basilar membrane

Summary

Summary: A basement membrane in the cochlea that supports the hair cells of the ORGAN OF CORTI, consisting keratin-like fibrils. It stretches from the SPIRAL LAMINA to the basilar crest. The movement of fluid in the cochlea, induced by sound, causes displacement of the basilar membrane and subsequent stimulation of the attached hair cells which transform the mechanical signal into neural activity.

Top Publications

  1. Fridberger A, de Monvel J, Zheng J, Hu N, Zou Y, Ren T, et al. Organ of Corti potentials and the motion of the basilar membrane. J Neurosci. 2004;24:10057-63 pubmed
    ..To test this theory, both electric potentials inside the organ of Corti and basilar membrane vibration were measured in response to acoustic stimulation...
  2. Cooper N. Two-tone suppression in cochlear mechanics. J Acoust Soc Am. 1996;99:3087-98 pubmed
    Mechanical responses to one- and two-tone stimuli were recorded from the basilar membrane (BM) in the hook region of the guinea-pig cochlea...
  3. Cooper N, Guinan J. Efferent-mediated control of basilar membrane motion. J Physiol. 2006;576:49-54 pubmed
    ..developments have allowed the effects of the MOCE system to be observed in vivo at the level of the basilar membrane (BM)...
  4. He W, Nuttall A, Ren T. Two-tone distortion at different longitudinal locations on the basilar membrane. Hear Res. 2007;228:112-22 pubmed
    ..In a recent study, the basilar membrane (BM) vibration at 2f1-f2 was measured as a function of the longitudinal location, using a scanning laser ..
  5. Andoh M, Nakajima C, Wada H. Phase of neural excitation relative to basilar membrane motion in the organ of Corti: theoretical considerations. J Acoust Soc Am. 2005;118:1554-65 pubmed
    ..transduction process is dependent on neural excitation of the auditory nerve in relation to motion of the basilar membrane (BM) in the organ of Corti (OC), specifics of this process are unclear...
  6. Ramamoorthy S, Deo N, Grosh K. A mechano-electro-acoustical model for the cochlea: response to acoustic stimuli. J Acoust Soc Am. 2007;121:2758-73 pubmed
    ..The model is vetted using a variety of experimental data on basilar membrane motion and data on voltages and currents in the OoC...
  7. Meaud J, Grosh K. The effect of tectorial membrane and basilar membrane longitudinal coupling in cochlear mechanics. J Acoust Soc Am. 2010;127:1411-21 pubmed publisher
    ..However, recent experimental data suggest that viscoelastic longitudinal coupling, in the basilar membrane (BM) and the tectorial membrane (TM), is non-negligible...
  8. Overstreet E, Temchin A, Ruggero M. Passive basilar membrane vibrations in gerbil neonates: mechanical bases of cochlear maturation. J Physiol. 2002;545:279-88 pubmed
    Using a laser velocimeter, basilar membrane (BM) responses to tones were measured in neonatal gerbils at a site near the round window of the cochlea...
  9. Nam J, Fettiplace R. Force transmission in the organ of Corti micromachine. Biophys J. 2010;98:2813-21 pubmed publisher
    ..via deformation of the organ of Corti, a complex assembly of sensory and supporting cells riding on the basilar membrane. Using finite element analysis, we present a three-dimensional model to illustrate deformation of the organ ..

More Information

Publications62

  1. Meaud J, Grosh K. Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model. Biophys J. 2011;100:2576-85 pubmed publisher
    ..The results suggest a new theory for high frequency active cochlear mechanics, in which fast adaptation controls the transduction channel sensitivity and thereby the magnitude of the energy delivered by somatic motility...
  2. Rhode W, Recio A. Basilar-membrane response to multicomponent stimuli in chinchilla. J Acoust Soc Am. 2001;110:981-94 pubmed
    The response of chinchilla basilar membrane in the basal region of the cochlea to multicomponent (1, 3, 5, 6, or 7) stimuli was studied using a laser interferometer...
  3. Shera C. Frequency glides in click responses of the basilar membrane and auditory nerve: their scaling behavior and origin in traveling-wave dispersion. J Acoust Soc Am. 2001;109:2023-34 pubmed
    Frequency modulations (or glides), reported in impulse responses of both the auditory nerve and the basilar membrane, represent a change over time in the instantaneous frequency of oscillation of the response waveform...
  4. Recio A, Rhode W. Basilar membrane responses to broadband stimuli. J Acoust Soc Am. 2000;108:2281-98 pubmed
    b>Basilar membrane (BM) responses to two types of broadband stimuli-clicks and Schroeder-phase complexes--were recorded at several sites at the base of the chinchilla cochlea. Recording sites (characteristic frequency, CF, in the range of 5...
  5. Legan P, Lukashkina V, Goodyear R, Kössi M, Russell I, Richardson G. A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron. 2000;28:273-85 pubmed
    ..b>Basilar membrane responses of wild-type mice exhibit a second resonance, indicating that the tectorial membrane provides an ..
  6. Khanna S, Hao L. Amplification in the apical turn of the cochlea with negative feedback. Hear Res. 2000;149:55-76 pubmed
    The apical turn of the anesthetized guinea pig cochlea was opened to examine the basilar membrane optically through the intact Reissner's membrane...
  7. Olson E. Intracochlear pressure measurements related to cochlear tuning. J Acoust Soc Am. 2001;110:349-67 pubmed
    Pressure in turn one of the scala tympani (s.t.) was measured close to the basilar membrane (b.m.) and at additional positions as the pressure sensor approached and/or withdrew from the b.m. The s.t...
  8. Giguere C, Woodland P. A computational model of the auditory periphery for speech and hearing research. I. Ascending path. J Acoust Soc Am. 1994;95:331-42 pubmed
    ..the propagation through the concha and auditory canal; (c) the transmission through the middle ear; (d) the basilar membrane motion and cochlear hydrodynamics; (e) the fast motile mechanism of the outer hair cells; and (f) the neural ..
  9. Siegel J, Cerka A, Recio Spinoso A, Temchin A, van Dijk P, Ruggero M. Delays of stimulus-frequency otoacoustic emissions and cochlear vibrations contradict the theory of coherent reflection filtering. J Acoust Soc Am. 2005;118:2434-43 pubmed
    ..with hypotheses of SFOAE propagation to the stapes via acoustic waves or fluid coupling, or via reverse basilar membrane traveling waves with speeds corresponding to the signal-front delays, rather than the group delays, of the ..
  10. Lukashkin A, Walling M, Russell I. Power amplification in the mammalian cochlea. Curr Biol. 2007;17:1340-4 pubmed
    ..that this process works by pumping energy to augment the otherwise damped sound-induced vibrations of the basilar membrane [2-4], a mechanism known as negative damping...
  11. Cheatham M. Comment on "Mutual suppression in the 6 kHz region of sensitive chinchilla cochleae" [J. Acoust. Soc. Am. 121, 2805-2818 (2007)]. J Acoust Soc Am. 2008;123:602-5 pubmed publisher
    ..acknowledges that two-tone neural rate responses for low-side suppression differ from those measured in basilar membrane mechanics, making one question whether this aspect of suppression has a mechanical correlate...
  12. Homer M, Champneys A, Hunt G, Cooper N. Mathematical modeling of the radial profile of basilar membrane vibrations in the inner ear. J Acoust Soc Am. 2004;116:1025-34 pubmed
    Motivated by recent experimental results, an explanation is sought for the asymmetry in the radial profile of basilar membrane vibrations in the inner ear...
  13. Grosh K, Zheng J, Zou Y, de Boer E, Nuttall A. High-frequency electromotile responses in the cochlea. J Acoust Soc Am. 2004;115:2178-84 pubmed
    ..in vivo electrical stimulation of the guinea pig cochlea is found to induce a mechanical response of the basilar membrane for frequencies to at least 100 kHz, nearly twice the upper limit of hearing for the guinea pig...
  14. Sisto R, Moleti A. Transient evoked otoacoustic emission input/output function and cochlear reflectivity: experiment and model. J Acoust Soc Am. 2008;124:2995-3008 pubmed publisher
    ..Possible interpretations of this phenomenology are critically reviewed and discussed, considering the theoretical uncertainties and the limitations of the experimental technique...
  15. Recio Spinoso A, Narayan S, Ruggero M. Basilar membrane responses to noise at a basal site of the chinchilla cochlea: quasi-linear filtering. J Assoc Res Otolaryngol. 2009;10:471-84 pubmed publisher
    b>Basilar membrane responses to clicks and to white noise were recorded using laser velocimetry at basal sites of the chinchilla cochlea with characteristic frequencies near 10 kHz...
  16. Temchin A, Recio Spinoso A, Cai H, Ruggero M. Traveling waves on the organ of corti of the chinchilla cochlea: spatial trajectories of inner hair cell depolarization inferred from responses of auditory-nerve fibers. J Neurosci. 2012;32:10522-9 pubmed publisher
    ..5-9 mm transition region, from where antiphasic reflections arise...
  17. Overstreet E, Temchin A, Ruggero M. Basilar membrane vibrations near the round window of the gerbil cochlea. J Assoc Res Otolaryngol. 2002;3:351-61 pubmed
    Using a laser velocimeter, responses to tones were measured at a basilar membrane site located about 1.2 mm from the extreme basal end of the gerbil cochlea...
  18. He W, Fridberger A, Porsov E, Ren T. Fast reverse propagation of sound in the living cochlea. Biophys J. 2010;98:2497-505 pubmed publisher
    ..emissions were provoked by two tones with a constant frequency ratio, and measured as vibrations at the basilar membrane and at the stapes, and as sound pressure in the ear canal...
  19. Meaud J, Grosh K. Response to a pure tone in a nonlinear mechanical-electrical-acoustical model of the cochlea. Biophys J. 2012;102:1237-46 pubmed publisher
    ..Compressive nonlinearity, harmonic distortion, and DC shift on the basilar membrane (BM), tectorial membrane (TM), and OHC potentials are predicted using a single set of parameters...
  20. Fleischer M, Schmidt R, Gummer A. Compliance profiles derived from a three-dimensional finite-element model of the basilar membrane. J Acoust Soc Am. 2010;127:2973-91 pubmed publisher
    ..conditions, and geometry, including coiling, on the spatial characteristics of the compliance of the unloaded basilar membrane (BM)...
  21. Chen F, Zha D, Fridberger A, Zheng J, Choudhury N, Jacques S, et al. A differentially amplified motion in the ear for near-threshold sound detection. Nat Neurosci. 2011;14:770-4 pubmed publisher
    ..Such faint sounds produce 0.1-nm basilar membrane displacements, a distance smaller than conformational transitions in ion channels...
  22. Parsa A, Webster P, Kalinec F. Deiters cells tread a narrow path--the Deiters cells-basilar membrane junction. Hear Res. 2012;290:13-20 pubmed publisher
    Deiters cells extend from the basilar membrane to the reticular lamina and, together with pillar cells and outer hair cells, structurally define the micro-architecture of the organ of Corti...
  23. de Boer E, Zheng J, Porsov E, Nuttall A. Inverted direction of wave propagation (IDWP) in the cochlea. J Acoust Soc Am. 2008;123:1513-21 pubmed publisher
    ..view on wave propagation is that propagating waves are possible in both directions along the length of the basilar membrane and that they have identical properties. Results of several recently executed experiments [T. Ren, Nat...
  24. Rhode W. Basilar membrane mechanics in the 6-9 kHz region of sensitive chinchilla cochleae. J Acoust Soc Am. 2007;121:2792-804 pubmed
    The vibration of the basilar membrane in the 6-9 kHz region in the chinchilla cochlea has been studied using a displacement sensitive interferometer. Displacements of 0.7-1.4 nm at 0 dB sound pressure level have been obtained...
  25. Kha H, Chen B. Finite element analysis of damage by cochlear implant electrode array's proximal section to the basilar membrane. Otol Neurotol. 2012;33:1176-80 pubmed publisher
    This study aims to examine the mechanism of damage to the basilar membrane caused by the proximal section of the cochlear implant electrode array.
  26. Versteegh C, van der Heijden M. Basilar membrane responses to tones and tone complexes: nonlinear effects of stimulus intensity. J Assoc Res Otolaryngol. 2012;13:785-98 pubmed publisher
    ..We measured responses of the gerbil basilar membrane to single-tone and wideband stimuli and compared them, while focusing on nonlinear aspects of the response...
  27. Ren T, He W, Porsov E. Localization of the cochlear amplifier in living sensitive ears. PLoS ONE. 2011;6:e20149 pubmed publisher
    ..Although the cochlear amplifier is thought to be a local cellular process at an area basal to the response peak on the spiral basilar membrane, its location has not been demonstrated experimentally.
  28. He W, Ren T. Basilar membrane vibration is not involved in the reverse propagation of otoacoustic emissions. Sci Rep. 2013;3:1874 pubmed publisher
    ..emission, exits the cochlea, we created a sound source electrically in the second turn and measured basilar membrane vibrations at two longitudinal locations in the first turn in living gerbil cochleae using a laser ..
  29. Naidu R, Mountain D. Basilar membrane tension calculations for the gerbil cochlea. J Acoust Soc Am. 2007;121:994-1002 pubmed
    Anatomical studies suggest that the basilar membrane (BM) supports a radial tension, which is potentially important in cochlear mechanics...
  30. Lu T, Zhak S, Dallos P, Sarpeshkar R. Fast cochlear amplification with slow outer hair cells. Hear Res. 2006;214:45-67 pubmed
    ..Thus, emergent closed-loop network dynamics differ significantly from open-loop component dynamics, a generally important principle in complex biological systems...
  31. Russell I, Legan P, Lukashkina V, Lukashkin A, Goodyear R, Richardson G. Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane. Nat Neurosci. 2007;10:215-23 pubmed
    Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane ..
  32. Cooper N. Harmonic distortion on the basilar membrane in the basal turn of the guinea-pig cochlea. J Physiol. 1998;509 ( Pt 1):277-88 pubmed
    1. Mechanical responses to pure-tone stimuli were recorded from the basilar membrane in the basal turn of the guinea-pig cochlea using a displacement-sensitive laser interferometer...
  33. Wada H, Sugawara M, Kobayashi T, Hozawa K, Takasaka T. Measurement of guinea pig basilar membrane using computer-aided three-dimensional reconstruction system. Hear Res. 1998;120:1-6 pubmed
    ..are known to have the ability to analyze a frequency widely, and this ability seems to be owed mostly to the basilar membrane (BM) configuration...
  34. Ren T. Reverse propagation of sound in the gerbil cochlea. Nat Neurosci. 2004;7:333-4 pubmed
    ..forward-traveling but not backward-traveling waves and found that the stapes vibrates earlier than the basilar membrane. These results contradict the current theory and show that the ear emits sounds through the cochlear fluids ..
  35. de Boer E, Nuttall A. The mechanical waveform of the basilar membrane. III. Intensity effects. J Acoust Soc Am. 2000;107:1497-507 pubmed
    ..All these findings illustrate the predictive power of the underlying model...
  36. Zou Y, Zheng J, Nuttall A, Ren T. The sources of electrically evoked otoacoustic emissions. Hear Res. 2003;180:91-100 pubmed
    ..It has been hypothesized that electrically evoked otoacoustic emissions (EEOAEs) are generated at a site on the basilar membrane near the stimulating electrode...
  37. Bhatt K, Liberman M, Nadol J. Morphometric analysis of age-related changes in the human basilar membrane. Ann Otol Rhinol Laryngol. 2001;110:1147-53 pubmed
    ..an "indeterminate category"; however, several studies have suggested that a disorder of the basilar membrane (BM) may underlie indeterminate presbycusis...
  38. Moore B, Alcántara J, Glasberg B. Behavioural measurement of level-dependent shifts in the vibration pattern on the basilar membrane. Hear Res. 2002;163:101-10 pubmed
    Physiological data suggest that the travelling wave on the basilar membrane evoked by a sinusoid of fixed frequency moves towards the base with increasing level...
  39. Mulroy M, Henry W, McNeil P. Noise-induced transient microlesions in the cell membranes of auditory hair cells. Hear Res. 1998;115:93-100 pubmed
    ..We propose that the Lucifer yellow entered the hair cells via noise-induced lesions in their cell membranes, and that the cells were able to survive and recover functionally...
  40. Hemmert W, Zenner H, Gummer A. Three-dimensional motion of the organ of Corti. Biophys J. 2000;78:2285-97 pubmed
    ..The frequency responses of the basilar membrane and the reticular lamina were similar, with little phase differences between the vibration components...
  41. Rhode W, Recio A. Study of mechanical motions in the basal region of the chinchilla cochlea. J Acoust Soc Am. 2000;107:3317-32 pubmed
    Measurements from the 1-4-mm basal region of the chinchilla cochlea indicate the basilar membrane in the hook region (12-18 kHz) vibrates essentially as it does more apically, in the 5-9-kHz region...
  42. Koike T, Sakamoto C, Sakashita T, Hayashi K, Kanzaki S, Ogawa K. Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane. Hear Res. 2012;283:117-25 pubmed publisher
    ..Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with ..
  43. Rhode W, Recio A. Multicomponent stimulus interactions observed in basilar-membrane vibration in the basal region of the chinchilla cochlea. J Acoust Soc Am. 2001;110:3140-54 pubmed
    ..Suppression decreased for multicomponent stimuli with component frequency spacing greater than 600 Hz. Mutual suppression occurred whenever stimulus components were within the compressive region of the basilar membrane.
  44. de B, Nuttall A. The mechanical waveform of the basilar membrane. IV. Tone and noise stimuli. J Acoust Soc Am. 2002;111:979-89 pubmed
    ..Therefore, the model explains why the type of filtering that tones undergo in the cochlea is essentially the same as that for noise signals (provided the tones are presented at the appropriate level)...
  45. Zidanic M. Cholinergic innervation of the chick basilar papilla. J Comp Neurol. 2002;445:159-75 pubmed
    ..The inferior efferent system was composed of thick fibers that coursed radially across the basilar membrane in small fascicles, gave off small branches that innervated short hair cells with large cup-like endings, and ..
  46. Moore B, Glasberg B. Behavioural measurement of level-dependent shifts in the vibration pattern on the basilar membrane at 1 and 2 kHz. Hear Res. 2003;175:66-74 pubmed
    Physiological data suggest that the peak of the travelling wave on the basilar membrane evoked by a high-frequency sinusoid moves towards the base with increasing level...
  47. Palmer A, Shackleton T. Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency. J Assoc Res Otolaryngol. 2009;10:233-50 pubmed publisher
    The directionality of hair cell stimulation combined with the vibration of the basilar membrane causes the auditory nerve fiber action potentials, in response to low-frequency stimuli, to occur at a particular phase of the stimulus ..
  48. Dallos P. Organ of Corti kinematics. J Assoc Res Otolaryngol. 2003;4:416-21 pubmed
    The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model...
  49. Liu S, White R. Orthotropic material properties of the gerbil basilar membrane. J Acoust Soc Am. 2008;123:2160-71 pubmed publisher
    ..Orthotropy ratios (the ratio of the two elastic moduli) are in the range of 65 close to the base to 10 in the upper middle turn of the cochlea...
  50. Xenellis J, Linthicum F, Webster P, Lopez R. Basilar membrane displacement related to endolymphatic sac volume. Laryngoscope. 2004;114:1953-9 pubmed
    To demonstrate that the amount of basilar membrane displacement toward the scala tympani and its attachment to the bony wall of the scala tympani (i.e...
  51. Holmes S, Sumner C, O Mard L, Meddis R. The temporal representation of speech in a nonlinear model of the guinea pig cochlea. J Acoust Soc Am. 2004;116:3534-45 pubmed
    ..The model consists of a bank of dual resonance nonlinear filters that simulate the vibratory response of the basilar membrane followed by a model of the inner hair cell/auditory nerve complex...
  52. Lukashkin A, Bashtanov M, Russell I. A self-mixing laser-diode interferometer for measuring basilar membrane vibrations without opening the cochlea. J Neurosci Methods. 2005;148:122-9 pubmed
    ..Measurements of sound-induced basilar membrane displacements were made in the intact cochleae of rodents by focusing the laser beam of the interferometer ..
  53. Naidu R, Mountain D. Longitudinal coupling in the basilar membrane. J Assoc Res Otolaryngol. 2001;2:257-67 pubmed
    A systematic and detailed study of the longitudinal coupling exhibited by the basilar membrane (BM) was performed in the excised gerbil cochlea...