organ of corti

Summary

Summary: The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.

Top Publications

  1. Schütz M, Scimemi P, Majumder P, De Siati R, Crispino G, Rodriguez L, et al. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet. 2010;19:4759-73 pubmed publisher
    ..Our findings link hearing loss to decreased biochemical coupling due to the point-mutated Cx30 in mice...
  2. Ladrech S, Mathieu M, Puel J, Lenoir M. Supporting cells regulate the remodelling of aminoglycoside-injured organ of Corti, through the release of high mobility group box 1. Eur J Neurosci. 2013;38:2962-72 pubmed publisher
    ..This increase coincided with epithelial remodelling of the injured organ of Corti, and occurred concomitantly with robust and transient cytoplasmic expression of acetylated HMGB1 within the ..
  3. Szarama K, Stepanyan R, Petralia R, Gavara N, Frolenkov G, Kelley M, et al. Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti. Bioarchitecture. 2012;2:214-9 pubmed publisher
    ..the surface stiffness of sensory outer hair cells (OHCs) and non-sensory supporting pillar cells (PCs) in the organ of Corti. Here, we used Atomic Force Microscopy (AFM) to measure the impact of loss of function of Fgf-receptor 3, on ..
  4. Martinez Monedero R, Yi E, Oshima K, Glowatzki E, Edge A. Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol. 2008;68:669-84 pubmed publisher
    ..Development of functional activity in cells with the markers of sensory neurons suggested that the inner ear stem cells might have the capacity to replace cells lost due to neural degeneration...
  5. Meenderink S, van Dijk P, Narins P. Comparison between distortion product otoacoustic emissions and nerve fiber responses from the basilar papilla of the frog. J Acoust Soc Am. 2005;117:3165-73 pubmed
    ..For larger stimulus frequency ratios, DPOAE recordings clearly deviate from model predictions. These differences are most likely caused by the oversimplified representation of the frog BP by the model...
  6. Grimsley Myers C, Sipe C, Géléoc G, Lu X. The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci. 2009;29:15859-69 pubmed publisher
    ..Together, these results reveal a critical function of Rac1 in morphogenesis of the auditory sensory epithelium and stereociliary bundle...
  7. de La Rochefoucauld O, Olson E. The role of organ of Corti mass in passive cochlear tuning. Biophys J. 2007;93:3434-50 pubmed
    The mechanism for passive cochlear tuning remains unsettled. Early models considered the organ of Corti complex (OCC) as a succession of spring-mass resonators...
  8. Dinh C, Bas E, Chan S, Dinh J, Vu L, Van De Water T. Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor hair cell survival. Neuroscience. 2011;188:157-67 pubmed publisher
    ..b>Organ of Corti (OC) explants from 3-day-old rats were cultured under one of the following conditions: (1) media only--no ..
  9. Johnson S, Beurg M, Marcotti W, Fettiplace R. Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant. Neuron. 2011;70:1143-54 pubmed publisher
    ..These data suggest that minimal ?(m) filtering in vivo ensures optimal activation of prestin...

More Information

Publications62

  1. Chen F, Choudhury N, Zheng J, Matthews S, Nutall A, Jacques S. In vivo imaging and low-coherence interferometry of organ of Corti vibration. J Biomed Opt. 2007;12:021006 pubmed
    ..coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig...
  2. Nowotny M, Gummer A. Vibration responses of the organ of Corti and the tectorial membrane to electrical stimulation. J Acoust Soc Am. 2011;130:3852-72 pubmed publisher
    Coupling of somatic electromechanical force from the outer hair cells (OHCs) into the organ of Corti is investigated by measuring transverse vibration patterns of the organ of Cori and tectorial membrane (TM) in response to intracochlear ..
  3. Nam J, Fettiplace R. Force transmission in the organ of Corti micromachine. Biophys J. 2010;98:2813-21 pubmed publisher
    ..Either process must exert its mechanical effect via deformation of the organ of Corti, a complex assembly of sensory and supporting cells riding on the basilar membrane...
  4. Hayashi T, Cunningham D, Bermingham McDonogh O. Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007;236:525-33 pubmed
    ..we found an extra row of outer hair cells, and accompanying Deiters' cells, in the apical two thirds of the organ of Corti in the Fgfr3 mutant...
  5. Weston M, Pierce M, Rocha Sanchez S, Beisel K, Soukup G. MicroRNA gene expression in the mouse inner ear. Brain Res. 2006;1111:95-104 pubmed
  6. Cai T, Seymour M, Zhang H, Pereira F, Groves A. Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti. J Neurosci. 2013;33:10110-22 pubmed publisher
    ..Together our data suggest that Atoh1 regulates multiple aspects of hair cell development and function. ..
  7. Thalmann I, Hughes I, Tong B, Ornitz D, Thalmann R. Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti. Electrophoresis. 2006;27:1598-608 pubmed
    ..Finally, we demonstrate techniques for the precise dissection of organ of Corti and its substructures, while preserving their near normal chemical state...
  8. Pan B, GELEOC G, Asai Y, Horwitz G, Kurima K, Ishikawa K, et al. TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron. 2013;79:504-15 pubmed publisher
    ..Gradients in TMC channel composition may also contribute to variation in sensory transduction along the tonotopic axis of the mammalian cochlea...
  9. Harding G, Bohne B. Relation of focal hair-cell lesions to noise-exposure parameters from a 4- or a 0.5-kHz octave band of noise. Hear Res. 2009;254:54-63 pubmed publisher
    ..into recovery times of 0 days (acute) and >0 days (chronic) and the apical and basal halves of the organ of Corti (OC). A substantial part of these hair-cell losses occurred in focal lesions (i.e...
  10. Wang Y, Chang Q, Tang W, Sun Y, Zhou B, Li H, et al. Targeted connexin26 ablation arrests postnatal development of the organ of Corti. Biochem Biophys Res Commun. 2009;385:33-7 pubmed publisher
    ..However, postnatal development of the organ of Corti was stalled as the tunnel of Corti and the Nuel's space were never opened...
  11. Batts S, Shoemaker C, Raphael Y. Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti. Hear Res. 2009;249:15-22 pubmed publisher
    ..signaling ends during maturity and cannot be reinitiated to alter the fate of new or existing cells in the organ of Corti. This is in contrast to non-mammalian species which reinitiate Delta 1-Notch1 signaling in response to trauma ..
  12. Taylor R, Jagger D, Forge A. Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. PLoS ONE. 2012;7:e30577 pubmed publisher
    ..For any cell replacement strategy to be successful, the cellular environment of the injured tissue has to be able to nurture new hair cells. This study defines characteristics of the auditory sensory epithelium after hair cell loss...
  13. Meaud J, Grosh K. Response to a pure tone in a nonlinear mechanical-electrical-acoustical model of the cochlea. Biophys J. 2012;102:1237-46 pubmed publisher
    ..The three-dimensional intracochlear fluid dynamics are coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochlear ducts and outer hair cells (OHC)...
  14. Zha D, Chen F, Ramamoorthy S, Fridberger A, Choudhury N, Jacques S, et al. In vivo outer hair cell length changes expose the active process in the cochlea. PLoS ONE. 2012;7:e32757 pubmed publisher
    ..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification...
  15. Waldhaus J, Cimerman J, Gohlke H, Ehrich M, Müller M, Löwenheim H. Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. PLoS ONE. 2012;7:e36066 pubmed publisher
    In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss...
  16. Temchin A, Recio Spinoso A, Cai H, Ruggero M. Traveling waves on the organ of corti of the chinchilla cochlea: spatial trajectories of inner hair cell depolarization inferred from responses of auditory-nerve fibers. J Neurosci. 2012;32:10522-9 pubmed publisher
    ..stimulus to their stereocilia, the present results suggest that distinct low-frequency forward waves of organ of Corti vibration are launched simultaneously at the extreme base of the cochlea and at the 6...
  17. Yu H, Lin Q, Wang Y, He Y, Fu S, Jiang H, et al. Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death. Cell Death Dis. 2013;4:e506 pubmed publisher
    ..Local delivery of BIX01294 also prevented neomycin-induced in vivo auditory hair cell loss in the organ of Corti in a mouse damage model...
  18. Gross J, Machulik A, Amarjargal N, Moller R, Ungethüm U, Kuban R, et al. Expression of apoptosis-related genes in the organ of Corti, modiolus and stria vascularis of newborn rats. Brain Res. 2007;1162:56-68 pubmed
    ..For the analyses, we used pooled samples of the organ of Corti (OC), modiolus (MOD) and stria vascularis (SV), respectively...
  19. Raphael Y, Kim Y, Osumi Y, Izumikawa M. Non-sensory cells in the deafened organ of Corti: approaches for repair. Int J Dev Biol. 2007;51:649-54 pubmed
    ..The flat organ of Corti can serve as a substrate for gene- and stem cell-based therapies...
  20. Oesterle E, Campbell S, Taylor R, Forge A, Hume C. Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear. J Assoc Res Otolaryngol. 2008;9:65-89 pubmed
    ..The present study delineates a protocol to drug damage the adult mouse auditory epithelium (organ of Corti) in situ and uses this protocol to investigate Sox2 and Jagged1 expression in damaged inner ear sensory ..
  21. Tiede L, Steyger P, Nichols M, Hallworth R. Metabolic imaging of the organ of corti--a window on cochlea bioenergetics. Brain Res. 2009;1277:37-41 pubmed publisher
    ..Using this method, we show evidence that the aminoglycoside gentamicin selectively affects the level of mitochondrial NADH in outer hair cells, but not inner hair cells, within minutes of administration...
  22. Teufert K, Linthicum F, Connell S. The effect of organ of corti loss on ganglion cell survival in humans. Otol Neurotol. 2006;27:1146-51 pubmed
    ..Severe spiral ganglion cell loss does not necessarily follow loss of hair cells or supporting cells in humans...
  23. Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel M, et al. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neurosci. 2007;27:1434-44 pubmed
  24. Bibas A, Xenellis J, Michaels L, Anagnostopoulou S, Ferekidis E, Wright A. Temporal bone study of development of the organ of Corti: correlation between auditory function and anatomical structure. J Laryngol Otol. 2008;122:336-42 pubmed
    To study the development of the organ of Corti in the human cochlea, and to correlate our findings with the onset of auditory function.
  25. Miller J. Sex differences in the length of the organ of Corti in humans. J Acoust Soc Am. 2007;121:EL151-5 pubmed
    ..11 mm in length and to 0.49 SD. The mean lengths of the male and female cochleas are approximately 34 and 33 mm, respectively, and the population SD is 2.28 mm. The statistical significance of the observed difference is questionable...
  26. Gross J, Stute K, Fuchs J, Angerstein M, Amarjargal N, Mazurek B. Effects of retinoic acid and butyric acid on the expression of prestin and Gata-3 in organotypic cultures of the organ of corti of newborn rats. Dev Neurobiol. 2011;71:650-61 pubmed publisher
    Prestin is the motor protein of the outer hair cells of the organ of Corti and a key factor in ensuring a high level of sensitivity of mammalian hearing. The factors that influence prestin expression are still largely unknown...
  27. Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, et al. Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res. 2011;275:66-80 pubmed publisher
    ..Only the posterior canal crista has Atoh1 expressing hair cells due to incomplete recombination. Most of the organ of Corti cells are lost in CKO mice via late embryonic cell death...
  28. Beurg M, Nam J, Chen Q, Fettiplace R. Calcium balance and mechanotransduction in rat cochlear hair cells. J Neurophysiol. 2010;104:18-34 pubmed publisher
    ..The model also indicated the endogenous mobile buffer was equivalent to 1 mM BAPTA...
  29. Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, et al. Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti. Dev Biol. 2009;335:327-39 pubmed publisher
    ..vesicle epithelium and becomes later restricted to supporting cells as cell differentiation proceeds in the organ of Corti. Morphological analyses of Sox10 mutant mice reveal a significant shortening of the cochlear duct likely ..
  30. Doetzlhofer A, Basch M, Ohyama T, Gessler M, Groves A, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009;16:58-69 pubmed publisher
    The organ of Corti, the auditory organ of the inner ear, contains two types of sensory hair cells and at least seven types of supporting cells...
  31. Inoshita A, Iizuka T, Okamura H, Minekawa A, Kojima K, Furukawa M, et al. Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice. Neuroscience. 2008;156:1039-47 pubmed publisher
    ..The present study attempted to evaluate postnatal development of the organ of Corti in the R75W+ mice...
  32. Piazza V, Ciubotaru C, Gale J, Mammano F. Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti. Cell Calcium. 2007;41:77-86 pubmed
    ..Further ongoing research will reveal the roles that such Ca2+ waves play in the inner ear...
  33. Frucht C, Uduman M, Duke J, Kleinstein S, Santos Sacchi J, Navaratnam D. Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. PLoS ONE. 2010;5:e11502 pubmed publisher
  34. Fritzsch B, Pan N, Jahan I, Duncan J, Kopecky B, Elliott K, et al. Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective. Evol Dev. 2013;15:63-79 pubmed publisher
    The tetrapod auditory system transmits sound through the outer and middle ear to the organ of Corti or other sound pressure receivers of the inner ear where specialized hair cells translate vibrations of the basilar membrane into ..
  35. Yu Y, Szczepek A, Haupt H, Mazurek B. Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants. J Biomed Sci. 2009;16:79 pubmed publisher
    ..The aim of our study was to investigate whether GA induces HSP70 in the organ of Corti (OC), which contains the auditory sensory cells, and whether GA can protect these cells from toxicity caused ..
  36. Gueta R, Barlam D, Shneck R, Rousso I. Measurement of the mechanical properties of isolated tectorial membrane using atomic force microscopy. Proc Natl Acad Sci U S A. 2006;103:14790-5 pubmed
    ..The longitudinal increase in TM stiffness is similar to that found for the OHC stereocilia, which supports the existence of mechanical coupling between these two structures...
  37. Yang T, Kersigo J, Jahan I, Pan N, Fritzsch B. The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti. Hear Res. 2011;278:21-33 pubmed publisher
    ..They project radial fibers to innervate the organ of Corti (type I neurons to inner hair cells, type II neurons to outer hair cells) and also project tonotopically to ..
  38. Previati M, Lanzoni I, Astolfi L, Fagioli F, Vecchiati G, Pagnoni A, et al. Cisplatin cytotoxicity in organ of Corti-derived immortalized cells. J Cell Biochem. 2007;101:1185-97 pubmed
    ..These data suggest that ERK pathways can play a role in mediating the cell death induction in presence of a CDDP challenge...
  39. Cotanche D. Genetic and pharmacological intervention for treatment/prevention of hearing loss. J Commun Disord. 2008;41:421-43 pubmed publisher
  40. Gross J, Machulik A, Moller R, Fuchs J, Amarjargal N, Ungethüm U, et al. MRNA expression of members of the IGF system in the organ of Corti, the modiolus and the stria vascularis of newborn rats. Growth Factors. 2008;26:180-91 pubmed publisher
    ..pathway genes using the Affymetrix microarray system and confirmatory RT-PCR in the freshly prepared organ of Corti (OC), modiolus (MOD) and stria vascularis (SV) from neonatal rats (3-5 days old) and after 24h in culture...
  41. Harding G, Bohne B. Distribution of focal lesions in the chinchilla organ of Corti following exposure to a 4-kHz or a 0.5-kHz octave band of noise. Hear Res. 2007;225:50-9 pubmed
    ..e., combined lesions) in a specific region of the organ of Corti (OC)...
  42. Dinh C, Haake S, Chen S, Hoang K, Nong E, Eshraghi A, et al. Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes. Neuroscience. 2008;157:405-13 pubmed publisher
    ..Determine the molecular mechanism(s) behind tumor necrosis factor-alpha (TNFalpha)-induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to protect against TNFalpha ototoxicity...
  43. Yoon Y, Puria S, Steele C. Intracochlear pressure and organ of corti impedance from a linear active three-dimensional model. ORL J Otorhinolaryngol Relat Spec. 2006;68:365-72 pubmed
    ..the motility of the outer hair cells (OHCs) to the passive model with the feed-forward approximation of the organ of Corti (OC), as was done previously...
  44. Kiernan A, Cordes R, Kopan R, Gossler A, Gridley T. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development. 2005;132:4353-62 pubmed
    The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic...
  45. Zagadou B, Mountain D. Analysis of the cochlear amplifier fluid pump hypothesis. J Assoc Res Otolaryngol. 2012;13:185-97 pubmed publisher
    ..cochlea tuned to the characteristic frequency (CF) of 4 kHz to show that the anatomical structure of the organ of Corti (OC) is consistent with the hypothesis that the cochlear amplifier functions as a fluid pump...
  46. Ladrech S, Wang J, Simonneau L, Puel J, Lenoir M. Macrophage contribution to the response of the rat organ of Corti to amikacin. J Neurosci Res. 2007;85:1970-9 pubmed
    ..By 3 weeks post-treatment, however, the Deiters cells began to degenerate and by 10 weeks post-treatment the organ of Corti was degraded fully...
  47. Yamamoto N, Okano T, Ma X, Adelstein R, Kelley M. Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development. 2009;136:1977-86 pubmed publisher
    ..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
  48. Oiticica J, Barboza Junior L, Batissoco A, Lezirovitz K, Mingroni Netto R, Haddad L, et al. Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea. J Transl Med. 2010;8:119 pubmed publisher
    Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss...
  49. Wang R, Nuttall A. Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study. J Biomed Opt. 2010;15:056005 pubmed publisher
    ..However, the biomechanical mechanisms of how the hearing organ, i.e., the organ of Corti (OC), responds to sound are still elusive, largely because there is currently no means available to image the ..
  50. Wang J, Mark S, Zhang X, Qian D, Yoo S, Radde Gallwitz K, et al. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet. 2005;37:980-5 pubmed
    The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium...
  51. Jahan I, Pan N, Kersigo J, Calisto L, Morris K, Kopecky B, et al. Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. PLoS ONE. 2012;7:e30853 pubmed publisher
    ..Homozygous KI mice develop patches of organ of Corti precursor cells that express Neurog1, Neurod1, several prosensory genes and neurotrophins...
  52. Beurg M, Fettiplace R, Nam J, Ricci A. Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nat Neurosci. 2009;12:553-8 pubmed publisher
    ..The observations, supported by theoretical simulations, suggest there are no functional mechanically sensitive transducer channels in first row stereocilia and imply the channels are present only at the bottom of the tip links...
  53. Poirrier A, Van den Ackerveken P, Kim T, VandenBosch R, Nguyen L, Lefebvre P, et al. Ototoxic drugs: difference in sensitivity between mice and guinea pigs. Toxicol Lett. 2010;193:41-9 pubmed publisher
    ..These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss...