human mammary glands


Summary: Glandular tissue in the BREAST of human that is under the influence of hormones such as ESTROGENS; PROGESTINS; and PROLACTIN. In WOMEN, after PARTURITION, the mammary glands secrete milk (MILK, HUMAN) for the nourishment of the young.

Top Publications

  1. Ahmed S, Campbell R, Li J, Wang L, Robinson Bostom L. Adenoma of anogenital mammary-like glands. J Am Acad Dermatol. 2007;57:896-8 pubmed
    ..The possibility of adenomas of anogenital mammary-like glands should be considered when evaluating patients with a mass in this area with confirmation by tissue biopsy or aspiration cytology...
  2. Carter J, Mizell K, Tucker J. Mammary-type fibroepithelial neoplasms of the vulva: a case report and review of the literature. J Cutan Pathol. 2008;35:246-9 pubmed publisher
    ..No ectopic breast tissue was identified outside the lesion. The theories of histogenesis of these neoplasms and additional cases of mammary-type lesions of the vulva reported in the medical literature are reviewed...
  3. Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704-15 pubmed publisher
    ..Moreover, stem-like cells isolated either from mouse or human mammary glands or mammary carcinomas express EMT markers...
  4. Adissu H, Asem E, LELIEVRE S. Three-dimensional cell culture to model epithelia in the female reproductive system. Reprod Sci. 2007;14:11-9 pubmed publisher
  5. Lanitis S, Filippakis G, Thomas J, Christofides T, Al Mufti R, Hadjiminas D. Microdochectomy for single-duct pathologic nipple discharge and normal or benign imaging and cytology. Breast. 2008;17:309-13 pubmed publisher
    ..Pre-operative workup and imaging may not be suspicious in patients with single-duct PND and underlying malignancy, therefore, microdochectomy should be considered in such cases...
  6. Liu S, Ginestier C, Charafe Jauffret E, Foco H, Kleer C, Merajver S, et al. BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A. 2008;105:1680-5 pubmed publisher
    ..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
  7. Tanos T, Brisken C. What signals operate in the mammary niche?. Breast Dis. 2008;29:69-82 pubmed
    ..Some of the downstream mediators are in common with other niches such as Wnt and possibly Notch signaling. Other signals are specific to the mammary gland such as amphiregulin and RANKL...
  8. Yu M, Smolen G, Zhang J, Wittner B, Schott B, Brachtel E, et al. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 2009;23:1737-42 pubmed publisher
    ..Thus, aberrant expression of LBX1 may lead to the activation of a developmentally regulated EMT pathway in human breast cancer...
  9. Joslin E, Opresko L, Wells A, Wiley H, Lauffenburger D. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J Cell Sci. 2007;120:3688-99 pubmed
    ..Thus, in our mammary epithelial cell system, migration and proliferation are differentially sensitive to the mode of EGF ligand presentation...

More Information

Publications109 found, 100 shown here

  1. Jones F. HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer. J Mammary Gland Biol Neoplasia. 2008;13:247-58 pubmed publisher
    ..In addition a developmental and temporal model of 4ICD action in the normal breast and during the progression of breast cancer will be presented to explain the paradox of divergent HER4 and 4ICD activities...
  2. Ansieau S, Bastid J, Doreau A, Morel A, Bouchet B, Thomas C, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell. 2008;14:79-89 pubmed publisher
    ..These findings suggest an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells...
  3. Plachot C, Chaboub L, Adissu H, Wang L, Urazaev A, Sturgis J, et al. Factors necessary to produce basoapical polarity in human glandular epithelium formed in conventional and high-throughput three-dimensional culture: example of the breast epithelium. BMC Biol. 2009;7:77 pubmed publisher
    ..Although factors important for the establishment of basal polarity have been identified, requirements for the formation of apical polarity in three-dimensional tissue structures have not been thoroughly investigated...
  4. Visvader J. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 2009;23:2563-77 pubmed publisher
    ..Potential relationships between normal epithelial populations and breast tumor subtypes are discussed, with implications for understanding the cellular etiology underpinning breast tumor heterogeneity...
  5. Brantley Sieders D, Zhuang G, Hicks D, Fang W, Hwang Y, Cates J, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118:64-78 pubmed
    ..Moreover, EphA2 function in tumor progression appeared to depend on oncogene context, an important consideration for the application of therapies targeting EphA2...
  6. Mailleux A, Overholtzer M, Brugge J. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle. 2008;7:57-62 pubmed
    ..Herein we put into perspective the relevance of our in vitro and in vivo findings to discuss luminal space formation and maintenance during mammary morphogenesis...
  7. Ginestier C, Hur M, Charafe Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007;1:555-67 pubmed publisher
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  8. Howard B. The role of NRG3 in mammary development. J Mammary Gland Biol Neoplasia. 2008;13:195-203 pubmed publisher
    ..Here evidence for a key function for NRG3 in promoting early mammary morphogenesis and the implication for the role of NRG3 in breast cancer and establishment of the mammary lineage are discussed...
  9. Chen A, Cuevas I, Kenny P, Miyake H, Mace K, Ghajar C, et al. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009;69:6721-9 pubmed publisher
    ..These data confirm the importance of tissue architecture and polarity in malignant progression...
  10. Farnie G, Clarke R. Mammary stem cells and breast cancer--role of Notch signalling. Stem Cell Rev. 2007;3:169-75 pubmed
  11. Monks J. TGFbeta as a potential mediator of progesterone action in the mammary gland of pregnancy. J Mammary Gland Biol Neoplasia. 2007;12:249-57 pubmed
    ..Yet no formal link between the two has ever been established. This work aims to review the evidence for and against a link between progesterone and TGFbeta, raise unanswered questions, and to propose further lines of research...
  12. Zhang H, Liu G, Dziubinski M, Yang Z, Ethier S, Wu G. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells. Breast Cancer Res Treat. 2008;112:217-27 pubmed
  13. Smith G, Medina D. Re-evaluation of mammary stem cell biology based on in vivo transplantation. Breast Cancer Res. 2008;10:203 pubmed publisher
    ..In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions...
  14. Rodland K, Bollinger N, Ippolito D, Opresko L, Coffey R, Zangar R, et al. Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells. J Biol Chem. 2008;283:31477-87 pubmed publisher
  15. Chen C, Nelson C, Khauv D, Bennett S, Radisky E, Hirai Y, et al. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem. 2009;284:6877-84 pubmed publisher
    ..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally...
  16. Lim E, Vaillant F, Wu D, Forrest N, Pal B, Hart A, et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med. 2009;15:907-13 pubmed publisher
    ..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
  17. Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman J, et al. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med. 2008;14:1384-9 pubmed publisher
    ..This new assay procedure sets the stage for investigations of mechanisms regulating normal human mammary stem cells (and possibly stem cells in other tissues) and their relationship to human cancer stem cell populations...
  18. Stingl J, Raouf A, Eirew P, Eaves C. Deciphering the mammary epithelial cell hierarchy. Cell Cycle. 2006;5:1519-22 pubmed
    ..Suggestive parallels between mouse and human mammary cells point to the likelihood that a similarly structured multi-step differentiation program characterizes the mammary gland from both species...
  19. Derksen P, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006;10:437-49 pubmed
    ..Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis...
  20. Fackler M, Malone K, Zhang Z, Schilling E, Garrett Mayer E, Swift Scanlan T, et al. Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid. Clin Cancer Res. 2006;12:3306-10 pubmed
    ..We hypothesized that quantitative analysis of methylated genes will provide enhanced detection of cancer cells present in cytologic specimens...
  21. Hunerbein M, Raubach M, Gebauer B, Schneider W, Schlag P. Ductoscopy and intraductal vacuum assisted biopsy in women with pathologic nipple discharge. Breast Cancer Res Treat. 2006;99:301-7 pubmed
    ..A major limitation of this technique is the inability to obtain tissue samples from suspicious intraductal lesions. We present a novel technique for ductoscopic biopsy of intraluminal tumors...
  22. Going J, Mohun T. Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer. Breast Cancer Res Treat. 2006;97:285-91 pubmed
  23. Dillon M, Mohd Nazri S, Nasir S, McDermott E, Evoy D, Crotty T, et al. The role of major duct excision and microdochectomy in the detection of breast carcinoma. BMC Cancer. 2006;6:164 pubmed
    ..The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma...
  24. Lakhani S, Bissell M. Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland. J Mammary Gland Biol Neoplasia. 2005;10:197-8 pubmed
  25. Dontu G, Liu S, Wicha M. Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem Cell Rev. 2005;1:207-13 pubmed
    ..Furthermore, the concept of cancer as a disease of stem and progenitor cells has profound implications for the development of new strategies for cancer prevention and therapy...
  26. Shipitsin M, Campbell L, Argani P, Weremowicz S, Bloushtain Qimron N, Yao J, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007;11:259-73 pubmed
    ..Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations...
  27. Song L, Miele L. Cancer stem cells--an old idea that's new again: implications for the diagnosis and treatment of breast cancer. Expert Opin Biol Ther. 2007;7:431-8 pubmed
    ..The authors present a brief overview of this theory, its potential implications and the evidence supporting it, focusing specifically on breast cancer...
  28. Grunwald S, Heyer H, Paepke S, Schwesinger G, Schimming A, Hahn M, et al. Diagnostic value of ductoscopy in the diagnosis of nipple discharge and intraductal proliferations in comparison to standard methods. Onkologie. 2007;30:243-8 pubmed
    ..Ductoscopy is gaining increased importance in the diagnosis of nipple discharge of unclear origin and intraductal proliferation. For this reason we compared its diagnostic value and feasibility to standard diagnostic methods...
  29. Kumar N, Zaman M, Kim H, Lauffenburger D. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. Biophys J. 2006;91:L32-4 pubmed
    ..Observed consistent increases in persistence associated with HER2 overexpression indicate a prospective mechanism for invasiveness previously documented in HER2-overexpressing human breast tumors...
  30. Grunwald S, Bojahr B, Schwesinger G, Schimming A, Kohler G, Schulz K, et al. Mammary ductoscopy for the evaluation of nipple discharge and comparison with standard diagnostic techniques. J Minim Invasive Gynecol. 2006;13:418-23 pubmed
    ..To describe performance of breast duct endoscopy and compare the method with conventional diagnostic techniques...
  31. Watson C. Post-lactational mammary gland regression: molecular basis and implications for breast cancer. Expert Rev Mol Med. 2006;8:1-15 pubmed
    ..In this review, I discuss the roles of the JAK-STAT, NF-kappaB and other signalling pathways in the regulation of apoptosis and tissue remodelling during involution...
  32. Lee G, Kenny P, Lee E, Bissell M. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods. 2007;4:359-65 pubmed
    ..Alternatively, the 3D 'on-top' assay, in which cells are cultured on top of a thin lrECM gel overlaid with a dilute solution of lrECM, may be used as described in Box 2 (Fig. 1 and Fig. 2)...
  33. Proia D, Kuperwasser C. Reconstruction of human mammary tissues in a mouse model. Nat Protoc. 2006;1:206-14 pubmed
    ..As a whole, this model system has the potential to improve the understanding of crosstalk between tissue stroma and the epithelium as well as factors involved in breast stem cell biology tumor initiation and progression...
  34. Cowling V, D Cruz C, Chodosh L, Cole M. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol. 2007;27:5135-46 pubmed
    ..DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation. We propose a positive feedback loop for activation of the c-myc and Wnt pathways in breast cancer...
  35. Liu S, Dontu G, Mantle I, Patel S, Ahn N, Jackson K, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006;66:6063-71 pubmed
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  36. Labrie F. Dehydroepiandrosterone, androgens and the mammary gland. Gynecol Endocrinol. 2006;22:118-30 pubmed
  37. Villadsen R, Fridriksdottir A, Rønnov Jessen L, Gudjonsson T, Rank F, Labarge M, et al. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007;177:87-101 pubmed
    ..These findings identify an adult human breast ductal stem cell activity and its earliest descendants...
  38. Hollosi P, Yakushiji J, Fong K, Csiszar K, Fong S. Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. Int J Cancer. 2009;125:318-27 pubmed publisher
    ..Additional data suggest epigenetic molecular mechanisms in tumor specific regulation of LOXL2 expression that could be explored as a molecular target in the prevention of breast cancer progression. ..
  39. Xu P, Li M, Zhang L, Sun Q, Lv S, Lian B, et al. Application of case classification in healthcare quality assessment in China. Health Inf Manag. 2012;41:22-9 pubmed
    ..Implementation of the case classification for healthcare quality assessment permitted the comparison of quality among different healthcare departments. ..
  40. Travis M, Streuli C. The Immunology of Breast Development. Dev Cell. 2015;34:487-8 pubmed publisher
    ..However, in this issue of Developmental Cell, Plaks et al. (2015) reveal that antigen-presenting cells and T cells have a key role in controlling the development of the mammary gland's epithelial ductal network. ..
  41. Lou P, Li C, Shi L, Xia T, Zhou W, Wu J, et al. RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer. Oncotarget. 2017;8:16387-16400 pubmed publisher
    ..Conclusively, we revealed a novel mechanism by which PR could be regulated by RNPC1 via stabilizing its mRNA. ..
  42. Chen W, Liu Y, Barkema H, Gao J, De Buck J, Kastelic J, et al. Short communication: Molecular characteristics, antimicrobial susceptibility, and pathogenicity of clinical Nocardia cyriacigeorgica isolates from an outbreak of bovine mastitis. J Dairy Sci. 2017;100:8414-8421 pubmed publisher
    ..Therefore, we concluded that N. cyriacigeorgica was involved in the current outbreak of mastitis. To our best knowledge, this is the first report to characterize N. cyriacigeorgica isolated from cases of bovine mastitis in China. ..
  43. Ambrosone C, Abrams S, Gorlewska Roberts K, Kadlubar F. Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells. Arch Biochem Biophys. 2007;464:169-75 pubmed
    ..2, 95% CI=1.1-109.2) but not tobacco usage. These data indicate that women are exposed to several classes of dietary and environmental carcinogens and that metabolic genotype can be a susceptibility factor. ..
  44. Na H, Kim E, Jung J, Lee H, Hyun J, Surh Y. (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Arch Biochem Biophys. 2008;476:171-7 pubmed publisher
  45. Osorio J, Lohakare J, Bionaz M. Biosynthesis of milk fat, protein, and lactose: roles of transcriptional and posttranscriptional regulation. Physiol Genomics. 2016;48:231-56 pubmed publisher
    ..This model encompasses a complex network of proteins that control milk synthesis with a cross talk between milk fat, protein, and lactose regulation, with mTOR functioning as a central hub. ..
  46. Adkins P, Middleton J, Fox L. Comparison of Virulence Gene Identification, Ribosomal Spacer PCR, and Pulsed-Field Gel Electrophoresis for Typing of Staphylococcus aureus Strains Isolated from Cases of Subclinical Bovine Mastitis in the United States. J Clin Microbiol. 2016;54:1871-1876 pubmed publisher
    ..These data suggest that genotype B may have a limited geographic distribution and that PFGE is more discriminatory than RS-PCR performed with conventional gel electrophoresis for typing of S. aureus isolates of bovine origin. ..
    ..Predicting role of tumoral stroma in patients, suffering MGC with p53 hyperexpression, was studied. ..
  48. Wang M, Zhang Y, Zhu J. Anti-Staphylococcus aureus single-chain variable region fragments provide protection against mastitis in mice. Appl Microbiol Biotechnol. 2016;100:2153-62 pubmed publisher
    ..05). These novel bovine scFvs may be suitable candidates for therapeutic agents for the prevention of S. aureus-induced bovine mastitis. ..
  49. Jerry D, Shull J, Hadsell D, Rijnkels M, Dunphy K, Schneider S, et al. Genetic variation in sensitivity to estrogens and breast cancer risk. Mamm Genome. 2018;29:24-37 pubmed publisher
    ..Genetic variants in these pathways may identify a subset of women who are especially sensitive to either endogenous estrogens or environmental xenoestrogens and render them at increased risk of breast cancer. ..
  50. Strizzi L, Postovit L, Margaryan N, Seftor E, Abbott D, Seftor R, et al. Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression. Breast Dis. 2008;29:91-103 pubmed
    ..Moreover, we emphasize the potential utility of this signaling pathway as a novel target for the treatment and diagnosis of breast cancer. ..
  51. Reutfors J, Wingård L, Brandt L, Wang Y, Qiu H, Kieler H, et al. Risk of breast cancer in risperidone users: A nationwide cohort study. Schizophr Res. 2017;182:98-103 pubmed publisher
    ..Risperidone use does not confer an increased short-term risk of breast cancer compared to other antipsychotic agents. ..
  52. Kolla S, Pokharel A, Vandenberg L. The mouse mammary gland as a sentinel organ: distinguishing 'control' populations with diverse environmental histories. Environ Health. 2017;16:25 pubmed publisher
    ..Finally, our results challenge the relatively common practice of using historical controls in toxicological experiments. ..
  53. Brenmoehl J, Ohde D, Wirthgen E, Hoeflich A. Cytokines in milk and the role of TGF-beta. Best Pract Res Clin Endocrinol Metab. 2018;32:47-56 pubmed publisher
    ..In light of the increasing prevalence of inflammatory diseases of the gastrointestinal system, the effects of probiotic microorganisms during milk fermentation may have immunotherapeutic potential in the future. ..
  54. Haines E, Minoo P, Feng Z, Resalatpanah N, Nie X, Campiglio M, et al. Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol. 2009;29:2505-20 pubmed publisher
    ..Together, our results define a novel negative cross-regulation between PRL and EGF involving the Jak2/Stat5a and Ras/MAPK pathways through tyrosine phosphorylation of Grb2. ..
  55. Toyoda Y, Ishikawa T. Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure. Anticancer Agents Med Chem. 2010;10:617-24 pubmed
    ..Furthermore we focus on the impact of ABCC11 538G>A on the apocrine phenotype, patients' response to nucleoside-based chemotherapy, and the potential risk of breast cancer...
  56. Kerekes A, Hoffmann O, Iski G, Lipták N, Gócza E, Kues W, et al. Secretion of a recombinant protein without a signal peptide by the exocrine glands of transgenic rabbits. PLoS ONE. 2017;12:e0187214 pubmed publisher
    ..This finding has relevance not only for the understanding of the biological function of exocrine glands, but also for the design of constructs for expression of recombinant proteins in dairy animals...
  57. Hu X, He X, Zhou K, Zhang C, Zhao W, Zhang T, et al. The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells. J Neuroinflammation. 2017;14:213 pubmed publisher
  58. Pal B, Chen Y, Vaillant F, Jamieson P, Gordon L, Rios A, et al. Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling. Nat Commun. 2017;8:1627 pubmed publisher
  59. Bittante G, Cecchinato A, Schiavon S. Dairy system, parity, and lactation stage affect enteric methane production, yield, and intensity per kilogram of milk and cheese predicted from gas chromatography fatty acids. J Dairy Sci. 2018;101:1752-1766 pubmed publisher
  60. John K, Keshava C, Richardson D, Weston A, Nath J. Transcriptional profiles of benzo(a)pyrene exposure in normal human mammary epithelial cells in the absence or presence of chlorophyllin. Mutat Res. 2008;640:145-52 pubmed publisher
    ..Additionally, cluster analysis identified a suite of 16 genes down-regulated by BP where induction was partially restored in the presence of chlorophyllin. ..
  61. Page R, Dittrich L, King R, Boulos F, Page D. Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. J Cutan Pathol. 2009;36:1206-9 pubmed publisher
  62. Walker K, Fletcher O, Johnson N, Coupland B, McCormack V, Folkerd E, et al. Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors. Cancer Res. 2009;69:6490-9 pubmed publisher
    ..Most of these hormone-density associations were attenuated with further adjustment for BMI. ..
  63. Cui Y, Borysova M, Johnson J, Guadagno T. Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. Cancer Res. 2010;70:675-84 pubmed publisher
    ..We propose that disruption of mitotic controls by oncogenic B-Raf has important implications for understanding melanoma tumor development. ..
  64. Bonsaglia E, Gomes M, Canisso I, Zhou Z, Lima S, Rall V, et al. Milk microbiome and bacterial load following dry cow therapy without antibiotics in dairy cows with healthy mammary gland. Sci Rep. 2017;7:8067 pubmed publisher
    ..Dry cow therapy based on teat sealant without antibiotics can be used with no detrimental impacts on milk microbiome and bacterial load in cows with a healthy mammary gland. ..
  65. Ooishi T, Nadano D, Matsuda T, Oshima K. Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells. Genes Cells. 2017;22:885-899 pubmed publisher
    ..These results suggest that MFG-E8 requires EVs to transduce cellular signals from the basolateral side of the adhesion cells by accumulating in ECM. ..
  66. Alfonso Avila A, Baumann E, Charbonneau E, Chouinard P, Tremblay G, Gervais R. Interaction of potassium carbonate and soybean oil supplementation on performance of early-lactation dairy cows fed a high-concentrate diet. J Dairy Sci. 2017;100:9007-9019 pubmed publisher
    ..Overall, results have shown that potential effect of K2CO3 on milk fat synthesis is dependent on the levels of dietary polyunsaturated FA. ..
  67. Cai S, Kalisky T, Sahoo D, Dalerba P, Feng W, Lin Y, et al. A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland. Cell Stem Cell. 2017;20:247-260.e5 pubmed publisher
    ..Taken together, these results suggest that Bcl11b acts as a central intrinsic regulator of mammary epithelial stem cell quiescence and exhaustion and is necessary for long-term maintenance of the mammary gland. ..
  68. Shahi P, Wang C, Lawson D, Slorach E, Lu A, Yu Y, et al. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017;114:3169-3174 pubmed publisher
    ..Our data provide insight into a mechanism of GATA3 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies. ..
  69. Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed publisher
    ..Together, these data suggest that the WNT pathway confers proliferative and survival advantages on cap cells via regulation of FOXO1 localization. ..
  70. Heibeck T, Ding S, Opresko L, Zhao R, Schepmoes A, Yang F, et al. An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res. 2009;8:3852-61 pubmed publisher
  71. Kouros Mehr H, Kim J, Bechis S, Werb Z. GATA-3 and the regulation of the mammary luminal cell fate. Curr Opin Cell Biol. 2008;20:164-70 pubmed publisher
    ..This review explores our current understanding of GATA-3 signaling in luminal cell differentiation, both in mammary development and breast cancer. ..
  72. Mizuno K, Nishida Y, Mizuno N, Taki M, Murase M, Itabashi K. The important role of deep attachment in the uniform drainage of breast milk from mammary lobe. Acta Paediatr. 2008;97:1200-4 pubmed publisher
    ..01). The results revealed that deep attachment is helpful in draining milk from all mammary lobe uniformly, which may contribute to successful breastfeeding. ..
  73. Cariati M. Evaluating the link between stem cells and breast cancer. Expert Rev Anticancer Ther. 2008;8:1313-22 pubmed publisher
  74. Murase M, Mizuno K, Nishida Y, Mizuno N, Taki M, Yoshizawa M, et al. Comparison of creamatocrit and protein concentration in each mammary lobe of the same breast: does the milk composition of each mammary lobe differ in the same breast?. Breastfeed Med. 2009;4:189-95 pubmed publisher
    ..The protein content in the milk from each mammary lobe is determined by other factors, presumably by the feedback inhibitor of lactation, accumulated in the corresponding mammary lobe. ..
  75. Sodir N, Evan G. Nursing some sense out of Myc. J Biol. 2009;8:77 pubmed publisher
  76. Burute M, Prioux M, Blin G, Truchet S, Letort G, Tseng Q, et al. Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition. Dev Cell. 2017;40:168-184 pubmed publisher
    ..Sequential release of cell confinement using dynamic micropatterns, and modulation of microtubule dynamics, confirmed that centrosome repositioning was responsible for further cell disengagement and scattering. ..
  77. Kurian A, Hartman A, Mills M, Logan L, Sawyer A, Ford J, et al. Magnetic resonance galactography: a feasibility study in women with prior atypical breast duct cytology. Breast J. 2008;14:211-4 pubmed publisher
  78. Schwab S, Uder M, Schulz Wendtland R, Bautz W, Janka R, Wenkel E. Direct MR galactography: feasibility study. Radiology. 2008;249:54-61 pubmed publisher
    ..The highest detection rate for ductal disease compared with that at conventional galactography was found with the direct MR galactography CISS and FLASH sequences. ..
  79. Nilsson G, Holmberg L, Garmo H, Terent A, Blomqvist C. Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke. Br J Cancer. 2009;100:811-6 pubmed publisher
    ..Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke. ..
  80. Demichelis S, Alberdi C, Servi W, Isla Larrain M, Segal Eiras A, Croce M. Comparative immunohistochemical study of MUC1 and carbohydrate antigens in breast benign disease and normal mammary gland. Appl Immunohistochem Mol Morphol. 2010;18:41-50 pubmed publisher
    ..With respect to the pattern of expression, an apical pattern was predominantly found in all the groups. ..
  81. Zhang Y, Opresko L, Shankaran H, Chrisler W, Wiley H, Resat H. HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells. BMC Cell Biol. 2009;10:78 pubmed publisher
    ..Our results for HME cells show that the weak linkage between EGFR and HER3 pathways can lead to distinct downstream cellular signaling patterns in response to the ligands of these two receptors. ..
  82. Hannezo E, Scheele C, Moad M, Drogo N, Heer R, Sampogna R, et al. A Unifying Theory of Branching Morphogenesis. Cell. 2017;171:242-255.e27 pubmed publisher
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