labyrinth supporting cells

Summary

Summary: Cells forming a framework supporting the sensory AUDITORY HAIR CELLS in the organ of Corti. Lateral to the medial inner hair cells, there are inner pillar cells, outer pillar cells, Deiters cells, Hensens cells, Claudius cells, Boettchers cells, and others.

Top Publications

  1. Zhao H, Yu N. Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs. J Comp Neurol. 2006;499:506-18 pubmed
    ..This further supports our previous reports that Cx26 and Cx30 can solely and concertedly perform different functions in the cochlea...
  2. Raphael Y, Kim Y, Osumi Y, Izumikawa M. Non-sensory cells in the deafened organ of Corti: approaches for repair. Int J Dev Biol. 2007;51:649-54 pubmed
    ..The mitotic potential of these cells should facilitate production of cells for therapies based on recapitulation of development or insertion of stem cells...
  3. Stone J, Cotanche D. Hair cell regeneration in the avian auditory epithelium. Int J Dev Biol. 2007;51:633-47 pubmed
    ..The continued study of mechanisms controlling regeneration in the avian auditory epithelium may lead to strategies for inducing significant and functional regeneration in mammals...
  4. Burns J, Burns J, Christophel J, Collado M, Magnus C, Carfrae M, et al. Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds. J Comp Neurol. 2008;511:396-414 pubmed publisher
  5. Oesterle E, Campbell S. Supporting cell characteristics in long-deafened aged mouse ears. J Assoc Res Otolaryngol. 2009;10:525-44 pubmed publisher
    ..These results suggest a lack of marked SC dedifferentiation in these aged and badly damaged ears...
  6. Parsa A, Webster P, Kalinec F. Deiters cells tread a narrow path--the Deiters cells-basilar membrane junction. Hear Res. 2012;290:13-20 pubmed publisher
    ..These previously unidentified morphological features of Deiters cells could be critical for the mechanical response of the organ of Corti...
  7. Liu Z, Walters B, Owen T, Brimble M, Steigelman K, Zhang L, et al. Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J Neurosci. 2012;32:10530-40 pubmed publisher
    ..Our studies suggest that manipulating Sox2 or p27(Kip1) expression is an effective approach to inducing proliferation of neonatal auditory IPCs, an initial but necessary step toward restoring hearing in mammals. ..
  8. Groves A. The challenge of hair cell regeneration. Exp Biol Med (Maywood). 2010;235:434-46 pubmed publisher
    ..In this review, we describe recent progress in understanding the limits to hair cell regeneration in mammals and discuss the obstacles that currently exist for therapeutic approaches to hair cell replacement...
  9. Kelley M. Regulation of cell fate in the sensory epithelia of the inner ear. Nat Rev Neurosci. 2006;7:837-49 pubmed
    ..However, new methodologies have resulted in significant steps forward in our understanding of the molecular pathways that direct cells towards these cell fates...

More Information

Publications62

  1. Bobbin R. ATP-induced movement of the stalks of isolated cochlear Deiters' cells. Neuroreport. 2001;12:2923-6 pubmed
    ..Results suggest that in vivo endogenous extracellular ATP released from unidentified locations could alter cochlear mechanics...
  2. Zhao H. Directional rectification of gap junctional voltage gating between dieters cells in the inner ear of guinea pig. Neurosci Lett. 2000;296:105-8 pubmed
    ..Multiple connexins may constitute non-homotypic channels with directional dependence of voltage gating to mediate functional gap junction pathways in the cochlea. This may explain how a single connexin mutation can produce hearing loss...
  3. Bird J, Daudet N, Warchol M, Gale J. Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear. J Neurosci. 2010;30:12545-56 pubmed publisher
    ..Our data show that supporting cells not only maintain epithelial integrity during trauma but suggest they may also be an integral part of the hair cell death process itself...
  4. Sato Y, Handa T, Matsumura M, Orita Y. Gap junction change in supporting cells of the organ of Corti with ryanodine and caffeine. Acta Otolaryngol. 1998;118:821-5 pubmed
    ..Therefore, Ca2+ plays a role in the uncoupling of the gap junctions in supporting cells of the organ of Corti from inside the cells...
  5. Minoda R, Izumikawa M, Kawamoto K, Zhang H, Raphael Y. Manipulating cell cycle regulation in the mature cochlea. Hear Res. 2007;232:44-51 pubmed
    ..The data also suggest that induced proliferation, by itself, does not generate new hair cells in the cochlea...
  6. Driver E, Sillers L, Coate T, Rose M, Kelley M. The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Dev Biol. 2013;376:86-98 pubmed publisher
    ..Our results demonstrate that the Atoh1-lineage is established early in cochlear development, but also show that expression of Atoh1 does not absolutely result in commitment to a HC fate. ..
  7. Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, et al. Localization of septin proteins in the mouse cochlea. Hear Res. 2012;289:40-51 pubmed publisher
    ..Immunohistochemical analysis of Sept4 null mice showed that compensatory expression of SEPT5 in the phalangeal process of Deiters' cells may have caused functional compensation of hearing ability in Sept4 null mice...
  8. Izumikawa M, Batts S, Miyazawa T, Swiderski D, Raphael Y. Response of the flat cochlear epithelium to forced expression of Atoh1. Hear Res. 2008;240:52-6 pubmed publisher
  9. Mann Z, Duchen M, Gale J. Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells. Cell Calcium. 2009;46:136-46 pubmed publisher
    ..Thus, mitochondria function as spatial Ca2+ buffers during agonist-evoked [Ca2+](cyt) signalling in cochlear supporting cells and play a significant role in regulating the spatio-temporal properties of intercellular Ca2+ waves...
  10. Yoo J, Kim H, Han K, Oh S, Chang S, Marcus D, et al. Na+ absorption by Claudius' cells is regulated by purinergic signaling in the cochlea. Acta Otolaryngol. 2012;132 Suppl 1:S103-8 pubmed publisher
    ..Claudius' cells absorb Na(+) through the amiloride-sensitive epithelial sodium channel (ENaC). Transepithelial ion transport through ENaC and possibly a Cl(-) secretory pathway is regulated by P2Y purinergic signaling...
  11. SPENCER N, Cotanche D, Klapperich C. Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. Biomaterials. 2008;29:1028-42 pubmed
    ..With further optimization, this system will enable the performance of many novel biophysical and pharmacological studies involving hair cells and supporting cells...
  12. Savary E, Hugnot J, Chassigneux Y, Travo C, Duperray C, Van De Water T, et al. Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysis. Stem Cells. 2007;25:332-9 pubmed
    ..Our observation that these SP cells are capable of differentiating into HC-like cells implies a possible use for such cells (i.e., the replacement of lost auditory HCs within damaged cochlea)...
  13. Fujinami Y, Mutai H, Kamiya K, Mizutari K, Fujii M, Matsunaga T. Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Neurochem Int. 2010;56:487-94 pubmed publisher
    ..These results contribute clarification of pathological mechanism of cochlear fibrocytes and may lead to development of novel therapeutic strategy for hearing loss...
  14. Tritsch N, Bergles D. Developmental regulation of spontaneous activity in the Mammalian cochlea. J Neurosci. 2010;30:1539-50 pubmed publisher
    ..These results suggest that supporting cells in the cochlea provide the primary excitatory stimulus responsible for initiating bursts of action potentials in auditory nerve fibers before the onset of hearing...
  15. Liang Y, Huang L, Yang J. Differential expression of ryanodine receptor in the developing rat cochlea. Eur J Histochem. 2009;53:e30 pubmed publisher
    ..Morphological and Ca imaging results suggested that RyRs expression is related to cochlear maturity, and may play an important role in its function...
  16. Moon I, So J, Jung Y, Lee W, Kim E, Choi J, et al. Fucoidan promotes mechanosensory hair cell regeneration following amino glycoside-induced cell death. Hear Res. 2011;282:236-42 pubmed publisher
    ..The aims of this study were to quantify the regenerative effects of LMWF and determine their relationship to the Notch and FGF signaling pathways...
  17. Diensthuber M, Heller S. [Characterization of stem cells derived from the neonatal auditory sensory epithelium]. HNO. 2010;58:1056, 1058, 1060-6 pubmed publisher
    ..Unexpectedly, the neonatal auditory sensory epithelium has recently been shown to harbor cells with stem cell features. The origin of these cells within the cochlea's sensory epithelium is unknown...
  18. Sheffield A, Gubbels S, Hildebrand M, Newton S, Chiorini J, Di Pasquale G, et al. Viral vector tropism for supporting cells in the developing murine cochlea. Hear Res. 2011;277:28-36 pubmed publisher
    ..Our results support the use of BAAV for safe and efficient targeting of supporting cell progenitors in the developing murine inner ear. ..
  19. Schimmang T, Pirvola U. Coupling the cell cycle to development and regeneration of the inner ear. Semin Cell Dev Biol. 2013;24:507-13 pubmed publisher
    ..Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia. ..
  20. Campbell D, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016;6:19484 pubmed publisher
  21. Pituello F, Medevielle F, Foulquier F, Duprat A. Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord. Development. 1999;126:587-96 pubmed
    ..All together these observations lead to the proposal that Pax6 activation is triggered by the paraxial mesoderm in phase with somitogenesis in the cervical spinal cord...
  22. Bryant J, Goodyear R, Richardson G. Sensory organ development in the inner ear: molecular and cellular mechanisms. Br Med Bull. 2002;63:39-57 pubmed
    ..Development of the hair cell's mechanosensory hair bundle involves interactions between the cytoskeleton, cell-surface adhesion molecules, receptors and associated extracellular matrix...
  23. Spicer S, Smythe N, Schulte B. Ultrastructure indicative of ion transport in tectal, Deiters, and tunnel cells: differences between gerbil and chinchilla basal and apical cochlea. Anat Rec A Discov Mol Cell Evol Biol. 2003;271:342-59 pubmed
  24. Schick B, Praetorius M, Eigenthaler M, Mack A, Plinkert P, Walter U, et al. Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?. Cell Tissue Res. 2003;311:315-23 pubmed
    ..Thus, pillar cells may be more dynamically involved in controlling longer-lasting mechanical properties of the cochlea as hitherto presumed...
  25. Ladrech S, Mathieu M, Puel J, Lenoir M. Supporting cells regulate the remodelling of aminoglycoside-injured organ of Corti, through the release of high mobility group box 1. Eur J Neurosci. 2013;38:2962-72 pubmed publisher
    ..Altogether, these results strongly suggest that, in stressful conditions, Deiters cells liberate HMGB1 to regulate the epithelial reorganization of the injured organ of Corti through engagement of RAGE in neighbouring epithelial cells. ..
  26. Nair T, Kozma K, Hoefling N, Kommareddi P, Ueda Y, Gong T, et al. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci. 2004;24:1772-9 pubmed publisher
    ..Sera from patients with autoimmune hearing loss bind to guinea pig inner ear with the same pattern as CTL2 antibodies. Thus, CTL2 is a possible target of autoimmune hearing loss in humans...
  27. Chang Q, Gong S, Ding J, Tang M, Hescheler J. [Isolation of partial outer supporting cells from guinea pig cochlea]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004;18:38-40 pubmed
  28. Liu Z, Liu Z, Walters B, Owen T, Kopan R, Zuo J. In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS ONE. 2013;8:e64903 pubmed publisher
    ..Such heterogeneity should elucidate how the development of the cochclear sensory epithelium is precisely controlled and how HC regeneration can be best achieved in postnatal cochleae...
  29. Merchant S, Burgess B, Adams J, Kashtan C, Gregory M, Santi P, et al. Temporal bone histopathology in alport syndrome. Laryngoscope. 2004;114:1609-18 pubmed
    ..To determine the histopathologic abnormalities within the cochlea in Alport syndrome...
  30. Li X, Li J, Yu H, Hou Z. [Inhibition of nifedipine on inward current of Hensen cell induced by ATP]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007;42:217-21 pubmed
    ..To investigate the effect of nifedipine on the non-selective inward current of cochlear Hensen cell induced by ATP in high concentrations...
  31. Zhu Y, Liang C, Chen J, Zong L, Chen G, Zhao H. Active cochlear amplification is dependent on supporting cell gap junctions. Nat Commun. 2013;4:1786 pubmed publisher
    ..Our study demonstrates that active cochlear amplification in vivo is dependent on supporting cell gap junctions. These new findings also show that connexin 26 deficiency can reduce active cochlear amplification to induce hearing loss...
  32. Kiernan A. Notch signaling during cell fate determination in the inner ear. Semin Cell Dev Biol. 2013;24:470-9 pubmed publisher
  33. Mellado Lagarde M, Cox B, Fang J, Taylor R, Forge A, Zuo J. Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice. J Neurosci. 2013;33:1564-76 pubmed publisher
    ..In addition, our results show that cochlear SC pools should be appropriately replenished during HC regeneration strategies. ..
  34. Stone I, Lurie D, Kelley M, Poulsen D. Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea. Mol Ther. 2005;11:843-8 pubmed
    ..In contrast, strong expression from the GFAP promoter was observed primarily in support cells. Thus, using AAV vectors and specific promoters, cell-type-specific expression of transgenes can be established within the cochlea...
  35. Sugawara M, Corfas G, Liberman M. Influence of supporting cells on neuronal degeneration after hair cell loss. J Assoc Res Otolaryngol. 2005;6:136-47 pubmed
    ..Results are consistent with the idea that supporting cells participate in the regulation of neuronal survival and neuronal sprouting in the organ of Corti...
  36. Doetzlhofer A, White P, Lee Y, Groves A, Segil N. Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Brain Res. 2006;1091:282-8 pubmed
  37. Yoshino T, Sato E, Nakashima T, Teranishi M, Yamamoto H, Otake H, et al. Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy. Eur Arch Otorhinolaryngol. 2006;263:699-704 pubmed
    ..Our study revealed that pendrin occurs in the organ of Corti. The role of pendrin in the organ of Corti and its association with the Cl- or pH regulation of neurotransmission require further study...
  38. Lou X, Zhang Y, Yuan C. Multipotent stem cells from the young rat inner ear. Neurosci Lett. 2007;416:28-33 pubmed
    ..This work raises the possibility that inner ear cells in the early post-natal rat have the character of pluripotent stem cells and might be a source for cell replacement therapy in the inner ear...
  39. Kelley M. Cellular commitment and differentiation in the organ of Corti. Int J Dev Biol. 2007;51:571-83 pubmed
    ..In this review I will present an overview of cochlear development and then discuss some of the most recent and enlightening results regarding the molecular mechanism underlying the formation of this remarkable structure...
  40. Hertzano R, Puligilla C, Chan S, Timothy C, Depireux D, Ahmed Z, et al. CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. J Assoc Res Otolaryngol. 2010;11:407-18 pubmed publisher
    ..Finally, our study reveals multiple potential new cell type-specific markers in the mouse inner ear and identifies a new marker for outer pillar cells...
  41. Slattery E, Warchol M. Cisplatin ototoxicity blocks sensory regeneration in the avian inner ear. J Neurosci. 2010;30:3473-81 pubmed publisher
    ..Taken together, our data show that cisplatin treatment causes maintained changes to inner ear supporting cells and severely impairs the ability of the avian ear to regenerate either via proliferation or by direct transdifferentiation...
  42. Adler H, Sanovich E, Brittan Powell E, Yan K, Dooling R. WDR1 presence in the songbird basilar papilla. Hear Res. 2008;240:102-11 pubmed publisher
    ..This may be due to the fact that the BW canary already has established hearing loss and/or to the possibility that the mechanism(s) involved in BW hearing loss may not be related to WDR1...
  43. Bohne B, Harding G. Neural regeneration in the noise-damaged chinchilla cochlea. Laryngoscope. 1992;102:693-703 pubmed
    ..The strongest response was found in ears exposed to a high-intensity, low-frequency noise. The results described here indicate that a potential exists for the biological restoration of the mammalian inner ear...
  44. Abello G, Alsina B. Establishment of a proneural field in the inner ear. Int J Dev Biol. 2007;51:483-93 pubmed
    ..Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved...
  45. Parker M, Corliss D, Gray B, Anderson J, Bobbin R, Snyder E, et al. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hear Res. 2007;232:29-43 pubmed
    ..Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea...
  46. Weston M, Pierce M, Rocha Sanchez S, Beisel K, Soukup G. MicroRNA gene expression in the mouse inner ear. Brain Res. 2006;1111:95-104 pubmed
  47. Vogalis F, Hegg C, Lucero M. Electrical coupling in sustentacular cells of the mouse olfactory epithelium. J Neurophysiol. 2005;94:1001-12 pubmed
    ..These data provide strong evidence for functional coupling between SCs, the physiological importance of which is discussed...
  48. Beltramello M, Piazza V, Bukauskas F, Pozzan T, Mammano F. Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Nat Cell Biol. 2005;7:63-9 pubmed
    ..Our data provide the first demonstration of a specific defect of metabolic coupling and offer a mechanistic explanation for the pathogenesis of an inherited human disease...
  49. Schick B, Praetorius M, Eigenthaler M, Jung V, Müller M, Walter U, et al. Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- mice. Cell Tissue Res. 2004;318:493-502 pubmed
    ..The finding of a cell-specific, and not organ-specific, redundancy of MENA protein expression noted for the first time in VASP-/- mice is proposed as the reason for the observed distinct cochlear phenotype...
  50. Cristobal R, Wackym P, Cioffi J, Erbe C, Popper P. Selective acquisition of individual cell types in the vestibular periphery for molecular biology studies. Otolaryngol Head Neck Surg. 2004;131:590-5 pubmed
    ..To develop a method for characterizing the transcriptome of individual cell types in the inner ear sensory epithelia...
  51. García Berrocal J, Ramírez Camacho R, Trinidad A, Zurita M, de la Fuente R, Lobo D. Controversies and criticisms on designs for experimental autoimmune labyrinthitis. Ann Otol Rhinol Laryngol. 2004;113:404-10 pubmed
    ..A new pathogenetic theory is suggested, involving the supporting cells of the organ of Corti...
  52. Jin Z, Kikuchi T, Tanaka K, Kobayashi T. Expression of glutamate transporter GLAST in the developing mouse cochlea. Tohoku J Exp Med. 2003;200:137-44 pubmed
    ..These results suggest that the expression of GLAST may be needed for the efficient removal and metabolism of the released glutamate in the cochlea and may play important roles in the onset and maturation of the auditory system...
  53. Zhou S, Pickles J. Postnatal changes in the reticular lamina of the guinea pig organ of Corti. Hear Res. 1996;100:33-40 pubmed
    ..The changes were seen before birth and continued for more than 3 weeks after birth. The results suggest that the guinea pig cochlea continues certain developmental processes for a considerable time after birth...