macula lutea

Summary

Summary: An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)

Top Publications

  1. Loughman J, Nolan J, Howard A, Connolly E, Meagher K, Beatty S. The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Invest Ophthalmol Vis Sci. 2012;53:7871-80 pubmed publisher
    ..To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations...
  2. Kang S, Park S, Cho H, Kang J. Triple therapy of vitrectomy, intravitreal triamcinolone, and macular laser photocoagulation for intractable diabetic macular edema. Am J Ophthalmol. 2007;144:878-885 pubmed
    ..To evaluate the effect of a sequentially combined triple therapy on intractable diabetic macular edema (DME)...
  3. Rossetti A, Doro D, Manfre A, Midena E. Long-term follow-up with optical coherence tomography and microperimetry in eyes with metamorphopsia after macula-off retinal detachment repair. Eye (Lond). 2010;24:1808-13 pubmed publisher
    ..to report the long-term sequential morphological and functional results in eyes with metamorphopsia after retinal detachment (RD) repair...
  4. Nakanishi H, Tsujikawa A, Gotoh N, Hayashi H, Iwama D, Tamura H, et al. Macular complications on the border of an inferior staphyloma associated with tilted disc syndrome. Retina. 2008;28:1493-501 pubmed publisher
    ..To describe the clinical characteristics of macular complications on the border of an inferior staphyloma associated with tilted disk syndrome...
  5. Johnson E, Chung H, Caldarella S, Snodderly D. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Am J Clin Nutr. 2008;87:1521-9 pubmed
    ..Lutein and docosahexaenoic acid (DHA) may protect against age-related macular degeneration (AMD). Lutein is a component of macular pigment. DHA is in the retina...
  6. Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T, et al. Macular microcirculation and macular oedema in branch retinal vein occlusion. Br J Ophthalmol. 2009;93:630-3 pubmed publisher
    ..The relationship between the blood-flow velocity in the perifoveal capillaries and macular oedema was investigated in patients with branch retinal vein occlusion (BRVO)...
  7. Kwon S, Hwang D, Seo J, Park I. Evaluation of changes of macular thickness in diabetic retinopathy after cataract surgery. Korean J Ophthalmol. 2011;25:238-42 pubmed publisher
    ..To assess the macular thickness changes after cataract surgery in diabetic patients using optical coherence tomography (OCT)...
  8. Henderson A, Trip S, Schlottmann P, Altmann D, Garway Heath D, Plant G, et al. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain. 2008;131:277-87 pubmed
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  9. Parikh R, Parikh S, Thomas R. Diagnostic capability of macular parameters of Stratus OCT 3 in detection of early glaucoma. Br J Ophthalmol. 2010;94:197-201 pubmed publisher
    ..To report the diagnostic capability of Stratus OCT macular parameters in early glaucoma...

More Information

Publications62

  1. Charbel Issa P, Berendschot T, Staurenghi G, Holz F, Scholl H. Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci. 2008;49:1172-7 pubmed publisher
    ..To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT)...
  2. Yeung L, Sun C, Ku W, Chuang L, Chen C, Huang B, et al. Associations between chronic glycosylated haemoglobin (HbA1c) level and macular volume in diabetes patients without macular oedema. Acta Ophthalmol. 2010;88:753-8 pubmed publisher
    ..This study aimed to examine the correlation between glycosylated haemoglobin (HbA1c) level and macular volume in diabetes patients without diabetic macular oedema (DMO)...
  3. Kumagai K, Furukawa M, Ogino N, Larson E, Iwaki M, Tachi N. Long-term follow-up of vitrectomy for diffuse nontractional diabetic macular edema. Retina. 2009;29:464-72 pubmed publisher
    ..To report the long-term results of pars plana vitrectomy for diffuse nontractional diabetic macular edema...
  4. VAN DER Veen R, Fuijkschot J, Willemsen M, Cruysberg J, Berendschot T, Theelen T. Patients with Sjögren-Larsson syndrome lack macular pigment. Ophthalmology. 2010;117:966-71 pubmed publisher
    ..Ophthalmic symptoms in SLS are reduced visual acuity and photophobia. This article reports the deficiency of macular pigment as a novel finding in this peculiar, congenital maculopathy...
  5. Hsu S, Tsai R. Analysis of retinal nerve fiber layer and macular thickness measurements in healthy Taiwanese individuals using optical coherence tomography (Stratus OCT). J Glaucoma. 2008;17:30-5 pubmed publisher
    ..To investigate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) and macular thickness measurements in healthy Taiwanese subjects using optical coherence tomography (Stratus OCT)...
  6. Menke M, Dabov S, Sturm V. Comparison of three different optical coherence tomography models for total macular thickness measurements in healthy controls. Ophthalmologica. 2009;223:352-6 pubmed publisher
    ..The purpose of this study was to compare 3 commercially available OCT models for retinal thickness measurements in healthy controls...
  7. Pierro L, Giatsidis S, Mantovani E, Gagliardi M. Macular thickness interoperator and intraoperator reproducibility in healthy eyes using 7 optical coherence tomography instruments. Am J Ophthalmol. 2010;150:199-204.e1 pubmed publisher
    ..To evaluate macular thickness measurement reproducibility using 6 new spectral-domain (SD) optical coherence tomography (OCT) devices and 1 time-domain OCT device..
  8. Yahia S, Kahloun R, Jelliti B, Khairallah M. Branch retinal artery occlusion associated with Behçet disease. Ocul Immunol Inflamm. 2011;19:293-5 pubmed publisher
    ..To report 2 cases of branch retinal artery occlusion (BRAO) associated with Behçet disease (BD)...
  9. Kirby M, Beatty S, Loane E, Akkali M, Connolly E, Stack J, et al. A central dip in the macular pigment spatial profile is associated with age and smoking. Invest Ophthalmol Vis Sci. 2010;51:6722-8 pubmed publisher
    ..To investigate the relationship between specific macular pigment (MP) spatial profiles and risk factors for age-related macular degeneration (AMD)...
  10. Wexler A, Sand T, Elsås T. Macular thickness measurements in healthy Norwegian volunteers: an optical coherence tomography study. BMC Ophthalmol. 2010;10:13 pubmed publisher
    ..Our purpose was to collect normative macular thickness data in Norwegians and to evaluate the association between macular thickness and age, gender, parity, and contraception status...
  11. Huang J, Liu X, Wu Z, Xiao H, Dustin L, Sadda S. Macular thickness measurements in normal eyes with time-domain and Fourier-domain optical coherence tomography. Retina. 2009;29:980-7 pubmed publisher
    ..To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT...
  12. Smith A, Telander D, Zawadzki R, Choi S, Morse L, Werner J, et al. High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repair. Ophthalmology. 2008;115:1923-9 pubmed publisher
  13. Warner C, Syc S, Stankiewicz A, Hiremath G, Farrell S, Crainiceanu C, et al. The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. PLoS ONE. 2011;6:e22947 pubmed publisher
  14. Leung C, Cheung C, Weinreb R, Lee G, Lin D, Pang C, et al. Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2008;49:4893-7 pubmed publisher
    ..To compare macular thickness measurements obtained from time domain optical coherence tomography (OCT) and spectral domain OCT and to evaluate their repeatability and agreement...
  15. Bernardes R, Santos T, Cunha Vaz J. Increased-resolution OCT thickness mapping of the human macula: a statistically based registration. Invest Ophthalmol Vis Sci. 2008;49:2046-52 pubmed publisher
    ..Dublin, CA). A retinal thickness atlas (RT-atlas) template was calculated, and a macular coordinate system was established, to pursue this objective...
  16. Moon S, Kim H, Kim S, Oh J, Huh K, Oh I. The change of macular thickness measured by optical coherence tomography in relation to glycemic control in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2011;249:839-48 pubmed publisher
    ..To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels...
  17. Kelty P, Payne J, Trivedi R, Kelty J, Bowie E, Burger B. Macular thickness assessment in healthy eyes based on ethnicity using Stratus OCT optical coherence tomography. Invest Ophthalmol Vis Sci. 2008;49:2668-72 pubmed publisher
    ..To assess the variation in macular thickness measurements in healthy Caucasian and African American men and women through Stratus OCT optical coherence tomography (OCT-3)...
  18. Song W, Lee S, Lee E, Kim C, Kim S. Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci. 2010;51:3913-8 pubmed publisher
    ..To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT)...
  19. Burkholder B, Osborne B, Loguidice M, Bisker E, Frohman T, Conger A, et al. Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis. Arch Neurol. 2009;66:1366-72 pubmed publisher
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  20. Lee S, Joe S, Kim J, Chung H, Yoon Y. Optical coherence tomography evaluation of detached macula from rhegmatogenous retinal detachment and central serous chorioretinopathy. Am J Ophthalmol. 2008;145:1071-1076 pubmed publisher
    ..To compare structural changes using optical coherence tomography (OCT) and visual acuity (VA) loss in patients with shallow macula-off rhegmatogenous retinal detachment (RD) and central serous chorioretinopathy (CSC) involving the macula...
  21. Browning D, Fraser C, Propst B. The variation in optical coherence tomography-measured macular thickness in diabetic eyes without clinical macular edema. Am J Ophthalmol. 2008;145:889-93 pubmed publisher
    ..To determine the variation in optical coherence tomography (OCT)-measured macular thickness in diabetic eyes without clinical edema and to investigate factors that might influence variation in macular thickness...
  22. Sabour Pickett S, Nolan J, Loughman J, Beatty S. A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. Mol Nutr Food Res. 2012;56:270-86 pubmed publisher
  23. Gardner T, Larsen M, Girach A, Zhi X. Diabetic macular oedema and visual loss: relationship to location, severity and duration. Acta Ophthalmol. 2009;87:709-13 pubmed publisher
    ..To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening...
  24. Asefzadeh B, Cavallerano A, Fisch B. Racial differences in macular thickness in healthy eyes. Optom Vis Sci. 2007;84:941-5 pubmed
    ..In this study, we compared macular thickness in healthy eyes of black and white subjects using optical coherence tomography (Stratus OCT)...
  25. Kim S, Oh J, Huh K. Macular infarction after intravitreal ganciclovir injection in a patient with acute retinal necrosis. Can J Ophthalmol. 2008;43:124-5 pubmed publisher
  26. Charbel Issa P, VAN DER Veen R, Stijfs A, Holz F, Scholl H, Berendschot T. Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2. Exp Eye Res. 2009;89:25-31 pubmed publisher
    ..This disease might serve as a model to further study abnormalities of MP distribution in retinal disorders and to elucidate the mechanisms of MP deposition in the retina...
  27. Stringham J, Hammond B. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008;85:82-8 pubmed publisher
    ..In this study, we assessed the causality of this relation by supplementing lutein and zeaxanthin for 6 months while measuring MP, glare disability, and photostress recovery...
  28. Stringham J, Hammond B, Nolan J, Wooten B, Mammen A, Smollon W, et al. The utility of using customized heterochromatic flicker photometry (cHFP) to measure macular pigment in patients with age-related macular degeneration. Exp Eye Res. 2008;87:445-53 pubmed publisher
    ..The ability to measure the retinal response to nutritional intervention is of practical importance for monitoring patients being supplemented with lutein and zeaxanthin in hopes of retarding visual loss and/or disease progression...
  29. Legarreta J, Gregori G, Punjabi O, Knighton R, Lalwani G, Puliafito C. Macular thickness measurements in normal eyes using spectral domain optical coherence tomography. Ophthalmic Surg Lasers Imaging. 2008;39:S43-9 pubmed
    ..The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT)...
  30. Gaucher D, Erginay A, Lecleire Collet A, Haouchine B, Puech M, Cohen S, et al. Dome-shaped macula in eyes with myopic posterior staphyloma. Am J Ophthalmol. 2008;145:909-14 pubmed publisher
    ..To describe an unusual feature in myopic eyes responsible for visual loss, which we call a dome-shaped macula...
  31. Domalpally A, Danis R, Zhang B, Myers D, Kruse C. Quality issues in interpretation of optical coherence tomograms in macular diseases. Retina. 2009;29:775-81 pubmed publisher
    ..To analyze the scan characteristics associated with poor-quality Stratus optical coherence tomograms submitted to a reading center for multicenter clinical trials...
  32. Kozulin P, Natoli R, O Brien K, Madigan M, Provis J. Differential expression of anti-angiogenic factors and guidance genes in the developing macula. Mol Vis. 2009;15:45-59 pubmed
    ..The aim of this study was to identify novel genes that may influence retinal vascular patterning and definition of the foveal avascular area...
  33. Noma H, Funatsu H, Mimura T, Tatsugawa M, Shimada K, Eguchi S. Vitreous inflammatory factors and serous macular detachment in branch retinal vein occlusion. Retina. 2012;32:86-91 pubmed publisher
  34. Nakanishi H, Hangai M, Unoki N, Sakamoto A, Tsujikawa A, Kita M, et al. Spectral-domain optical coherence tomography imaging of the detached macula in rhegmatogenous retinal detachment. Retina. 2009;29:232-42 pubmed publisher
    ..To assess detached macula in rhegmatogenous retinal detachment by using spectral-domain optical coherence tomography...
  35. El Ashry M, Hegde V, James P, Pagliarini S. Analysis of macular thickness in British population using optical coherence tomography (OCT): an emphasis on interocular symmetry. Curr Eye Res. 2008;33:693-9 pubmed publisher
    ..To evaluate macular thickness measurements in normal subjects from British origin, to assess interocular asymmetry using optical coherence tomography (OCT) and to establish standard values for macular and foveal thickness...
  36. Goel N, Kumar V, Seth A, Raina U, Ghosh B. Role of intravitreal bevacizumab in adult onset Coats' disease. Int Ophthalmol. 2011;31:183-90 pubmed publisher
    ..Intravitreal bevacizumab was well tolerated by our patients, and no adverse effects were observed...
  37. Grover S, Murthy R, Brar V, Chalam K. Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (spectralis). Am J Ophthalmol. 2009;148:266-71 pubmed publisher
    ..To establish normative data for the macular thickness by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease...
  38. Ibrahim M, Sepah Y, Symons R, Channa R, Hatef E, Khwaja A, et al. Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema. Eye (Lond). 2012;26:454-62 pubmed publisher
    ..To report macular thickness values in normal eyes and eyes with diabetic macular edema (DME) using time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT), and to derive a conversion equation...
  39. Imamura Y, Iida T, Maruko I, Zweifel S, Spaide R. Enhanced depth imaging optical coherence tomography of the sclera in dome-shaped macula. Am J Ophthalmol. 2011;151:297-302 pubmed publisher
    ..To examine the posterior anatomic structure of eyes with dome-shaped macula using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT)...
  40. Yang Z, Stratton C, Francis P, Kleinman M, Tan P, Gibbs D, et al. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008;359:1456-63 pubmed publisher
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  41. Hikichi T, Ohtsuka H, Higuchi M, Matsushita T, Ariga H, Kosaka S, et al. Causes of macular serous retinal detachments in Japanese patients 40 years and older. Retina. 2009;29:395-404 pubmed publisher
    ..To investigate the causes of macular serous retinal detachment without hemorrhage at the macula in patients 40 years and older...
  42. Huang J, Liu X, Wu Z, Guo X, Xu H, Dustin L, et al. Macular and retinal nerve fiber layer thickness measurements in normal eyes with the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000. J Glaucoma. 2011;20:118-25 pubmed publisher
    ..To compare retinal nerve fiber layer (RNFL) and macular thickness measurements using time-domain optical coherence tomography (TD OCT) and 2 Fourier-domain OCTs (FD OCT)...
  43. Hung K, Lee S, Lee S, Lee F, Yang C. Intravitreal bevacizumab (avastin) in the treatment of macular edema associated with perfused retinal vein occlusion. J Ocul Pharmacol Ther. 2010;26:85-90 pubmed publisher
    ..To evaluate the efficacy and safety of intravitreal bevacizumab (Avastin) injection in patients with macular edema (ME) secondary to retinal vein occlusive diseases...
  44. Arevalo J, Sanchez J, Wu L, Maia M, Alezzandrini A, Brito M, et al. Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months. Ophthalmology. 2009;116:1488-97, 1497.e1 pubmed publisher
    ..San Francisco, CA; 1.25 or 2.5 mg) in patients with diffuse diabetic macular edema (DDME). In addition, a comparison of the 2 different doses of intravitreal bevacizumab (IVB) used is presented...
  45. Ogino K, Tsujikawa A, Nakamura H, Miyamoto K, Murakami T, Muraoka Y, et al. Focal macular electroretinogram in macular edema secondary to central retinal vein occlusion. Invest Ophthalmol Vis Sci. 2011;52:3514-20 pubmed publisher
    ..To evaluate the usefulness of focal macular electroretinography (fmERG) for evaluation of macular function in eyes with central retinal vein occlusion (CRVO)...
  46. Gugleta K, Mehling M, Kochkorov A, Grieshaber M, Katamay R, Flammer J, et al. Pattern of macular thickness changes measured by ocular coherence tomography in patients with multiple sclerosis. Klin Monbl Augenheilkd. 2008;225:408-12 pubmed publisher
    ..An analysis of the pattern of retinal thickness changes in macula in patients with multiple sclerosis (MS) was performed...
  47. Dragostinoff N, Werkmeister R, Kaya S, Weigert G, Pemp B, Sacu S, et al. Short- and mid-term repeatability of macular pigment optical density measurements using spectral fundus reflectance. Graefes Arch Clin Exp Ophthalmol. 2012;250:1261-6 pubmed publisher
    ..A key issue for the clinical applicability of a method is its repeatability. In this study, we investigated short- and mid-term repeatability of MPOD measurements using reflectometry...
  48. Pak J, Narkar A, Gangaputra S, Klein R, Klein B, Meuer S, et al. Effect of optical coherence tomography scan decentration on macular center subfield thickness measurements. Invest Ophthalmol Vis Sci. 2013;54:4512-8 pubmed publisher
    ..To investigate the effect of optical coherence tomography macular grid displacement on retinal thickness measurements...
  49. Kim M, Jeoung J, Park K, Choi Y, Kim D. Topographic profiles of retinal nerve fiber layer defects affect the diagnostic performance of macular scans in preperimetric glaucoma. Invest Ophthalmol Vis Sci. 2014;55:2079-87 pubmed publisher
  50. Silva R. Myopic maculopathy: a review. Ophthalmologica. 2012;228:197-213 pubmed publisher
    ..This paper is an updated review of pathological myopia--its definition and progression, epidemiology and genetics--and a review of myopic CNV including the natural history, epidemiology, risk factors, pathogenic mechanisms and treatment...
  51. Mitry D, Awan M, Borooah S, Syrogiannis A, Lim Fat C, Campbell H, et al. Long-term visual acuity and the duration of macular detachment: findings from a prospective population-based study. Br J Ophthalmol. 2013;97:149-52 pubmed publisher
    ..Using a joinpoint model we estimated the effect of duration of macular detachment on final visual outcome...
  52. Barrio Barrio J, Noval S, Galdos M, Ruiz Canela M, Bonet E, Capote M, et al. Multicenter Spanish study of spectral-domain optical coherence tomography in normal children. Acta Ophthalmol. 2013;91:e56-63 pubmed publisher
    ..To analyse variations in the OCT measurements as a function of age, sex, refraction, and axial length (AL)...
  53. Kaizu Y, Nakao S, Yoshida S, Hayami T, Arima M, Yamaguchi M, et al. Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017;58:4889-4897 pubmed publisher
    ..Our purpose is to evaluate the spatial bias of macular capillary dropout accompanying diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA)...