anterior eye segment

Summary

Summary: The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.

Top Publications

  1. Kim G, Ki C, Seo S, Yoo J, Han Y, Chung I, et al. A novel forkhead box C1 gene mutation in a Korean family with Axenfeld-Rieger syndrome. Mol Vis. 2013;19:935-43 pubmed
    ..To report a case series of patients with novel forkhead box CI (FOXC1) mutations in a Korean family with Axenfeld-Rieger syndrome (ARS)...
  2. Shapiro B, Cort├ęs D, Chin E, Li J, Werner J, Redenbo E, et al. High-resolution spectral domain anterior segment optical coherence tomography in type 1 Boston keratoprosthesis. Cornea. 2013;32:951-5 pubmed publisher
    ..To report the results of imaging using high-resolution, Fourier domain anterior segment optical coherence tomography (AS-OCT) to evaluate patients with a type 1 Boston Keratoprosthesis (KPro)...
  3. Day A, Garway Heath D, Broadway D, Jiang Y, Hayat S, Dalzell N, et al. Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study. Br J Ophthalmol. 2013;97:189-95 pubmed publisher
    ..To measure the dimensions of aqueous outflow structures and to investigate associations with intraocular pressure (IOP) and ocular biometry parameters in an older British population...
  4. Bhandari R, Ferri S, Whittaker B, Liu M, Lazzaro D. Peters anomaly: review of the literature. Cornea. 2011;30:939-44 pubmed publisher
    ..We performed a literature review of multiple case reports and case series to better define the common characteristics and unusual findings associated with Peters anomaly...
  5. Chang T, Summers C, Schimmenti L, Grajewski A. Axenfeld-Rieger syndrome: new perspectives. Br J Ophthalmol. 2012;96:318-22 pubmed publisher
  6. Jeng B, Holland G, Lowder C, Deegan W, Raizman M, Meisler D. Anterior segment and external ocular disorders associated with human immunodeficiency virus disease. Surv Ophthalmol. 2007;52:329-68 pubmed
    ..This article reviews the spectrum of HIV-associated anterior segment and external ocular disorders, with recommendations for their evaluation and management...
  7. Holland S, Morck D, Lee T. Update on toxic anterior segment syndrome. Curr Opin Ophthalmol. 2007;18:4-8 pubmed
    ..To review, summarize and update our present understanding of toxic anterior segment syndrome...
  8. Yasuno Y, Yamanari M, Kawana K, Oshika T, Miura M. Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography. Opt Express. 2009;17:3980-96 pubmed
    A sequential case series of post-glaucoma-surgery structures examined by three-dimensional corneal and anterior eye segment optical coherence tomography (3D-CASOCT) and 3D polarization sensitive CASOCT (PS-CASOCT) is presented...
  9. Sarunic M, Asrani S, Izatt J. Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography. Arch Ophthalmol. 2008;126:537-42 pubmed publisher
    ..Quantitative surface height maps of the corneal epithelium and endothelium were obtained from the volumetric data and used to generate corneal thickness maps...

More Information

Publications62

  1. Yi J, Hong S, Seong G, Kang S, Ma K, Kim C. Anterior chamber measurements by pentacam and AS-OCT in eyes with normal open angles. Korean J Ophthalmol. 2008;22:242-5 pubmed publisher
    ..To assess the reproducibility and agreement of anterior chamber measurements between the Pentacam (PTC) and the Anterior segment optical coherence tomography (AOCT) in normal healthy eyes with open angle...
  2. Berry F, Lines M, Oas J, Footz T, Underhill D, Gage P, et al. Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum Mol Genet. 2006;15:905-19 pubmed
    ..Our findings indicate that the functional interaction between FOXC1 and PITX2A underlies the sensitivity to FOXC1 gene dosage in Axenfeld-Rieger syndrome and related anterior segment dysgeneses...
  3. Wirbelauer C, Gochmann R, Pham D. [Imaging of the anterior eye chamber with optical coherence tomography]. Klin Monbl Augenheilkd. 2005;222:856-62 pubmed
    ..tomography (OCT) represents a high-resolution diagnostic method which can be used to precisely image the anterior eye segment. Further developments in scanning technology and data evaluation allowed to visualize the entire anterior ..
  4. Selbach J, Buschnack S, Steuhl K, Kremmer S, Muth Selbach U. Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study. J Anat. 2005;206:237-42 pubmed
    ..The aim of this study was to investigate the opioid peptidergic innervation of the anterior eye segment and to compare it with the innervation pattern of SP in order to shed light on the functional relationship ..
  5. Asrani S, Sarunic M, Santiago C, Izatt J. Detailed visualization of the anterior segment using fourier-domain optical coherence tomography. Arch Ophthalmol. 2008;126:765-71 pubmed publisher
    ..To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities...
  6. Dorairaj S, Liebmann J, Ritch R. Quantitative evaluation of anterior segment parameters in the era of imaging. Trans Am Ophthalmol Soc. 2007;105:99-108; discussion 108-10 pubmed
    ..To review the parameters for quantitative assessment of the anterior segment and iridocorneal angle and to develop a comprehensive schematic for the evaluation of angle anatomy and pathophysiology by high-resolution imaging...
  7. Tumer Z, Bach Holm D. Axenfeld-Rieger syndrome and spectrum of PITX2 and FOXC1 mutations. Eur J Hum Genet. 2009;17:1527-39 pubmed publisher
    ..In this study, we will attempt to give a brief review of the clinical features and the relevant diagnostic approaches, together with a detailed review of published PITX2 and FOXC1 mutations...
  8. Emre S, Doganay S, Yologlu S. Evaluation of anterior segment parameters in keratoconic eyes measured with the Pentacam system. J Cataract Refract Surg. 2007;33:1708-12 pubmed
    ..To evaluate the alteration in anterior chamber parameters with the progression of keratoconus using a rotating Scheimpflug camera...
  9. Ostojic J, Grozdanic S, Syed N, Hargrove M, Trent J, Kuehn M, et al. Neuroglobin and cytoglobin distribution in the anterior eye segment: a comparative immunohistochemical study. J Histochem Cytochem. 2008;56:863-72 pubmed publisher
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  10. Dada T, Sihota R, Gadia R, Aggarwal A, Mandal S, Gupta V. Comparison of anterior segment optical coherence tomography and ultrasound biomicroscopy for assessment of the anterior segment. J Cataract Refract Surg. 2007;33:837-40 pubmed
    ..To compare anterior segment parameters using quantitative imaging by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM)...
  11. Doors M, Berendschot T, de Brabander J, Webers C, Nuijts R. Value of optical coherence tomography for anterior segment surgery. J Cataract Refract Surg. 2010;36:1213-29 pubmed publisher
    ..The most frequently used devices are time-domain AS-OCT, but new Fourier-domain OCT devices, which have faster image acquisition and higher resolution, are currently under investigation...
  12. Potsaid B, Baumann B, Huang D, Barry S, Cable A, Schuman J, et al. Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Opt Express. 2010;18:20029-48 pubmed publisher
    ..These advantages suggest that swept source OCT at 1050 nm wavelengths will play an important role in future ophthalmic instrumentation...
  13. Keller K, Bradley J, Acott T. Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci. 2009;50:5769-77 pubmed publisher
    ..In this study, the authors examined the effects of ADAMTS-1, -4, and -5 on outflow facility and investigated their mRNA levels and protein expression in the trabecular meshwork (TM)...
  14. Scott P, Lu Z, Liu Y, Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp Eye Res. 2009;89:942-9 pubmed publisher
    ..Altogether, these data suggest that outflow hydrodynamics and the tissue structure work together to regulate outflow resistance...
  15. Murata C, Mallmann F, Yamazaki E, Campos M. [Anterior ocular segment study with the Scheimpflug rotational camera in refractive surgery candidates]. Arq Bras Oftalmol. 2007;70:619-24 pubmed
  16. Sowden J. Molecular and developmental mechanisms of anterior segment dysgenesis. Eye (Lond). 2007;21:1310-8 pubmed
    ..Interplay between PITX2 and FOXC1 in the development of different anterior segment tissues may partly explain the phenotypic variability and the genetic heterogeneity characteristic of ASD...
  17. Garcia J, Rosen R. Anterior segment imaging: optical coherence tomography versus ultrasound biomicroscopy. Ophthalmic Surg Lasers Imaging. 2008;39:476-84 pubmed
    ..To determine the clinical indications of anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy in anterior segment imaging...
  18. Wegener A, Laser Junga H. Photography of the anterior eye segment according to Scheimpflug's principle: options and limitations - a review. Clin Exp Ophthalmol. 2009;37:144-54 pubmed publisher
    ..They provide reproducible data on the characteristics of the anterior eye segment in clinical and experimental studies and the set of data obtained allows discrimination of light scattering ..
  19. Sakata L, Lavanya R, Friedman D, Aung H, Seah S, Foster P, et al. Assessment of the scleral spur in anterior segment optical coherence tomography images. Arch Ophthalmol. 2008;126:181-5 pubmed publisher
    ..To assess visibility of the scleral spur in anterior segment optical coherence tomography (AS-OCT) images...
  20. Miyazawa A, Yamanari M, Makita S, Miura M, Kawana K, Iwaya K, et al. Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography. Opt Express. 2009;17:17426-40 pubmed publisher
    ..The algorithm was applied for discriminating tissues of the human anterior eye segment. The conjunctiva, sclera, trabecular meshwork (TM), cornea, and uvea were well separated in the 3D feature ..
  21. Nonaka A, Kondo T, Kikuchi M, Yamashiro K, Fujihara M, Iwawaki T, et al. Angle widening and alteration of ciliary process configuration after cataract surgery for primary angle closure. Ophthalmology. 2006;113:437-41 pubmed
    ..To evaluate quantitatively, by means of ultrasound biomicroscopy (UBM), changes in the anterior segment configuration, including the ciliary processes, induced by cataract surgery in eyes with primary angle closure...
  22. Werner L, Sher J, Taylor J, Mamalis N, Nash W, Csordas J, et al. Toxic anterior segment syndrome and possible association with ointment in the anterior chamber following cataract surgery. J Cataract Refract Surg. 2006;32:227-35 pubmed
    ..To report clinical and laboratory findings of 8 cases of toxic anterior segment syndrome (TASS) related to an oily substance in the anterior chamber of patients following cataract surgery with intraocular lens (IOL) implantation...
  23. Baikoff G, Lutun E, Ferraz C, Wei J. Static and dynamic analysis of the anterior segment with optical coherence tomography. J Cataract Refract Surg. 2004;30:1843-50 pubmed
    ..To study biometric modifications of the anterior segment with accommodation and age and determine possible applications in areas of anterior segment surgery, particularly implantation of refractive lenses...
  24. Shih C, Ritterband D, Palmiero P, Seedor J, Papachristou G, Harizman N, et al. The use of postoperative slit-lamp optical coherence tomography to predict primary failure in descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2009;147:796-800, 800.e1 pubmed publisher
  25. Robertson J, Golesic E, Gauldie J, West Mays J. Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats. Invest Ophthalmol Vis Sci. 2010;51:308-18 pubmed publisher
    ..Gene transfer of TGF-beta can, therefore, be used to induce anatomic changes in the anterior segment in a rodent model that result in ocular hypertension...
  26. See J. Imaging of the anterior segment in glaucoma. Clin Exp Ophthalmol. 2009;37:506-13 pubmed publisher
    ..The aim of this paper is to review the anterior segment imaging technologies that are currently available...
  27. Murphy T, Saleem R, Footz T, Ritch R, McGillivray B, Walter M. The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions. Invest Ophthalmol Vis Sci. 2004;45:2531-8 pubmed
    ..To determine the biochemical defects that underlie Axenfeld-Rieger malformations, to determine a functional role for wing 2 in FOXC1, and to understand how mutations in this region disrupt FOXC1 function...
  28. Addison P, Berry V, Ionides A, Francis P, Bhattacharya S, Moore A. Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. Br J Ophthalmol. 2005;89:138-41 pubmed
    ..The authors recently identified three large genetically unrelated families with an identical 17 base pair duplication mutation in exon 4 of the PITX3 gene. Here, they report the detailed clinical phenotype...
  29. Ciancaglini M, Carpineto P, Agnifili L, Nubile M, Lanzini M, Fasanella V, et al. Filtering bleb functionality: a clinical, anterior segment optical coherence tomography and in vivo confocal microscopy study. J Glaucoma. 2008;17:308-17 pubmed publisher
    ..To provide a microscopic and macroscopic analysis by a clinical, in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) assessment of filtering blebs after glaucoma surgery...
  30. Mamalis N, Edelhauser H, Dawson D, Chew J, LeBoyer R, Werner L. Toxic anterior segment syndrome. J Cataract Refract Surg. 2006;32:324-33 pubmed
    ..An outbreak of TASS is an environmental and toxic control issue that requires complete analysis of all medications and fluids used during surgery, as well as complete review of operating room and sterilization protocols...
  31. Dada T, Aggarwal A, Vanathi M, Gadia R, Panda A, Gupta V, et al. Ultrasound biomicroscopy in opaque grafts with post-penetrating keratoplasty glaucoma. Cornea. 2008;27:402-5 pubmed publisher
    ..To evaluate the anterior segment in opaque grafts with post-penetrating keratoplasty glaucoma (PPKG) by using ultrasound biomicroscopy (UBM)...
  32. Nolan W, See J, Aung T, Friedman D, Chan Y, Smith S, et al. Changes in angle configuration after phacoemulsification measured by anterior segment optical coherence tomography. J Glaucoma. 2008;17:455-9 pubmed publisher
    ..To measure changes in angle width after phacoemulsification and intraocular lens (IOL) implantation using anterior segment optical coherence tomography (AS-OCT)...
  33. Camelo S, Shanley A, Voon A, McMenamin P. An intravital and confocal microscopic study of the distribution of intracameral antigen in the aqueous outflow pathways and limbus of the rat eye. Exp Eye Res. 2004;79:455-64 pubmed
    ..In conclusion our data reveal that the majority of intracamerally injected soluble Ag retained in the eye is taken up by resident macrophages not only in the iris but in all tissues lining the AC of the eye...
  34. Idrees F, Vaideanu D, Fraser S, Sowden J, Khaw P. A review of anterior segment dysgeneses. Surv Ophthalmol. 2006;51:213-31 pubmed
    ..We also suggest a new approach to the classification of anterior segment dysgeneses, based upon the embryological contribution to the formation of the anterior segment of the eye...
  35. Weisschuh N, Dressler P, Schuettauf F, Wolf C, Wissinger B, Gramer E. Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations. Invest Ophthalmol Vis Sci. 2006;47:3846-52 pubmed
    ..To determine the prevalence of FOXC1 and PITX2 mutations and to assess clinical phenotypes in a cohort of German patients with Axenfeld-Rieger malformations...
  36. Fontes B, Ambrosio R, Jardim D, Velarde G, Nose W. Corneal biomechanical metrics and anterior segment parameters in mild keratoconus. Ophthalmology. 2010;117:673-9 pubmed publisher
  37. Baikoff G. Anterior segment OCT and phakic intraocular lenses: a perspective. J Cataract Refract Surg. 2006;32:1827-35 pubmed
    ..It is difficult to know the posterior chamber's exact diameter as it varies with the horizontal or vertical axis. It also undergoes constant modifications due to accommodation and aging...
  38. Ramani K, Mani B, Ronnie G, Joseph R, Lingam V. Gender variation in ocular biometry and ultrasound biomicroscopy of primary angle closure suspects and normal eyes. J Glaucoma. 2007;16:122-8 pubmed
    ..To compare A-scan biometry and ultrasound biomicroscopy of primary angle closure suspects (PACS) with age-matched normal Indian eyes...
  39. Shankar H, Taranath D, Santhirathelagan C, Pesudovs K. Anterior segment biometry with the Pentacam: comprehensive assessment of repeatability of automated measurements. J Cataract Refract Surg. 2008;34:103-13 pubmed publisher
    ..To comprehensively assess the reliability of automated Pentacam (Oculus, Inc.) measurements...
  40. Strungaru M, Dinu I, Walter M. Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations. Invest Ophthalmol Vis Sci. 2007;48:228-37 pubmed
    ..To improve the understanding of Axenfeld-Rieger Malformation (ARM)-associated glaucoma and to determine the best glaucoma treatment for patients with ARM who have known genetic defects in FOXC1 or PITX2...
  41. Park S, Kim H, Heo H, Park Y. Anomalous scleral insertion of superior oblique in Axenfeld-Rieger syndrome. Korean J Ophthalmol. 2009;23:62-4 pubmed publisher
    ..During surgery we observed that the SO inserted more posteriorly than normal. We believe this finding is one of the abnormal manifestations of the development of the extraocular muscles in ARS...
  42. Prakash G, Ashokumar D, Jacob S, Kumar K, Agarwal A, Agarwal A. Anterior segment optical coherence tomography-aided diagnosis and primary posterior chamber intraocular lens implantation with fibrin glue in traumatic phacocele with scleral perforation. J Cataract Refract Surg. 2009;35:782-4 pubmed publisher
    ..To our knowledge, this is the first report of successful implantation of a glued IOL as a primary procedure combined with scleral perforation repair...
  43. Volkmann B, Zinkevich N, Mustonen A, Schilter K, Bosenko D, Reis L, et al. Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. Invest Ophthalmol Vis Sci. 2011;52:1450-9 pubmed publisher
    ..Identification of cis-regulatory elements of PITX2 is important to better understand the mechanisms of disease...
  44. Gabelt B, Hu Y, Vittitow J, Rasmussen C, Grosheva I, Bershadsky A, et al. Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp Eye Res. 2006;82:935-44 pubmed
    ..This suggests that over-expression of the caldesmon gene in the TM may be an effective approach for the gene therapy of glaucoma...
  45. Console J, Sakata L, Aung T, Friedman D, He M. Quantitative analysis of anterior segment optical coherence tomography images: the Zhongshan Angle Assessment Program. Br J Ophthalmol. 2008;92:1612-6 pubmed publisher
    ..To describe a new image analysis method and software for anterior chamber images obtained by the anterior-segment optical coherence tomography (AS-OCT) and to assess its intraobserver and interobserver measurement reproducibility...
  46. Ishikawa H. Anterior segment imaging for glaucoma: OCT or UBM?. Br J Ophthalmol. 2007;91:1420-1 pubmed
  47. Nolan W, See J, Chew P, Friedman D, Smith S, Radhakrishnan S, et al. Detection of primary angle closure using anterior segment optical coherence tomography in Asian eyes. Ophthalmology. 2007;114:33-9 pubmed
  48. Di Pascuale M, Prasher P, Schlecte C, Arey M, Bowman R, Cavanagh H, et al. Corneal deturgescence after Descemet stripping automated endothelial keratoplasty evaluated by Visante anterior segment optical coherence tomography. Am J Ophthalmol. 2009;148:32-7.e1 pubmed publisher
    ..To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA)...
  49. Nolan W. Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography. Curr Opin Ophthalmol. 2008;19:115-21 pubmed publisher
    ..This review will describe the two main anterior segment imaging modalities and summarize their applications, strengths and weaknesses...
  50. Winn B, Lin S, Hee M, Chiu C. Repair of descemet membrane detachments with the assistance of anterior segment optical coherence tomography. Arch Ophthalmol. 2008;126:730-2 pubmed publisher
  51. Challa P. Glaucoma genetics. Int Ophthalmol Clin. 2008;48:73-94 pubmed publisher
  52. Kucumen R, Yenerel N, Gorgun E, Kulacoglu D, Dinc U, Alimgil M. Anterior segment optical coherence tomography measurement of anterior chamber depth and angle changes after phacoemulsification and intraocular lens implantation. J Cataract Refract Surg. 2008;34:1694-8 pubmed publisher
    ..To use anterior segment optical coherence tomography (AS-OCT) to evaluate anterior chamber depth (ACD) and angle after phacoemulsification and intraocular lens (IOL) implantation...
  53. Su D, Friedman D, See J, Chew P, Chan Y, Nolan W, et al. Degree of angle closure and extent of peripheral anterior synechiae: an anterior segment OCT study. Br J Ophthalmol. 2008;92:103-7 pubmed
    ..To evaluate the relationship between angle width as determined by anterior segment optical coherence tomography (AS-OCT) and the presence of peripheral anterior synechiae (PAS)...