retinal neurons


Summary: Nerve cells of the RETINA in the pathway of transmitting light signals to the CENTRAL NERVOUS SYSTEM. They include the outer layer of PHOTORECEPTOR CELLS, the intermediate layer of RETINAL BIPOLAR CELLS and AMACRINE CELLS, and the internal layer of RETINAL GANGLION CELLS.

Top Publications

  1. Park H, Kim S, Park C. Influence of the lamina cribrosa on the rate of global and localized retinal nerve fiber layer thinning in open-angle glaucoma. Medicine (Baltimore). 2017;96:e6295 pubmed publisher
    ..001). A deeper and thinner LC was related to the rate of superior RNFL thinning, and the presence of focal LC defects was related to the rate of inferior RNFL thinning. ..
  2. Thigpen N, Bartsch F, Keil A. The malleability of emotional perception: Short-term plasticity in retinotopic neurons accompanies the formation of perceptual biases to threat. J Exp Psychol Gen. 2017;146:464-471 pubmed publisher
    ..These changes were location-, eye-, and orientation-specific, supporting the hypothesis that short-term plasticity in primary visual neurons mediates the formation of perceptual biases to threat. (PsycINFO Database Record ..
  3. Do Y, Sul J, Jang K, Kang N, Kim Y, Kim Y, et al. A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model. Exp Cell Res. 2017;359:30-38 pubmed publisher
    ..Conversely, Nec-1 and Cpd27 protected RGCs from TNF-stimulated death, while RIC failed to inhibit the death of RGCs. This implies that RIPK1 activates alternative pathways depending on the context of the ischemic insults. ..
  4. Govetto A, Su D, Farajzadeh M, Megerdichian A, Platner E, Ducournau Y, et al. Microcystoid Macular Changes in Association With Idiopathic Epiretinal Membranes in Eyes With and Without Glaucoma: Clinical Insights. Am J Ophthalmol. 2017;181:156-165 pubmed publisher
    ..In glaucomatous eyes, pars plana vitrectomy with epiretinal and internal limiting membrane peel was ineffective in the treatment of microcystoid macular changes. ..
  5. Okado S, Ueno S, Kominami T, Nakanishi A, Inooka D, Sayo A, et al. Temporal Properties of Flicker ERGs in Rabbit Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2017;58:5518-5525 pubmed publisher
    ..The temporal properties of the flicker ERGs of Tg rabbits were affected markedly by the remodeling of the retinal neurons. Evaluations of the flicker ERGs in RP eyes must be done with careful considerations of the current findings.
  6. Ciudin A, Hernandez C, Simo R. Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms?. Exp Diabetes Res. 2010;2010: pubmed publisher
    ..Further studies addressed to explore not only the role of iron in the pathogenesis of diabetic retinopathy, but also to design novel therapeutic strategies based on the regulation of iron homeostasis are needed. ..
  7. Amini N, Daneshvar R, Sharifipour F, Romero P, Henry S, Caprioli J, et al. Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters. Invest Ophthalmol Vis Sci. 2017;58:4623-4631 pubmed publisher
    ..Bruch's membrane opening-MRW normalization did not significantly change SF relationships in this group of eyes with mild departures from average BMO size. ..
  8. Kung F, Wang W, Tran T, Townes Anderson E. Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro. Invest Ophthalmol Vis Sci. 2017;58:4318–4331 pubmed publisher
    ..Our results suggest that Sema3A contributes to axonal retraction in retinal injury, whereas rod neuritic sprouting and regenerative synaptogenesis may require a reduction in semaphorin signaling. ..
  9. Fan N, Silverman S, Liu Y, Wang X, Kim B, Tang L, et al. Rapid repeatable in vivo detection of retinal reactive oxygen species. Exp Eye Res. 2017;161:71-81 pubmed publisher
    ..Furthermore, the results also show that reduction of ROS is a potential therapeutic approach for protection from these retinal injuries. ..

More Information


  1. Santos A, Ribeiro L, Bandello F, Lattanzio R, Egan C, Frydkjaer Olsen U, et al. Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Project. Diabetes. 2017;66:2503-2510 pubmed publisher
    ..We raise the hypothesis that neurodegeneration may play a role in the pathogenesis of DR in many but not in all patients with type 2 diabetes. ..
  2. Laprell L, Tochitsky I, Kaur K, Manookin M, Stein M, Barber D, et al. Photopharmacological control of bipolar cells restores visual function in blind mice. J Clin Invest. 2017;127:2598-2611 pubmed publisher
    ..the photoswitch to rapidly and effectively cross biological barriers and thereby access and photosensitize retinal neurons. Intravitreal injection of DAD restored retinal light responses and light-driven behavior to blind mice...
  3. Wang S, Hu T, Wang Z, Li N, Zhou L, Liao L, et al. Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure. PLoS ONE. 2017;12:e0185388 pubmed publisher
    ..on retinal injury and repair following elevated intraocular pressure suggest that the survival ratio of retinal neurons has been improved by various measures. However, the visual function recovery is far lower than expected...
  4. Gauthier A, Liu J. Epigenetics and Signaling Pathways in Glaucoma. Biomed Res Int. 2017;2017:5712341 pubmed publisher
    ..Novel therapeutic agents targeting these pathway members have shown preliminary success in animal models and even human trials, demonstrating that they may eventually be used to preserve retinal neurons and vision.
  5. Akopian A, Kumar S, Ramakrishnan H, Roy K, Viswanathan S, Bloomfield S. Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma. J Clin Invest. 2017;127:2647-2661 pubmed publisher
    ..blockade of GJs or genetic ablation of connexin 36 (Cx36) subunits, which are highly expressed by retinal neurons, markedly reduced loss of neurons and optic nerve axons in a mouse model of glaucoma...
  6. Arcaro M, Livingstone M. Retinotopic Organization of Scene Areas in Macaque Inferior Temporal Cortex. J Neurosci. 2017;37:7373-7389 pubmed publisher
  7. Neri P. Object segmentation controls image reconstruction from natural scenes. PLoS Biol. 2017;15:e1002611 pubmed publisher
    ..Taken together, our results challenge compartmentalized notions of bottom-up/top-down perception and suggest instead that these two modes are best viewed as an integrated perceptual mechanism. ..
  8. Stellmann J, Cetin H, Young K, Hodecker S, Pöttgen J, Bittersohl D, et al. Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing-remitting MS. Brain Behav. 2017;7:e00614 pubmed publisher
    ..Thus, OCT should be further investigated as a marker for neurodegeneration in MS. ..
  9. Humplik J, Tkacik G. Probabilistic models for neural populations that naturally capture global coupling and criticality. PLoS Comput Biol. 2017;13:e1005763 pubmed publisher
    ..Our method is independent of the underlying system's state space; hence, it can be applied to other systems such as natural scenes or amino acid sequences of proteins which are also known to exhibit criticality. ..
  10. Mukherjee N, McBurney Lin S, Kuo A, Bedlack R, TSENG H. Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease. PLoS ONE. 2017;12:e0185242 pubmed publisher
    ..To determine whether there are differences in retinal neurons in ALS patients utilizing spectral-domain optical coherence tomography (SD-OCT)...