stria vascularis

Summary

Summary: A layer of stratified EPITHELIUM forming the endolymphatic border of the cochlear duct at the lateral wall of the cochlea. Stria vascularis contains primarily three cell types (marginal, intermediate, and basal), and capillaries. The marginal cells directly facing the ENDOLYMPH are important in producing ion gradients and endochoclear potential.

Top Publications

  1. Trowe M, Maier H, Petry M, Schweizer M, Schuster Gossler K, Kispert A. Impaired stria vascularis integrity upon loss of E-cadherin in basal cells. Dev Biol. 2011;359:95-107 pubmed publisher
    ..endolymph, both of which are maintained by a highly specialized epithelium at the cochlear lateral wall, the stria vascularis. The generation of the EP by the stria vascularis, in turn, relies on the insulation of an intrastrial ..
  2. Sawada S, Takeda T, Kitano H, Takeuchi S, Okada T, Ando M, et al. Aquaporin-1 (AQP1) is expressed in the stria vascularis of rat cochlea. Hear Res. 2003;181:15-9 pubmed
    Cochlea endolymph, produced by the stria vascularis, is essential for normal inner ear function. Abnormal endolymphatic volumes correlate closely with pathological conditions such as Ménière's disease...
  3. Gratton M, Rao V, Meehan D, Askew C, Cosgrove D. Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology. Am J Pathol. 2005;166:1465-74 pubmed
    ..Alport syndrome noted thickening of strial capillary basement membranes in the cochlea, suggesting that the stria vascularis is the primary site of cochlear pathogenesis...
  4. Ishiyama G, Tokita J, Lopez I, Tang Y, Ishiyama A. Unbiased stereological estimation of the spiral ligament and stria vascularis volumes in aging and Ménière's disease using archival human temporal bones. J Assoc Res Otolaryngol. 2007;8:8-17 pubmed
    ..present study applies the unbiased stereological technique-Cavalieri principle to measure the volumes of the stria vascularis (SV) and the spiral ligament (SL) using postmortem archival human temporal bones from normal young and older ..
  5. Jin Z, Mannstrom P, Jarlebark L, Ulfendahl M. Malformation of stria vascularis in the developing inner ear of the German waltzing guinea pig. Cell Tissue Res. 2007;328:257-70 pubmed
    ..The embryonic stria vascularis, consisting of a simple epithelium, failed to transform into the complex trilaminar tissue seen in normal ..
  6. Takeuchi S, Ando M, Kakigi A. Mechanism generating endocochlear potential: role played by intermediate cells in stria vascularis. Biophys J. 2000;79:2572-82 pubmed
    The endocochlear DC potential (EP) is generated by the stria vascularis, and essential for the normal function of hair cells. Intermediate cells are melanocytes in the stria vascularis...
  7. Gross J, Machulik A, Amarjargal N, Moller R, Ungethüm U, Kuban R, et al. Expression of apoptosis-related genes in the organ of Corti, modiolus and stria vascularis of newborn rats. Brain Res. 2007;1162:56-68 pubmed
    ..For the analyses, we used pooled samples of the organ of Corti (OC), modiolus (MOD) and stria vascularis (SV), respectively...
  8. Souter M, Forge A. Intercellular junctional maturation in the stria vascularis: possible association with onset and rise of endocochlear potential. Hear Res. 1998;119:81-95 pubmed
    The postnatal maturation of intercellular junctions of marginal and basal cells of the stria vascularis was examined in the gerbil using thin sections and freeze fracture techniques...
  9. Takeuchi S, Ando M. Marginal cells of the stria vascularis of gerbils take up glucose via the facilitated transporter GLUT: application of autofluorescence. Hear Res. 1997;114:69-74 pubmed
    ..g., Fura-2 and SBFI) are similar to those of NADH, possible effects of autofluorescence on recording signals should always be taken into account when these dyes are utilized...

More Information

Publications62

  1. Ando M, Edamatsu M, Fukuizumi S, Takeuchi S. Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathway. Cell Tissue Res. 2008;331:763-9 pubmed publisher
    Immunoreactivity for the facilitated glucose transporter 1 (GLUT-1) has been found in the cochlear stria vascularis, but whether the strial marginal cells are immunopositive for GLUT-1 remains uncertain...
  2. Wackym P, Runge Samuelson C, Nash J, Poetker D, Albano K, Bovi J, et al. Gamma knife surgery of vestibular schwannomas: volumetric dosimetry correlations to hearing loss suggest stria vascularis devascularization as the mechanism of early hearing loss. Otol Neurotol. 2010;31:1480-7 pubmed publisher
    ..Determine which variables are correlated with early hearing changes after gamma knife surgery of vestibular schwannomas (VSs)...
  3. Dai C, Steyger P. A systemic gentamicin pathway across the stria vascularis. Hear Res. 2008;235:114-24 pubmed
  4. Laurell G, Ekborn A, Viberg A, Canlon B. Effects of a single high dose of cisplatin on the melanocytes of the stria vascularis in the guinea pig. Audiol Neurootol. 2007;12:170-8 pubmed
    ..Auditory brainstem response (ABR) thresholds and morphological analysis of the hair cells and the stria vascularis were made 96 h after injection...
  5. Wang Q, Steyger P. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J Assoc Res Otolaryngol. 2009;10:205-19 pubmed publisher
    ..In murine cochleae, GTTR is preferentially taken up by the stria vascularis compared to the spiral ligament, peaking 3 h after intra-peritoneal injection, following GTTR kinetics in ..
  6. Song M, Choi S, Wu L, Oh S, Lee H, Lee D, et al. Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms. Biochem Biophys Res Commun. 2011;404:528-33 pubmed publisher
    ..In addition, we found that stria vascularis in the cochlear lateral wall was also affected in Pou3f4-deficient cochlea...
  7. Spicer S, Schulte B. Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells. Hear Res. 2005;205:225-40 pubmed
    ..The reduced ATP level may cause cytotoxic alteration of the cytosolic Na(+)/K(+) ratio first in MC secondary processes and later in the primaries, with consequent degeneration of these structures...
  8. Castiglioni A, REMIS N, Flores E, Garcia Anoveros J. Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neurons. J Comp Neurol. 2011;519:1095-1114 pubmed publisher
    ..Both marginal cells of the stria vascularis and hair cells express Trpml3 mRNA...
  9. McMenomey S, Russell N, Morton J, Trune D. Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: a potential mechanism for immune-related hearing loss. Otolaryngol Head Neck Surg. 1992;106:288-95 pubmed
    The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear...
  10. Florian P, Amasheh S, Lessidrensky M, Todt I, Bloedow A, Ernst A, et al. Claudins in the tight junctions of stria vascularis marginal cells. Biochem Biophys Res Commun. 2003;304:5-10 pubmed
    ..We investigated the expression of integral tight junction-proteins, claudin-1 to -4, and occludin, in stria vascularis of the guinea-pig cochlea, as compared to kidney...
  11. Campbell K, Meech R, Rybak L, Hughes L. D-Methionine protects against cisplatin damage to the stria vascularis. Hear Res. 1999;138:13-28 pubmed
    ..1996). However, D-met's protective effects on the stria vascularis has not been previously investigated...
  12. Takeuchi S, Ando M. Voltage-dependent outward K(+) current in intermediate cell of stria vascularis of gerbil cochlea. Am J Physiol. 1999;277:C91-9 pubmed
    A voltage-dependent outward K(+) (K(V)) current in the intermediate cell (melanocyte) of the cochlear stria vascularis was studied using the whole cell patch-clamp technique...
  13. Bartels S, Ito S, Trune D, Nuttall A. Noise-induced hearing loss: the effect of melanin in the stria vascularis. Hear Res. 2001;154:116-23 pubmed
    ..hearing loss have suggested that eumelanin and pheomelanin may have differing effects within the stria vascularis. Three strains of C57BL/6J mice, (+/+, a/a) wild-types (dark coats/black eyes), (c2j/c2j, a/a), albinos (..
  14. Marcus D, Wu T, Wangemann P, Kofuji P. KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential. Am J Physiol Cell Physiol. 2002;282:C403-7 pubmed
    b>Stria vascularis of the cochlea generates the endocochlear potential and secretes K(+). K(+) is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing...
  15. Kitajiri S, Miyamoto T, Mineharu A, Sonoda N, Furuse K, Hata M, et al. Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J Cell Sci. 2004;117:5087-96 pubmed
    ..These conditions are thought to be generated by the stria vascularis, which is adjacent to the endolymph compartment...
  16. Ciuman R. Stria vascularis and vestibular dark cells: characterisation of main structures responsible for inner-ear homeostasis, and their pathophysiological relations. J Laryngol Otol. 2009;123:151-62 pubmed publisher
    ..Many structures are involved in the complex process of inner-ear homeostasis. The stria vascularis and vestibular dark cells are the two main structures responsible for endolymph secretion, and possess many ..
  17. Gratton M, Schulte B, Smythe N. Quantification of the stria vascularis and strial capillary areas in quiet-reared young and aged gerbils. Hear Res. 1997;114:1-9 pubmed
    The area of the stria vascularis (StV) and of StV capillaries was measured in radial sections from regions corresponding to 0.5, 2, 4, 10, 20 and 40 kHz...
  18. Hibino H, Nin F, Tsuzuki C, Kurachi Y. How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus. Pflugers Arch. 2010;459:521-33 pubmed publisher
    ..A key element is the stria vascularis, which displays a characteristic tissue structure and expresses multiple ion-transport apparatus...
  19. Castaldo A, Linthicum F. Stria vascularis hearing loss. Otol Neurotol. 2006;27:285-6 pubmed
  20. Cohen Salmon M, Regnault B, Cayet N, Caille D, Demuth K, Hardelin J, et al. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A. 2007;104:6229-34 pubmed
    ..The EP is produced by the stria vascularis (SV), a vascularized bilayer epithelium of the cochlea lateral wall...
  21. Gow A, Davies C, Southwood C, Frolenkov G, Chrustowski M, Ng L, et al. Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function. J Neurosci. 2004;24:7051-62 pubmed
    ..Together, these data demonstrate the central importance of basal cell tight junctions in the stria vascularis and directly verify the two-cell hypothesis for generation of endocochlear potential...
  22. Sone M, Muramatsu H, Muramatsu T, Nakashima T. Morphological observation of the stria vascularis in midkine and pleiotrophin knockout mice. Auris Nasus Larynx. 2011;38:41-5 pubmed publisher
    ..In the present study, we focused on the roles of midkine and pleiotrophin in the stria vascularis and investigated morphological changes using mice deficient in these genes.
  23. Higashiyama K, Takeuchi S, Azuma H, Sawada S, Yamakawa K, Kakigi A, et al. Bumetanide-induced enlargement of the intercellular space in the stria vascularis critically depends on Na+ transport. Hear Res. 2003;186:1-9 pubmed
    The intercellular space in the stria vascularis (intrastrial space) is a closed space and isolated from both the endolymph and the perilymph in normal tissue...
  24. Cable J, Huszar D, Jaenisch R, Steel K. Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse. Pigment Cell Res. 1994;7:17-32 pubmed
    ..The primary cochlear defect in Viable Dominant Spotting (Wv/Wv) mutants is a lack of melanocytes within the stria vascularis (SV) associated with an endocochlear potential (EP) close to zero and hearing impairment...
  25. Patuzzi R. Ion flow in stria vascularis and the production and regulation of cochlear endolymph and the endolymphatic potential. Hear Res. 2011;277:4-19 pubmed publisher
    This paper reviews some of what is known about ion transport through the cells of the mammalian stria vascularis, and discusses how the endolymph and endocochlear potential in scala media are produced by the stria's main cell types...
  26. Lee J, Marcus D. Nongenomic effects of corticosteroids on ion transport by stria vascularis. Audiol Neurootol. 2002;7:100-6 pubmed
    b>Stria vascularis electrogenically secretes potassium into endolymph and this secretion is known to be under acute control of several hormone receptors including purinergic, adrenergic and muscarinic receptors...
  27. Wang Q, Kachelmeier A, Steyger P. Competitive antagonism of fluorescent gentamicin uptake in the cochlea. Hear Res. 2010;268:250-9 pubmed publisher
    ..competitive antagonism of unconjugated aminoglycosides on the uptake of fluorescent gentamicin (GTTR) in the stria vascularis and kidney cells at an early time point...
  28. Singh R, Wangemann P. Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model. Am J Physiol Renal Physiol. 2008;294:F139-48 pubmed
    ..Loss of pendrin causes deafness via a loss of the K(+) channel Kcnj10 in stria vascularis and consequent loss of the endocochlear potential. Pendrin and Kcnj10 are expressed in different cell types...
  29. Nin F, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y. The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear. Proc Natl Acad Sci U S A. 2008;105:1751-6 pubmed publisher
    ..Although the regulation of K(+) concentration ([K(+)]) in various compartments of the cochlear stria vascularis seems crucial for the formation of the EP, the mechanism remains uncertain...
  30. Gross J, Machulik A, Moller R, Fuchs J, Amarjargal N, Ungethüm U, et al. MRNA expression of members of the IGF system in the organ of Corti, the modiolus and the stria vascularis of newborn rats. Growth Factors. 2008;26:180-91 pubmed publisher
    ..microarray system and confirmatory RT-PCR in the freshly prepared organ of Corti (OC), modiolus (MOD) and stria vascularis (SV) from neonatal rats (3-5 days old) and after 24h in culture...
  31. Cable J, Barkway C, Steel K. Characteristics of stria vascularis melanocytes of viable dominant spotting (Wv/Wv) mouse mutants. Hear Res. 1992;64:6-20 pubmed
    ..The majority of these animals have no melanocytes within the stria vascularis and no endocochlear potential (EP)...
  32. Kim H, Wangemann P. Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. PLoS ONE. 2011;6:e17949 pubmed publisher
    ..pH changes occurred first in the cochlea at E15.5 and in the endolymphatic sac at E17.5. At postnatal day 2, stria vascularis, outer sulcus and Reissner's membrane epithelial cells, and utricular and saccular transitional cells were ..
  33. Watanabe K, Inai S, Jinnouchi K, Bada S, Hess A, Michel O, et al. Nuclear-factor kappa B (NF-kappa B)-inducible nitric oxide synthase (iNOS/NOS II) pathway damages the stria vascularis in cisplatin-treated mice. Anticancer Res. 2002;22:4081-5 pubmed
    Cisplatin is reported to damage the stria vascularis of the cochlea. Free radicals, especially large amounts of nitric oxide catalyzed by inducible nitric oxide synthase, are considered to have an important role in this toxicity...
  34. Chen J, Nathans J. Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis. Dev Cell. 2007;13:325-37 pubmed
    ..A systematic comparison of transcripts in the WT versus Nr3b2(-/-) stria vascularis has identified a set of genes that is likely to play a role in the development and/or function of endolymph-..
  35. Takeuchi S, Ando M, Sato T, Kakigi A. Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis. Hear Res. 2001;155:103-12 pubmed
    Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4...
  36. Jabba S, Oelke A, Singh R, Maganti R, Fleming S, Wall S, et al. Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model. BMC Med. 2006;4:37 pubmed
    ..Previously, we reported that stria vascularis of adult Slc26a4-/- mice is hyperpigmented and that marginal cells appear disorganized...
  37. Doherty J, Linthicum F. Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level. Otol Neurotol. 2004;25:457-64 pubmed
    To investigate the effect of changes within the spiral ligament and stria vascularis on hearing in cochlear otosclerosis, we examined spiral ligament hyalinization, stria vascularis atrophy, and sensory hearing loss in cochlear ..
  38. Knipper M, Claussen C, Ruttiger L, Zimmermann U, Lüllmann Rauch R, Eskelinen E, et al. Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis. J Physiol. 2006;576:73-86 pubmed
    ..KCNQ1 and its beta-subunit KCNE1 were almost completely lost in the luminal part of marginal cells in the stria vascularis, affecting first higher and later also lower frequency processing cochlear turns...
  39. Kono M, Belyantseva I, Skoura A, Frolenkov G, Starost M, Dreier J, et al. Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem. 2007;282:10690-6 pubmed
    ..However, some of the earliest cellular lesions in the cochlea were found within the stria vascularis, a barrier epithelium containing the primary vasculature of the inner ear...
  40. Shi X, Nuttall A. Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress. Brain Res. 2003;967:1-10 pubmed
    ..In the normal animals, iNOS expression was not observed in the vascular endothelium of the stria vascularis and only weak iNOS immunoactivity was detected in the marginal cells...
  41. Nelson E, Hinojosa R. Presbycusis: a human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume. Laryngoscope. 2003;113:1672-86 pubmed
    The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with presbycusis and flat audiometric patterns of hearing loss...
  42. Cable J, Jackson I, Steel K. Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear. Pigment Cell Res. 1993;6:215-25 pubmed
    ..studies on W-locus spotting mutants, from which melanocytes are absent, have shown that melanocytes in the stria vascularis of the inner ear are essential for the development and/or maintenance of the endocochlear potential (EP) ..
  43. Kohn S, Fradis M, Podoshin L, Ben David J, Zidan J, Robinson E. Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin. Ultrastruct Pathol. 1997;21:289-99 pubmed
    ..The authors report a detailed electron microscopic study of blood vessels in stria vascularis of guinea pigs after treatment with cisplatin alone and in combination with gentamicin...
  44. Iwanaga T, Tanaka F, Tsukasaki N, Terakado M, Kaieda S, Takasaki K, et al. Does topical application of 5-fluorouracil ointment influence inner ear function?. Otolaryngol Head Neck Surg. 2006;134:961-5 pubmed
    ..To investigate the effect of 5-fluorouracil (5-FU) ointment on the inner ear of guinea pigs...
  45. Wang W, Yang J, Lin Y, Yang J, Li S. Novel expression patterns of connexin 30.3 in adult rat cochlea. Hear Res. 2010;265:77-82 pubmed publisher
    ..Expression of the Cx30.3 protein was detected in the spiral limbus, spiral ligament, spiral ganglion, and stria vascularis by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analyses...
  46. Nadol J, Shiao J, Burgess B, Ketten D, Eddington D, Gantz B, et al. Histopathology of cochlear implants in humans. Ann Otol Rhinol Laryngol. 2001;110:883-91 pubmed
    ..This finding suggests that abnormalities in the central auditory pathways are at least as important as spiral ganglion cell loss in limiting the performance of implant users...
  47. Kada S, Nakagawa T, Ito J. A mouse model for degeneration of the spiral ligament. J Assoc Res Otolaryngol. 2009;10:161-72 pubmed publisher
    ..These findings indicate that cochleae injected with 3 mM 3-NP may be useful in investigations designed to test the feasibility of new therapeutic manipulations for functional SL regeneration...
  48. Mustapha M, Fang Q, Gong T, Dolan D, Raphael Y, Camper S, et al. Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants. J Neurosci. 2009;29:1212-23 pubmed publisher
    ..novel defects of hormone deficiency related to deafness: (1) permanently impaired expression of KCNJ10 in the stria vascularis of Pit1(dw) mice, which likely contributes to the reduced endocochlear potential, (2) significant outer hair ..
  49. Umemura K, Kohno Y, Matsuno H, Uematsu T, Nakashima M. A new model for photochemically induced thrombosis in the inner ear microcirculation and the use of hearing loss as a measure for microcirculatory disorders. Eur Arch Otorhinolaryngol. 1990;248:105-8 pubmed
    ..suggest that the photochemical occlusion in the inner ear's microcirculation led to ischemic damage of the stria vascularis and the hair cells in the inner ear...
  50. Imamura S, Adams J. Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas. J Assoc Res Otolaryngol. 2003;4:196-218 pubmed
    ..Cytochemical changes in hair cells, spiral ganglion cells, and cells of the stria vascularis, spiral ligament, and spiral limbus were found beginning 4 days post administration...
  51. Sage C, Marcus D. Immunolocalization of P2Y4 and P2Y2 purinergic receptors in strial marginal cells and vestibular dark cells. J Membr Biol. 2002;185:103-15 pubmed
    ..Membrane proteins from gerbil brain, gerbil vestibular labyrinth and gerbil stria vascularis were isolated and analyzed by Western blot...
  52. Qiao L, Han Y, Zhang P, Cao Z, Qiu J. Detection of atrial natriuretic peptide and its receptor in marginal cells and cochlea tissues from the developing rats. Neuro Endocrinol Lett. 2011;32:187-92 pubmed
  53. Komune S, Wakizono S, Nakagawa T, Kimituki T, Hisashi K, Uemura T. Ototoxic effect of potassium canrenoate on the guinea pig cochlea. Acta Otolaryngol. 1991;111:719-27 pubmed
    ..This drug has been reported to damage only the marginal cells of the stria vascularis in the cochlea...