. Mol Vis. 2007;13:1608-17 pubmed
    ..To describe gene expression differences between healthy, young human retinal pigment epithelium (RPE) cells from the macular area and RPE cells from two locations in the retinal periphery...
  16. De Jong P. Age-related macular degeneration. N Engl J Med. 2006;355:1474-85 pubmed
  17. Bloom S, Singal I. The outer Bruch membrane layer: a previously undescribed spectral-domain optical coherence tomography finding. Retina. 2011;31:316-23 pubmed publisher
    To report a previously undescribed spectral-domain optical coherence tomography finding, the outer Bruch membrane layer.
  18. Park S, De Moraes C, Tello C, Liebmann J, Ritch R. In-vivo microstructural anatomy of beta-zone parapapillary atrophy in glaucoma. Invest Ophthalmol Vis Sci. 2010;51:6408-13 pubmed publisher
    ..To assess the microstructural anatomy of clinical ?-zone parapapillary atrophy (?PPA) by using Fourier-domain optical coherence tomography (FD-OCT)...
  19. Fernández Robredo P, Recalde S, Arnáiz G, Salinas Alaman A, Sadaba L, Moreno Orduña M, et al. Effect of zeaxanthin and antioxidant supplementation on vascular endothelial growth factor (VEGF) expression in apolipoprotein-E deficient mice. Curr Eye Res. 2009;34:543-52 pubmed
    ..We studied the oxidative status and vascular endothelial growth factor (VEGF) expression in murine retinal pigment epithelium-choroid (RPE) and Bruch's membrane (BM) ultrastructure and the effect of zeaxanthin...
  20. Espinosa Heidmann D, Suner I, Catanuto P, Hernandez E, Marin Castano M, Cousins S. Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. Invest Ophthalmol Vis Sci. 2006;47:729-37 pubmed
    ..This study was an investigation of the effects of cigarette smoke (CS) and HQ in the development of sub-RPE deposits in an experimental mouse model...
  21. Nakata K, Crabb J, Hollyfield J. Crystallin distribution in Bruch's membrane-choroid complex from AMD and age-matched donor eyes. Exp Eye Res. 2005;80:821-6 pubmed
    ..These findings suggest that the accumulation of these small heat shock proteins at this critical interface below the RPE reflects a disease-related stress response manifested during the progression of AMD...
  22. Guo L, Hussain A, Limb G, Marshall J. Age-dependent variation in metalloproteinase activity of isolated human Bruch's membrane and choroid. Invest Ophthalmol Vis Sci. 1999;40:2676-82 pubmed
    ..To characterize and determine the effect of aging on the matrix metalloproteinase (MMP) component of the extracellular matrix-remodeling mechanism of isolated human Bruch's-choroid...
  23. Ida H, Ishibashi K, Reiser K, Hjelmeland L, Handa J. Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the D-galactose-treated mouse. Invest Ophthalmol Vis Sci. 2004;45:2348-54 pubmed
    ..The purpose of this study was to identify ultrastructural aging in the retinal pigment epithelium (RPE)-Bruch's membrane-choriocapillaris...
  24. Russell S, Mullins R, Schneider B, Hageman G. Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration. Am J Ophthalmol. 2000;129:205-14 pubmed
    ..To determine whether basal laminar drusen differ in their location, ultrastructure, or composition from drusen associated with aging and age-related macular degeneration...
  25. Anderson D, Ozaki S, Nealon M, Neitz J, Mullins R, Hageman G, et al. Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. Am J Ophthalmol. 2001;131:767-81 pubmed
    ..Accordingly, we assessed the potential biosynthetic contribution of local ocular cell types to the apolipoprotein E found in drusen...
  26. Dithmar S, Curcio C, Le N, Brown S, Grossniklaus H. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci. 2000;41:2035-42 pubmed
    ..To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched control animals...
  27. Yuan X, Gu X, Crabb J, Yue X, Shadrach K, Hollyfield J, et al. Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes. Mol Cell Proteomics. 2010;9:1031-46 pubmed publisher
    A quantitative proteomics analysis of the macular Bruch membrane/choroid complex was pursued for insights into the molecular mechanisms of age-related macular degeneration (AMD)...
  28. Reis A, Sharpe G, Yang H, Nicolela M, Burgoyne C, Chauhan B. Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography. Ophthalmology. 2012;119:738-47 pubmed publisher
    ..To characterize optic nerve head (ONH) anatomy related to the clinical optic disc margin with spectral domain-optical coherence tomography (SD-OCT)...
  29. Kamei M, Hollyfield J. TIMP-3 in Bruch's membrane: changes during aging and in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:2367-75 pubmed
    ..To assess the distribution, content, and function of tissue inhibitor of metalloproteinases (TIMP)-3 during aging in normal eyes for comparison with the levels observed in eyes with age-related macular degeneration (AMD)...
  30. Manjunath V, Shah H, Fujimoto J, Duker J. Analysis of peripapillary atrophy using spectral domain optical coherence tomography. Ophthalmology. 2011;118:531-6 pubmed publisher
    ..To study retinal morphologic changes around the optic disc in patients with peripapillary atrophy (PPA) with high-resolution spectral domain optical coherence tomography (SD OCT)...
  31. Fujihara M, Nagai N, Sussan T, Biswal S, Handa J. Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice. PLoS ONE. 2008;3:e3119 pubmed publisher
    ..7% of RPE cells counted compared to 9.5+/-3.9% in controls (p<0.00001). Bruch membrane was thicker in mice exposed to smoke (1086+/-332 nm) than those raised in air (543+/-132 nm; p = 0.0069)...
  32. Ruberti J, Curcio C, Millican C, Menco B, Huang J, Johnson M. Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membrane. Invest Ophthalmol Vis Sci. 2003;44:1753-9 pubmed
    ..To examine age-related changes in the ultrastructure of Bruch's membrane with quick-freeze/deep-etch (QFDE) and conventional thin-section transmission electron microscopy (TEM)...
  33. Schmidt Erfurth U, Rudolf M, Funk M, Hofmann Rummelt C, Franz Haas N, Aherrahrou Z, et al. Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. Invest Ophthalmol Vis Sci. 2008;49:390-8 pubmed publisher
    ..lipoprotein (LDL) receptor knockout (R(-/-)) mice consuming different diets as a potential model of Bruch membrane (BM) lipoidal degeneration and to determine the distribution and concentration of VEGF(164) in this mouse model...
  34. Huang J, Presley J, Chimento M, Curcio C, Johnson M. Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etch. Exp Eye Res. 2007;85:202-18 pubmed
  35. Marneros A, Fan J, Yokoyama Y, Gerber H, Ferrara N, Crouch R, et al. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol. 2005;167:1451-9 pubmed
    ..Thus, hypoxia-inducible factor-1alpha-independent expression of VEGF is essential for choroid development...
  36. Yamada Y, Ishibashi K, Ishibashi K, Bhutto I, Tian J, Lutty G, et al. The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas. Exp Eye Res. 2006;82:840-8 pubmed
    ..These results suggest that AGE receptors could influence the formation of basal deposits during aging and AMD...
  37. Curcio C, Johnson M, Rudolf M, Huang J. The oil spill in ageing Bruch membrane. Br J Ophthalmol. 2011;95:1638-45 pubmed publisher
    ..Oil red O binding neutral lipid represents a major age-related deposition in the Bruch membrane (BrM) and the first identified druse component...
  38. Picard E, Houssier M, Bujold K, Sapieha P, Lubell W, Dorfman A, et al. CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits. Aging (Albany NY). 2010;2:981-9 pubmed
    ..In conclusion, our data uncover a new role for CD36 in the clearance of oxidized lipids from BM and in the prevention of age-dependent sub-retinal laminar deposits...
  39. Jonas J, Jonas S, Jonas R, Holbach L, Panda Jonas S. Histology of the parapapillary region in high myopia. Am J Ophthalmol. 2011;152:1021-9 pubmed publisher
    ..To examine histomorphometrically the parapapillary region in highly myopic eyes...
  40. Marneros A, She H, Zambarakji H, Hashizume H, Connolly E, Kim I, et al. Endogenous endostatin inhibits choroidal neovascularization. FASEB J. 2007;21:3809-18 pubmed
    ..Endostatin may have a regulatory role in the pathogenesis of CNV and could be used therapeutically to inhibit growth and leakage of CNV lesions...
  41. Curcio C, Johnson M, Huang J, Rudolf M. Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. Prog Retin Eye Res. 2009;28:393-422 pubmed publisher
    ..2007). This approach provides a wide knowledge base and sophisticated clinical armamentarium that can be readily exploited for the development of new model systems and the future benefit of ARMD patients...
  42. Wang L, Li C, Rudolf M, Belyaeva O, Chung B, Messinger J, et al. Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile. Invest Ophthalmol Vis Sci. 2009;50:870-7 pubmed publisher
    Throughout adulthood, Bruch membrane (BrM) accumulates esterified cholesterol (EC) associated with abundant 60- to 80-nm-diameter lipoprotein-like particles (LLP), putative apolipoprotein B (apoB) lipoproteins secreted by the retinal ..
  43. Bhutto I, Uno K, Merges C, Zhang L, McLeod D, Lutty G. Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration. Arch Ophthalmol. 2008;126:670-8 pubmed publisher
  44. Yu H, Liu X, Kiss S, Connolly E, Gragoudas E, Michaud N, et al. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci. 2008;49:2599-605 pubmed publisher
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  45. Curcio C, Millican C. Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol. 1999;117:329-39 pubmed
    To determine the distributions of basal laminar and basal linear deposits in Bruch membrane (BM) with respect to age and early age-related maculopathy (ARM).
  46. Courtois Y. The role of CD36 receptor in the phagocytosis of oxidized lipids and AMD. Aging (Albany NY). 2010;2:888-9 pubmed
  47. Wasmuth S. [Pathogenetic concepts for pigment epithelial detachment in exudative AMD]. Ophthalmologe. 2010;107:1109-14 pubmed publisher
    ..The association of newly formed vessels and an unaltered RPE pump activity can lead to the clinical picture of serous PED during exudative AMD...
  48. Gullapalli V, Sugino I, Van Patten Y, Shah S, Zarbin M. Impaired RPE survival on aged submacular human Bruch's membrane. Exp Eye Res. 2005;80:235-48 pubmed
  49. Itaya H, Gullapalli V, Sugino I, Tamai M, Zarbin M. Iris pigment epithelium attachment to aged submacular human Bruch's membrane. Invest Ophthalmol Vis Sci. 2004;45:4520-8 pubmed
  50. Miura Y, Klettner A, Noelle B, Hasselbach H, Roider J. Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture. Ophthalmic Res. 2010;43:122-33 pubmed publisher
    ..To evaluate the changes of morphological and functional characteristics of the retinal pigment epithelium (RPE)-choroid perfusion culture during cultivation...
  51. Elliot S, Catanuto P, Espinosa Heidmann D, Fernandez P, Hernandez E, Saloupis P, et al. Estrogen receptor beta protects against in vivo injury in RPE cells. Exp Eye Res. 2010;90:10-6 pubmed publisher
    ..These data suggest that mice which lack ERbeta are more susceptible to in vivo injury associated with environmental light and high fat diet...
  52. Glenn J, Mahaffy H, Dasari S, Oliver M, Chen M, Boulton M, et al. Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate. Graefes Arch Clin Exp Ophthalmol. 2012;250:349-59 pubmed publisher
  53. Hoh Kam J, Lenassi E, Malik T, Pickering M, Jeffery G. Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. Am J Pathol. 2013;183:480-92 pubmed publisher
    ..Our data show that both uncontrolled C3 activation (CFH(-/-)) and complete absence of C3 (CFH(-/-).C3(-/-) and C3(-/-)) negatively affect aged retinas. These findings suggest that strategies that inhibit C3 in AMD may be deleterious. ..