otolithic membrane

Summary

Summary: A gelatinous membrane overlying the acoustic maculae of SACCULE AND UTRICLE. It contains minute crystalline particles (otoliths) of CALCIUM CARBONATE and protein on its outer surface. In response to head movement, the otoliths shift causing distortion of the vestibular hair cells which transduce nerve signals to the BRAIN for interpretation of equilibrium.

Top Publications

  1. Lu W, Zhou D, Freeman J, Thalmann I, Ornitz D, Thalmann R. In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure. Hear Res. 2010;268:172-83 pubmed publisher
  2. Strimbu C, Ramunno Johnson D, Fredrickson L, Arisaka K, Bozovic D. Correlated movement of hair bundles coupled to the otolithic membrane in the bullfrog sacculus. Hear Res. 2009;256:58-63 pubmed publisher
    ..To maintain the natural degree of intercell coupling, the overlying otolithic membrane was left intact atop the in vitro preparation...
  3. Checkley D, Dickson A, Takahashi M, Radich J, Eisenkolb N, Asch R. Elevated CO2 enhances otolith growth in young fish. Science. 2009;324:1683 pubmed publisher
    ..We hypothesize that CO2 moves freely through the epithelium around the otoliths in young fish, accelerating otolith growth while the local pH is controlled. This is the converse of the effect commonly reported for structural biominerals...
  4. Strimbu C, Kao A, Tokuda J, Ramunno Johnson D, Bozovic D. Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculus. Hear Res. 2010;265:38-45 pubmed publisher
    ..under more natural loading conditions, innate oscillations are suppressed by the presence of the overlying otolithic membrane, indicating that hair bundles lie in the quiescent rather than the unstable regime...
  5. Walker M, Tian J, Shan X, Tamargo R, Ying H, Zee D. Lesions of the cerebellar nodulus and uvula in monkeys: effect on otolith-ocular reflexes. Prog Brain Res. 2008;171:167-72 pubmed publisher
  6. Yamane H, Sunami K, Iguchi H, Sakamoto H, Imoto T, Rask Andersen H. Assessment of Meniere's disease from a radiological aspect - saccular otoconia as a cause of Meniere's disease?. Acta Otolaryngol. 2012;132:1054-60 pubmed
    ..These structures could be involved in the pathogenesis of MD...
  7. Zhao X, Jones S, Thoreson W, Lundberg Y. Osteopontin is not critical for otoconia formation or balance function. J Assoc Res Otolaryngol. 2008;9:191-201 pubmed publisher
    ..When compared with findings on other otoconins, the data manifest a hierarchy of importance of proteins in crystallization and indicate mechanistic similarities and differences between bone and otoconia calcification...
  8. Jones T, Jones S, Hoffman L. Resting discharge patterns of macular primary afferents in otoconia-deficient mice. J Assoc Res Otolaryngol. 2008;9:490-505 pubmed publisher
    ..The robust discharge rates are interesting in that they may reflect the presence of a functionally 'up-regulated' tonic excitatory process in the absence of natural sensory stimulation...
  9. Lambert F, Beck J, Baker R, Straka H. Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval Xenopus. J Neurosci. 2008;28:8086-95 pubmed publisher

More Information

Publications62

  1. Iwasaki S, Chihara Y, Smulders Y, Burgess A, Halmagyi G, Curthoys I, et al. The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz. Clin Neurophysiol. 2009;120:588-93 pubmed publisher
    ..If the n10 is due primarily to utricular activation then diseases which affect only the superior division of the vestibular nerve (SVN) should reduce or eliminate n10...
  2. Petko J, Millimaki B, Canfield V, Riley B, Levenson R. Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish. Dev Neurobiol. 2008;68:209-22 pubmed
    ..Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths...
  3. Zhao X, Yang H, Yamoah E, Lundberg Y. Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix. Dev Biol. 2007;304:508-24 pubmed
    ..Our data demonstrate the critical roles of otoconins in otoconia seeding, growth and anchoring and suggest mechanistic similarities and differences between otoconia and bone calcification...
  4. Hoffman L, Ross M, Varelas J, Jones S, Jones T. Afferent synapses are present in utricular hair cells from otoconia-deficient mice. Hear Res. 2006;222:35-42 pubmed
    ..These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity...
  5. Yamane H, Takayama M, Sunami K, Sakamoto H, Imoto T, Anniko M. Blockage of reuniting duct in Meniere's disease. Acta Otolaryngol. 2010;130:233-9 pubmed publisher
  6. Xu Y, Zhang H, Yang H, Zhao X, Lovas S, Lundberg Y. Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn. 2010;239:2659-73 pubmed publisher
    ..Analysis and modeling of Oc90 and Sc1 protein structures show common features that may be critical requirements for the otoconial matrix backbone protein. Such information will serve as the foundation for future regenerative purposes...
  7. Thalmann R, Thalmann I, Lu W. Significance of tertiary conformation of otoconial matrix proteins - clinical implications. Acta Otolaryngol. 2011;131:382-90 pubmed publisher
    ..Co-option of the enzyme secretory phospholipase A2 (sPLA2) and adoption of tertiary conformation are essential factors in the multifunctionality of otoconin 90 (OC90) and homologous modulators...
  8. Calzada A, Lopez I, Ishiyama G, Ishiyama A. Otolithic membrane damage in patients with endolymphatic hydrops and drop attacks. Otol Neurotol. 2012;33:1593-8 pubmed publisher
    1. Evaluate the otolithic membrane in patients with endolymphatic hydrops (EH) and vestibular drop attacks (VDA) undergoing ablative labyrinthectomy. 2...
  9. Yoder R, Taube J. Head direction cell activity in mice: robust directional signal depends on intact otolith organs. J Neurosci. 2009;29:1061-76 pubmed publisher
    ..Furthermore, compared with rats, the HD signal in mice appears to be less reliably anchored to prominent environmental cues...
  10. Valli P, Botta L, Zucca G, Valli S, Buizza A. Simulation of cupulolithiasis and canalolithiasis by an animal model. J Vestib Res. 2008;18:89-96 pubmed
  11. Rooker J, Secor D, De Metrio G, Schloesser R, Block B, Neilson J. Natal homing and connectivity in Atlantic bluefin tuna populations. Science. 2008;322:742-4 pubmed publisher
    ..The largest (oldest) bluefin tuna collected near the northern extent of their range in North American waters were almost exclusively of western origin, indicating that this region represents critical habitat for the western population...
  12. Colantonio J, Vermot J, Wu D, Langenbacher A, Fraser S, Chen J, et al. The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature. 2009;457:205-9 pubmed publisher
    ..These results demonstrate a requirement for the dynein regulatory complex in vertebrates and show that cilia-driven flow is a key epigenetic factor in controlling otolith biomineralization...
  13. Whitfield T, Granato M, van Eeden F, Schach U, Brand M, Furutani Seiki M, et al. Mutations affecting development of the zebrafish inner ear and lateral line. Development. 1996;123:241-54 pubmed
    ..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
  14. Maruta J, Simpson J, Raphan T, Cohen B. Orienting otolith-ocular reflexes in the rabbit during static and dynamic tilts and off-vertical axis rotation. Vision Res. 2001;41:3255-70 pubmed
    ..Semicircular canal input broadened the band-pass of these orienting reflexes, which would make them more appropriate when compensating for head movement during active motion...
  15. Murayama E, Takagi Y, Nagasawa H. Immunohistochemical localization of two otolith matrix proteins in the otolith and inner ear of the rainbow trout, Oncorhynchus mykiss: comparative aspects between the adult inner ear and embryonic otocysts. Histochem Cell Biol. 2004;121:155-66 pubmed publisher
    ..These results indicate that these proteins are required as essential components for otolith formation and calcification...
  16. Lu Z, Popper A. Morphological polarizations of sensory hair cells in the three otolithic organs of a teleost fish: fluorescent imaging of ciliary bundles. Hear Res. 1998;126:47-57 pubmed
    ..Thus, the sleeper goby's ear is morphologically capable of being a three-dimensional sound detector...
  17. Thorrold S, Latkoczy C, Swart P, Jones C. Natal homing in a marine fish metapopulation. Science. 2001;291:297-9 pubmed
    ..Our findings highlight the need for consideration of spatial processes in fisheries models and have implications for the design of marine reserves in coastal regions...
  18. Uchino Y, Sasaki M, Sato H, Bai R, Kawamoto E. Otolith and canal integration on single vestibular neurons in cats. Exp Brain Res. 2005;164:271-85 pubmed
    ..Some of the convergent neurons that receive both canal and otolith input may contribute to the short-latency pathway of the vestibulocollic reflex. The functional significance of these convergences is discussed...
  19. Buttner Ennever J. A review of otolith pathways to brainstem and cerebellum. Ann N Y Acad Sci. 1999;871:51-64 pubmed
    ..The graviceptive information could be channeled by the cerebellar efferents back to the vestibular and inferior olive complex, or fed into ascending pathways that would innervate the mescencephalon, the thalamus, and cerebral cortex...
  20. Blasiole B, Canfield V, Vollrath M, Huss D, Mohideen M, Dickman J, et al. Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Dev Biol. 2006;294:148-60 pubmed
    ..Our results highlight zebrafish gene knockdown-mRNA rescue as an approach that can be used to dissect the functional properties of zebrafish and mammalian Na,K-ATPase genes...
  21. Thalmann I, Hughes I, Tong B, Ornitz D, Thalmann R. Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti. Electrophoresis. 2006;27:1598-608 pubmed
    ..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
  22. Musallam S, Tomlinson R. Asymmetric integration recorded from vestibular-only cells in response to position transients. J Neurophysiol. 2002;88:2104-13 pubmed
    ..Instead a neuron with a long membrane time constant and an excitatory postsynaptic potential duration that increases with the firing rate of the presynaptic cell can emulate the observed behavior...
  23. Verpy E, Leibovici M, Petit C. Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals. Proc Natl Acad Sci U S A. 1999;96:529-34 pubmed
    ..In addition, multiple isoforms generated by differential splicing were observed in different combinations during development. Based on the present results, we propose a model for the formation of the otoconia...
  24. Moore S, Clement G, Dai M, Raphan T, Solomon D, Cohen B. Ocular and perceptual responses to linear acceleration in microgravity: alterations in otolith function on the COSMOS and Neurolab flights. J Vestib Res. 2003;13:377-93 pubmed
    ..The findings also raise the possibility that 'artificial gravity' during the Neurolab flight counteracted adaptation of these otolith-ocular responses...
  25. Wiest G, Tian J, Baloh R, Crane B, Demer J. Otolith function in cerebellar ataxia due to mutations in the calcium channel gene CACNA1A. Brain. 2001;124:2407-16 pubmed
    ..These findings suggest a critical role of the cerebellum in the modulation of otolith-ocular signals that is independent of motor vergence...
  26. Thalmann R, Ignatova E, Kachar B, Ornitz D, Thalmann I. Development and maintenance of otoconia: biochemical considerations. Ann N Y Acad Sci. 2001;942:162-78 pubmed
  27. Straka H, Holler S, Goto F. Patterns of canal and otolith afferent input convergence in frog second-order vestibular neurons. J Neurophysiol. 2002;88:2287-301 pubmed
    ..Comparison of data from frog and cat demonstrated the presence of a similar organization pattern of maculo- and canal-ocular reflexes in both species...
  28. Jones S, Erway L, Johnson K, Yu H, Jones T. Gravity receptor function in mice with graded otoconial deficiencies. Hear Res. 2004;191:34-40 pubmed
    ..It also shows that behavior alone may be an unreliable indicator of the extent of gravity receptor deficits...
  29. Murayama E, Herbomel P, Kawakami A, Takeda H, Nagasawa H. Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mech Dev. 2005;122:791-803 pubmed
  30. Pisam M, Jammet C, Laurent D. First steps of otolith formation of the zebrafish: role of glycogen?. Cell Tissue Res. 2002;310:163-8 pubmed
    ..As a result, glycogen might play a key role in initiating the formation of otoliths and possibly that of other calcified tissues...
  31. Wang Y, Kowalski P, Thalmann I, Ornitz D, Mager D, Thalmann R. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. Proc Natl Acad Sci U S A. 1998;95:15345-50 pubmed
    ..The cloning of Oc90 will allow an examination of the role of this protein in otoconial biosynthesis and in diseases that affect the vestibular system...
  32. Riley B, Zhu C, Janetopoulos C, Aufderheide K. A critical period of ear development controlled by distinct populations of ciliated cells in the zebrafish. Dev Biol. 1997;191:191-201 pubmed
    ..5 to 24 h, and that interfering with the functions of tether cell kinocilia or beating cilia impairs otolith seeding and subsequent otolith morphogenesis...
  33. Hughes I, Thalmann I, Thalmann R, Ornitz D. Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res. 2006;1091:58-74 pubmed
  34. Green A, Angelaki D. Resolution of sensory ambiguities for gaze stabilization requires a second neural integrator. J Neurosci. 2003;23:9265-75 pubmed
  35. Serrador J, Wood S, Picot P, Stein F, Kassam M, Bondar R, et al. Effect of acute exposure to hypergravity (GX vs. GZ) on dynamic cerebral autoregulation. J Appl Physiol (1985). 2001;91:1986-94 pubmed
    ..We speculate that this leftward shift may have been due to vestibular activation (especially during +GX) or potentially to an adaptation to reduced cerebral perfusion pressure during +GZ...
  36. Sand O, Karlsen H. Detection of infrasound and linear acceleration in fishes. Philos Trans R Soc Lond B Biol Sci. 2000;355:1295-8 pubmed
    ..Sensitivity to infrasound may be a widespread ability among aquatic organisms, and has also been reported in cephalopods and crustaceans...
  37. Bergstrom R, You Y, Erway L, Lyon M, Schimenti J. Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics. 1998;150:815-22 pubmed
    ..This approach demonstrates the utility of chromosome deletions as reagents for mapping and characterizing mutations, particularly in situations where recombinational mapping is inadequate...
  38. Curthoys I, Kim J, McPhedran S, Camp A. Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pig. Exp Brain Res. 2006;175:256-67 pubmed
    ..The BCV generates compressional and shear waves, which travel through the skull and constitute head accelerations, which are sufficient to stimulate the most sensitive otolithic receptor cells...
  39. Andreescu C, de Ruiter M, De Zeeuw C, de Jeu M. Otolith deprivation induces optokinetic compensation. J Neurophysiol. 2005;94:3487-96 pubmed
  40. Ramcharitar J, Deng X, Ketten D, Popper A. Form and function in the unique inner ear of a teleost: the silver perch (Bairdiella chrysoura). J Comp Neurol. 2004;475:531-9 pubmed
    ..The findings of this study support the proposal that sciaenids are excellent model species for investigating structure-function relations in the teleost auditory system...
  41. Wood S. Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness. Neurosci Lett. 2002;323:41-4 pubmed
    ..3 Hz is the result of frequency segregation of ambiguous otolith information being inadequate to distinguish between tilt and translation...
  42. Riley B, Moorman S. Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish. J Neurobiol. 2000;43:329-37 pubmed
    ..The presence of a utricular otolith in at least one inner ear is necessary and sufficient for vestibular function and survival. In contrast, saccular otoliths are dispensable for these functions...
  43. Bever M, Jean Y, Fekete D. Three-dimensional morphology of inner ear development in Xenopus laevis. Dev Dyn. 2003;227:422-30 pubmed
  44. Ornitz D, Bohne B, Thalmann I, Harding G, Thalmann R. Otoconial agenesis in tilted mutant mice. Hear Res. 1998;122:60-70 pubmed
    ..We further demonstrate that protein expression in the macular sensory epithelium is qualitatively unaltered in tilted mutant mice...
  45. Steffen H. [Diagnosis of supranuclear eye movement disorders. Part II: Vertical and torsional oculomotoricity]. Ophthalmologe. 2006;103:977-88; quiz 989. pubmed
    ..Examination of eye movements is thus a valuable clinical tool in many neurological and neuro-ophthalmological diseases...
  46. Morales Nin B, Grau A, PĂ©rez Mayol S, Pastor E, Palmer M. Oxytetracycline hydrochloride vital labelling revisited: the case of Dicentrarchus labrax and Diplodus puntazzo. J Fish Biol. 2011;78:762-82 pubmed publisher
    ..Species-specific experiments for assessing the long-term mortality should be undertaken when OTC marking is used on wild fishes...
  47. Friedrich L, Halden N. Laser ablation inductively coupled plasma mass spectrometric analyses of base metals in arctic char (Salvelinus alpinus) otoliths collected from a flooded base metal mine. Environ Sci Technol. 2011;45:4256-61 pubmed publisher
    ..The chemical record retained within otoliths provides a method of monitoring trace elements affecting fish on a yearly basis and may be regarded as a useful assessment tool for examining the exposure of wild organisms to trace elements...
  48. Huh Y, Koo J, Lee H, Kim J. Head-shaking aids in the diagnosis of acute audiovestibular loss due to anterior inferior cerebellar artery infarction. Audiol Neurootol. 2013;18:114-24 pubmed publisher
    ..To determine the patterns and diagnostic value of head-shaking nystagmus (HSN) in patients with acute audiovestibular loss...
  49. Harada Y. The relation between the migration function of birds and fishes and their lagenal function. Acta Otolaryngol. 2008;128:432-9 pubmed publisher
    ..The lagena of pigeons may have a navigational function as a geomagnetic sensor...
  50. Kondrachuk A, Shipov A, Astakhova T, Boil R. [Modeling of the Otolith's structure and functions]. Aviakosm Ekolog Med. 2006;40:5-21 pubmed
    ..The review is dedicated to these models and their applicability to demonstrate the variety of processes associated with the otolith...
  51. Paddack M, Sponaugle S, Cowen R. Small-scale demographic variation in the stoplight parrotfish Sparisoma viride. J Fish Biol. 2009;75:2509-26 pubmed publisher
    ..viride from Caribbean reefs but differed significantly from published values from reefs at a similar latitude (Bahamas), reflecting high demographic plasticity on both local and regional scales...
  52. Han Y, Mu Y, Li X, Xu P, Tong J, Liu Z, et al. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Hum Mol Genet. 2011;20:3213-26 pubmed publisher
    ..Thus, this work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss...
  53. Caron A, Xu X, Lin X. Wnt/?-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012;139:514-24 pubmed publisher
    ..Moreover, our results also prompt a hypothesis that certain developmental effects of the Wnt/?-catenin pathway are due to the activation of Foxj1 and cilia formation...