endolymphatic duct

Summary

Summary: The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.

Top Publications

  1. Varghese C, Scampion P, Das V, Gillespie J, Umapathy D. Enlarged vestibular aqueduct in two male siblings. Dev Med Child Neurol. 2002;44:706-11 pubmed
    ..MRI showed an enlarged endolymphatic duct and sac bilaterally in both children...
  2. Wada T, Fujisaki T, Satoh H, Takahashi S. Endolymphatic sac tumor located around semicircular canals. Auris Nasus Larynx. 2006;33:173-7 pubmed
    ..The tumor was highly suspected to have originated from the rugose portion of the endolymphatic sac or the endolymphatic duct, based on surgical and imaging studies...
  3. Colvin I, Beale T, Harrop Griffiths K. Long-term follow-up of hearing loss in children and young adults with enlarged vestibular aqueducts: relationship to radiologic findings and Pendred syndrome diagnosis. Laryngoscope. 2006;116:2027-36 pubmed
    ..The relationship between the hearing loss (HL) and the dimensions of the EVA, enlarged endolymphatic duct (EED), or enlarged endolymphatic sac (EES) was also investigated...
  4. Hofman R, Segenhout J, Buytaert J, Dirckx J, Wit H. Morphology and function of Bast's valve: additional insight in its functioning using 3D-reconstruction. Eur Arch Otorhinolaryngol. 2008;265:153-7 pubmed
    ..The shape of the duct at the utricular side is that of a flattened funnel. In the direction of the endolymphatic duct and sac this funnel runs into a very narrow duct. The valve itself has a rigid 'arch-like' configuration...
  5. Hultgård Ekwall A, Mayerl C, Rubin K, Wick G, Rask Andersen H. An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. J Assoc Res Otolaryngol. 2006;7:38-47 pubmed
    The human endolymphatic duct (ED) with encompassing interstitial connective tissue (CT) is believed to be important for endolymph resorption and fluid pressure regulation of the inner ear...
  6. Mancini F, Catalani M, Carru M, Monti B. History of Meniere's disease and its clinical presentation. Otolaryngol Clin North Am. 2002;35:565-80 pubmed
    ..mechanism of production/absorption of endolymph, which is mainly due to defective absorptive activity of the endolymphatic duct and sac. Hyperproduction of endolymph cannot be excluded in some cases...
  7. Sugiura M, Naganawa S, Sato E, Nakashima T. Visualization of a high protein concentration in the cochlea of a patient with a large endolymphatic duct and sac, using three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging. J Laryngol Otol. 2006;120:1084-6 pubmed
    ..To evaluate the inner ear of a patient with an enlarged vestibular aqueduct and acute hearing deterioration, using three-dimensional fluid-attenuated inversion recovery (3D FLAIR) magnetic resonance imaging (MRI)...
  8. Miyazaki H, Kobayashi T, Nakamura H, Funahashi J. Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct. Dev Growth Differ. 2006;48:429-38 pubmed
    ..In the otic vesicle, Gbx2 is expressed in the dorso-medial region including the endolymphatic duct, and Otx2 in the ventral region...
  9. Koesling S, Rasinski C, Amaya B. Imaging and clinical findings in large endolymphatic duct and sac syndrome. Eur J Radiol. 2006;57:54-62 pubmed
    Large endolymphatic duct and sac syndrome (LEDS) is known as the most common kind of inner ear malformations, which is radiologically detectable...

More Information

Publications62

  1. Glasker S, Lonser R, Tran M, Ikejiri B, Butman J, Zeng W, et al. Effects of VHL deficiency on endolymphatic duct and sac. Cancer Res. 2005;65:10847-53 pubmed
    ..In addition, we investigated effects of VHL deficiency on "tumor-free" endolymphatic duct and sac of VHL patients...
  2. Rask Andersen H, DeMott J, Bagger Sjoback D, Salt A. Morphological changes of the endolymphatic sac induced by microinjection of artificial endolymph into the cochlea. Hear Res. 1999;138:81-90 pubmed
    ..The exact mechanism governing these regulatory systems, and their relationship to ion and water movements across the epithelium of the sac, remain to be elucidated...
  3. Wit H, Hofman R. Does the endolymphatic sinus function as a one-way valve?. Hear Res. 2007;224:115-6 pubmed
  4. Lane J, Ward H, Witte R, Bernstein M, Driscoll C. 3-T imaging of the cochlear nerve and labyrinth in cochlear-implant candidates: 3D fast recovery fast spin-echo versus 3D constructive interference in the steady state techniques. AJNR Am J Neuroradiol. 2004;25:618-22 pubmed
    ..5 T is often performed by using three-dimensional (3D) fast spin-echo or T2* techniques. We evaluated both techniques at 3 T in the preoperative assessment of patients being considered for cochlear implants...
  5. Schmerber S, Lefournier V, Lavieille J, Boubagra K. Endolymphatic duct obstruction related to a jugular bulb diverticulum: high resolution CT and MR imaging findings. Clin Radiol. 2002;57:424-8 pubmed
  6. Zou Y, Zheng J, Ren T, Nuttall A. Cochlear transducer operating point adaptation. J Acoust Soc Am. 2006;119:2232-41 pubmed
    ..Removing the force induced recovery of the second harmonic to its normal level described by a single time constant. The force applied over the SV caused an opposite result. These data indicate an active mechanism for OHC transduction OP...
  7. Michaels L, Soucek S, Linthicum F. The intravestibular source of the vestibular aqueduct. II: its structure and function clarified by a developmental study of the intra-skeletal channels of the otic capsule. Acta Otolaryngol. 2010;130:420-8 pubmed publisher
    ..Chemical changes, possibly produced by breakdown of cells within the channels, may provide a homeostatic environment for the functions of hearing and balance that take place in the endolymphatic fluid...
  8. Teranishi M, Naganawa S, Katayama N, Sugiura M, Nakata S, Sone M, et al. Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo. Eur Arch Otorhinolaryngol. 2009;266:1871-7 pubmed publisher
    ..In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with fluctuating hearing loss without vertigo...
  9. Lacombe H. [Surgery for vertigo]. Neurochirurgie. 2009;55:268-71 pubmed publisher
  10. Sargent M. Diameter of the vestibular aqueduct. Pediatr Radiol. 2007;37:241 pubmed
  11. Lin Z, Cantos R, Patente M, Wu D. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development. 2005;132:2309-18 pubmed
    ..Here, we show that Gbx2 is required for the development of the mouse inner ear. Absence of the endolymphatic duct and swelling of the membranous labyrinth are common features in Gbx2-/- inner ears...
  12. Gibson W. Hypothetical mechanism for vertigo in Meniere's disease. Otolaryngol Clin North Am. 2010;43:1019-27 pubmed publisher
    ..anatomy, physiology, and pathophysiology of the inner ear, and in particular of the endolymphatic sac and endolymphatic duct are reviewed...
  13. Matsuoka I, Kurata K, Nishida Y, Ogata T, Iwasaki S, Ishizaki H. Effects of endolymphatic mastoid shunt operation for patients with Menière's disease. Acta Otolaryngol Suppl. 1989;468:105-16 pubmed
    ..4 dB; that for the patients with a short period of illness (within 23 months of the first onset to the operation) was 25.2 +/- 14.5 dB and that for the patients with a longer period of illness (over 24 months) was only 13.8 +/- 10.6 dB...
  14. Barbara M, Rask Andersen H, Bagger Sjoback D. Morphology of the endolymphatic duct and sac in the Mongolian gerbil. Acta Otolaryngol. 1988;105:31-8 pubmed
    A light microscopical study of the endolymphatic duct and sac of the Mongolian gerbil is presented...
  15. Kobayashi M, Tsunoda A, Akita K, Yamada I. Estimation of the endolymphatic sac and vestibular aqueduct using magnetic resonance imaging. Laryngoscope. 2003;113:1015-21 pubmed
    ..To evaluate the diagnostic accuracy of magnetic resonance imaging for assessment of the endolymphatic sac and vestibular aqueduct...
  16. Dimitrov E, Duckert L, Lonsbury Martin B, Martin G. The effect of cochleostomy on the development of endolymphatic hydrops--morphologic changes in the rabbit cochlea. Otolaryngol Head Neck Surg. 1988;98:283-90 pubmed
    ..Fistulization of the cochlear partition and simultaneous obstruction of the endolymphatic duct was performed in one group of animals (n = 13)...
  17. Nam B, Park C, Jung T. Early histopathologic changes after lateral semicircular canal transection and occlusion in guinea pigs. Ann Otol Rhinol Laryngol. 2002;111:402-6 pubmed
    ..These findings suggest that occlusion after semicircular canal injuries, by making blind ducts in the membranous endolymphatic canal, is important for the preservation of postoperative hearing...
  18. Pollak A. Otosclerosis associated with Ménière's disease: a histological study. Adv Otorhinolaryngol. 2007;65:50-2 pubmed
    ..Severe endolympathic hydrops results from otosclerotic endolympahtic duct occlusion. Our unique histopathological findings show that a causal association exists between these two entities...
  19. Kim S, Kim U, Lee W, Bok J, Song J, Seong J, et al. Albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic sac. PLoS ONE. 2011;6:e21656 pubmed publisher
    ..endolymphatic sac (ES) is an inner ear organ that is connected to the cochleo-vestibular system through the endolymphatic duct. The luminal fluid of the ES contains a much higher concentration of proteins than any other compartment of ..
  20. Ye Y. [Experimental endolymphatic hydrops and its related morphological and functional changes in guinea pigs]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990;12:84-9 pubmed
    The endolymphatic hydrops was induced successfully in 13 guinea pigs by blocking the endolymphatic duct and sac, and the morphological and functional alterations (especially on semicircular canal function) after hydrops were studied by ..
  21. de Groot J, Veldman J. Early effects of gentamicin on inner ear glycocalyx cytochemistry. Hear Res. 1988;35:39-45 pubmed
    ..Cationized ferritin reactivity of the perilymphatic and endolymphatic glycocalyx was not significantly influenced. The cytochemistry of the inner ear glycocalyx and the possible biochemical changes induced by gentamicin are discussed...
  22. Michaels L, Soucek S, Linthicum F. The intravestibular source of the vestibular aqueduct: Its structure and pathology in Ménière's disease. Acta Otolaryngol. 2009;129:592-601 pubmed publisher
    We describe a thin, highly vascular layer of mineralized cartilage, which surrounds most of the endolymphatic duct. In the normal ear this may act in helping to control the chemical composition of endolymph...
  23. Ahmad M, Bohne B, Harding G. An in vivo tracer study of noise-induced damage to the reticular lamina. Hear Res. 2003;175:82-100 pubmed
  24. Bartel Friedrich S, Fuchs M, Amaya B, Rasinski C, Meuret S, Kösling S. [Large endolymphatic duct and sac syndrome : part 2: clinical manifestations]. HNO. 2008;56:225-30 pubmed publisher
    The aim of this study was to clarify the clinical course of large endolymphatic duct and sac syndrome (LEDS)...
  25. Megerian C, Semaan M, Aftab S, Kisley L, Zheng Q, Pawlowski K, et al. A mouse model with postnatal endolymphatic hydrops and hearing loss. Hear Res. 2008;237:90-105 pubmed publisher
    ..and (b) the development of ELH in the Phex Hyp-Duk/Y mouse is associated with obstruction of the endolymphatic duct (ED) due to thickening of the surrounding bone...
  26. Zou D, Silvius D, Rodrigo Blomqvist S, Enerback S, Xu P. Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev Biol. 2006;298:430-41 pubmed
  27. Wangemann P, Nakaya K, Wu T, Maganti R, Itza E, Sanneman J, et al. Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2007;292:F1345-53 pubmed
    ..Degeneration of the hair cells closes a window of opportunity to restore the normal development of hearing in Slc26a4(-/-) mice and possibly human patients suffering from Pendred syndrome...
  28. Shimizu S, Tanaka R, Oka H, Fujii K. Risk of damage to the endolymphatic sac and duct during removal of the posterior meatal wall: an anatomic study. Neurosurgery. 2006;59:ONS435-9; discussion ONS439-40 pubmed
    ..The authors performed an anatomic study to clarify the risk of damage to the endolymphatic sac and endolymphatic duct during this maneuver.
  29. Oh S, Choi B, Son K, Lee K, Chang S, Kim C. Can magnetic resonance imaging provide clues to the inner ear functional status of enlarged vestibular aqueduct subjects with PDS mutation?. Otol Neurotol. 2008;29:593-600 pubmed publisher
    The goal of this study was to characterize the signal intensity (SI) pattern in the endolymphatic duct/sac from T2-weighted spin echo magnetic resonance (MR) images and T2*-weighted 3-dimensional (3-D) constructive interference in steady ..
  30. Seibert C, Dreisbach J, Arenberg I. CT imaging of radiopaque shunt catheter after endolymphatic duct surgery. Am J Otol. 1996;17:81-4 pubmed
    ..underwent endolymphatic system decompressive surgery with a new opaque shunt catheter placed at or into the endolymphatic duct (ELD)...
  31. Okubo H, Tachihara N, Satoh S, Hara A, Kusakari J. Effect of isosorbide on distortion-product otoacoustic emissions and endocochlear DC potential in experimentally induced hydropic ears. Acta Otolaryngol Suppl. 1997;528:59-62 pubmed
    ..DPOAEs and EP in the hydropic ears decreased after obliteration of the endolymphatic duct and sac...
  32. Shinomori Y, Spack D, Jones D, Kimura R. Volumetric and dimensional analysis of the guinea pig inner ear. Ann Otol Rhinol Laryngol. 2001;110:91-8 pubmed
    ..691 mm3, of which 1.501 mm3 was in the cochlea, 3.090 mm3 in the vestibular labyrinth, and 0.100 mm3 in the endolymphatic duct and sac. The total perilymph volume was 15.938 mm3, of which 8.867 mm3 was in the cochlea and 7...
  33. Sawada S, Takeda T, Kitano H, Takeuchi S, Kakigi A, Azuma H. Aquaporin-2 regulation by vasopressin in the rat inner ear. Neuroreport. 2002;13:1127-9 pubmed
    ..We speculate that over-expression of AQP2 may be involved in the formation of endolymphatic hydrops...
  34. Vendrell V, Vázquez Echeverría C, López Hernández I, Alonso B, Martinez S, Pujades C, et al. Roles of Wnt8a during formation and patterning of the mouse inner ear. Mech Dev. 2013;130:160-8 pubmed publisher
    ..Further reduction of Wnt signalling by the inactivation of Wnt1 in a Wnt8a mutant background revealed a redundant requirement for both genes during morphogenesis of the dorsal portion of the otic vesicle...
  35. Becvarovski Z, Zappia J. The ZB mastoid oscillation protocol (ZBMOP) in Meniere's disease and ductolithiasis. Otolaryngol Head Neck Surg. 2002;127:491-2; author reply 492 pubmed
  36. Shimizu S, Cureoglu S, Yoda S, Suzuki M, Paparella M. Blockage of longitudinal flow in Meniere's disease: A human temporal bone study. Acta Otolaryngol. 2011;131:263-8 pubmed publisher
    Blockage of the endolymphatic duct is a significant finding in Meniere's disease...
  37. Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Sato E, Sugiura M, et al. Enlarged endolymphatic duct and sac syndrome: relationship between MR findings and genotype of mutation in Pendred syndrome gene. Magn Reson Imaging. 2004;22:25-30 pubmed
    ..PDS is often associated with enlarged endolymphatic duct and sac (EEDS), and recently, PDS gene mutations have been reported even in those patients with EEDS without ..
  38. Nabi S, Parnes L. Bilateral Ménière's disease. Curr Opin Otolaryngol Head Neck Surg. 2009;17:356-62 pubmed publisher
    ..This study reviews the most up-to-date concepts in its diagnosis and treatment, with a special focus on recent advances...
  39. Ma X, Yang Y, Xia M, Li D, Xu A. Computed tomography findings in large vestibular aqueduct syndrome. Acta Otolaryngol. 2009;129:700-8 pubmed publisher
    ..Patients with large vestibular aqueduct syndrome (LVAS) have disturbed morphogenesis of bony labyrinth. Semicircular canal anomalies are common in LVAS...
  40. Linthicum F, DOHERTY J, Webster P, Makarem A. The periductal channels of the endolymphatic duct, hydrodynamic implications. Otolaryngol Head Neck Surg. 2014;150:441-7 pubmed publisher
    To describe the anatomy of a small network of channels surrounding the human endolymphatic duct.
  41. Berlinger N. Meniere's disease: new concepts, new treatments. Minn Med. 2011;94:33-6 pubmed
    ..This article describes the new thinking about Meniere's and explains why current treatment approaches, although they are based on outdated understanding, may still be valuable for alleviating symptoms in some patients...
  42. Akagi N, Takumida M, Anniko M. Effect of inner ear blood flow changes on the endolymphatic sac. Acta Otolaryngol. 2008;128:1187-95 pubmed publisher
    ..That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure...
  43. Legeais M, Haguenoer K, Cottier J, Sirinelli D. Can a fixed measure serve as a pertinent diagnostic criterion for large vestibular aqueduct in children?. Pediatr Radiol. 2006;36:1037-42 pubmed
    ..A vestibular aqueduct midpoint width greater than 1.50 mm is currently considered to be pathognomonic for a large vestibular aqueduct syndrome...
  44. Steinbach S, Brockmeier S, Kiefer J. The large vestibular aqueduct--case report and review of the literature. Acta Otolaryngol. 2006;126:788-95 pubmed
    ..At the age of 18 years, LVA was confirmed radiologically, revealing an enlarged endolymphatic duct and sac in MRI scans and an enlarged vestibular aqueduct in the CT scan...
  45. Thomsen J, Sass K, Odkvist L, Arlinger S. Local overpressure treatment reduces vestibular symptoms in patients with Meniere's disease: a clinical, randomized, multicenter, double-blind, placebo-controlled study. Otol Neurotol. 2005;26:68-73 pubmed
    ..2 kPa, the pressure oscillates between 0.4 and 1.2 kPa. It is believed that the pressure changes are conveyed to the inner ear, inducing a transport of fluids via the pressure outlets and thus reducing the endolymphatic hydrops...
  46. Gerlach Bank L, Cleveland A, Barald K. DAN directs endolymphatic sac and duct outgrowth in the avian inner ear. Dev Dyn. 2004;229:219-30 pubmed
    ..Unique to the DAN implantations, however, were effects on the developing endolymphatic duct and sac...
  47. Hultgård Ekwall A, Couloigner V, Rubin K, Rask Andersen H. Network organization of interstitial connective tissue cells in the human endolymphatic duct. J Histochem Cytochem. 2003;51:1491-500 pubmed
    The human endolymphatic duct (ED) and sac of the inner ear have been suggested to control endolymph volume and pressure. However, the physiological mechanisms for these processes remain obscure...
  48. Huang T. Three new surgeries for treatment of intractable Meniere's disease. Am J Otol. 1999;20:233-7 pubmed
    ..for the treatment of intractable Meniere's disease, all involving insertion of a capillary tube into the endolymphatic duct. This study also aimed to compare the contrasting surgical strategies of endolymphatic sac enhancement ..
  49. Takumida M, Akagi N, Anniko M. A new animal model for Ménière's disease. Acta Otolaryngol. 2008;128:263-71 pubmed
    ..Induction of vestibular dysfunction in the hydropic animal model may entail additional stress such as reduced inner ear blood flow, and sudden acute changes in endolymph volume and/or pressure...
  50. Megerian C, Semaan M. Evaluation and management of endolymphatic sac and duct tumors. Otolaryngol Clin North Am. 2007;40:463-78, viii pubmed
    ..This article describes the latest rationale and techniques for hearing preservation surgery and a review of the latest developments surrounding this disease entity...
  51. Tran Ba Huy P. ["Endolymphatic" cochleo-vestibular disorders]. Rev Laryngol Otol Rhinol (Bord). 2005;126:217-22 pubmed
    ..We hope that in the next years new investigation tools will allow to explore in a noninvasive way the endolymphatic contents and dysfunctions of these structures...
  52. Ciric I, Zhao J, Rosenblatt S, Wiet R, O Shaughnessy B. Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation. Neurosurgery. 2005;56:560-70; discussion 560-70 pubmed
    ..Positive prognostic factors for hearing preservation are also highlighted...
  53. Yamane H, Takayama M, Sunami K, Sakamoto H, Imoto T, Anniko M. Visualization and assessment of saccular duct and endolymphatic sinus. Acta Otolaryngol. 2011;131:469-73 pubmed publisher
    ..This strategy can be useful to assess the condition of the saccular duct and endolymphatic sinus concerning the longitudinal flow system of endolymph...